LOCUS       NM_012640                674 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus retinol binding protein 2 (Rbp2), mRNA.
ACCESSION   NM_012640
VERSION     NM_012640.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 674)
  AUTHORS   Cottin,S.C., Gambling,L., Hayes,H.E., Stevens,V.J. and McArdle,H.J.
  TITLE     Pregnancy and maternal iron deficiency stimulate hepatic CRBPII
            expression in rats
  JOURNAL   J Nutr Biochem 32, 55-63 (2016)
   PUBMED   27142737
  REMARK    GeneRIF: Data suggest that, as compared to controls, CrbpII
            expression in liver is up-regulated by pregnancy and further
            increased by iron deficiency; maternal iron deficiency has little
            impact on vitamin A levels and gene expression in placenta, but
            increases retinol storage in fetal liver; regulation of CrbpII
            expression in liver may play important roles in vitamin A
            metabolism in pregnant females and in fetal development.
REFERENCE   2  (bases 1 to 674)
  AUTHORS   Hebiguchi,T., Mezaki,Y., Morii,M., Watanabe,R., Yoshikawa,K.,
            Miura,M., Imai,K., Senoo,H. and Yoshino,H.
  TITLE     Massive bowel resection upregulates the intestinal mRNA expression
            levels of cellular retinol-binding protein II and apolipoprotein
            A-IV and alters the intestinal vitamin A status in rats
  JOURNAL   Int J Mol Med 35 (3), 724-730 (2015)
   PUBMED   25585692
  REMARK    GeneRIF: These results suggest that the elevated mRNA expression
            levels of Rbp2 and Apoa4 in the rats with SB contribute to the
            effective esterification and transport of vitamin A.
REFERENCE   3  (bases 1 to 674)
  AUTHORS   Harrison,E.H.
  TITLE     Mechanisms involved in the intestinal absorption of dietary vitamin
            A and provitamin A carotenoids
  JOURNAL   Biochim Biophys Acta 1821 (1), 70-77 (2012)
   PUBMED   21718801
  REMARK    Review article
REFERENCE   4  (bases 1 to 674)
  AUTHORS   Franzoni,L., Cavazzini,D., Rossi,G.L. and Lucke,C.
  TITLE     New insights on the protein-ligand interaction differences between
            the two primary cellular retinol carriers
  JOURNAL   J Lipid Res 51 (6), 1332-1343 (2010)
   PUBMED   19965581
  REMARK    GeneRIF: protein-ligand interaction differences between CRBP-I and
            CRBP-II
REFERENCE   5  (bases 1 to 674)
  AUTHORS   Ogura,Y., Mochizuki,K. and Goda,T.
  TITLE     Induction of histone acetylation on the CRBPII gene in perinatal
            rat small intestine
  JOURNAL   Biochim Biophys Acta 1770 (9), 1289-1296 (2007)
   PUBMED   17692466
  REMARK    GeneRIF: results suggest that CRBPII gene expression during the
            perinatal period is associated with abrupt acetylation of histones
            H3 and H4 followed by the binding of CBP/p300 and RXRalpha.
REFERENCE   6  (bases 1 to 674)
  AUTHORS   Winter,N.S., Bratt,J.M. and Banaszak,L.J.
  TITLE     Crystal structures of holo and apo-cellular retinol-binding protein
            II
  JOURNAL   J Mol Biol 230 (4), 1247-1259 (1993)
   PUBMED   8487303
REFERENCE   7  (bases 1 to 674)
  AUTHORS   Gonzalez-Fernandez,F., Van Niel,E., Edmonds,C., Beaver,H.,
            Nickerson,J.M., Garcia-Fernandez,J.M., Campohiaro,P.A. and
            Foster,R.G.
  TITLE     Differential expression of interphotoreceptor retinoid-binding
            protein, opsin, cellular retinaldehyde-binding protein, and basic
            fibroblastic growth factor
  JOURNAL   Exp Eye Res 56 (4), 411-427 (1993)
   PUBMED   7916695
  REMARK    Erratum:[Exp Eye Res 1993 Jul;57(1):127]
REFERENCE   8  (bases 1 to 674)
  AUTHORS   Schaefer,W.H., Kakkad,B., Crow,J.A., Blair,I.A. and Ong,D.E.
