LOCUS       NM_001034135            1482 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ring-box 1 (Rbx1), mRNA.
ACCESSION   NM_001034135 XM_216991
VERSION     NM_001034135.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1482)
  AUTHORS   Ye,B., Liu,B., Hao,L., Zhu,X., Yang,L., Wang,S., Xia,P., Du,Y.,
            Meng,S., Huang,G., Qin,X., Wang,Y., Yan,X., Li,C., Hao,J., Zhu,P.,
            He,L., Tian,Y. and Fan,Z.
  TITLE     Klf4 glutamylation is required for cell reprogramming and early
            embryonic development in mice
  JOURNAL   Nat Commun 9 (1), 1261 (2018)
   PUBMED   29593216
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1482)
  AUTHORS   Chu,W.K., Payne,M.J., Beli,P., Hanada,K., Choudhary,C. and
            Hickson,I.D.
  TITLE     FBH1 influences DNA replication fork stability and homologous
            recombination through ubiquitylation of RAD51
  JOURNAL   Nat Commun 6, 5931 (2015)
   PUBMED   25585578
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1482)
  AUTHORS   Hayes,J.D. and Dinkova-Kostova,A.T.
  TITLE     The Nrf2 regulatory network provides an interface between redox and
            intermediary metabolism
  JOURNAL   Trends Biochem Sci 39 (4), 199-218 (2014)
   PUBMED   24647116
  REMARK    Review article
REFERENCE   4  (bases 1 to 1482)
  AUTHORS   Fernandez-Saiz,V., Targosz,B.S., Lemeer,S., Eichner,R., Langer,C.,
            Bullinger,L., Reiter,C., Slotta-Huspenina,J., Schroeder,S.,
            Knorn,A.M., Kurutz,J., Peschel,C., Pagano,M., Kuster,B. and
            Bassermann,F.
  TITLE     SCFFbxo9 and CK2 direct the cellular response to growth factor
            withdrawal via Tel2/Tti1 degradation and promote survival in
            multiple myeloma
  JOURNAL   Nat Cell Biol 15 (1), 72-81 (2013)
   PUBMED   23263282
REFERENCE   5  (bases 1 to 1482)
  AUTHORS   Tron,A.E., Arai,T., Duda,D.M., Kuwabara,H., Olszewski,J.L.,
            Fujiwara,Y., Bahamon,B.N., Signoretti,S., Schulman,B.A. and
            DeCaprio,J.A.
  TITLE     The glomuvenous malformation protein Glomulin binds Rbx1 and
            regulates cullin RING ligase-mediated turnover of Fbw7
  JOURNAL   Mol Cell 46 (1), 67-78 (2012)
   PUBMED   22405651
REFERENCE   6  (bases 1 to 1482)
  AUTHORS   Kim,J., Kim,J.H., Lee,S.H., Kim,D.H., Kang,H.Y., Bae,S.H., Pan,Z.Q.
            and Seo,Y.S.
  TITLE     The novel human DNA helicase hFBH1 is an F-box protein
  JOURNAL   J Biol Chem 277 (27), 24530-24537 (2002)
   PUBMED   11956208
REFERENCE   7  (bases 1 to 1482)
  AUTHORS   Ohh,M., Kim,W.Y., Moslehi,J.J., Chen,Y., Chau,V., Read,M.A. and
            Kaelin,W.G. Jr.
  TITLE     An intact NEDD8 pathway is required for Cullin-dependent
            ubiquitylation in mammalian cells
  JOURNAL   EMBO Rep 3 (2), 177-182 (2002)
   PUBMED   11818338
REFERENCE   8  (bases 1 to 1482)
  AUTHORS   Kamura,T., Burian,D., Yan,Q., Schmidt,S.L., Lane,W.S., Querido,E.,
            Branton,P.E., Shilatifard,A., Conaway,R.C. and Conaway,J.W.
  TITLE     Muf1, a novel Elongin BC-interacting leucine-rich repeat protein
            that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin
            ligase
  JOURNAL   J Biol Chem 276 (32), 29748-29753 (2001)
   PUBMED   11384984
REFERENCE   9  (bases 1 to 1482)
  AUTHORS   Kamura,T., Koepp,D.M., Conrad,M.N., Skowyra,D., Moreland,R.J.,
            Iliopoulos,O., Lane,W.S., Kaelin,W.G. Jr., Elledge,S.J.,
            Conaway,R.C., Harper,J.W. and Conaway,J.W.
