LOCUS       NM_001108586            3073 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus reticulocalbin 1 (Rcn1), mRNA.
ACCESSION   NM_001108586 XM_001073225 XM_342481
VERSION     NM_001108586.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3073)
  AUTHORS   Kramann N, Hasenfuss G and Seidler T.
  TITLE     B-RAF and its novel negative regulator reticulocalbin 1 (RCN1)
            modulates cardiomyocyte hypertrophy
  JOURNAL   Cardiovasc Res 102 (1), 88-96 (2014)
   PUBMED   24492844
  REMARK    GeneRIF: B-RAF kinase activity is essential for cardiac hypertrophy
            and RCN1, its newly identified negative regulator
            Erratum:[Cardiovasc Res. 2021 Jan 1;117(1):330-332. PMID: 33078187]
REFERENCE   2  (bases 1 to 3073)
  AUTHORS   Favor J, Bradley A, Conte N, Janik D, Pretsch W, Reitmeir P,
            Rosemann M, Schmahl W, Wienberg J and Zaus I.
  TITLE     Analysis of Pax6 contiguous gene deletions in the mouse, Mus
            musculus, identifies regions distinct from Pax6 responsible for
            extreme small-eye and belly-spotting phenotypes
  JOURNAL   Genetics 182 (4), 1077-1088 (2009)
   PUBMED   19474196
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_342481.3, XM_001073225.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5756307,
                              SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3073
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q33"
     gene            1..3073
                     /gene="Rcn1"
                     /gene_synonym="Rcn"
                     /note="reticulocalbin 1"
                     /db_xref="GeneID:362182"
                     /db_xref="RGD:1311292"
     exon            1..688
                     /gene="Rcn1"
                     /gene_synonym="Rcn"
                     /inference="alignment:Splign:2.1.0"
     CDS             453..1430
                     /gene="Rcn1"
                     /gene_synonym="Rcn"
                     /note="reticulocalbin 1, EF-hand calcium binding domain"
                     /codon_start=1
                     /product="reticulocalbin-1 precursor"
                     /protein_id="NP_001102056.1"
                     /db_xref="GeneID:362182"
                     /db_xref="RGD:1311292"
                     /translation="MARGGRLGLALGLLLALVLALRAKPTVRKERVVRPDSELGERPP
                     EDNQSFQYDHEAFLGKEDSKTFDQLSPDESKERLGKIVDRIDSDGDGLVTTEELKVWI
                     KRVQKRYIYDNVAKVWKDYDRDKDEKISWEEYKQATYGYYLGNPAEFQDSSDHHTFKK
                     MLPRDERRFKASDLDGDLTATREEFTAFLHPEEFEHMKEIVVLETLEDIDKNGDGFVD
                     QDEYIADMFSHEDNGPEPDWVLSEREQFNDFRDLNKDGKLDKDEIRHWILPQDYDHAQ
                     AEARHLVYESDKNKDEMLTKEEILDNWNMFVGSQATNYGEDLTKNHDEL"
     exon            689..882
                     /gene="Rcn1"
                     /gene_synonym="Rcn"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1061
                     /gene="Rcn1"
                     /gene_synonym="Rcn"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1122
                     /gene="Rcn1"
                     /gene_synonym="Rcn"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1322
                     /gene="Rcn1"
                     /gene_synonym="Rcn"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..3073
                     /gene="Rcn1"
                     /gene_synonym="Rcn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgcaaatt gtgttaaccg ggtttaaatg ctcatctccg gggtagcctt gggctgaggt
       61 ttgggctttc agctggaagc tgagcgggag cgctgcttct ctaaccgcgg agaagagcta
      121 tcatccaaaa catctgttgc attttcacaa agtacttctt tccggtcttg cagagagccc
