LOCUS       NM_153724               2165 bp    mRNA    linear   ROD 18-JUL-2024
DEFINITION  Rattus norvegicus regulator of calcineurin 1 (Rcan1), transcript
            variant 2, mRNA.
ACCESSION   NM_153724
VERSION     NM_153724.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2165)
  AUTHORS   Gong,M., Tao,L. and Li,X.
  TITLE     MicroRNA-21-3p/Rcan1 signaling axis affects apoptosis of
            cardiomyocytes of sepsis rats
  JOURNAL   Gen Physiol Biophys 42 (3), 217-227 (2023)
   PUBMED   37098739
  REMARK    GeneRIF: MicroRNA-21-3p/Rcan1 signaling axis affects apoptosis of
            cardiomyocytes of sepsis rats.
REFERENCE   2  (bases 1 to 2165)
  AUTHORS   Huang,B., He,Y., Li,S., Wei,X., Liu,J., Shan,Z., Huang,Y., Chen,J.
            and Zhao,F.
  TITLE     The RCAN1.4-calcineurin/NFAT signaling pathway is essential for
            hypoxic adaption of intervertebral discs
  JOURNAL   Exp Mol Med 52 (5), 865-875 (2020)
   PUBMED   32467610
  REMARK    GeneRIF: The RCAN1.4-calcineurin/NFAT signaling pathway is
            essential for hypoxic adaption of intervertebral discs.
REFERENCE   3  (bases 1 to 2165)
  AUTHORS   Wang,G., Zhao,Y., Liu,S., Jia,J. and Lu,T.
  TITLE     Critical role of regulator of calcineurin 1 in spinal cord injury
  JOURNAL   J Physiol Biochem 72 (4), 605-613 (2016)
   PUBMED   27339639
  REMARK    GeneRIF: RCAN1 plays a critical role in spinal cord injury.
REFERENCE   4  (bases 1 to 2165)
  AUTHORS   Redina,O.E., Smolenskaya,S.E., Fedoseeva,L.A. and Markel,A.L.
  TITLE     [Differentially expressed genes in the locus associated with
            relative kidney weight and resting blood pressure in hypertensive
            rats of the ISIAH strain]
  JOURNAL   Mol Biol (Mosk) 50 (6), 944-952 (2016)
   PUBMED   28064310
  REMARK    GeneRIF: Six differentially expressed genes (Kcne1, Rcan1, Mx1,
            Mx2, Tmprss2, and RGD1559516) were identified in the renal cortex,
            and three genes (Rcan1, Mx2, and Tmprss2) were identified in the
            renal medulla.
REFERENCE   5  (bases 1 to 2165)
  AUTHORS   Emrani,R., Rebillard,A., Lefeuvre,L., Gratas-Delamarche,A.,
            Davies,K.J. and Cillard,J.
  TITLE     The calcineurin antagonist RCAN1-4 is induced by exhaustive
            exercise in rat skeletal muscle
  JOURNAL   Free Radic Biol Med 87, 290-299 (2015)
   PUBMED   26122706
  REMARK    GeneRIF: We propose that increased RCAN1-4 expression and the
            signal transduction pathways it regulates represent important
            components of the physiological adaptation to exercise-induced
            oxidative stress.
REFERENCE   6  (bases 1 to 2165)
  AUTHORS   Bush,E., Fielitz,J., Melvin,L., Martinez-Arnold,M., McKinsey,T.A.,
            Plichta,R. and Olson,E.N.
  TITLE     A small molecular activator of cardiac hypertrophy uncovered in a
            chemical screen for modifiers of the calcineurin signaling pathway
  JOURNAL   Proc Natl Acad Sci U S A 101 (9), 2870-2875 (2004)
   PUBMED   14976250
  REMARK    GeneRIF: In the heart MCIP1 gene is activated by calcineurin and
            has been proposed to fulfill a negative feedback loop that
            restrains potentially pathological calcineurin signaling
REFERENCE   7  (bases 1 to 2165)
  AUTHORS   Genesca,L., Aubareda,A., Fuentes,J.J., Estivill,X., De La Luna,S.
            and Perez-Riba,M.
