LOCUS       NM_001415131            5639 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus REST corepressor 1 (Rcor1), mRNA.
ACCESSION   NM_001415131 XM_017593974
VERSION     NM_001415131.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5639)
  AUTHORS   Xu,H., Yu,X., Xie,R., Wang,Y. and Li,C.
  TITLE     RCOR1 improves neurobehaviors and neuron injury in rat cerebral
            palsy by Endothelin-1 targeting-induced Akt/GSK-3beta pathway
            upregulation
  JOURNAL   Brain Dev 46 (2), 93-102 (2024)
   PUBMED   37978036
  REMARK    GeneRIF: RCOR1 improves neurobehaviors and neuron injury in rat
            cerebral palsy by Endothelin-1 targeting-induced Akt/GSK-3beta
            pathway upregulation.
REFERENCE   2  (bases 1 to 5639)
  AUTHORS   Upadhyay,G., Chowdhury,A.H., Vaidyanathan,B., Kim,D. and Saleque,S.
  TITLE     Antagonistic actions of Rcor proteins regulate LSD1 activity and
            cellular differentiation
  JOURNAL   Proc Natl Acad Sci U S A 111 (22), 8071-8076 (2014)
   PUBMED   24843136
REFERENCE   3  (bases 1 to 5639)
  AUTHORS   Yao,H., Goldman,D.C., Nechiporuk,T., Kawane,S., McWeeney,S.K.,
            Tyner,J.W., Fan,G., Kerenyi,M.A., Orkin,S.H., Fleming,W.H. and
            Mandel,G.
  TITLE     Corepressor Rcor1 is essential for murine erythropoiesis
  JOURNAL   Blood 123 (20), 3175-3184 (2014)
   PUBMED   24652990
REFERENCE   4  (bases 1 to 5639)
  AUTHORS   Mosammaparast,N., Kim,H., Laurent,B., Zhao,Y., Lim,H.J.,
            Majid,M.C., Dango,S., Luo,Y., Hempel,K., Sowa,M.E., Gygi,S.P.,
            Steen,H., Harper,J.W., Yankner,B. and Shi,Y.
  TITLE     The histone demethylase LSD1/KDM1A promotes the DNA damage response
  JOURNAL   J Cell Biol 203 (3), 457-470 (2013)
   PUBMED   24217620
REFERENCE   5  (bases 1 to 5639)
  AUTHORS   Saleque,S., Kim,J., Rooke,H.M. and Orkin,S.H.
  TITLE     Epigenetic regulation of hematopoietic differentiation by Gfi-1 and
            Gfi-1b is mediated by the cofactors CoREST and LSD1
  JOURNAL   Mol Cell 27 (4), 562-572 (2007)
   PUBMED   17707228
REFERENCE   6  (bases 1 to 5639)
  AUTHORS   Wang,J., Scully,K., Zhu,X., Cai,L., Zhang,J., Prefontaine,G.G.,
            Krones,A., Ohgi,K.A., Zhu,P., Garcia-Bassets,I., Liu,F., Taylor,H.,
            Lozach,J., Jayes,F.L., Korach,K.S., Glass,C.K., Fu,X.D. and
            Rosenfeld,M.G.
  TITLE     Opposing LSD1 complexes function in developmental gene activation
            and repression programmes
  JOURNAL   Nature 446 (7138), 882-887 (2007)
   PUBMED   17392792
REFERENCE   7  (bases 1 to 5639)
  AUTHORS   Ballas,N., Grunseich,C., Lu,D.D., Speh,J.C. and Mandel,G.
  TITLE     REST and its corepressors mediate plasticity of neuronal gene
            chromatin throughout neurogenesis
  JOURNAL   Cell 121 (4), 645-657 (2005)
   PUBMED   15907476
REFERENCE   8  (bases 1 to 5639)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   9  (bases 1 to 5639)
  AUTHORS   Grimes,J.A., Nielsen,S.J., Battaglioli,E., Miska,E.A., Speh,J.C.,
            Berry,D.L., Atouf,F., Holdener,B.C., Mandel,G. and Kouzarides,T.
