LOCUS       NM_175578               3348 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus regulator of calcineurin 2 (Rcan2), mRNA.
ACCESSION   NM_175578
VERSION     NM_175578.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3348)
  AUTHORS   Fouillade,C., Baron-Menguy,C., Domenga-Denier,V., Thibault,C.,
            Takamiya,K., Huganir,R. and Joutel,A.
  TITLE     Transcriptome analysis for Notch3 target genes identifies Grip2 as
            a novel regulator of myogenic response in the cerebrovasculature
  JOURNAL   Arterioscler Thromb Vasc Biol 33 (1), 76-86 (2013)
   PUBMED   23117660
REFERENCE   2  (bases 1 to 3348)
  AUTHORS   Sanna,B., Brandt,E.B., Kaiser,R.A., Pfluger,P., Witt,S.A.,
            Kimball,T.R., van Rooij,E., De Windt,L.J., Rothenberg,M.E.,
            Tschop,M.H., Benoit,S.C. and Molkentin,J.D.
  TITLE     Modulatory calcineurin-interacting proteins 1 and 2 function as
            calcineurin facilitators in vivo
  JOURNAL   Proc Natl Acad Sci U S A 103 (19), 7327-7332 (2006)
   PUBMED   16648267
REFERENCE   3  (bases 1 to 3348)
  AUTHORS   Wang,Y., De Keulenaer,G.W., Weinberg,E.O., Muangman,S.,
            Gualberto,A., Landschulz,K.T., Turi,T.G., Thompson,J.F. and
            Lee,R.T.
  TITLE     Direct biomechanical induction of endogenous calcineurin inhibitor
            Down Syndrome Critical Region-1 in cardiac myocytes
  JOURNAL   Am J Physiol Heart Circ Physiol 283 (2), H533-H539 (2002)
   PUBMED   12124198
REFERENCE   4  (bases 1 to 3348)
  AUTHORS   Siddiq,A., Miyazaki,T., Takagishi,Y., Kanou,Y., Hayasaka,S.,
            Inouye,M., Seo,H. and Murata,Y.
  TITLE     Expression of ZAKI-4 messenger ribonucleic acid in the brain during
            rat development and the effect of hypothyroidism
  JOURNAL   Endocrinology 142 (5), 1752-1759 (2001)
   PUBMED   11316738
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 27, 2020 this sequence version replaced NM_175578.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086974.1, SRR26360194.83930.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               JAXUCZ010000009.1  24671964-24672189   c
            227-453             JAXUCZ010000009.1  24638521-24638747   c
            454-627             JAXUCZ010000009.1  24478788-24478961   c
            628-799             JAXUCZ010000009.1  24475948-24476119   c
            800-3348            JAXUCZ010000009.1  24456861-24459409   c
FEATURES             Location/Qualifiers
     source          1..3348
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q13"
     gene            1..3348
                     /gene="Rcan2"
                     /gene_synonym="Dcip2; Dscr1l1; Zaki-4"
                     /note="regulator of calcineurin 2"
                     /db_xref="GeneID:140666"
                     /db_xref="RGD:69198"
     exon            1..226
                     /gene="Rcan2"
                     /gene_synonym="Dcip2; Dscr1l1; Zaki-4"
                     /inference="alignment:Splign:2.1.0"
     exon            227..453
                     /gene="Rcan2"
                     /gene_synonym="Dcip2; Dscr1l1; Zaki-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..960
                     /gene="Rcan2"
                     /gene_synonym="Dcip2; Dscr1l1; Zaki-4"
                     /note="calcineurin inhibitory protein ZAKI-4; down
                     syndrome candidate region 1-like protein 1; Down syndrome
                     critical region gene1-like 1; Down syndrome critical
                     region gene 1-like 1"
                     /codon_start=1
                     /product="calcipressin-2"
                     /protein_id="NP_783168.1"
                     /db_xref="GeneID:140666"
                     /db_xref="RGD:69198"
                     /translation="MRGDAYFIGMRSLGQQASVPEDGGLFFLCCIDRDWAVTQCFAEE
                     AFQALTDFNDLPNSLFACNVHQSVFEEEESKEKFEGLFRTYDECVTFQLFKSFRRVRI
                     NFSHPKAAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPP
                     SSPPVGWKPISDATPVLNYDLLYAVAKLGPGEKYELHAGTESTPSVVVHVCDSDLEEE
                     EDPKTSPKPKIIQTRRPGLPPSVSN"
     exon            454..627
                     /gene="Rcan2"
                     /gene_synonym="Dcip2; Dscr1l1; Zaki-4"
                     /inference="alignment:Splign:2.1.0"
     exon            628..799
                     /gene="Rcan2"
                     /gene_synonym="Dcip2; Dscr1l1; Zaki-4"
