LOCUS       NM_001271244            1060 bp    mRNA    linear   ROD 14-APR-2024
DEFINITION  Rattus norvegicus RNA binding protein, mRNA processing factor
            (Rbpms), mRNA.
ACCESSION   NM_001271244 XM_573923
VERSION     NM_001271244.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1060)
  AUTHORS   Yang,Y., Lee,G.C., Nakagaki-Silva,E., Huang,Y., Peacey,M.,
            Partridge,R., Gooding,C. and Smith,C.W.J.
  TITLE     Cell-type specific regulator RBPMS switches alternative splicing
            via higher-order oligomerization and heterotypic interactions with
            other splicing regulators
  JOURNAL   Nucleic Acids Res 51 (18), 9961-9982 (2023)
   PUBMED   37548402
REFERENCE   2  (bases 1 to 1060)
  AUTHORS   Nakagaki-Silva,E.E., Gooding,C., Llorian,M., Jacob,A.G.,
            Richards,F., Buckroyd,A., Sinha,S. and Smith,C.W.J.
  TITLE     Identification of RBPMS as a mammalian smooth muscle master
            splicing regulator via proximity of its gene with super-enhancers
  JOURNAL   Elife 8, e46327 (2019)
   PUBMED   31283468
  REMARK    GeneRIF: Data indicate RNA-Binding Protein with Multiple Splicing
            (RBPMS) as a critical regulator of numerous alternative splicing
            (AS) events in vascular smooth muscle cells (SMCs)
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1060)
  AUTHORS   Teplova,M., Farazi,T.A., Tuschl,T. and Patel,D.J.
  TITLE     Structural basis underlying CAC RNA recognition by the RRM domain
            of dimeric RNA-binding protein RBPMS
  JOURNAL   Q Rev Biophys 49, e1 (2016)
   PUBMED   26347403
REFERENCE   4  (bases 1 to 1060)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 1060)
  AUTHORS   Kwong,J.M., Caprioli,J. and Piri,N.
  TITLE     RNA binding protein with multiple splicing: a new marker for
            retinal ganglion cells
  JOURNAL   Invest Ophthalmol Vis Sci 51 (2), 1052-1058 (2010)
   PUBMED   19737887
  REMARK    GeneRIF: The data indicate that in the retina RBPMS is selectively
            expressed in RGCs and therefore could serve as a marker for RGC
            quantification in normal retinas and for estimation of RGC loss in
            ocular neuropathies.
REFERENCE   6  (bases 1 to 1060)
  AUTHORS   Sun,Y., Ding,L., Zhang,H., Han,J., Yang,X., Yan,J., Zhu,Y., Li,J.,
            Song,H. and Ye,Q.
  TITLE     Potentiation of Smad-mediated transcriptional activation by the
            RNA-binding protein RBPMS
  JOURNAL   Nucleic Acids Res 34 (21), 6314-6326 (2006)
   PUBMED   17099224
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Sep 8, 2012 this sequence version replaced XM_573923.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.38392.1,
                                           SRR26643288.55932.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-355               JAXUCZ010000016.1  64942609-64942963
            356-433             JAXUCZ010000016.1  65012216-65012293
            434-472             JAXUCZ010000016.1  65013860-65013898
            473-535             JAXUCZ010000016.1  65015256-65015318
            536-686             JAXUCZ010000016.1  65045105-65045255
            687-820             JAXUCZ010000016.1  65075161-65075294
            821-1060            JAXUCZ010000016.1  65077846-65078085
FEATURES             Location/Qualifiers
     source          1..1060
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.2-q12.3"
     gene            1..1060
                     /gene="Rbpms"
                     /gene_synonym="RBP-MS; RGD1561067"
