LOCUS       NM_001013994            2870 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus REST corepressor 2 (Rcor2), mRNA.
ACCESSION   NM_001013994 XM_223926
VERSION     NM_001013994.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2870)
  AUTHORS   Upadhyay,G., Chowdhury,A.H., Vaidyanathan,B., Kim,D. and Saleque,S.
  TITLE     Antagonistic actions of Rcor proteins regulate LSD1 activity and
            cellular differentiation
  JOURNAL   Proc Natl Acad Sci U S A 111 (22), 8071-8076 (2014)
   PUBMED   24843136
REFERENCE   2  (bases 1 to 2870)
  AUTHORS   Toffolo,E., Rusconi,F., Paganini,L., Tortorici,M., Pilotto,S.,
            Heise,C., Verpelli,C., Tedeschi,G., Maffioli,E., Sala,C.,
            Mattevi,A. and Battaglioli,E.
  TITLE     Phosphorylation of neuronal Lysine-Specific Demethylase 1LSD1/KDM1A
            impairs transcriptional repression by regulating interaction with
            CoREST and histone deacetylases HDAC1/2
  JOURNAL   J Neurochem 128 (5), 603-616 (2014)
   PUBMED   24111946
  REMARK    GeneRIF: phosphorylation, without affecting demethylase activity,
            causes in neurons CoREST and HDAC1/2 corepressors detachment from
            LSD1-8a
REFERENCE   3  (bases 1 to 2870)
  AUTHORS   Noh,K.M., Hwang,J.Y., Follenzi,A., Athanasiadou,R., Miyawaki,T.,
            Greally,J.M., Bennett,M.V. and Zukin,R.S.
  TITLE     Repressor element-1 silencing transcription factor (REST)-dependent
            epigenetic remodeling is critical to ischemia-induced neuronal
            death
  JOURNAL   Proc Natl Acad Sci U S A 109 (16), E962-E971 (2012)
   PUBMED   22371606
  REMARK    GeneRIF: Data show that neuronal insults trigger activation of REST
            and CoREST in a clinically relevant model of ischemic stroke and
            that REST binds a subset of transcriptionally responsive genes.
REFERENCE   4  (bases 1 to 2870)
  AUTHORS   Wang,J., Scully,K., Zhu,X., Cai,L., Zhang,J., Prefontaine,G.G.,
            Krones,A., Ohgi,K.A., Zhu,P., Garcia-Bassets,I., Liu,F., Taylor,H.,
            Lozach,J., Jayes,F.L., Korach,K.S., Glass,C.K., Fu,X.D. and
            Rosenfeld,M.G.
  TITLE     Opposing LSD1 complexes function in developmental gene activation
            and repression programmes
  JOURNAL   Nature 446 (7138), 882-887 (2007)
   PUBMED   17392792
REFERENCE   5  (bases 1 to 2870)
  AUTHORS   Ballas,N., Battaglioli,E., Atouf,F., Andres,M.E., Chenoweth,J.,
            Anderson,M.E., Burger,C., Moniwa,M., Davie,J.R., Bowers,W.J.,
            Federoff,H.J., Rose,D.W., Rosenfeld,M.G., Brehm,P. and Mandel,G.
  TITLE     Regulation of neuronal traits by a novel transcriptional complex
  JOURNAL   Neuron 31 (3), 353-365 (2001)
   PUBMED   11516394
REFERENCE   6  (bases 1 to 2870)
  AUTHORS   Grimes,J.A., Nielsen,S.J., Battaglioli,E., Miska,E.A., Speh,J.C.,
            Berry,D.L., Atouf,F., Holdener,B.C., Mandel,G. and Kouzarides,T.