                     /inference="alignment:Splign:2.1.0"
     exon            800..3348
                     /gene="Rcan2"
                     /gene_synonym="Dcip2; Dscr1l1; Zaki-4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttgcgggag caccagcagg aggcacagcc cgggtgaccc tgcgacccgg agagcgggag
       61 gcggcgctca gtgcgcacgg ttccacgccc aggcccgcgg gcaccgcgct caccccggcc
      121 gtcaggtgag caggcagagc cgcgcccgca gcctgctgcc ccgaggaccc tcgagccgcc
      181 accactgtca ccgccgccac agcggcgcat cgcagacgtc ctgcagggat gaggggagac
      241 gcctacttca ttggaatgag gagcctaggg cagcaggcat cggtccctga agatggggga
      301 cttttcttcc tctgctgcat agacagagac tgggctgtca ctcagtgttt tgctgaagag
      361 gccttccaag cactcaccga cttcaatgat ctccccaact cattgtttgc ctgcaatgtt
      421 caccagtccg tgtttgaaga agaagagagc aaggaaaaat ttgagggact gttccggacc
      481 tatgacgaat gtgtgacgtt tcagctgttt aagagtttcc gacgggttcg aataaatttc
      541 agccacccca aagctgcagc ccgtgcccgg atagagcttc atgagaccca gttcagaggg
      601 aagaagctga aactctactt tgcacaggtc cagaccccag agacagatgg agacaaactg
      661 catttggcac ccccacagcc tgccaaacag ttcctcatct cacccccttc atctcctccc
      721 gttggctgga agcctatcag cgatgccaca ccagtcctca actacgacct cctttatgcc
      781 gtggccaaac taggaccagg agagaaatat gagctgcatg cgggaactga gtctacaccg
      841 agcgttgtcg tgcacgtgtg tgacagcgac ttggaggagg aggaggatcc aaagacttcc
      901 ccaaagccaa aaatcatcca gacccggcgt cctggcctgc caccctccgt gtccaactga
      961 gcacgtccat gataacatgc atctcctctt atcatgcttt ttctcccttg ttcgtccaaa
     1021 aattaattgc cttgaagtcc ctgggtgttt ggttgtttga gaatccttcc ttgtaattaa
     1081 gcctctcgga caaaagggct aggaaaaggt gatatgtctc ccagtcaact catacccatt
     1141 aaccagagtc cattatttag aaagttctag acaaagggta gtattttctt attaaacaat
     1201 cagtacagcc tatatctctg ttctctcatg ttgatccaag ccagagacat cagtaaccaa
     1261 tagccttcat gttgtttgtg agctgctcca attgagtcct ctgtgtgtgt gtgtgtgtgt
     1321 gtgtgtgtgt gtgtgtgtgt gtgtatgtgt gtgtgtgtgt tgtttattcc tggccactta
     1381 tataggacca taagtaaact tggctttgac tgcatgagat ccccctatct ggtctcaccc
     1441 agtcctctgc atcccgacat tcccaggaca tgcacaatca ccagcattta ttttgatgat
     1501 ttgagggtat gccccacctt gtggtatccc agccctgtcc tgtatagaca aggggcatcc
     1561 acggcaccat ttggctcaat aagtctggga atcatgatta gtttgagtca atacatcatc
     1621 gtatagcttt gtccaaattc ctggaggtaa aattgagcgt ggccccaaag agattcctca
     1681 gtagattcta aacatcacta tcacatagga ctacccagtg ctactgggga ggcttgcccg
     1741 agtgacagag accgatttca gacaaaccta tttattataa aagtctcaca gtgtctgaat
     1801 gattgtcgtc cccccccacc tctttgtata tttgtacaga tgtttgagct gtgcttttaa
     1861 aatctggatt tttttttttt tgatttagtg attgttcaac cattagctgc ttaatgacat
     1921 catacctgtg ttgcttctga atgcatcctg attctaatgt agataatccg atactatcac
     1981 acgctattac ggttcatgct atgttgtaaa aggctacagc aatgtctcat gccaatagat
     2041 aaacgactag ctaatttctt tgctgtcaag atcacctgtt tgcaaacaaa gatccaagta
     2101 tcagttgtaa gcaacttggg tggcgcttaa tccaagatcg tatacagctg agcatttccg
     2161 aacacaaagg atgatgggta aacggacggc ccctcccatt catccagtgc ccgtgtgctc
     2221 aaaagttcct tgttttcgtt acctgtgatt ttgtatttct ctagcccaaa gtgcattaca
     2281 gaagatacac ctgcagaacc atactttctg ctccatgtgt caagcctcat ctattcctgt
     2341 tcattaacta gtaactttgg atgcaaatac tatttaccac acaacgggca aggacttcaa
     2401 tgacctaagc ctcagaatac cacacaagaa cactaacaca gccacctgat ggggggatta
     2461 tgtggttttt tgactaaggt gtatgttagt ttcagcagaa acttcaaacc tagactgatc
     2521 actcagaaaa ttaaagtccg ttctactgtg aaatatagca atatagtgcc ggacacggta
     2581 cagtacggtt gagaccgagg ccagcattgc ttgtggaatc ctgagtttcc acggggataa
     2641 caagtctcct tttcaaactc agatctgagg agtgtacagc aaaggctttg actttccttt
     2701 gttgtggaag gatttggttt tttcattggc cacggaacga ctacaaatag tggcgagatg
     2761 ctgccctctg gtggccgaaa cgttgaactc ggttgtatag gtggattgat tacaacagtc
     2821 aactcccagg gtctgacttt ctaatccgcg ttaactttca ggatgcaggt tctgagaaag
     2881 agagaaaaat gaacagtcta aatgagatta aagccttgga aataatttgt gcttccaaac
     2941 aatgatagca gagatttcca gtttagtaaa agttgatgtg actaccttgg gtaggcatta
     3001 agaactcagt gttacagatg gcccaggtga ttagtcttag taaactgtat tgccatatgt
     3061 cgatgttaac ctgctgcaga gcaagggatt ctcgcactag gttgagcacg gagaggggag
     3121 aaggggagct ttccccagaa agaataggga agccatggga cctcccagca ccgagaaagt
     3181 cgcctcaaca cttccttcca tgatgctcat tatgcaaacc tctttagcgc tctttttaag
     3241 tttgaaacgt tttaaatgga ggggaagggg aaggtttcca ccaactgaat catttgtgca
     3301 cgtgtaaagc tcaaagagct tagagttcaa atatatctgg tgaatgaa
//
