LOCUS       NM_001107839            3930 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus ring finger and CCCH-type domains 2 (Rc3h2),
            mRNA.
ACCESSION   NM_001107839 XM_001053333 XM_001053613 XM_001053668 XM_231249
VERSION     NM_001107839.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3930)
  AUTHORS   Zhang Q, Fan L, Hou F, Dong A, Wang YX and Tong Y.
  TITLE     New Insights into the RNA-Binding and E3 Ubiquitin Ligase
            Activities of Roquins
  JOURNAL   Sci Rep 5, 15660 (2015)
   PUBMED   26489670
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3930)
  AUTHORS   Sakurai S, Ohto U and Shimizu T.
  TITLE     Structure of human Roquin-2 and its complex with constitutive-decay
            element RNA
  JOURNAL   Acta Crystallogr F Struct Biol Commun 71 (Pt 8), 1048-1054 (2015)
   PUBMED   26249698
REFERENCE   3  (bases 1 to 3930)
  AUTHORS   Srivastava M, Duan G, Kershaw NJ, Athanasopoulos V, Yeo JH, Ose T,
            Hu D, Brown SH, Jergic S, Patel HR, Pratama A, Richards S, Verma A,
            Jones EY, Heissmeyer V, Preiss T, Dixon NE, Chong MM, Babon JJ and
            Vinuesa CG.
  TITLE     Roquin binds microRNA-146a and Argonaute2 to regulate microRNA
            homeostasis
  JOURNAL   Nat Commun 6, 6253 (2015)
   PUBMED   25697406
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3930)
  AUTHORS   Jeltsch KM, Hu D, Brenner S, Zoller J, Heinz GA, Nagel D, Vogel KU,
            Rehage N, Warth SC, Edelmann SL, Gloury R, Martin N, Lohs C, Lech
            M, Stehklein JE, Geerlof A, Kremmer E, Weber A, Anders HJ, Schmitz
            I, Schmidt-Supprian M, Fu M, Holtmann H, Krappmann D, Ruland J,
            Kallies A, Heikenwalder M and Heissmeyer V.
  TITLE     Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases
            their cooperatively repressed targets to promote T(H)17
            differentiation
  JOURNAL   Nat Immunol 15 (11), 1079-1089 (2014)
   PUBMED   25282160
REFERENCE   5  (bases 1 to 3930)
  AUTHORS   Maruyama T, Araki T, Kawarazaki Y, Naguro I, Heynen S, Aza-Blanc P,
            Ronai Z, Matsuzawa A and Ichijo H.
  TITLE     Roquin-2 promotes ubiquitin-mediated degradation of ASK1 to
            regulate stress responses
  JOURNAL   Sci Signal 7 (309), ra8 (2014)
   PUBMED   24448648
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3930)
  AUTHORS   Vogel KU, Edelmann SL, Jeltsch KM, Bertossi A, Heger K, Heinz GA,
            Zoller J, Warth SC, Hoefig KP, Lohs C, Neff F, Kremmer E, Schick J,
            Repsilber D, Geerlof A, Blum H, Wurst W, Heikenwalder M,
            Schmidt-Supprian M and Heissmeyer V.
  TITLE     Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40
            costimulator mRNAs and control follicular helper T cell
            differentiation
  JOURNAL   Immunity 38 (4), 655-668 (2013)
   PUBMED   23583643
REFERENCE   7  (bases 1 to 3930)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   8  (bases 1 to 3930)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   9  (bases 1 to 3930)
  AUTHORS   Siess DC, Vedder CT, Merkens LS, Tanaka T, Freed AC, McCoy SL,
            Heinrich MC, Deffebach ME, Bennett RM and Hefeneider SH.