  TITLE     The co-repressor mSin3A is a functional component of the
            REST-CoREST repressor complex
  JOURNAL   J Biol Chem 275 (13), 9461-9467 (2000)
   PUBMED   10734093
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Mar 9, 2021 this sequence version replaced NM_001013994.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089209.1, SRR26643429.4746.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-848               JAXUCZ010000001.1  213883560-213884407
            849-905             JAXUCZ010000001.1  213885075-213885131
            906-986             JAXUCZ010000001.1  213885388-213885468
            987-1039            JAXUCZ010000001.1  213885697-213885749
            1040-1201           JAXUCZ010000001.1  213885840-213886001
            1202-1326           JAXUCZ010000001.1  213886116-213886240
            1327-1396           JAXUCZ010000001.1  213886330-213886399
            1397-1612           JAXUCZ010000001.1  213886482-213886697
            1613-1690           JAXUCZ010000001.1  213887928-213888005
            1691-1748           JAXUCZ010000001.1  213888636-213888693
            1749-1978           JAXUCZ010000001.1  213888821-213889050
            1979-2870           JAXUCZ010000001.1  213889131-213890022
FEATURES             Location/Qualifiers
     source          1..2870
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2870
                     /gene="Rcor2"
                     /note="REST corepressor 2"
                     /db_xref="GeneID:305811"
                     /db_xref="RGD:1359467"
     exon            1..848
                     /gene="Rcor2"
                     /inference="alignment:Splign:2.1.0"
     CDS             722..2293
                     /gene="Rcor2"
                     /note="RE1-silencing transcription factor (REST)
                     co-repressor 2"
                     /codon_start=1
                     /product="REST corepressor 2"
                     /protein_id="NP_001014016.1"
                     /db_xref="GeneID:305811"
                     /db_xref="RGD:1359467"
                     /translation="MPSVMEKPSAGSGILSRSRAKTAPNGGQPHSEDDSSEEEHSHDS
                     MIRVGTNYQAVIPECKPESPARYSNKELKGMLVWSPNHCVSDAKLDKYIAMAKEKHGY
                     NIEQALGMLLWHKHDVEKSLADLANFTPFPDEWTVEDKVLFEQAFGFHGKCFQRIQQM
                     LPDKLIPSLVKYYYSWKKTRSRTSVMDRQARRLGGRKDKEDSDELEEGRGAVSEGEPD
                     TGDPKREPLPSRPLNARPGPGKKEIQVSQYRHHPLRTRRRPPKGMYLSPEGLTAVSGS
                     PDLANLTLRGLDSQLISLKRQVQSMKQTNSSLRQALEGGIDPLRPPEANTKFNSRWTT
                     DEQLLAVQAIRRYGKDFGAIAEVIGNKTLTQVKTFFVSYRRRFNLEEVLQEWEAEQDG
                     APTAPVPVEEARRGAPVPATALEEDDEVQITSVSTSVPRSVPPAPPPPPPPTSLSQPP
                     PLLRPPLPTAPTLLRQPPPLQQGRFLQPRLAPNQPPPPLIRPALAASRHSARPGPQPP
                     PTLVGAQLEPPAPSL"
     exon            849..905
                     /gene="Rcor2"
                     /inference="alignment:Splign:2.1.0"
     exon            906..986
                     /gene="Rcor2"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1039
                     /gene="Rcor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1201
                     /gene="Rcor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1326
                     /gene="Rcor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1396
                     /gene="Rcor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1612
                     /gene="Rcor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1690
                     /gene="Rcor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1748
                     /gene="Rcor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1978
