LOCUS       NM_001007618            1718 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Rattus norvegicus ring finger and CHY zinc finger domain containing
            1 (Rchy1), mRNA.
ACCESSION   NM_001007618 XM_214006
VERSION     NM_001007618.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1718)
  AUTHORS   Singh,A., Tiwari,S. and Singh,S.
  TITLE     Pirh2 modulates the mitochondrial function and cytochrome
            c-mediated neuronal death during Alzheimer's disease
  JOURNAL   Cell Death Dis 15 (5), 331 (2024)
   PUBMED   38740775
  REMARK    GeneRIF: Pirh2 modulates the mitochondrial function and cytochrome
            c-mediated neuronal death during Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1718)
  AUTHORS   Escarcega,R.D., Patil,A.A., Moruno-Manchon,J.F., Urayama,A.,
            Marrelli,S.P., Kim,N., Monchaud,D., McCullough,L.D. and
            Tsvetkov,A.S.
  TITLE     Pirh2-dependent DNA damage in neurons induced by the G-quadruplex
            ligand pyridostatin
  JOURNAL   J Biol Chem 299 (10), 105157 (2023)
   PUBMED   37579947
  REMARK    GeneRIF: Pirh2-dependent DNA damage in neurons induced by the
            G-quadruplex ligand pyridostatin.
REFERENCE   3  (bases 1 to 1718)
  AUTHORS   Dong,L., Cheng,Q., Wang,Z., Yuan,P., Li,Z., Sun,Y., Han,S., Yin,J.,
            Peng,B., He,X. and Liu,W.
  TITLE     Human Pirh2 is a novel inhibitor of prototype foamy virus
            replication
  JOURNAL   Viruses 7 (4), 1668-1684 (2015)
   PUBMED   25848801
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1718)
  AUTHORS   Li,H., Deng,J., Chen,H., Chen,T., Cao,X., Hou,H., Huan,W.,
            Zhang,G., Yu,B. and Wang,Y.
  TITLE     Dynamic changes of PIRH2 and p27kip1 expression in injured rat
            sciatic nerve
  JOURNAL   Neurol Sci 33 (4), 749-757 (2012)
   PUBMED   21959983
REFERENCE   5  (bases 1 to 1718)
  AUTHORS   Wu,X., Shi,W., Zhao,W., Shao,B., Yuan,Q., Li,C., Zhang,S., Sun,B.,
            Wu,Q. and Chen,J.
  TITLE     Changes in Pirh2 and p27kip1 expression following traumatic brain
            injury in adult rats
  JOURNAL   J Mol Neurosci 46 (1), 184-191 (2012)
   PUBMED   21728064
  REMARK    GeneRIF: Pirh2 may be a negative regulator of p27(kip1) and
            associated with glial proliferation.
REFERENCE   6  (bases 1 to 1718)
  AUTHORS   Kruse,J.P. and Gu,W.
  TITLE     Modes of p53 regulation
  JOURNAL   Cell 137 (4), 609-622 (2009)
   PUBMED   19450511
  REMARK    Review article
REFERENCE   7  (bases 1 to 1718)
  AUTHORS   Sheng,Y., Laister,R.C., Lemak,A., Wu,B., Tai,E., Duan,S., Lukin,J.,
            Sunnerhagen,M., Srisailam,S., Karra,M., Benchimol,S. and
            Arrowsmith,C.H.
  TITLE     Molecular basis of Pirh2-mediated p53 ubiquitylation
  JOURNAL   Nat Struct Mol Biol 15 (12), 1334-1342 (2008)
   PUBMED   19043414
REFERENCE   8  (bases 1 to 1718)
  AUTHORS   Abe,K., Hattori,T., Isobe,T., Kitagawa,K., Oda,T., Uchida,C. and
            Kitagawa,M.
  TITLE     Pirh2 interacts with and ubiquitylates signal recognition particle
            receptor beta subunit
  JOURNAL   Biomed Res 29 (1), 53-60 (2008)
   PUBMED   18344599
REFERENCE   9  (bases 1 to 1718)
  AUTHORS   Zhang,L., Li,J., Wang,C., Ma,Y. and Huo,K.
  TITLE     A new human gene hNTKL-BP1 interacts with hPirh2
  JOURNAL   Biochem Biophys Res Commun 330 (1), 293-297 (2005)
   PUBMED   15781263
REFERENCE   10 (bases 1 to 1718)
  AUTHORS   Leng,R.P., Lin,Y., Ma,W., Wu,H., Lemmers,B., Chung,S., Parant,J.M.,
            Lozano,G., Hakem,R. and Benchimol,S.
  TITLE     Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53
            degradation
  JOURNAL   Cell 112 (6), 779-791 (2003)
   PUBMED   12654245
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083739.1.