  TITLE     Phosphorylation of calcipressin 1 increases its ability to inhibit
            calcineurin and decreases calcipressin half-life
  JOURNAL   Biochem J 374 (Pt 2), 567-575 (2003)
   PUBMED   12809556
REFERENCE   8  (bases 1 to 2165)
  AUTHORS   Wang,Y., De Keulenaer,G.W., Weinberg,E.O., Muangman,S.,
            Gualberto,A., Landschulz,K.T., Turi,T.G., Thompson,J.F. and
            Lee,R.T.
  TITLE     Direct biomechanical induction of endogenous calcineurin inhibitor
            Down Syndrome Critical Region-1 in cardiac myocytes
  JOURNAL   Am J Physiol Heart Circ Physiol 283 (2), H533-H539 (2002)
   PUBMED   12124198
REFERENCE   9  (bases 1 to 2165)
  AUTHORS   Ermak,G., Morgan,T.E. and Davies,K.J.
  TITLE     Chronic overexpression of the calcineurin inhibitory gene DSCR1
            (Adapt78) is associated with Alzheimer's disease
  JOURNAL   J Biol Chem 276 (42), 38787-38794 (2001)
   PUBMED   11483593
REFERENCE   10 (bases 1 to 2165)
  AUTHORS   Rothermel,B., Vega,R.B., Yang,J., Wu,H., Bassel-Duby,R. and
            Williams,R.S.
  TITLE     A protein encoded within the Down syndrome critical region is
            enriched in striated muscles and inhibits calcineurin signaling
  JOURNAL   J Biol Chem 275 (12), 8719-8725 (2000)
   PUBMED   10722714
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC072478.1.
            
            On Jun 13, 2004 this sequence version replaced NM_153724.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072478.1, EX488565.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132292, SAMEA5756307
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2165
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..2165
                     /gene="Rcan1"
                     /gene_synonym="Dscr1; Mcip1"
                     /note="regulator of calcineurin 1"
                     /db_xref="GeneID:266766"
                     /db_xref="RGD:631338"
     exon            1..149
                     /gene="Rcan1"
                     /gene_synonym="Dscr1; Mcip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..662
                     /gene="Rcan1"
                     /gene_synonym="Dscr1; Mcip1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     calcipressin-1; down syndrome critical region protein 1
                     homolog; myocyte-enriched calcineurin-interacting protein
                     1; Down syndrome critical region homolog 1; Down syndrome
                     critical region gene 1"
                     /codon_start=1
                     /product="calcipressin-1 isoform 2"
                     /protein_id="NP_714946.2"
                     /db_xref="GeneID:266766"
                     /db_xref="RGD:631338"
                     /translation="MHFRDFNYNFSSLIACVANGDVFSESETRAKFESLFRTYDKDIT
                     FQYFKSFKRVRINFSNPLSAADARLQLHKTEFLGKEMKLYFAQTLHIGSSHLAPPNPD
                     KQFLISPPASPPVGWKQVEDATPVINYDLLYAISKLGPGEKYELHAATDTTPSVVVHV
                     CESDQEEEEEEEEEMERMKRPKPKIIQTRRPEYTPIHLS"
     exon            150..323
                     /gene="Rcan1"
                     /gene_synonym="Dscr1; Mcip1"
