LOCUS       NP_001178761            1234 aa            linear   ROD 03-APR-2025
DEFINITION  retinol-binding protein 3 precursor [Rattus norvegicus].
ACCESSION   NP_001178761 XP_341401
VERSION     NP_001178761.1
DBSOURCE    REFSEQ: accession NM_001191832.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1234)
  AUTHORS   Chiasserini,D., van Weering,J.R., Piersma,S.R., Pham,T.V.,
            Malekzadeh,A., Teunissen,C.E., de Wit,H. and Jimenez,C.R.
  TITLE     Proteomic analysis of cerebrospinal fluid extracellular vesicles: a
            comprehensive dataset
  JOURNAL   J Proteomics 106, 191-204 (2014)
   PUBMED   24769233
REFERENCE   2  (residues 1 to 1234)
  AUTHORS   Daiger,S.P., Sullivan,L.S. and Bowne,S.J.
  TITLE     Genes and mutations causing retinitis pigmentosa
  JOURNAL   Clin Genet 84 (2), 132-141 (2013)
   PUBMED   23701314
  REMARK    Review article
REFERENCE   3  (residues 1 to 1234)
  AUTHORS   Li,S., Yang,Z., Hu,J., Gordon,W.C., Bazan,N.G., Haas,A.L., Bok,D.
            and Jin,M.
  TITLE     Secretory defect and cytotoxicity: the potential disease mechanisms
            for the retinitis pigmentosa (RP)-associated interphotoreceptor
            retinoid-binding protein (IRBP)
  JOURNAL   J Biol Chem 288 (16), 11395-11406 (2013)
   PUBMED   23486466
REFERENCE   4  (residues 1 to 1234)
  AUTHORS   Garlipp,M.A., Nowak,K.R. and Gonzalez-Fernandez,F.
  TITLE     Cone outer segment extracellular matrix as binding domain for
            interphotoreceptor retinoid-binding protein
  JOURNAL   J Comp Neurol 520 (4), 756-769 (2012)
   PUBMED   21935947
REFERENCE   5  (residues 1 to 1234)
  AUTHORS   Kiser,P.D., Golczak,M., Maeda,A. and Palczewski,K.
  TITLE     Key enzymes of the retinoid (visual) cycle in vertebrate retina
  JOURNAL   Biochim Biophys Acta 1821 (1), 137-151 (2012)
   PUBMED   21447403
  REMARK    Review article
REFERENCE   6  (residues 1 to 1234)
  AUTHORS   Suzuki,H., Tsuchiya,K. and Takezaki,N.
  TITLE     A molecular phylogenetic framework for the Ryukyu endemic rodents
            Tokudaia osimensis and Diplothrix legata
  JOURNAL   Mol Phylogenet Evol 15 (1), 15-24 (2000)
   PUBMED   10764531
REFERENCE   7  (residues 1 to 1234)
  AUTHORS   Serizawa,K., Suzuki,H. and Tsuchiya,K.
  TITLE     A phylogenetic view on species radiation in Apodemus inferred from
            variation of nuclear and mitochondrial genes
  JOURNAL   Biochem Genet 38 (1-2), 27-40 (2000)
   PUBMED   10862357
REFERENCE   8  (residues 1 to 1234)
  AUTHORS   Katz,M.L., Gao,C.L. and Stientjes,H.J.
  TITLE     Regulation of the interphotoreceptor retinoid-binding protein
            content of the retina by vitamin A
  JOURNAL   Exp Eye Res 57 (4), 393-401 (1993)
   PUBMED   8282025
REFERENCE   9  (residues 1 to 1234)
  AUTHORS   Gonzalez-Fernandez,F., Van Niel,E., Edmonds,C., Beaver,H.,
            Nickerson,J.M., Garcia-Fernandez,J.M., Campohiaro,P.A. and
            Foster,R.G.
  TITLE     Differential expression of interphotoreceptor retinoid-binding
            protein, opsin, cellular retinaldehyde-binding protein, and basic
            fibroblastic growth factor
  JOURNAL   Exp Eye Res 56 (4), 411-427 (1993)
   PUBMED   7916695
  REMARK    Erratum:[Exp Eye Res 1993 Jul;57(1):127]
REFERENCE   10 (residues 1 to 1234)
  AUTHORS   Gonzalez-Fernandez,F. and Healy,J.I.
