LOCUS       NM_001414973            5488 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus recombination signal binding protein for
            immunoglobulin kappa J region (Rbpj), transcript variant 2, mRNA.
ACCESSION   NM_001414973 XM_039092404
VERSION     NM_001414973.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5488)
  AUTHORS   Wang,Y., Wu,B., Farrar,E., Lui,W., Lu,P., Zhang,D., Alfieri,C.M.,
            Mao,K., Chu,M., Yang,D., Xu,D., Rauchman,M., Taylor,V.,
            Conway,S.J., Yutzey,K.E., Butcher,J.T. and Zhou,B.
  TITLE     Notch-Tnf signalling is required for development and homeostasis of
            arterial valves
  JOURNAL   Eur Heart J 38 (9), 675-686 (2017)
   PUBMED   26491108
REFERENCE   2  (bases 1 to 5488)
  AUTHORS   Lu,J., Zhou,Y., Hu,T., Zhang,H., Shen,M., Cheng,P., Dai,W.,
            Wang,F., Chen,K., Zhang,Y., Wang,C., Li,J., Zheng,Y., Yang,J.,
            Zhu,R., Wang,J., Lu,W., Zhang,H., Wang,J., Xia,Y., De
            Assuncao,T.M., Jalan-Sakrikar,N., Huebert,R.C., Bin,Zhou. and
            Guo,C.
  TITLE     Notch Signaling Coordinates Progenitor Cell-Mediated Biliary
            Regeneration Following Partial Hepatectomy
  JOURNAL   Sci Rep 6, 22754 (2016)
   PUBMED   26951801
  REMARK    GeneRIF: RBPJ promotes hepatic progenitor cell differentiation
            toward cholangiocytes in vitro and blocks hepatocyte
            differentiation through mechanisms involving Hippo-Notch crosstalk.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5488)
  AUTHORS   Garcia,T.X., Farmaha,J.K., Kow,S. and Hofmann,M.C.
  TITLE     RBPJ in mouse Sertoli cells is required for proper regulation of
            the testis stem cell niche
  JOURNAL   Development 141 (23), 4468-4478 (2014)
   PUBMED   25406395
REFERENCE   4  (bases 1 to 5488)
  AUTHORS   Bi,P., Shan,T., Liu,W., Yue,F., Yang,X., Liang,X.R., Wang,J.,
            Li,J., Carlesso,N., Liu,X. and Kuang,S.
  TITLE     Inhibition of Notch signaling promotes browning of white adipose
            tissue and ameliorates obesity
  JOURNAL   Nat Med 20 (8), 911-918 (2014)
   PUBMED   25038826
REFERENCE   5  (bases 1 to 5488)
  AUTHORS   Satpathy,A.T., Briseno,C.G., Lee,J.S., Ng,D., Manieri,N.A., Kc,W.,
            Wu,X., Thomas,S.R., Lee,W.L., Turkoz,M., McDonald,K.G.,
            Meredith,M.M., Song,C., Guidos,C.J., Newberry,R.D., Ouyang,W.,
            Murphy,T.L., Stappenbeck,T.S., Gommerman,J.L., Nussenzweig,M.C.,
            Colonna,M., Kopan,R. and Murphy,K.M.
  TITLE     Notch2-dependent classical dendritic cells orchestrate intestinal
            immunity to attaching-and-effacing bacterial pathogens
  JOURNAL   Nat Immunol 14 (9), 937-948 (2013)
   PUBMED   23913046
REFERENCE   6  (bases 1 to 5488)
  AUTHORS   Apelqvist,A., Li,H., Sommer,L., Beatus,P., Anderson,D.J., Honjo,T.,
            Hrabe de Angelis,M., Lendahl,U. and Edlund,H.
  TITLE     Notch signalling controls pancreatic cell differentiation
  JOURNAL   Nature 400 (6747), 877-881 (1999)
   PUBMED   10476967
REFERENCE   7  (bases 1 to 5488)
  AUTHORS   Hsieh,J.J., Zhou,S., Chen,L., Young,D.B. and Hayward,S.D.
  TITLE     CIR, a corepressor linking the DNA binding factor CBF1 to the
            histone deacetylase complex
  JOURNAL   Proc Natl Acad Sci U S A 96 (1), 23-28 (1999)
   PUBMED   9874765
REFERENCE   8  (bases 1 to 5488)
  AUTHORS   Issack,P.S. and Ziff,E.B.
  TITLE     Genetic elements regulating HES-1 induction in Wnt-1-transformed
            PC12 cells
  JOURNAL   Cell Growth Differ 9 (10), 827-836 (1998)
   PUBMED   9790494
REFERENCE   9  (bases 1 to 5488)
  AUTHORS   Minoguchi,S., Taniguchi,Y., Kato,H., Okazaki,T., Strobl,L.J.,
            Zimber-Strobl,U., Bornkamm,G.W. and Honjo,T.