  TITLE     A human gene coding for a membrane-associated nucleic acid-binding
            protein
  JOURNAL   J Biol Chem 275 (43), 33655-33662 (2000)
   PUBMED   10938276
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473983.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001053668.1, XM_001053333.1, XM_001053613.1, XM_231249.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3930
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q11"
     gene            1..3930
                     /gene="Rc3h2"
                     /gene_synonym="Mnab"
                     /note="ring finger and CCCH-type domains 2"
                     /db_xref="GeneID:311909"
                     /db_xref="RGD:1304833"
     exon            1..89
                     /gene="Rc3h2"
                     /gene_synonym="Mnab"
                     /inference="alignment:Splign:2.1.0"
     exon            90..125
                     /gene="Rc3h2"
                     /gene_synonym="Mnab"
                     /inference="alignment:Splign:2.1.0"
     exon            126..422
                     /gene="Rc3h2"
                     /gene_synonym="Mnab"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..3755
                     /gene="Rc3h2"
                     /gene_synonym="Mnab"
                     /EC_number="2.3.2.27"
                     /note="membrane associated DNA binding protein; RING
                     finger and CCCH-type zinc finger domain-containing protein
                     2; ring finger and CCCH-type zinc finger domains 2"
                     /codon_start=1
                     /product="roquin-2"
                     /protein_id="NP_001101309.1"
                     /db_xref="GeneID:311909"
                     /db_xref="RGD:1304833"
                     /translation="MPVQAAQWTEFLSCPICYNEFDENVHKPISLGCSHTVCKTCLNK
                     LHRKACPFDQTAINTDIDVLPVNFALLQLVGAQVPDHQSIKLSNLGENKHYEVAKKCV
                     EDLALYLKPLSGGKGVASLNQSALSRPMQRKLVTLVNCQLVEEEGRVRAMRAARSLGE
                     RTVTELILQHQNPQQLSANLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKV
                     LVLFVVQRLEPRFPQASKTSIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEFRSYEAL
                     RREHDAQIVHIAMEAGLRISPEQWSSLLYGDLAHKSHMQSIIDKLQSPESFAKSVQEL
                     TIVLQRTGDPANLNRLRPHLELLANIDPNPDAVSPTWEQLENAMVAVKTVVHGLVDFI
                     QNYSRKGHETPQPQPNSKYKTSMCRDLRQQGGCPRGTNCTFAHSQEELEKYRLRNKKM
                     SATVRTFPLLNKVAVNSTVTTTAGNVISVIGSTETTGKIVPSTNGISNTESSVSQLIP
                     RSADSAGRTLETVKKVGKVGTNGQNAGPSAESVSENKIGSPPKTPVSNAAATSAGPSN
                     FGTELNSLPPKSSPFLTRVPVYPQHSENIQYFQDPRTQIPFEVPQYPQTGYYPPPPTV
                     PAGVTPCVPRFVRSNNVPESSLPPASMPYADHYSTFSPRDRMNSSPYQPPPPQQYGPV
                     PPVPSGMYAPVYDSRRIWRPAMYQRDDIIRSNSLPPMDVMHSSVYQTSLRERYNSLDG
                     YYSVTCQPPNDPRTTVPLPREPCGHLKSSCEEQLRRKPDQWTQYHTQKTPVSSTLPVA
                     TQSPTPPSPLFSVDFRSDFSESGSGTKFEEDHLSHYSPWSCGTIGSCINAIDSEPKDV
                     IANSNAVLMDLDSGDVKRRVHLFEAQRRTKEEDPIIPFSDGPIISKWGAISRSSRTGY
                     HTTDPVQATASQGSATKPISVSDYVPYVNAVDSRWSSYGNDATSSAHYIERDRFIVTD
                     LSGHRKHSSTGDLLSLELQQAKSNSLLLQREANALAMQQKWNSLDEGRHLTLNLLSKE
                     IELRNGENDYTEDTVDTKPDRDIELELSALDTDEPDGQSEQIEEILDIQLGISSQNDQ
                     LLNGTAVENGHPVQQHQKDPVKQKRQSLGEDHVILEEQKPILPVTSCFSQPRPVSISS
                     ASCLPITTSVSVGNLILKTHVMSEEKNDFLKPIANGKMVNS"
     exon            423..540
                     /gene="Rc3h2"
                     /gene_synonym="Mnab"
                     /inference="alignment:Splign:2.1.0"
     exon            541..774
                     /gene="Rc3h2"
                     /gene_synonym="Mnab"