  TITLE     Purification, primary structure characterization, and cellular
            distribution of two forms of cellular retinol-binding protein, type
            II from adult rat small intestine
  JOURNAL   J Biol Chem 264 (7), 4212-4221 (1989)
   PUBMED   2645288
REFERENCE   9  (bases 1 to 674)
  AUTHORS   Demmer,L.A., Birkenmeier,E.H., Sweetser,D.A., Levin,M.S.,
            Zollman,S., Sparkes,R.S., Mohandas,T., Lusis,A.J. and Gordon,J.I.
  TITLE     The cellular retinol binding protein II gene. Sequence analysis of
            the rat gene, chromosomal localization in mice and humans, and
            documentation of its close linkage to the cellular retinol binding
            protein gene
  JOURNAL   J Biol Chem 262 (6), 2458-2467 (1987)
   PUBMED   3029082
REFERENCE   10 (bases 1 to 674)
  AUTHORS   Li,E., Demmer,L.A., Sweetser,D.A., Ong,D.E. and Gordon,J.I.
  TITLE     Rat cellular retinol-binding protein II: use of a cloned cDNA to
            define its primary structure, tissue-specific expression, and
            developmental regulation
  JOURNAL   Proc Natl Acad Sci U S A 83 (16), 5779-5783 (1986)
   PUBMED   3461459
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M13949.1 and CN542437.1.
            
            On Oct 26, 2005 this sequence version replaced NM_012640.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M13949.1, CB729037.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-559               M13949.1           1-559
            560-674             CN542437.1         1-115               c
FEATURES             Location/Qualifiers
     source          1..674
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..674
                     /gene="Rbp2"
                     /note="retinol binding protein 2"
                     /db_xref="GeneID:24710"
                     /db_xref="RGD:3544"
     exon            1..128
                     /gene="Rbp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..460
                     /gene="Rbp2"
                     /note="Retinol-binding protein 2, cellular; CRBP-II;
                     cellular retinol-binding protein II; retinol binding
                     protein 2, cellular"
                     /codon_start=1
                     /product="retinol-binding protein 2"
                     /protein_id="NP_036772.2"
                     /db_xref="GeneID:24710"
                     /db_xref="RGD:3544"
                     /translation="MTKDQNGTWEMESNENFEGYMKALDIDFATRKIAVRLTQTKIIV
                     QDGDNFKTKTNSTFRNYDLDFTVGVEFDEHTKGLDGRNVKTLVTWEGNTLVCVQKGEK
                     ENRGWKQWVEGDKLYLELTCGDQVCRQVFKKK"
     exon            129..307
                     /gene="Rbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            308..409
                     /gene="Rbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            410..659
                     /gene="Rbp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagcttgtt ccttcacggt caccaaacgt ccgcatcaaa ccagaggccg ccatcatgac
       61 gaaggaccag aatggaacct gggaaatgga gagtaatgag aactttgaag gctacatgaa
      121 ggccctagat attgattttg ccacccgcaa gattgcagtg cgtctgactc agacgaagat
      181 catcgttcaa gacggtgata acttcaagac aaaaaccaac agcacgttcc gcaactatga
      241 cctagatttc acagtggggg tggagtttga cgaacacaca aagggtctgg atggccggaa
      301 cgtcaagacc ctagtcacct gggaaggaaa caccctggtg tgtgtgcaga aaggggagaa
      361 ggagaatcgt ggctggaagc agtgggtcga gggagacaag ctgtacctgg agctgacctg
      421 cggtgaccag gtgtgtcgac aagtgttcaa aaagaagtga tgggcccagg ggaagcctgg
      481 aacatgtgta gagttctctg ccattctgaa aagcagcatt gggactccct ggttcctgac
      541 agagcccccc ttgcatcacc tgcctgggtt tgaaacaggg tgtgttaaag gaacctaccc
      601 cctccccctt agaacctatt attaaataaa aaaacaaaac atcctctcgg cctttgaaaa
      661 aaaaaaaaaa aaaa
//