  TITLE     RBP-L, a transcription factor related to RBP-Jkappa
  JOURNAL   Mol Cell Biol 17 (5), 2679-2687 (1997)
   PUBMED   9111338
REFERENCE   10 (bases 1 to 5488)
  AUTHORS   de la Pompa,J.L., Wakeham,A., Correia,K.M., Samper,E., Brown,S.,
            Aguilera,R.J., Nakano,T., Honjo,T., Mak,T.W., Rossant,J. and
            Conlon,R.A.
  TITLE     Conservation of the Notch signalling pathway in mammalian
            neurogenesis
  JOURNAL   Development 124 (6), 1139-1148 (1997)
   PUBMED   9102301
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000014.1.
            
            On Dec 16, 2022 this sequence version replaced XM_039092404.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.54678.1,
                                           SRR26643294.50074.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               JAXUCZ010000014.1  61615065-61615260   c
            197-235             JAXUCZ010000014.1  61578503-61578541   c
            236-331             JAXUCZ010000014.1  61570942-61571037   c
            332-497             JAXUCZ010000014.1  61563613-61563778   c
            498-672             JAXUCZ010000014.1  61560438-61560612   c
            673-810             JAXUCZ010000014.1  61558579-61558716   c
            811-923             JAXUCZ010000014.1  61558308-61558420   c
            924-1064            JAXUCZ010000014.1  61557242-61557382   c
            1065-1220           JAXUCZ010000014.1  61556118-61556273   c
            1221-1324           JAXUCZ010000014.1  61555650-61555753   c
            1325-5488           JAXUCZ010000014.1  61551366-61555529   c
FEATURES             Location/Qualifiers
     source          1..5488
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q11"
     gene            1..5488
                     /gene="Rbpj"
                     /note="recombination signal binding protein for
                     immunoglobulin kappa J region"
                     /db_xref="GeneID:679028"
                     /db_xref="RGD:1593096"
     exon            1..196
                     /gene="Rbpj"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..1640
                     /gene="Rbpj"
                     /note="isoform 2 is encoded by transcript variant 2;
                     recombining binding protein suppressor of hairless"
                     /codon_start=1
                     /product="recombining binding protein suppressor of
                     hairless isoform 2"
                     /protein_id="NP_001401902.1"
                     /db_xref="GeneID:679028"
                     /db_xref="RGD:1593096"
                     /translation="MAPVVTGKFGERPPPKRLTREAMRNYLKERGDQTVLILHAKVAQ
                     KSYGNEKRFFCPPPCVYLMGSGWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQL
                     NLEGKNYCTAKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKKKQS
                     LKNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFYIHLLDDDESE
                     GEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALLDADDPVSQLHKCAFY
                     LKDTERMYLCLSQERIIQFQATPCPKEQNKEMINDGASWTIISTDKAEYTFYEGMGPV
                     LAPVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVWFGDVEAETMYRCGESMLCVV
                     PDISAFREGWRWVRQPVQVPVTLVRNDGIIYSTSLTFTYTPEPGPRPHCSAAGAILRA
                     NSSQVPTNESNTNSEGNYTNASTNSTSVTSSTATVVS"
     exon            197..235
                     /gene="Rbpj"
                     /inference="alignment:Splign:2.1.0"
     exon            236..331
                     /gene="Rbpj"
                     /inference="alignment:Splign:2.1.0"
     exon            332..497
                     /gene="Rbpj"
                     /inference="alignment:Splign:2.1.0"
     exon            498..672
                     /gene="Rbpj"