                     /note="RNA binding protein, mRNA processing factor"
                     /db_xref="GeneID:498642"
                     /db_xref="RGD:1561067"
     exon            1..355
                     /gene="Rbpms"
                     /gene_synonym="RBP-MS; RGD1561067"
                     /inference="alignment:Splign:2.1.0"
     CDS             290..952
                     /gene="Rbpms"
                     /gene_synonym="RBP-MS; RGD1561067"
                     /note="RNA binding protein gene with multiple splicing;
                     RNA binding protein with multiple splicing"
                     /codon_start=1
                     /product="RNA-binding protein with multiple splicing"
                     /protein_id="NP_001258173.1"
                     /db_xref="GeneID:498642"
                     /db_xref="RGD:1561067"
                     /translation="MNGGGKAEKENTPSEANLQEEEVRTLFVSGLPLDIKPRELYLLF
                     RPFKGYEGSLIKLTSKQPVGFVSFDSRSEAEAAKNALNGIRFDPEIPQTLRLEFAKAN
                     TKMAKNKLVGTPNPSTPLPNTVPQFIAREPYELTVPALYPSSPEVWAPYPLYPAELAP
                     ALPPPAAFTYPASLHAQCFSPEAKPNTPVFCPLLQQIRFVSGNVFVTYQPTADQQREL
                     PC"
     exon            356..433
                     /gene="Rbpms"
                     /gene_synonym="RBP-MS; RGD1561067"
                     /inference="alignment:Splign:2.1.0"
     exon            434..472
                     /gene="Rbpms"
                     /gene_synonym="RBP-MS; RGD1561067"
                     /inference="alignment:Splign:2.1.0"
     exon            473..535
                     /gene="Rbpms"
                     /gene_synonym="RBP-MS; RGD1561067"
                     /inference="alignment:Splign:2.1.0"
     exon            536..686
                     /gene="Rbpms"
                     /gene_synonym="RBP-MS; RGD1561067"
                     /inference="alignment:Splign:2.1.0"
     exon            687..820
                     /gene="Rbpms"
                     /gene_synonym="RBP-MS; RGD1561067"
                     /inference="alignment:Splign:2.1.0"
     exon            821..1060
                     /gene="Rbpms"
                     /gene_synonym="RBP-MS; RGD1561067"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgagagaa agcgcgctgc gtgcggcccc gctgcccaga gcctgccagc tgcgcgccct
       61 cggccgctcg ggtcctaacc gcgcccgccg cctcgcctcc tccgcctcgg ccgcgtcccg
      121 actcccgggc tcgcccggcc tctcggaggt ccccgcccga ctccgctctc cgctgtgccg
      181 cccggctcca gccccgcagc ccgccccggg gggaaggtag cagcgggcga gcgcgccctc
      241 gcctccagcc ccgcgcccca gccccgcgcg gcgacgaagg accgggaaga tgaacggcgg
      301 cggcaaagcc gagaaggaga acaccccgag cgaggccaac cttcaggagg aggaggtccg
      361 gaccctgttt gtcagtggcc tgcctctgga catcaagccc cgagagctgt acctgctctt
      421 caggccattc aagggctatg aaggttctct cataaagctc acatctaaac agcccgtagg
      481 ctttgtcagt ttcgacagtc gctcagaagc agaggccgca aagaatgctt tgaacggcat
      541 ccgcttcgat cctgaaatcc cgcaaacact acgactagag tttgctaagg caaacacgaa
      601 gatggccaag aacaaactcg tagggactcc aaaccccagt actcctctgc ccaacactgt
      661 acctcagttc attgccaggg agccatatga gctcacagta cctgcacttt accccagtag
      721 ccctgaagtg tgggccccgt accctctgta cccagcggag ttagcgcctg ctcttcctcc
      781 tcctgccgct ttcacctatc ccgcttcact gcatgcccag tgtttctctc cagaggcaaa
      841 gcccaacaca cctgtctttt gtccacttct tcagcaaatt agatttgtct ctgggaatgt
      901 gtttgtcacg tatcaaccca ctgcagacca acagagggag ctcccatgtt gaatttatta
      961 gcaagcctcc cctgccccct tttgcaaaaa ctatttcttg atgatatttg agagatttca
     1021 ataaaaattt taatcagagc aaaaaaaaaa tggtctcaag
//
