LOCUS       NM_001100548            3018 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus RNA binding motif protein 5 (Rbm5), mRNA.
ACCESSION   NM_001100548 XM_001073543 XM_217263
VERSION     NM_001100548.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3018)
  AUTHORS   Jackson,T.C., Kotermanski,S.E. and Kochanek,P.M.
  TITLE     Whole-transcriptome microarray analysis reveals regulation of Rab4
            by RBM5 in neurons
  JOURNAL   Neuroscience 361, 93-107 (2017)
   PUBMED   28818525
  REMARK    GeneRIF: RBM5 regulates Rab4a in rat neurons
REFERENCE   2  (bases 1 to 3018)
  AUTHORS   Zhang,J., Cui,Z., Feng,G., Bao,G., Xu,G., Sun,Y., Wang,L., Chen,J.,
            Jin,H., Liu,J., Yang,L. and Li,W.
  TITLE     RBM5 and p53 expression after rat spinal cord injury: implications
            for neuronal apoptosis
  JOURNAL   Int J Biochem Cell Biol 60, 43-52 (2015)
   PUBMED   25578565
  REMARK    GeneRIF: findings indicate that RBM5 promotes neuronal apoptosis
            through modulating p53 signaling pathway following SCI.
REFERENCE   3  (bases 1 to 3018)
  AUTHORS   Loiselle,J.J. and Sutherland,L.C.
  TITLE     Differential downregulation of Rbm5 and Rbm10 during skeletal and
            cardiac differentiation
  JOURNAL   In Vitro Cell Dev Biol Anim 50 (4), 331-339 (2014)
   PUBMED   24178303
  REMARK    GeneRIF: This work establishes myoblast differentiation as a
            relevant model in which to conduct functional studies regarding
            Rbm5 and Rbm10.
REFERENCE   4  (bases 1 to 3018)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 3018)
  AUTHORS   Kotlajich,M.V. and Hertel,K.J.
  TITLE     Death by splicing: tumor suppressor RBM5 freezes splice-site
            pairing
  JOURNAL   Mol Cell 32 (2), 162-164 (2008)
   PUBMED   18951082
REFERENCE   6  (bases 1 to 3018)
  AUTHORS   Fushimi,K., Ray,P., Kar,A., Wang,L., Sutherland,L.C. and Wu,J.Y.
  TITLE     Up-regulation of the proapoptotic caspase 2 splicing isoform by a
            candidate tumor suppressor, RBM5
  JOURNAL   Proc Natl Acad Sci U S A 105 (41), 15708-15713 (2008)
   PUBMED   18840686
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166477.1.
            
            [WARNING] On Aug 9, 2024 this sequence was replaced by
            NM_001100548.2.
            
            On or before Sep 4, 2008 this sequence version replaced
            XM_217263.4, XM_001073543.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166477.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3018
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..3018
                     /gene="Rbm5"
                     /note="RNA binding motif protein 5"
                     /db_xref="GeneID:300996"
                     /db_xref="RGD:1305059"
     exon            1..233
                     /gene="Rbm5"
                     /inference="alignment:Splign:2.1.0"
     exon            234..305
                     /gene="Rbm5"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..2736
                     /gene="Rbm5"
                     /codon_start=1
                     /product="RNA-binding protein 5"
                     /protein_id="NP_001094018.1"
                     /db_xref="GeneID:300996"
                     /db_xref="RGD:1305059"
                     /translation="MGSDKRVSRTERSGRYGSIIDRDDRDERESRSRRRDSDYKRSSD
                     DRRGDRYDDYRDYDSPERERERRNSDRSEDGYHSDGDYGEHDYRHDISDERESKTIML
                     RGLPITITESDIREMMESFEGPQPADVRLMKRKTGVSRGFAFVEFYHLQDATSWMEAN
                     QKKLVIQGKHIAMHYSNPRPKFEDWLCNKCCLNNFRKRLKCFRCGADKFDSEQEVPPG
                     TTESVQSVDYYCDTIILRNIAPHTVVDSIMTALSPYASLAVNNIRLIKDKQTQQNRGF
                     AFVQLSSAMDASQLLQILQSLHPPLKIDGKTIGVDFAKSARKDLVLPDGNRVSAFSVA
                     STAIAAAQWSSTQSQSGEGGNVDYSYMQPGQDGYTQYTQYSQDYQQFYQQQTGGLESD
                     ASATSGTTVTTTSAAVVSQSPQLYNQTSNPPGSPTEEAQPSTSTSTQAPAASPTGVVP
                     GTKYAVPDTSTYQYDESSGYYYDPTTGLYYDPNSQYYYNSLTQQYLYWDGEKETYVPA
                     AESSSNQQAGLPSTKEGKEKKEKPKSKTAQQIAKDMERWAKSLNKQKENFKNSFQPVN
                     SLREEERRESAAADAGFALFEKKGALAERQQLIPELVRNGDEENPLKRGLVAAYSGDS
                     DNEEELVERLESEEEKLADWKKMACLLCRRQFPNRDALVRHQQLSDLHKQNMDIYRRS
                     RLSEQELEALELREREMKYRDRAAERREKYGIPEPPEPKRKKQFDAGTVNYEQPTKDG