                     /inference="alignment:Splign:2.1.0"
     exon            673..810
                     /gene="Rbpj"
                     /inference="alignment:Splign:2.1.0"
     exon            811..923
                     /gene="Rbpj"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1064
                     /gene="Rbpj"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1220
                     /gene="Rbpj"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1324
                     /gene="Rbpj"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..5488
                     /gene="Rbpj"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccgcggg cggcgcgagg tggctggctc ctggcggcgg cggagcaggg aaagacggcg
       61 cgggggccgg gtggcagcga tcagcgaggc cgagggaagg ggcgggggag aggagcaggg
      121 aaaggcggcg gggggaatct cgcgagggtt ggagttttgg cgagagtttg tggaagatgg
      181 cgcctgttgt gacagggaag tttggtgagc ggcctccacc taaacgactt actagggaag
      241 ctatgcgaaa ttatttaaaa gaacgagggg atcaaacagt actcattctt catgcaaaag
      301 ttgcacagaa gtcatatgga aatgaaaaac gatttttttg ccctcctcct tgtgtgtatc
      361 ttatgggcag tggttggaag aaaaaaaaag aacaaatgga acgagatggt tgttctgaac
      421 aagagtctca accctgtgca tttattggaa taggaaatag tgaccaagaa atgcagcagc
      481 tgaacttgga agggaagaac tactgcacag ccaaaacatt gtacatatct gattcagaca
      541 agaggaaaca tttcatgttg tctgtaaaga tgttctatgg caacagtgat gacatcggtg
      601 tgttccttag caagcggata aaggtcatct ccaaaccttc caaaaagaag caatcattga
      661 aaaatgctga cttgtgcatt gcctcaggga caaaggtggc gctgtttaat cgacttcggt
      721 cccagaccgt tagcaccaga tacctgcacg tagaaggagg gaatttccat gctagttcac
      781 agcagtgggg agcattttac attcatctct tggatgatga tgaatcggaa ggagaggaat
      841 tcacagttag agatggctac atccattatg gacagactgt caagctggtg tgctcagtta
      901 ctggcatggc actcccaaga ctgataatta ggaaagttga taagcagaca gcattactgg
      961 atgcagacga ccctgtatca caactccaca aatgtgcatt ttaccttaag gacacagaaa
     1021 gaatgtactt gtgcctttct caagaaagaa taatccaatt tcaggccact ccatgtccaa
     1081 aagaacaaaa taaagaaatg ataaatgatg gagcgtcctg gacaatcatc agcacagaca
     1141 aggctgagta cacgttctat gagggaatgg gccctgtcct tgccccggtc actcctgtgc
     1201 ctgtcgtaga aagtctccag ttgaatggcg gcggggatgt agccatgctt gaactcacag
     1261 gacaaaactt tactccaaat ttacgagtgt ggtttgggga tgtagaggcc gaaacaatgt
     1321 acagatgtgg agagagcatg ctctgtgtgg tcccagacat ctctgcattc cgagaaggtt
     1381 ggcgatgggt ccggcagcca gtccaggttc cagtaacttt ggtccgtaat gatggaatca
     1441 tttactccac cagccttacc tttacctaca ccccagaacc agggccaagg ccgcactgca
     1501 gcgcagcggg agccattctc agagccaact caagccaagt gcccaccaat gagtcaaaca
     1561 caaacagcga gggaaattac acaaatgcca gcacaaattc taccagtgtc acgtcgtcca
     1621 cagcaaccgt ggtgtcctaa ctaccgtctt tttgctggga cttaaactga cttgaatgcg
     1681 gcaaaaagtt gacagaaaaa ggcaaggata aagtgaacaa tcttttgtgg tttcttgggg
     1741 aaacgttcca taccaggtga tctattcaaa actgcaagtg cagatgtgaa atgcagaagc
     1801 cacagtgaaa tgaacaacat cacaatgtac aggctgctgg aaatccagtt ttcagctgtc
     1861 tctcacacac accccttttg gttgtttttg gtttggtttt gatttaatgg tcaagagata
     1921 gacatgcggc tgagtacagg ttaagctaga agacacaaac ctaacctagt ttttatggac
     1981 caagggactt gcataagctt tagtaaaagg tacattttca ccatgccttt tttatactgc
     2041 agtatgtcaa acaccttgtt accaaacagg ttgcgctccc cacccgttga gggttggctc
     2101 taaagtctaa tcaggttcta gcctgacctt gcttgttcaa tctgagtacc gaacacttcc
     2161 aggttctttt ggtctaaggc tggaactttt tttaagctga agtcttatga ctttttcata
     2221 agttggaatt attttgattt cagcaagtca aattttgtaa aggcctgcat atttttttta
     2281 tgattatatg aagtctgcaa aagctttaaa aatgcctctg ccttgcctgc aatacatgca
     2341 atgtatgtta acttagtctg ttctcagata ctgttggtag ttacttctgt gttttcccct
     2401 ttttaaagaa atgtatttat agtggtaatc taagagatgc taacagctca gtcggggtgg