      181 tccagtccgc agcccccatc atctgggccc gcccctcgca acgagatcgc ggggaggggc
      241 cgaggcgaaa ccggagccca gcgcccacca ccctggctgg cgacgtggct ccgcggcccc
      301 ggcctccccc ggcggcgccg tggccaatgg gcgcgtgagt ggggcggccc gagcctcccg
      361 gagccagccg ggcgcgcccc tcgctgggga ggggacagcg gctgcggcgc tacgagcccc
      421 cactgcccgg cagcctccct ttgctcgcga ctatggcgcg cggtggccgc ctgggactcg
      481 ccctggggct gctgctggca ctggtgctgg cgctgcgggc caagcccacg gtgcgcaagg
      541 agcgcgtggt tcggcccgat tcagagctgg gcgagcggcc gcccgaggac aaccagagct
      601 tccagtacga tcatgaggcc ttcctaggca aggaggattc caagaccttc gatcagctaa
      661 gcccggacga gagcaaggag aggctgggga aaattgttga tcgaatcgac agtgatggag
      721 acggccttgt tactactgag gagctgaaag tttggatcaa acgggtacag aaaagataca
      781 tctacgataa tgtggctaaa gtctggaagg attatgatag ggacaaagac gaaaagatct
      841 cctgggaaga atacaagcag gccacctatg gctactacct gggaaaccct gctgaattcc
      901 aagatagctc tgatcatcac acctttaaaa agatgctgcc acgggatgag aggaggttta
      961 aggcttcaga cctcgatggc gacctgacag ctactcggga ggagttcact gcctttctgc
     1021 acccagagga gtttgaacat atgaaggaga ttgtagttct ggaaaccctg gaggatatcg
     1081 acaagaacgg ggatggtttt gtggaccagg atgagtacat tgcggacatg ttttctcacg
     1141 aggacaatgg ccctgagcca gactgggttt tgtctgaacg ggagcagttc aatgatttcc
     1201 gagatctgaa caaggacggg aagctggaca aggatgagat tcgccactgg atcctccctc
     1261 aggactacga ccatgcacag gccgaggccc ggcatctggt gtatgagtca gacaaaaaca
     1321 aggatgagat gctaaccaag gaggagattc tagacaactg gaacatgttt gtgggaagcc
     1381 aagccaccaa ttacggggaa gatctgacca aaaatcatga tgaactttga aggacactca
     1441 tcctcatgtg gccaacggcc tccggctttc tgcgatgttc tgggtgattg ctataggtgt
     1501 caagtgtata gcagttgtgt ccctcaacaa tgctattata cctcagattg gggtagaaat
     1561 tatttttcac tccatattta ctggaaaata accatcacta tttattccag taggattttt
     1621 cctgaagcac attaaactct tggcaaattg cagttctctg aggggataca ttgctacagc
     1681 atgattttct agactcctcc tctacttaat taattaatgg gcaagaaatc atgaaagggt
     1741 tctgtagctc aaggtgggtg ggtgggtggg acactgcaca gaataatcac tatgtgtttg
     1801 aactattaaa ttttgggttt ttttagttgc cactgttaaa tggtggtgaa ggtaaggctt
     1861 ggaggagtca atattgtatt ttcctaggtc agccaacctt ggaataggca tggtatttct
     1921 aactctttat atttggagct gttatcataa atggtatata aacttttgtg tgttttcctt
     1981 atgggcctgc taatgtgcac agtaaaccca catctttggg gttttgtttt gctttgtttt
     2041 taatactaag aagcaatcaa aaaaaaaaaa gataatgtga acaagaaaga aatgttagga
     2101 ttaggaaaaa agatgaatgc caggtatttg aaaaactgta tgaccatggt caacacttta
     2161 atatacttga gaaatttttt tacatgttaa tgaaccgggt ctgttttttt aaaaaatagt
     2221 gaatagaaat gcagtccctt cctggctgtg aggctaggga tccagatgta gtggaattta
     2281 ttatttgttg agtcctgaac ctttgagcct gcttctagca cagcttatgc caaggagaca
     2341 gggcaaggtg atagctaagc cattgaccaa actatctgga ggaataatta caggtgcaat
     2401 tccaccttgt aaatgggagg agaagaataa aggatgtctt tgcggatttc cccatgtgtc
     2461 ttgtgtttga tttcatagaa agcgtgcttt ctttgttcct ctgggattaa acgttcaaca
     2521 gggtccgtgg tctagatcaa aatggactca gtatttacta gcaagttcag aatctatcag
     2581 tagctgctga tttcatccct ctgtacttcg tgtccgtctc tgcagttagg gaacccagtg
     2641 tcatttccac agtagaatcc gtcctgagac aaaatccaga tcttggtatt gcctgtgggg
     2701 cctgccgaac agatctggtc ctgcttccct tctgagaact gcctctttct ttagtcttct
     2761 tttttctccc cctttcccca cccttttacc ccatcctcca ccctcactga ttttgttgct
     2821 tagatgaact ccctgggtga gaaatgaaca aagccctaaa cagcgccagc cagcgtagtt
     2881 caggctgggg aagtagagag cttcctgagc ttgtgtatag agcgtgagtg acggtatact
     2941 gacaagaaca tggttgatcc atcccaaagc agccatgcaa caaagtcttt acccagcgtg
     3001 gactgtgtgg cttcctcaca tccagagacc aagccccaag gccacacact gtattgcctg
     3061 gttctgtgtg tca
//