  TITLE     The co-repressor mSin3A is a functional component of the
            REST-CoREST repressor complex
  JOURNAL   J Biol Chem 275 (13), 9461-9467 (2000)
   PUBMED   10734093
REFERENCE   10 (bases 1 to 5639)
  AUTHORS   Andres,M.E., Burger,C., Peral-Rubio,M.J., Battaglioli,E.,
            Anderson,M.E., Grimes,J., Dallman,J., Ballas,N. and Mandel,G.
  TITLE     CoREST: a functional corepressor required for regulation of
            neural-specific gene expression
  JOURNAL   Proc Natl Acad Sci U S A 96 (17), 9873-9878 (1999)
   PUBMED   10449787
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Dec 21, 2022 this sequence version replaced XM_017593974.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.23842.1,
                                           SRR26643291.18954.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-525               JAXUCZ010000006.1  135890851-135891375
            526-585             JAXUCZ010000006.1  135891455-135891514
            586-669             JAXUCZ010000006.1  135929478-135929561
            670-722             JAXUCZ010000006.1  135943870-135943922
            723-884             JAXUCZ010000006.1  135948527-135948688
            885-1003            JAXUCZ010000006.1  135950213-135950331
            1004-1082           JAXUCZ010000006.1  135952203-135952281
            1083-1277           JAXUCZ010000006.1  135953835-135954029
            1278-1355           JAXUCZ010000006.1  135959288-135959365
            1356-1413           JAXUCZ010000006.1  135959576-135959633
            1414-1643           JAXUCZ010000006.1  135960506-135960735
            1644-5639           JAXUCZ010000006.1  135963372-135967367
FEATURES             Location/Qualifiers
     source          1..5639
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..5639
                     /gene="Rcor1"
                     /gene_synonym="RGD1305743"
                     /note="REST corepressor 1"
                     /db_xref="GeneID:102554884"
                     /db_xref="RGD:7505493"
     exon            1..525
                     /gene="Rcor1"
                     /gene_synonym="RGD1305743"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..1685
                     /gene="Rcor1"
                     /gene_synonym="RGD1305743"
                     /note="Mtfp1-like proline rich protein"
                     /codon_start=1
                     /product="REST corepressor 1"
                     /protein_id="NP_001402060.1"
                     /db_xref="GeneID:102554884"
                     /db_xref="RGD:7505493"
                     /translation="MPAMVEKGPEVSGKRRGRNTASAAASAAAASAASAAASAAASAG
                     TASASAAATASAAAAPNNGQNKSLAAAAPNGNSGSNSWEEGSSGSSSDEEHGGGGMRV
                     GPQYQAAVPDFDPAKLARRSQERDNLGMLVWSPNQSLSEAKLDEYIAIAKEKHGYNME
                     QALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPD
                     KSIASLVKFYYSWKKTRTKTSVMDRHARKQKREREESEDELEEPNGSNPVDIDIDPNR