                     /inference="alignment:Splign:2.1.0"
     exon            324..483
                     /gene="Rcan1"
                     /gene_synonym="Dscr1; Mcip1"
                     /inference="alignment:Splign:2.1.0"
     exon            484..2134
                     /gene="Rcan1"
                     /gene_synonym="Dscr1; Mcip1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttgggctt gactgcgagt gagtgagtcg ttccttaagc gtctgcccgt tgaaaaagca
       61 gaatgcattt tagggacttt aactacaatt ttagctccct gattgcctgt gtggcaaacg
      121 gtgatgtctt cagcgaaagt gagaccaggg ccaaatttga atccctcttc aggacgtatg
      181 acaaggacat caccttccag tattttaaga gcttcaagcg tgtccgaata aacttcagca
      241 accccctgtc tgcggcggac gccaggctgc agctgcataa gacagagttc ctggggaagg
      301 agatgaaact gtactttgcc cagactttac acataggaag ttcacacctg gctccgccca
      361 atccagacaa acagtttctc atctctcccc ctgcctctcc acctgttggc tggaaacaag
      421 tagaagacgc taccccagtc ataaactacg atcttttata tgctatctcc aagctgggac
      481 caggagagaa gtacgagcta cacgcagcga cagacaccac gcccagcgtg gtggtccacg
      541 tgtgtgagag tgaccaagag gaggaggagg aagaggagga ggagatggag agaatgaaga
      601 gacccaagcc aaaaatcatc cagactcgga ggccagagta cacacccatc cacctcagct
      661 gaacaggcac actgaccgac acgcgcgttc tgattcccac atgtgggaag gaatctttta
      721 ctgtgcaagt ggctggtcat agctttggag gtaacagccg tgaccacgtg accatggcag
      781 aaattccagt tcatgttgct cagaagagag tcaaggcctc ctctccttgt tctgatgccg
      841 cacctcagtc tatgtccatg gcatctggga atgtcccagg ccatccactg agtgtgtggc
      901 aatcacacag gacactggcg acgtcctgag aaaactgata gtgtctcata ctcgctcttt
      961 tctaggttct gtttttggaa ggacaggttg actggtggcc agggagagat ttctgtttcc
     1021 agccaacatt cagggtgcag cccccactgg taggcagagg cacccccaaa gccactaagt
     1081 gtccagtgca gaaagttgtg ggacaactcc catgccgtgt ggaaattgtc cttctcgttc
     1141 cttccctcgt ggtctaacgt tcatgcatgt gtattactgg gtctcaagac ttcacgtagg
     1201 aagttgtgct gttgttttca tcttgggaag ctagaaaagt tctgaaacac ttaccatgtg
     1261 tcctggtcct ggctgtctcc acacagcgcc cacacacgtg gggtctcggc tggagacgtc
     1321 catgtatcac cctgcccagt gcaccatgtc acttgtgctt tcttgcaaaa tgagttgatc
     1381 tcgaagtaga acttagctta cctggtggga gagcagcagt ttcgtgccag tcggctgcgg
     1441 gtgggtaggt ttggtttggg tgtttgggtt ccccattgtt cccttcatgt agtggtttgt
     1501 acgtgaatct cagctgaaac cctctttggg aactgttggt tgacagtttc tcacccccat
     1561 ggaaacatga ggatgaactt gtaaataaag ccaagagcta tcttaatacc tgtctgtact
     1621 tgggtgggaa cagagggcag agggagtttc aagccacccg tgacctgtgc gtggtagaag
     1681 ttaagttcct gtcatgtgtt taatggggtg aatctggagc atgtggagta tgccgtagcc
     1741 atgtgttcct agagggacac agtgcctttc ccctttcctt cagcggagtg acactcagtt
     1801 tgggtatttc tccttttcta gtcattgtgt gtgtctggca aataggaatt cttctatctt
     1861 ggtcctacga tgccattaca aagtttgtca cgctgaataa ctgaatgcca gttaacagtg
     1921 catgcctcgg gagctcagaa ggtggcttcc cctgaggagc aaatgggttg atgttctcca
     1981 aaccctgctt ccagtgctcg ctcgcacaag tgggcggcca tcctgtcaac acccagtgtt
     2041 tctagttctg cactttgaac cggagaggcc aacctcaaag atattttttt ttaactgcat
     2101 tgtataataa atcagcacaa taagctcctc tggaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2161 aaaaa
//