            
            On Nov 29, 2004 this sequence version replaced XM_214006.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083739.1, CF110566.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1718
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1718
                     /gene="Rchy1"
                     /gene_synonym="Pirh2"
                     /note="ring finger and CHY zinc finger domain containing
                     1"
                     /db_xref="GeneID:289508"
                     /db_xref="RGD:1359180"
     exon            1..482
                     /gene="Rchy1"
                     /gene_synonym="Pirh2"
                     /inference="alignment:Splign:2.1.0"
     CDS             393..1178
                     /gene="Rchy1"
                     /gene_synonym="Pirh2"
                     /EC_number="2.3.2.27"
                     /note="ring finger and CHY zinc finger domain containing
                     1, E3 ubiquitin protein ligase"
                     /codon_start=1
                     /product="RING finger and CHY zinc finger
                     domain-containing protein 1"
                     /protein_id="NP_001007619.1"
                     /db_xref="GeneID:289508"
                     /db_xref="RGD:1359180"
                     /translation="MAATAQEDGVRSPAPGPRGCEHYDRACLLKAPCCDKLYTCRLCH
                     DTHEDHQLDRFKVKEVQCINCEKLQHAQQTCEDCSTLFGEYYCSICHLFDKDKKQYHC
                     ESCGICRIGPKEDFFHCLKCNLCLAMTLRGKHKCIENVSRQNCPICLEDIHTSRVVAH
                     VLPCGHLLHRTCYEEMLKEGYRCPLCMHSALDMTRYWRQLDIEVAQTPMPSEYQNVTV
                     DILCNDCNGRSTVQFHILGMKCKLCDSYNTAQAGGRTVSMDEQ"
     exon            483..602
                     /gene="Rchy1"
                     /gene_synonym="Pirh2"
                     /inference="alignment:Splign:2.1.0"
     exon            603..718
                     /gene="Rchy1"
                     /gene_synonym="Pirh2"
                     /inference="alignment:Splign:2.1.0"
     exon            719..797
                     /gene="Rchy1"
                     /gene_synonym="Pirh2"
                     /inference="alignment:Splign:2.1.0"
     exon            798..842
                     /gene="Rchy1"
                     /gene_synonym="Pirh2"
                     /inference="alignment:Splign:2.1.0"
     exon            843..901
                     /gene="Rchy1"
                     /gene_synonym="Pirh2"
                     /inference="alignment:Splign:2.1.0"
     exon            902..928
                     /gene="Rchy1"
                     /gene_synonym="Pirh2"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1049
                     /gene="Rchy1"
                     /gene_synonym="Pirh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1673
                     /gene="Rchy1"
                     /gene_synonym="Pirh2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgctcctc acaggcgctg gcggcccagg gcggcctaca gcagcgcccg cccggcgtcg
       61 cagtggtccc cttcgccccg caatctgggc tggcagcaat gggggggggg aagaagagcc
      121 aacctaagag ttattaccgt tagcagcgac gacagcgact aacgtcgacg acggaataag
      181 cgtctcactt ggctttcgcc ccttcctcca ggaaccggac atccggctgc tccagatcac
      241 gtgatcatcc gccatattga ctgtagtggc ctctgctccg aggaggaggg gtatcagacc
      301 ggctctgctt ctttaaggcg tggcttccaa gctgggggaa ggttctgtgg attgtgtgga
      361 gggaggtgga ggaggaggag gaggaggagg agatggcggc gacggcgcag gaagatggcg
      421 tccgcagccc ggctccaggg ccgcggggtt gcgagcacta tgacagagcc tgtctcctca
      481 aggcaccttg ttgtgacaag ctctatacat gccggctatg tcacgacacc cacgaagatc
      541 atcagctgga ccgcttcaaa gtaaaggaag tgcagtgcat caactgtgaa aaactccagc
      601 atgcccagca gacttgtgag gactgcagca cactgtttgg agaatattac tgcagtattt
      661 gccacctgtt tgacaaagac aagaagcagt atcactgtga gagctgtggg atttgtagga
      721 ttggtccaaa ggaagatttt tttcattgct tgaaatgtaa cttatgccta gccatgactc
      781 ttcgaggaaa acacaagtgt attgaaaatg tttcccggca gaattgtcca atatgcttgg
      841 aggacattca tacctcccgt gtcgttgctc atgtcttgcc atgcgggcat ctcctacata
      901 gaacgtgtta tgaagaaatg ttgaaagaag gttacagatg cccattgtgt atgcattctg
      961 ccctagacat gactcggtac tggagacaat tagacattga ggtagcacag actcctatgc
     1021 catccgaata ccagaacgtg accgttgata ttctctgcaa tgactgtaat ggacgatcca
     1081 cagtccagtt ccatatctta ggcatgaaat gtaagctttg tgactcctac aatactgctc
     1141 aggctggagg ccgcacagtg tccatggatg agcagtgaga agcctgtcct tggctggaga
     1201 acagctctgg gatgtagatg aagctctgtg tggaagaccc cgatgtccgg atgtgtccta
     1261 actatgcgta gagatgtttg tacctgtcaa cagatcatac ctatacacca aggactcaag
     1321 atctcagatg gaatcagaat atcactcact ggatgaagcc tctgagcgtg tgttgattgg
     1381 aaagtcactt agtgtcaagt tttgaagcca atgatgtttg tcccagatat agtcacagtc
     1441 atcgaaatat tttatatttt catggaactt taagtgacac tatgcacgca gacttaattt
     1501 ctagttcttg atagaactac attcaatttt aactagtctt tgattttaag ggctgtacta
     1561 taatttttaa gttcttattg ttaaaatcta attacatgtg ctttttaatt ttctgacagt
     1621 ccttaggatc ctatacataa aattttatgt aataaactac taatgaaatt gtaaaaaaaa
     1681 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