                     ESKKEVPPTETVPQVKKEKHSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLR
                     QLDMELVSIKRQIQNMKQTNSALKEKLAGGIEPYRLPEVIQKCNARWTTEEQLLAVQA
                     IRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFSIDEVLQEWEAEHGKEEANGPTNQ
                     KPAKSPESSVKIQEEEDEAASVLDVRYASAS"
     exon            526..585
                     /gene="Rcor1"
                     /gene_synonym="RGD1305743"
                     /inference="alignment:Splign:2.1.0"
     exon            586..669
                     /gene="Rcor1"
                     /gene_synonym="RGD1305743"
                     /inference="alignment:Splign:2.1.0"
     exon            670..722
                     /gene="Rcor1"
                     /gene_synonym="RGD1305743"
                     /inference="alignment:Splign:2.1.0"
     exon            723..884
                     /gene="Rcor1"
                     /gene_synonym="RGD1305743"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1003
                     /gene="Rcor1"
                     /gene_synonym="RGD1305743"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1082
                     /gene="Rcor1"
                     /gene_synonym="RGD1305743"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1277
                     /gene="Rcor1"
                     /gene_synonym="RGD1305743"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1355
                     /gene="Rcor1"
                     /gene_synonym="RGD1305743"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1413
                     /gene="Rcor1"
                     /gene_synonym="RGD1305743"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1643
                     /gene="Rcor1"
                     /gene_synonym="RGD1305743"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..5639
                     /gene="Rcor1"
                     /gene_synonym="RGD1305743"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagccagcg aagtgcgggc ggcgatgaga gccaaagttg cgctccgttc ggcgtcgggg
       61 gcttgaggcg gctcgttgct ctgccagtct gggccccctt tagcctcaac tcgcaccagc
      121 ggatcccgcg cgctcgcccg cccggcccgg cgcccacctg cgccccctgc ccgcggcccg
      181 tcgcccgcgc ctcgcgagcc ggggtccccg tcactttggc ccggccccgg gccccgccga
      241 tgccggccat ggtggagaag ggccccgagg tctcagggaa gaggcgaggg aggaacacgg
      301 catccgccgc agcctcggcc gccgccgcct cggccgcctc ggccgccgcc tcagccgccg
      361 cctcggccgg caccgcctcc gcctcggccg ccgccaccgc ctcggccgcc gccgccccca
      421 ataatggcca gaataaaagt ttggcggcgg cggctcccaa cgggaacagc ggcagcaact
      481 cttgggagga aggcagctcg ggctcgtcca gcgacgagga gcacggtggc ggtggcatgc
      541 gggtgggacc ccagtaccaa gccgcggtgc ccgacttcga ccctgccaaa ctggcaaggc
      601 gcagtcaaga acgagacaat cttggcatgt tggtctggtc acctaatcag agtctttctg
      661 aagcaaaact ggacgagtac atcgctattg ccaaagagaa gcacgggtac aacatggagc
      721 aggctcttgg gatgctcttt tggcataagc ataacatcga gaaatcactg gccgacttgc
      781 ccaacttcac cccctttccc gatgagtgga cggtagaaga caaagtctta tttgagcaag