  TITLE     Rbx1, a component of the VHL tumor suppressor complex and SCF
            ubiquitin ligase
  JOURNAL   Science 284 (5414), 657-661 (1999)
   PUBMED   10213691
REFERENCE   10 (bases 1 to 1482)
  AUTHORS   Ohta,T., Michel,J.J., Schottelius,A.J. and Xiong,Y.
  TITLE     ROC1, a homolog of APC11, represents a family of cullin partners
            with an associated ubiquitin ligase activity
  JOURNAL   Mol Cell 3 (4), 535-541 (1999)
   PUBMED   10230407
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001034135.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100258.1, DV213784.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                JAXUCZ010000007.1  114870979-114871061
            84-162              JAXUCZ010000007.1  114873539-114873617
            163-233             JAXUCZ010000007.1  114875969-114876039
            234-319             JAXUCZ010000007.1  114878770-114878855
            320-1482            JAXUCZ010000007.1  114880032-114881194
FEATURES             Location/Qualifiers
     source          1..1482
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1482
                     /gene="Rbx1"
                     /note="ring-box 1"
                     /db_xref="GeneID:300084"
                     /db_xref="RGD:1308453"
     exon            1..83
                     /gene="Rbx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..332
                     /gene="Rbx1"
                     /note="RING-box protein 1; ring-box 1, E3 ubiquitin
                     protein ligase"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase RBX1"
                     /protein_id="NP_001029307.1"
                     /db_xref="GeneID:300084"
                     /db_xref="RGD:1308453"
                     /translation="MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAI
                     CRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWE
                     FQKYGH"
     exon            84..162
                     /gene="Rbx1"
                     /inference="alignment:Splign:2.1.0"
     exon            163..233
                     /gene="Rbx1"
                     /inference="alignment:Splign:2.1.0"
     exon            234..319
                     /gene="Rbx1"
                     /inference="alignment:Splign:2.1.0"
     exon            320..1482
                     /gene="Rbx1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaaaatggc ggcggcgatg gatgtggata cccccagcgg caccaacagc ggcgcgggca
       61 agaagcgctt tgaagttaaa aagtggaatg cagtagccct ctgggcctgg gatattgtgg
      121 ttgataactg tgccatctgc aggaaccaca ttatggatct ttgtatcgag tgtcaggcca
      181 accaggcctc agctacttcg gaagagtgca cggttgcttg gggagtctgt aaccacgctt
      241 ttcatttcca ctgcatctct cggtggctca aaaccaggca ggtgtgcccc ttggacaaca
      301 gagagtggga gttccaaaag tatgggcatt aggaaagact ctcccgtaaa gcttacccat
      361 ttgttactcg tttagtgact tcctgttaat tatacattag atagaaccat ggttcttttc
      421 ctttcctttg tctttggagt ttggtgttcc cgcagccata ctgtgttttg tgtcaaataa
      481 agcctttaag ttggagacgg ttgctgtttc atgtatgtgg aaagagtgag ctgagaagga
      541 gcctcttcag agccaggaag ccagcctcag aaagtgcact gttcttgacg agaacacact
      601 tgtcttcaca aggtcacaag gaacctgtta aagtctgcaa gtgcgggtca ctggcacctg
      661 gaaatgcctg aggctctgtc ttccttctga gatagcacca ggcaggaatg aggaagcaca
      721 tggcagcctt ggaccagcca ggcctgctct gggctctcac ctctcctgag ggagtctgag
      781 aatgagtgaa tggcatcaaa tgggcacaga aaggctttgt aagctctgaa caccacagag
      841 ttggtgctga ttgtggatga catgttgcag tctctagaac aaaacttgac aaaaaaaatc
      901 ataatatgta atcttggctg gcaatagaat gatcttaaag tcaacttgaa aactgatatt
      961 tggacagttt gagtatatgc ctgtaattcc aggtacttgg gaattaggta gaaggatcct
     1021 ttgaatccag gagaccttgt ttctaaatga gattctagtt tggggtctag ggggtgctgt
     1081 agctcagctg ctgtaaggcc ttgagttcat ttgctggtgt gaattttttt tttttttttt
     1141 aaaaaaggtc gaaattaaat taagttaaca agaactcagg tttcctttaa acatgctggc
     1201 caggaaaggc gtggccaccc tgatgctgat tcagtggctg tagtctactg agacactgtt
     1261 tctgttgttg tgattttcat gtagttaacc atcctacaaa ggtcctgaaa cccttcaggg
     1321 gagctttcct ctctccggtg ccattccatg tgtccagata aagcaggtct gagactccca
     1381 accatcttct gttgtcaagc agagaaagat tgcaaaaatg tgaaacaatg ctgtcattat
     1441 tcatgtttcc aaagttaatt ttaataaaaa tatttatgtt aa
//
