LOCUS       NP_037294                201 aa            linear   ROD 03-APR-2024
DEFINITION  retinol-binding protein 4 precursor [Rattus norvegicus].
ACCESSION   NP_037294 XP_001080229 XP_215285
VERSION     NP_037294.1
DBSOURCE    REFSEQ: accession NM_013162.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 201)
  AUTHORS   Zhang,Y., Zhang,Y., Tan,Y., Luo,X. and Jia,R.
  TITLE     Increased RBP4 and Asprosin Are Novel Contributors in Inflammation
            Process of Periodontitis in Obese Rats
  JOURNAL   Int J Mol Sci 24 (23), 16739 (2023)
   PUBMED   38069063
  REMARK    GeneRIF: Increased RBP4 and Asprosin Are Novel Contributors in
            Inflammation Process of Periodontitis in Obese Rats.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 201)
  AUTHORS   Sheng,B.W., Zhang,J.Q., Chen,M. and Ma,M.
  TITLE     The inverse association between fasting blood glucose and the
            occurrence of gallbladder cancer in type 2 diabetes mellitus
            patients: a case-control study
  JOURNAL   J Cancer Res Clin Oncol 149 (12), 10387-10398 (2023)
   PUBMED   37273108
REFERENCE   3  (residues 1 to 201)
  AUTHORS   Zhou,W., Yuan,X., Li,J., Wang,W. and Ye,S.
  TITLE     Retinol binding protein 4 promotes the phenotypic transformation of
            vascular smooth muscle cells under high glucose condition via
            modulating RhoA/ROCK1 pathway
  JOURNAL   Transl Res 259, 13-27 (2023)
   PUBMED   37003483
  REMARK    GeneRIF: Retinol binding protein 4 promotes the phenotypic
            transformation of vascular smooth muscle cells under high glucose
            condition via modulating RhoA/ROCK1 pathway.
REFERENCE   4  (residues 1 to 201)
  AUTHORS   Valencia-Martinez,A., Schaefer-Graf,U., Amusquivar,E., Herrera,E.
            and Ortega-Senovilla,H.
  TITLE     Relationship of ANGPTL6 With Neonatal Glucose Homeostasis and Fat
            Mass Is Disrupted in Gestational Diabetic Pregnancies
  JOURNAL   J Clin Endocrinol Metab 107 (10), e4078-e4085 (2022)
   PUBMED   35876300
REFERENCE   5  (residues 1 to 201)
  AUTHORS   Liu,C., Zhou,X.R., Ye,M.Y., Xu,X.Q., Zhang,Y.W., Liu,H. and
            Huang,X.Z.
  TITLE     RBP4 Is Associated With Insulin Resistance in Hyperuricemia-Induced
            Rats and Patients With Hyperuricemia
  JOURNAL   Front Endocrinol (Lausanne) 12, 653819 (2021)
   PUBMED   34177800
  REMARK    GeneRIF: RBP4 Is Associated With Insulin Resistance in
            Hyperuricemia-Induced Rats and Patients With Hyperuricemia.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 201)
  AUTHORS   Wu,Q.X.
  TITLE     [Amplification and desensitization in platelet activation]
  JOURNAL   Sheng Li Ke Xue Jin Zhan 23 (3), 199-203 (1992)
   PUBMED   1299958
  REMARK    Review article
REFERENCE   7  (residues 1 to 201)
  AUTHORS   Laurent,B.C., Nilsson,M.H., Bavik,C.O., Jones,T.A., Sundelin,J. and
            Peterson,P.A.
  TITLE     Characterization of the rat retinol-binding protein gene and its
            comparison to the three-dimensional structure of the protein
  JOURNAL   J Biol Chem 260 (21), 11476-11480 (1985)
   PUBMED   4044565
REFERENCE   8  (residues 1 to 201)
  AUTHORS   Sundelin,J., Laurent,B.C., Anundi,H., Tragardh,L., Larhammar,D.,
            Bjorck,L., Eriksson,U., Akerstrom,B., Jones,A., Newcomer,M. et al.
  TITLE     Amino acid sequence homologies between rabbit, rat, and human serum
            retinol-binding proteins
  JOURNAL   J Biol Chem 260 (10), 6472-6480 (1985)
   PUBMED   3838985
REFERENCE   9  (residues 1 to 201)
  AUTHORS   Fex,G. and Hansson,B.
  TITLE     Retinol-binding protein from human urine and its interaction with
            retinol and prealbumin
  JOURNAL   Eur J Biochem 94 (1), 307-313 (1979)
   PUBMED   571335
REFERENCE   10 (residues 1 to 201)
  AUTHORS   Peterson,P.A., Rask,L., Ostberg,L., Andersson,L., Kamwendo,F. and
            Pertoft,H.
  TITLE     Studies on the transport and cellular distribution of vitamin A in
            normal and vitamin A-deficient rats with special reference to the
            vitamin A-binding plasma protein
  JOURNAL   J Biol Chem 248 (11), 4009-4022 (1973)
   PUBMED   4708098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CO561550.1 and DV725071.1.
            
            On or before Oct 13, 2007 this sequence version replaced
            XP_001080229.1, XP_215285.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF108847.1, BC167099.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..201
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q53"
     Protein         1..201
                     /product="retinol-binding protein 4 precursor"
                     /note="retinol binding protein 4, plasma; RBP; PRBP;
                     plasma retinol-binding protein"
                     /calculated_mol_wt=21394
     sig_peptide     1..18
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1844
     mat_peptide     19..201
                     /product="Retinol-binding protein 4.
                     /evidence=ECO:0000250|UniProtKB:P02753,
                     ECO:0000305|PubMed:3838985. /id=PRO_0000017970"
                     /note="propagated from UniProtKB/Swiss-Prot (P04916.1)"
                     /calculated_mol_wt=21394
     Region          22..192
                     /region_name="lipocalin_RBP_like"
                     /note="retinol-binding protein 4 and similar proteins;
                     cd00743"
                     /db_xref="CDD:381184"
     Site            order(38,42,47,50,53..55,61,63,71,73..75,79,81,91..93,95,
                     104,106,108,114..116,120,122,124,133,135,137,139,151,153,
                     155)
                     /site_type="other"
                     /note="ligand binding cavity [chemical binding]"
                     /db_xref="CDD:381184"
     Site            order(47,50,53..55,61,63,73..75,79,81,91..93,95,106,108,
                     114..116,120,122,135,139,151,153,155)
                     /site_type="other"
                     /note="retinol binding site [chemical binding]"
                     /db_xref="CDD:381184"
     Site            order(81..85,107,109,113..117)
                     /site_type="other"
                     /note="transthyretin interface [polypeptide binding]"
                     /db_xref="CDD:381184"
     Site            139
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q00724; propagated from
                     UniProtKB/Swiss-Prot (P04916.1)"
     CDS             1..201
                     /gene="Rbp4"
                     /gene_synonym="RBPA"
                     /coded_by="NM_013162.1:51..656"
                     /db_xref="GeneID:25703"
                     /db_xref="RGD:3546"
ORIGIN      
        1 mewvwalvll aalgggsaer dcrvssfrvk enfdkarfsg lwyaiakkdp eglflqdnii
       61 aefsvdekgh msatakgrvr llsnwevcad mvgtftdted pakfkmkywg vasflqrgnd
      121 dhwiidtdyd tfalqyscrl qnldgtcads ysfvfsrdpn gltpetrrlv rqrqeelcle
      181 rqyrwiehng ycqsrpsrns l
//