      841 cctttagttt ccatgggaag acttttcata gaatccagca aatgcttccc gataaatcca
      901 tagccagctt ggtgaagttt tactactctt ggaagaaaac cagaactaaa accagtgtga
      961 tggaccgtca cgctcggaaa caaaagcgtg agcgagaaga aagtgaggac gaactggaag
     1021 aaccaaacgg cagtaatccc gtcgacatcg acatcgaccc aaacagagaa agcaaaaagg
     1081 aggtaccccc tactgagaca gttcctcagg tcaaaaaaga aaaacatagc acacaagcta
     1141 aaaatagagc aaaaaggaaa cctccaaaag gcatgtttct ttctcaagaa gatgtggagg
     1201 ctgtgtctgc taatgctact gctgcgacca cggtgctgag acagctggac atggagctgg
     1261 tctccatcaa acgacagatt cagaacatga agcagacgaa cagcgctctt aaagaaaagc
     1321 tcgctggtgg gatagagcct tatcgacttc cggaggttat tcagaaatgt aacgcacgct
     1381 ggacaacaga agagcagctt ctcgccgtac aagccattag gaaatacggg cgagattttc
     1441 aggcaatctc agatgtgatc gggaacaagt cagttgttca ggtgaaaaac ttttttgtga
     1501 attaccggcg ccgcttcagc atagatgaag ttttacagga gtgggaagcc gagcatggca
     1561 aagaggaggc caacgggccc accaaccaga agcctgccaa gtccccggaa agctctgtca
     1621 agatccagga ggaggaagat gaggctgctt ctgtcctcga cgtaagatat gcatctgcct
     1681 catgaaaact atgggtagct ttgaacactt ggtatggacg acatgttatc cagatatcag
     1741 gtatcccaag acatcaccta gccatctgca tcacatctct gtggacaagc agctattacc
     1801 aaaaaaggca tacacttccg gtcctcgcta catctgcctt aatcctttgc tccttcctcc
     1861 atgctggcac gacttcccag agagctccgt tgcatctcac tctgcctaag ggctggggga
     1921 cccacggcct gcacacctcc ctcgagtctg ggacctaccc tccagttggc tccccctgag
     1981 ccccaacaat ggcagctctc ccaggcaaca gcttcagaac aggtagtctt gaaaggccca
     2041 gctctgttcc tgcatggcct gcagtttcta ctttgtgcat agtgtaattc tcagaaggcc
     2101 cagtaggcct tctagaaaga ttctcccctt cttttctggg gcagccacct aaatacaatc
     2161 atgcttcttt ggaaatcaca gcccatcagc agaccacatc gtgtaacctc catcaccaag
     2221 cttctcatgc aactccggtc cctaaagaga gggcagttat ggctatggat caggtggctt
     2281 ctctcccctt ctctctcccc taactctttc cctcttctcc tttccaagtg gtaaaagctc
     2341 acttgcagca actgtccttg gacattgtag cttaacggga gcgtggacct cagcgctttc
     2401 tgccttcagc cttcagcatt ggagtcccag gaagtgggtg cgcccatctc ttcttgatcc
     2461 ccagccacca ccatcaccac ccagctctga gagatttggt tcatatcact gtacctggtg
     2521 cttgtacatt tggaattggt gccttctcct tctggcaacc atcctatcag tcctttttct
     2581 gttcaagtgt cttattcaaa gtttattgct tgccaaagat gacatcattg aggtgtagca
     2641 gatggggagt gtctgcagac ttgagtgcag actttaatgt cgggtcagtt cagtaaggat
     2701 aatagagaag ccaaggatgc ttttctagat gctacacagc gttagctctc atcctcttgg
     2761 tgcctggcca ttttatgtca ctccatgtgt ccttttgtgt catttgtgta ctggtgtgat
     2821 cacacgagca ctgtcccctg tcttttagca gcagatagga cggaaaagtg atgggtgtgt
     2881 cgttagtgag accgagagga aacagaacag cgtaccgagt ggtgtgtgat gccgagtgtt
     2941 tggactggga gcgagcagag attgctcatg agtgctctct taccagactg tgggcctgca
     3001 gggctcgagg agcagccggc cagactgggc tcgagcatcc atggcgtctt gagaccgcac
     3061 taaccatgtg gaaatacctt ttgttgttgt ttgcagcttt caatattttt tctgctttca
     3121 gtaccaaaaa ggaaaaaaaa aagtagatgc tttaaagtat ttaaggtatg gatggagttc
     3181 ttaggaattt aaaatatgca attaaaattc ggtgttttgt ctcctgagca cctccccctc
