LOCUS       NM_001008694            1436 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus reticulocalbin 3 (Rcn3), mRNA.
ACCESSION   NM_001008694
VERSION     NM_001008694.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1436)
  AUTHORS   Martinez-Martinez,E., Ibarrola,J., Fernandez-Celis,A.,
            Santamaria,E., Fernandez-Irigoyen,J., Rossignol,P., Jaisser,F. and
            Lopez-Andres,N.
  TITLE     Differential Proteomics Identifies Reticulocalbin-3 as a Novel
            Negative Mediator of Collagen Production in Human Cardiac
            Fibroblasts
  JOURNAL   Sci Rep 7 (1), 12192 (2017)
   PUBMED   28939891
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1436)
  AUTHORS   Jin,J., Li,Y., Ren,J., Man Lam,S., Zhang,Y., Hou,Y., Zhang,X.,
            Xu,R., Shui,G. and Ma,R.Z.
  TITLE     Neonatal Respiratory Failure with Retarded Perinatal Lung
            Maturation in Mice Caused by Reticulocalbin 3 Disruption
  JOURNAL   Am J Respir Cell Mol Biol 54 (3), 410-423 (2016)
   PUBMED   26252542
REFERENCE   3  (bases 1 to 1436)
  AUTHORS   Tsuji,A., Kikuchi,Y., Sato,Y., Koide,S., Yuasa,K., Nagahama,M. and
            Matsuda,Y.
  TITLE     A proteomic approach reveals transient association of
            reticulocalbin-3, a novel member of the CREC family, with the
            precursor of subtilisin-like proprotein convertase, PACE4
  JOURNAL   Biochem J 396 (1), 51-59 (2006)
   PUBMED   16433634
  REMARK    GeneRIF: Ectopic expression of the human RCN3 ortholog in rat GH4C1
            cells, and demonstration that it increases the autoactivation and
            secretion of rat PACE4.
REFERENCE   4  (bases 1 to 1436)
  AUTHORS   Asakura,K., Pogulis,R.J., Pease,L.R. and Rodriguez,M.
  TITLE     A monoclonal autoantibody which promotes central nervous system
            remyelination is highly polyreactive to multiple known and novel
            antigens
  JOURNAL   J Neuroimmunol 65 (1), 11-19 (1996)
   PUBMED   8642059
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK601329.1, CB315609.1 and BQ192961.1.
            
            On Oct 27, 2007 this sequence version replaced NM_001008694.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083719.1, FQ228883.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115, SAMN16093042
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-694               CK601329.1         1-694
            695-1070            CB315609.1         145-520
            1071-1436           BQ192961.1         1-366               c
FEATURES             Location/Qualifiers
     source          1..1436
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1436
                     /gene="Rcn3"
                     /gene_synonym="Rem1; Rlp49"
                     /note="reticulocalbin 3"
                     /db_xref="GeneID:494125"
                     /db_xref="RGD:1359365"
     exon            1..99
                     /gene="Rcn3"
                     /gene_synonym="Rem1; Rlp49"
                     /inference="alignment:Splign:2.1.0"
     exon            100..347
                     /gene="Rcn3"
                     /gene_synonym="Rem1; Rlp49"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1092
                     /gene="Rcn3"
                     /gene_synonym="Rem1; Rlp49"
                     /note="reticulocalbin 3, EF-hand calcium binding domain"