  TITLE     Early expression of the gene for interphotoreceptor retinol-binding
            protein during photoreceptor differentiation suggests a critical
            role for the interphotoreceptor matrix in retinal development
  JOURNAL   J Cell Biol 111 (6 Pt 1), 2775-2784 (1990)
   PUBMED   1703544
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Jul 17, 2010 this sequence version replaced XP_341401.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.1203846.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1234
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     Protein         1..1234
                     /product="retinol-binding protein 3 precursor"
                     /note="retinol-binding protein 2; interphotoreceptor
                     retinol- binding protein; interphotoreceptor retinoid
                     binding protein; retinol binding protein 3, interstitial"
                     /calculated_mol_wt=132774
     sig_peptide     1..17
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1978
     Region          27..318
                     /region_name="Peptidase_S41_IRBP"
                     /note="Interphotoreceptor retinoid-binding protein; serine
                     protease family S41; cd07563"
                     /db_xref="CDD:143479"
     Site            order(86,237,297)
                     /site_type="active"
                     /note="active site triad [active]"
                     /db_xref="CDD:143479"
     Region          329..624
                     /region_name="Peptidase_S41_IRBP"
                     /note="Interphotoreceptor retinoid-binding protein; serine
                     protease family S41; cd07563"
                     /db_xref="CDD:143479"
     Site            order(384,545,605)
                     /site_type="active"
                     /note="active site triad [active]"
                     /db_xref="CDD:143479"
     Region          637..929
                     /region_name="Peptidase_S41_IRBP"
                     /note="Interphotoreceptor retinoid-binding protein; serine
                     protease family S41; cd07563"
                     /db_xref="CDD:143479"
     Site            order(696,848,906)
                     /site_type="active"
                     /note="active site triad [active]"
                     /db_xref="CDD:143479"
     Region          938..1224
                     /region_name="Peptidase_S41_IRBP"
                     /note="Interphotoreceptor retinoid-binding protein; serine
                     protease family S41; cd07563"
                     /db_xref="CDD:143479"
     Site            order(995,1147,1205)
                     /site_type="active"
                     /note="active site triad [active]"
                     /db_xref="CDD:143479"
     CDS             1..1234
                     /gene="Rbp3"
                     /gene_synonym="Irbp"
                     /coded_by="NM_001191832.1:73..3777"
                     /db_xref="GeneID:24711"
                     /db_xref="RGD:3545"
ORIGIN      
        1 mmrewvlvls tllcvlagpt hlfqpslvld makvlldnyc fpenlmgmqa aieqamkshe
       61 ilgisdpqtl ahvltvgvqs slndprlfis yepstleapq qapaltdltr eellaqiqrn
      121 irhevlednv gylrvddlpg qevlselgef lvshvwkqlt gtsslvldlr hcagghvsgi
      181 pyvisylhpg ntvlhvdtiy drpsntttei wtlpkvlger ysadkdvvvl tsghtggvae
      241 diayilkqmr raivvgerte ggaldlqklr igqsdffltv pvsrslgplg gggqtwegsg
      301 vlpcvgipae qalekalail tlrralpgvv lrlqealqdy ytlvdrvpgl lhhlasmdys
      361 avvseedlvt klnaglqavs edprllvrat gpretpsrpe tgpneppavt pevpkeedar
      421 ralvdsvfqv svlpgnvgyl rfdrfadasv lktlgpyvlr qvweplqdte hlimdlrhnp
      481 ggpssavplv lsyfqgpeag pvrlfttydr rtnitqehfs hkellgqryg nrrgvyllts
      541 hrtataaeef aflmqslswa tlvgeitags llhtctvpll dspeggltlt vpvltfidnh
      601 geawlgggvv pdaivlaeea leraqevldf hrslgalveg tgrlleahya rpeiaeqard
      661 llqsklaqga yrtavdlesl asqltadlqe vsedhrllvf hspgelvaee vplpppaips
      721 peelsyliea lfktdvlpgh lgylrfdama eletvkaigp qlvrlvwqrl vdtaalvvdl
      781 rynpgsyssa vpllcsyffe eeprqhlysv fdratsrvte iwtlplvagq rygshkdlyi
      841 lmshtsgsaa eafahtmqdl qratvigept aggalsvgiy qvdnsplyas mptqmalsat
      901 tgeawdlagv epditvpmse alstaqdiva lrakvptvlq tagklvadny aspelgakma
      961 aklsglqsry arvtsegala emlgadlqml sgdphlktah ipedakdrip givpmqipsp
     1021 evfedlikfs fhtnvfedni gylrfdmfgd celliqvsel lvehiwkkiv htdaliidmr
     1081 fniggptssi salcsyffde appvlldkiy nrpndsisel wthsqltger ygskksvail
     1141 tsgvtagaae eftyimkrlg ralvvgevts ggcqppqtyh vddthlyiti ptarsvgatd
     1201 gsswegvgvt pnvvvssela ltrakeilqr alra
//