                     /gene="Rcor2"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2870
                     /gene="Rcor2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccgcagcc ggcactactt ccctgccagc agcttcattg tgtgcgcgag gagcgagcgg
       61 cggcggagag cgggcgagcg agcggcggta gcgcgagcgc ggcggggcga gcgagcgcgc
      121 cggggagggt gcgaggcggc gcccgcggct gcgctccgcc cgcctcccgg caactctgct
      181 ccagcgccgc acgccgtgcg cgccgtcctg ccgctggggc tccagcccgc tggcgtggtt
      241 gccgtggggt cgggtcggca gggttaccac cgttggggac cggggcatcc tcagcacagc
      301 cgaggggtgc ggagtcagct gcggcggcct ctgcacggta gcccttgccg gccaaacagc
      361 gtgggcaggc gcccggtgca gctccgggtc tccccgaggg cagcgcgccc tgactctccc
      421 cgggggagca tcaaccccga ggggcgcaca gagcgagcgt gcccccggcc gcgccgtccc
      481 ccacgtaccc ccacttcttc acaaactttt ctgccgtcct cgcccgtggg ggtcgcagtg
      541 agcgttaggg ctgccctccg gggccccgac ctcacggacc ctagccacgc tgacctcctg
      601 cctctcatag cctcactggc gacccctcca ggccgggccg ggcgcagcac tccaggcaag
      661 cgcggcaagc tcctgcgctc tccaaaggat cccgtgcccc ccggggcagc agggaagggt
      721 aatgccctct gtaatggaga agcccagtgc gggctccggg atcttgtccc gaagtcgggc
      781 caagacggca cccaacggcg gacagccgca ctcggaggat gacagcagcg aggaggagca
      841 ctctcatgac agcatgatcc gagttggaac caattaccaa gcagtaattc cggagtgcaa
      901 gcctgagagc cctgcgcgct acagcaacaa ggagctgaag gggatgctgg tgtggtcacc
      961 caaccactgt gtatccgatg ccaagcttga caagtacatt gcgatggcca aggagaagca
     1021 tggctacaac attgaacagg cacttggcat gcttctgtgg cacaaacatg acgtggagaa
     1081 gtcactggct gatctagcca acttcactcc cttccctgat gagtggacgg tagaggacaa
     1141 agtgctgttc gagcaggcct ttgggttcca tggcaagtgc ttccagcgga tccagcagat
     1201 gctccctgac aagctgatcc ccagcctggt gaagtattac tactcttgga agaagacccg
     1261 aagtcgaact agtgtgatgg acaggcaggc caggcggctg ggtggccgca aggacaaaga
     1321 agacagtgat gagctagaag agggacgagg agctgtgagc gagggagaac cggataccgg
     1381 ggaccccaag cgagagcctc tgccatccag acctctgaac gcacggcctg gtcctgggaa
     1441 gaaagagatc caggtatctc agtaccgcca ccacccactt cgaactcgga gacgtccgcc
     1501 caagggcatg tacctgagtc ctgaaggcct cactgcagta tcgggaagcc cagaccttgc
     1561 taacctcaca ctccgaggtc tcgactcaca gctcatctct cttaagcgcc aggttcagag
     1621 catgaagcag accaacagca gcctccgcca agcactggag ggtggcatcg accctctccg
     1681 cccccctgag gccaatacca agttcaactc ccgctggacc acagatgagc agcttctggc
     1741 tgtacaagcg attcgtagat atggcaaaga ctttggggct attgcagagg tgattgggaa
     1801 caagactctg acccaagtga agaccttctt tgtgagctac cgtcgccgct tcaacctgga
     1861 agaggtgttg caggaatggg aggctgagca ggatggggcc cccacagctc cagtccctgt
     1921 ggaagaggcc aggcgagggg ctcctgtacc agccacagcc ctggaagaag atgacgaggt
     1981 ccagattaca tctgtctcaa catcagtacc ccgatcagta ccccctgctc cgcccccacc
     2041 tccaccaccc acctcgcttt cccagcctcc tccactgctg aggccacctc tgcccacagc
     2101 tcccacactg ctccgccagc cacctcccct gcagcagggc cgcttcctgc agccccggct
     2161 ggcccccaac cagcctccac cacctctcat ccgccctgcc ctggctgcct ctcgccacag
     2221 tgcccgccct ggtcctcagc ccccacctac cctggttgga gcccaattgg agccccctgc
     2281 accctcactt tgagccctga atcctccact gcccaggggc tcctgaaccc cttggctggg
     2341 tatctctggc agcactaagg atagaaggga ctagggctct tgccaggtct ttcaaatacc
     2401 cagagctgcc agctggcaca gcttggacct gtgggttctg catgtgttcc tggcagttga
     2461 gcttgtaaac ccccagccag gggctagatc tcagggcctg cagggactct ggcttcctgg
     2521 ctgtgactgg aatggctgcc tccttgcctg cctgcctgcc tgcctttgga gggcttggcc
     2581 tctgggccta ccctttgtgt gtggtagtga ctgagcctgg gggctgaggg agagctggtg
     2641 tgttagctgg cctcacccac ctttccttcc ttttagcaat aagtcaggtg cagtggaagg
     2701 ggactggggt gggcatggca gaagccttgt gggaagaatg ttgggaagct gtgaggaggc
     2761 ccactctgtc cacccccaaa agcttggaga aagaagggtt ggggacttac acagacatgg
     2821 gtttattttt caacattttt taaaaagaaa taaatgcaac cttaaatgta
//