                     /inference="alignment:Splign:2.1.0"
     exon            775..950
                     /gene="Rc3h2"
                     /gene_synonym="Mnab"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1151
                     /gene="Rc3h2"
                     /gene_synonym="Mnab"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1284
                     /gene="Rc3h2"
                     /gene_synonym="Mnab"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1403
                     /gene="Rc3h2"
                     /gene_synonym="Mnab"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1516
                     /gene="Rc3h2"
                     /gene_synonym="Mnab"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1822
                     /gene="Rc3h2"
                     /gene_synonym="Mnab"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..2037
                     /gene="Rc3h2"
                     /gene_synonym="Mnab"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2471
                     /gene="Rc3h2"
                     /gene_synonym="Mnab"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2639
                     /gene="Rc3h2"
                     /gene_synonym="Mnab"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2786
                     /gene="Rc3h2"
                     /gene_synonym="Mnab"
                     /inference="alignment:Splign:2.1.0"
     exon            2787..3000
                     /gene="Rc3h2"
                     /gene_synonym="Mnab"
                     /inference="alignment:Splign:2.1.0"
     exon            3001..3085
                     /gene="Rc3h2"
                     /gene_synonym="Mnab"
                     /inference="alignment:Splign:2.1.0"
     exon            3086..3167
                     /gene="Rc3h2"
                     /gene_synonym="Mnab"
                     /inference="alignment:Splign:2.1.0"
     exon            3168..3302
                     /gene="Rc3h2"
                     /gene_synonym="Mnab"
                     /inference="alignment:Splign:2.1.0"
     exon            3303..3410
                     /gene="Rc3h2"
                     /gene_synonym="Mnab"
                     /inference="alignment:Splign:2.1.0"
     exon            3411..3559
                     /gene="Rc3h2"
                     /gene_synonym="Mnab"
                     /inference="alignment:Splign:2.1.0"
     exon            3560..3930
                     /gene="Rc3h2"
                     /gene_synonym="Mnab"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccggcgaga cgaggcgcct ccgtcgccga gccgcgccgt cgcggggccc ccgggagcgg
       61 cccttagcga ccccgccagg gcccctcagt accggggatt gaatttaaag cttcacaaac
      121 attagcttaa aaaacactac acagcaaaat aatgatctgc tagtctgcta acccgagcat
      181 cagcttccac aatgcctgtg caggccgctc aatggacaga gtttctgtcc tgtccaatct
      241 gctataatga atttgatgag aatgtgcaca aacccatcag tttaggttgt tcacacactg
      301 tttgcaagac ctgcttgaat aaacttcacc gaaaagcgtg tccttttgac cagactgcca
      361 taaacacaga cattgatgtg ctccctgtca actttgcact tcttcagtta gttggagccc
      421 aggtaccaga tcatcagtca ataaagttaa gtaatctagg tgagaataaa cactatgaag
      481 tggcaaaaaa atgtgtggag gatttggcac tctacttaaa accactaagt ggaggtaaag
      541 gtgtagctag tttgaaccag agtgccctga gccgtccaat gcaaaggaaa ctagttacac
      601 ttgtaaactg tcaactggtg gaggaagaag gtcgtgtcag agctatgcga gcggcccgtt
      661 cactaggaga aagaactgtg acagaactga tactgcagca ccagaaccct cagcagctgt
      721 ctgccaacct gtgggctgct gtcagggctc gaggatgcca gtttctaggg ccagctatgc
      781 aagaagaagc cttgaagttg gtattgctgg cattagaaga tggttctgct ctctctagga
      841 aagttctggt actttttgtt gtgcaaagac tagaaccaag atttcctcag gcatcaaaaa
      901 caagtattgg ccatgttgtg cagctactgt accgagcttc ttgttttaag gttactaaaa