                     /codon_start=1
                     /product="reticulocalbin-3 precursor"
                     /protein_id="NP_001008694.1"
                     /db_xref="GeneID:494125"
                     /db_xref="RGD:1359365"
                     /translation="MMWRWTLMLLLLLLRHWALGKPSPDAGPHGQDRVHHGTPLSEAP
                     HDDAHGNFQYDHEAFLGRDVAKEFDQLTPEESQARLGRIVDRMDLAGDSDGWVSLAEL
                     RAWIAHTQQRHIRDSVSAAWHTYDTDRDGRVGWEELRNATYGHYEPGEEFHDVEDAET
                     YKKMLARDERRFRVADQDGDSMATREELTAFLHPEEFPHMRDIVVAETLEDLDKNKDG
                     YVQVEEYIADLYSAEPGEEEPAWVQTERQQFRDFRDLNKDGRLDGSEVGYWVLPPSQD
                     QPLVEANHLLHESDTDKDGRLSKAEILSNWNMFVGSQATNYGEDLTRHHDEL"
     exon            348..550
                     /gene="Rcn3"
                     /gene_synonym="Rem1; Rlp49"
                     /inference="alignment:Splign:2.1.0"
     exon            551..723
                     /gene="Rcn3"
                     /gene_synonym="Rem1; Rlp49"
                     /inference="alignment:Splign:2.1.0"
     exon            724..784
                     /gene="Rcn3"
                     /gene_synonym="Rem1; Rlp49"
                     /inference="alignment:Splign:2.1.0"
     exon            785..984
                     /gene="Rcn3"
                     /gene_synonym="Rem1; Rlp49"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1418
                     /gene="Rcn3"
                     /gene_synonym="Rem1; Rlp49"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctctggac tgcctgtggc agagcttaac tggaagcagg ccaagttggg catctttgcg
       61 tgaaagcaga gctcagcgtg gggagcgaac ccaggccagg aaccgatgat gtggcgatgg
      121 acgcttatgt tgcttctctt actgctgagg cactgggccc tggggaagcc atctcctgat
      181 gcaggacctc atggccagga tagggtgcat catggaaccc ccctgagtga ggccccccac
      241 gatgacgccc acgggaattt ccagtacgac catgaggcgt tcctgggacg agacgtggcc
      301 aaggaatttg accaactcac cccagaagaa agccaggccc gacttgggcg gattgtagac
      361 cgcatggacc ttgctgggga cagcgatggc tgggtgtcct tagctgagct ccgcgcgtgg
      421 attgcgcaca cacagcagcg gcacatccgt gactcggtga gcgcagcctg gcacacctac
      481 gacacggacc gcgacgggcg cgtgggttgg gaggagttgc gcaatgccac ctatggccat
      541 tatgagcccg gggaggaatt tcatgatgtg gaggatgccg agacttacaa gaagatgctg
      601 gctcgggatg agcgccgatt ccgggtagct gaccaagatg gggactccat ggctactcgg
      661 gaagagctga cggcctttct gcatcctgag gagttccctc acatgcggga catcgtggtg
      721 gcagagaccc tggaggacct tgacaagaac aaagatggct acgtgcaggt ggaagagtac
      781 atcgcggact tgtactctgc ggagcctggg gaggaggaac cggcctgggt acagacagag
      841 aggcagcagt tccgagactt ccgggatctg aacaaggatg ggcggctgga cggcagtgaa
      901 gtcggttact gggtgctgcc tccgtcccag gaccagcccc tggtggaggc caatcacctg
      961 ctgcatgaga gcgacacaga caaggatggc cgactgagca aagctgagat cctaagcaac
     1021 tggaacatgt ttgtgggtag ccaggccacc aactacggtg aggatctgac aaggcaccac
     1081 gatgagctct gattccccgg tctgctcaga cttctgaccc catgaccaca tgggggcaac
     1141 tgcggggggc cactgcagcc agcccctccc tccaggacac agactcagct ctggtgttcc
     1201 tggttcttgg gccctcagtc accttctctt ccagagaccc ctgtcaccag ccctggtacc
     1261 ccccccaacc tgcccaggac actcaggcac ttaaatgaca ctgataccat ccccagcaca
     1321 gacccagggg accacatcct gactgaacct caatctgaac taaaacagca caagctaacc
     1381 tgtcctgcct aggagcaata aaagctgttg ctggggtcaa aaaaaaaaaa aaaaaa
//