     3241 ccctttttta aagttcactg attttctctt tagaaagaga ttcagctgaa tagaaatcta
     3301 ggctggggat agggtgtaca ttcttcttga agtctggaga aaggtcattc tgaggttgag
     3361 tgctgaggga ctctgtccct cctctcacac cagcccactg atcggaagag ccagagagtc
     3421 accgtgccag aggcacagcc cacagtcccc gcagggacca gtaacagagg aacactagta
     3481 acttttttta tgtttttatc ataaacctgc tgtgtagctg aaggggaagg aaaacacggg
     3541 acgaggtcag cctacgctgt gtgtatgact gtgtgtatga ctcacaggga cactaaggca
     3601 catacctgat agaaccctgc tcgctgagca ttttgcatgc cctcccctcc agtgagcaga
     3661 gctgtgctcc agggtggctg ctgcaatggc ttcgctctct ccctgccggc agctctgtgc
     3721 ccatcttcct gcccaggctg ttttccttaa ggtctgctcc gcctcggcag tgcggcttcg
     3781 gcagtgcggc ctcggcagtg cgggcatggt gatcatctgg gatggtgagg caagcagggt
     3841 ggccatgccc ggctccaggc actgggctca ttctgtcttt gtcctggtta tgagcactga
     3901 gtggcctcta gccgtgcaga gtcaggtgtc gctcggtatg gttaagacca gagtagctga
     3961 ccttggcctt ttctccaagg aacagaggcg tgctgtttcc acatggcggg ggagagcatg
     4021 gtccttgccg ggctgctgct ggagcagtct ccatgtttta aagttttcat gacatagtcc
     4081 gcagtgatgt aagtccaaga aactgcttag ctttcaaagc cgagggctct ggtctgcact
     4141 gtgactgtca tgtcagaagg gaggtgcatc cgcaggttag gtttggaacg tgatgcctgc
     4201 ttctgtggaa tgtcacttaa gctttgcgat cttaaaaagt atcaatggga atgtcataat
     4261 tatatatttt tgtgggaaaa tcttctaaat ataagttatt gtgcaaaata tagtatcatg
     4321 gacacaaata atagtctaac tttagtttag agatccctaa agatataaac tgtattgcat
     4381 atgcattaaa agtttgtttt atttaatttt atgtaaacat gtaaagtgtt taggtaattc
     4441 ttttcccttg tccatttaaa caccctgtta cttgaatatt gttgactggt cagcacagtg
     4501 atcaactctg taatgtagct cttcacccag aggtccccat gcctcagtcg tgcggtcaga
     4561 ttagtgtcac acagtgggtg ctgtgtccca ggagcagagg ctcacagcat acctgctgcc
     4621 tctttgttta tttgtcaaaa cagcttccta agaaggtttc cacagtttct gtacgacccc
     4681 ccaatggcgg tcacaaacct taatcaaaac aacagaagtt tgacaaagct catggtggtg
     4741 gactaatgaa gcaggagctc tgtttataca gttttcccag tgctgtgtct gagtgagttc
     4801 cgtgtcactt taaattcagc tctaccctgc ttcgttttct gactatgaga tgtactattg
     4861 gtaaaattgc acaccaaaaa taagccaaac agtgcattac atacactaac taactggatc
     4921 cctgctttca tgtaagcaaa ggaaagacac gtctcacgtc cgtcctgttg tacacctagt
     4981 gacccaggat tcaagttttt aatatcaagt aagtcttgcc tcagactgac cacaggcagt
     5041 ctgaggtcac ctgagtctaa tgaccgtgtg caatgaatgc cctttccgcc cctccctggg
     5101 tctcagcttc tcctcactgc agcgaagcac aattgcagga gcgtctcagt ccaacaggaa
     5161 ggtcagcaga gtctatgcat gttgtaaagt aatgagtgtt tacagtctcc ttctctaaaa
     5221 cgaacattta tcctggagtg gatagcattc cattatgtag acttaaaact ttgctaagtg
     5281 ctttttagat tgcttaaaat tttttcaaga ttttaaaaga tgtataaggt taagtttgca
     5341 aatataacgg aaatgctgta tatcttttga agtgataaaa tccatgttaa aattttaaag
     5401 aagacatgtt gtaataacgc tgttgtaagt aacatttcca tgcctctctt tgcttgtttt
     5461 cgtgcaagtg tccatagcat tataactgct tagccattga gttattataa catttgttag
     5521 tggagattgg gaaatctatt tgtgaaattc tgcagaattc atttttctat ttccaatatt
     5581 tgctgaagtt aaataaaaat tttcaagcca ttgatgtaat aaaatatgaa acaaaacaa
//