      961 gggatgaaga ctcttccctg atgcagctga aggaggaatt tcggagttat gaggcactac
     1021 gcagagaaca tgatgcccaa attgttcata ttgccatgga agcaggactc cgtatttcac
     1081 ctgagcagtg gtcttcactg ctatatgggg acttggctca taaatcacac atgcagtcta
     1141 tcattgataa gctacagtct ccagaatcat ttgcaaagag tgtccaagaa ttgacaattg
     1201 ttttgcaacg aacaggtgac cccgctaatt taaatagact gaggcctcat ttagagcttc
     1261 ttgcaaacat agatcctaat ccagatgctg tttcaccaac ttgggagcaa ctggaaaatg
     1321 caatggtagc tgttaaaaca gtggttcatg gtcttgtgga cttcatacaa aattatagta
     1381 ggaaaggtca tgagacaccc cagccacagc caaacagcaa gtataaaact agtatgtgcc
     1441 gagatttacg acaacaaggg ggttgtccac gaggaacaaa ttgtacattt gcccattctc
     1501 aggaagagct tgaaaagtac cgattaagga acaaaaagat gagcgcgact gtaagaacat
     1561 ttcctcttct gaataaagtt gctgtaaaca gcactgtcac aaccacagcc ggaaatgtca
     1621 tttctgtcat aggaagtact gaaacaactg ggaaaattgt tccaagtaca aatggaattt
     1681 caaatacaga aagcagtgtt tcccagctaa tcccacgaag tgctgacagt gcaggaagga
     1741 ctttggagac tgtgaagaaa gttgggaaag ttggcactaa tggtcagaat gctgggccct
     1801 ctgcagagtc tgtgtctgaa aataaaattg gttctccacc caagactcct gtaagtaatg
     1861 cagcagctac ctccgctggg ccctctaatt ttggaacaga gctgaattcc ctgcctccca
     1921 aatccagccc atttctaact cgagttccag tatatcctca gcattctgaa aacatccagt
     1981 attttcaaga tccaaggact cagatacctt ttgaagtccc acaataccca caaacaggat
     2041 actacccacc acctccaacg gtaccagctg gtgtgactcc ctgtgttcct cgctttgtga
     2101 ggtccaataa tgttccagag tcctccctcc cacctgcttc catgccatat gctgatcatt
     2161 acagtacatt ttcccctcga gatcgaatga attcttctcc ttaccaacct cctcctccgc
     2221 agcagtatgg accagttcct ccagtaccct ctgggatgta tgctcctgtg tatgacagca
     2281 ggcgcatctg gcgcccagct atgtaccagc gagatgacat tattagaagc aattctttac
     2341 ctccaatgga tgtgatgcac tcatctgtct atcagacatc tttacgggaa agatacaact
     2401 cattagatgg ttattattca gtgacttgtc agccaccaaa tgacccaagg acaactgtgc
     2461 ctttaccaag ggaaccttgt ggtcatttaa aaagcagttg tgaggaacag ttaagaagaa
     2521 agccagatca gtggacacag tatcataccc agaagacacc tgtctcttca actcttcctg
     2581 tggcaacaca gtcaccaaca ccaccttctc ctttgttcag tgtagacttc agatcggatt
     2641 tctctgagag tgggagtggc acaaaatttg aggaagacca tctttcccat tattctcctt
     2701 ggtcttgtgg cactataggc tcttgtataa atgccattga ttcagagccc aaagatgtaa
     2761 ttgccaattc aaatgctgtg ctgatggacc tggacagtgg tgatgtaaag agaagagtgc
     2821 atttatttga agctcagaga aggacaaaag aagaagaccc aattattccc tttagtgacg
     2881 gacccattat ctcaaaatgg ggtgcaattt cccgatcctc ccgaacaggt taccatacaa
     2941 cagatcccgt ccaggcaact gcttcccaag gaagtgcaac taagcccatc agtgtatcag
     3001 attatgtccc ttatgttaat gctgtcgatt caaggtggag ttcatatggt aacgatgcca
     3061 catcatcagc acactatatt gaacgggaca gattcattgt taccgattta tctggtcata
     3121 gaaagcactc cagtaccgga gacctcttga gccttgagct tcagcaggcc aagagtaact
     3181 cattacttct tcagagggaa gctaatgctc tggccatgca acaaaagtgg aattccctgg
     3241 atgaaggccg tcatcttact ttaaatctcc taagcaagga aattgaactg agaaatggag
     3301 agaatgatta cacagaagac actgtagata ccaagcctga tagagatatt gagttagaac
     3361 tttcagccct tgatactgat gagcctgatg gccaaagtga acaaattgaa gaaattctgg
     3421 acatacaact tggtatcagt tctcaaaatg atcagttgct aaatggaact gcagtggaaa
     3481 atggtcatcc tgtccagcag caccaaaagg accccgtaaa gcagaagaga cagagtttag
     3541 gtgaagacca tgtgattctg gaggagcaaa aaccaattct gccagtaaca tcttgcttta
     3601 gccagccacg cccagtgtct attagcagtg caagctgcct ccctatcacc acatctgtca
     3661 gtgttggcaa cctcattctg aaaactcacg ttatgtctga agagaaaaac gactttttaa
     3721 aacctattgc aaatgggaag atggttaaca gctgaaagga ggctcatctt tcaaatctgt
     3781 gaccacatca tggaagcatt tacactagct ttttatatat ataatatata ttatataatg
     3841 tatatttttt ttaaaaaaaa gatattactg ggggcatcca tttcctgtgg actctttgat
     3901 acttcaagcc ctcttgcatt agcattatga
//