     2461 ccgttcggtg atcctgagtt gatggcactg aacaccgcca tttgacagct gtgcgcctct
     2521 gcctgtccat cacttcatct gtgttccagg agtcgtccag gtcccctccc caagtctgta
     2581 cataacttgt attatgtgta agttaaacat ttttaaacat tttatcttta cttggaatgt
     2641 tcccagtgat tacatttaac agggtgtttc ctaccttgtt ggcaaatggc aaaaaatatc
     2701 atgagaatta tttgctacca agttggtgcc cttagggtaa aatgaggaaa gtctctgcag
     2761 gatgatttat tgtatttttt ttcctttttt ttagcctagc cagaacatca ttataatttt
     2821 aaacttaaga ccataagatg gcttttatta gatgataact aaataaactg aactaagtag
     2881 ccagaagaca gtaccttaga gacagatagt tgtaagttta taaaaataca aatgtaactt
     2941 atatttccat tttcctcttt gcccctttgt ttatttttcc ccaatagaaa tattctgtcc
     3001 aattttcccc tttttaaaaa gttaagcttt gcttaccttc aggcgtgtgt gtcagcctgt
     3061 gtgctaatat tgccagtttt gttgtttcca tccatccctg cactttgggt aaaaccttgt
     3121 tcagtttctt aggaattgca gcagactcat tgggctacat ttagtacaag aaccacatat
     3181 tgatgttaaa ggacacagtc tagtgatgcc accatccttg agtaagaact acctctagat
     3241 tgtggtaagc gtttactgtc ccttaaacag cggccactag taccttacaa acgcagacta
     3301 acttctaatg gcggtttgtc tttctggcta tctgggcgtc tgaaagtttt cacgtagacc
     3361 cttagcctcc cgtcaggacc attgctttcc agctttgctg cctttctctc tctgtctcat
     3421 agactgtgcc actgtaaatg ccactccgaa cacctttaaa ctgcctcctc cttgtttgtc
     3481 aaggggaagg ccacctgtaa aatgtggtgg tgacagcctt cttactcacc ccaagctggg
     3541 gctgcgctgg acagccattt ctcttgagat cagctgcagc ccgctgcctc cccacctcac
     3601 acctccaggc tgtgtcagtg gtgcagggcg gagctcactg tggccttacc tatctgtgca
     3661 gtaactgttc ttggttccct tcagccctgc ttctttccaa gcacctctcc tcagctgcca
     3721 tggaagcagg gcactgcggt ctggagcagt ttgcagtgcc gctgtgcttt ctgagggcct
     3781 agatttaggg tttagttagg tcgttaactg agaacagatg agatgctttt gaagaacaaa
     3841 ctattcctta cccagctttg tagcttaaag taagttttca agttcatggc tttattaaaa
     3901 tgaactttga ctttttaaaa tgcttatatc tcatttcggt tcttttgttt attttagtaa
     3961 gaattgaaac aattagacta taagtcgttt tcctgtttgt ttgtttgttt tttttacaaa
     4021 gttcaagaat gtaacaataa aggcattttc ctatggtttt atgtcagact cctaccacag
     4081 agtagcctga acagatacgt ctgttttacc atgttcttga tagttctttt gtcagctgct
     4141 tttattaaaa gtcctttctg tggatttgta agtcagtttc agtatgtgat gtacaggagt
     4201 cttgtcccgg ttactgtgga atgttccctc cctgttgatg ctgttgtaga tgctggccct
     4261 ttatcctctt accttcttag agcgggaatt cttcagtcgt ggtgtgtggg tgtgtttttc
     4321 cattctgttt agtgagtcta cacagcttct taaaacatgt ctaaatgcag agtccgagac
     4381 ccacggtgta tttcagctcc ttgaatttgt caagagattg gaaggcaggc cagaaactga
     4441 aaatgtgggc tgtcctttgt gcagttgcag agcggaacac tgggactttg agctgctgac
     4501 tactcagact gcggcggctt ccctgtgtac agtaaaatgc ctgccattct tactgccacc
     4561 atcttaacct taacaatttt gtttcttttc tgtgtggtgc tggggtcaca aatctagggc
     4621 ctcaggcttc tttgctaagg ctttttgtta gtgttttcag gagacaaggg tctcacccat
     4681 gtagcccctc agggcattct tgaaagttcc tgccttagtc tccaggtcct ggggtgggta
     4741 ccagctatgg ccgggtgcct gtactgcttt tgcctagaga acctggtctg tgttcaacca
     4801 cagaggaatt ccaatgcaat ttttaataat taatccacta gttatttaat caaaatcttc
     4861 ttgtgggaag agattcctgt ttgaaagaaa atgttaattg attattaacc aagttaacag
     4921 acatcgtttt ccaaagcagc tgtgtctctg gtgagtactg aacaaatgtg cgaacttctt
     4981 gtcacttttg atttactttt caagcactgt tacttgggat ggatggttag aaacataata
     5041 accctttcag gactgagctg tatcgccttc tattgatttc tccctgtgtc atgataaatg
     5101 tttgccagtg ttcagtactg tgtcggtcca gatgtaggtt tatgtaaaag ctcagtttta
     5161 gcttatttct tgtaccttgc agcatgctct acacattcag tccttaaggg gtttacttta
     5221 caaactgtgc gtctgtaagg gttattagca ataagataga aaatcgagca agtttatacc
     5281 ataattttgt agaaaaagga atctgctcaa ttccatattt catccatgaa aactctgcaa
     5341 tacgggcagt ttctaggaat aaataaaaag gaaatgtcaa ccattgtaaa tgtcttctgt
     5401 gggatgtgcc caatgcatgt atcatcgtct ttgacttcag atacttcata aagataaaat
     5461 taaattctat attacagttt gcggacta
//