                     IDHSNIGNKMLQAMGWREGSGLGRKCQGITAPIEAQVRLKGAGLGAKGSAYGLSGADS
                     YKDAVRKAMFARFTEME"
     exon            306..471
                     /gene="Rbm5"
                     /inference="alignment:Splign:2.1.0"
     exon            472..627
                     /gene="Rbm5"
                     /inference="alignment:Splign:2.1.0"
     exon            628..697
                     /gene="Rbm5"
                     /inference="alignment:Splign:2.1.0"
     exon            698..771
                     /gene="Rbm5"
                     /inference="alignment:Splign:2.1.0"
     exon            772..855
                     /gene="Rbm5"
                     /inference="alignment:Splign:2.1.0"
     exon            856..916
                     /gene="Rbm5"
                     /inference="alignment:Splign:2.1.0"
     exon            917..982
                     /gene="Rbm5"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1143
                     /gene="Rbm5"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1241
                     /gene="Rbm5"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1329
                     /gene="Rbm5"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1407
                     /gene="Rbm5"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1480
                     /gene="Rbm5"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1566
                     /gene="Rbm5"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1651
                     /gene="Rbm5"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1743
                     /gene="Rbm5"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1905
                     /gene="Rbm5"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2055
                     /gene="Rbm5"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2127
                     /gene="Rbm5"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2307
                     /gene="Rbm5"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2382
                     /gene="Rbm5"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2480
                     /gene="Rbm5"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2610
                     /gene="Rbm5"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..2995
                     /gene="Rbm5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggcgatcca gtccttcgga cacccctcgg aagcgcctgg caatctctta agccatcatc
       61 gccctgcgtc tgcaactgaa tctcgctctg cgaaaggtgg ttaggaatag tgacttgagg
      121 actgggaacc tcctcagagg ttgggaggga tgtatgtaat atgggaaaga tggactgaat
      181 gctggaatgc actggtctta gcgccgccat ctcggctgcg ataccccgca gagggggaaa
      241 aaaaaaatta aaccttttga agcagtgtgc tagatcttcg gtgagacaat gggttcagac
      301 aaaagagtga gtagaacaga gcgtagtgga agatatggtt ccatcataga cagggatgac
      361 cgtgacgagc gtgaatctag aagcaggcgg agggactcag attacaaaag atcaagtgat
      421 gatcggagag gcgatagata tgatgactat cgagactatg atagtccgga gagagaacgt
      481 gaaagaagga acagtgaccg gtctgaggat ggctaccatt cagatggtga ctatggagaa
      541 catgactata gacatgacat cagtgacgag agagagagca agaccatcat gctccgtggc
      601 cttcctatca ccatcaccga gagcgatatt cgagaaatga tggagtcctt tgaaggccct
      661 cagcctgcag atgtgaggct gatgaagagg aaaacaggtg taagccgtgg tttcgccttc
      721 gtggagtttt atcacttgca agatgctacc agctggatgg aagccaatca gaaaaaattg
      781 gtgattcaag gaaagcacat tgcaatgcat tatagcaatc ccagacctaa gtttgaagat
      841 tggctttgta acaagtgctg ccttaacaat ttcaggaaaa gactaaaatg cttccgatgt
      901 ggagcagaca agtttgactc tgaacaggaa gtgccccctg gaaccacaga gtctgtgcag
      961 tctgtggact actactgtga cacgatcatc cttcggaaca tagctccgca tactgtggtg
     1021 gactccatca tgacagcact gtctccctat gcttccttag ctgtcaataa cattcgcctc
     1081 ataaaagaca aacagacaca acagaacaga ggctttgcct ttgtgcagct atcttctgcg
     1141 atggatgcct ctcagctgct tcagatattg cagagtctcc atccaccatt gaaaattgat
     1201 gggaaaacta ttggagttga ctttgcaaaa agtgccagaa aagatttggt ccttccagat
     1261 ggtaaccgtg tcagtgcctt ctctgtagct agtacagcca tcgctgctgc tcagtggtca
     1321 tccactcagt ctcaaagtgg tgaaggaggc aatgttgact acagttacat gcaaccaggc
     1381 caggatggct atacacagta cactcaatac tcacaggatt accagcagtt ttatcaacaa
     1441 cagactggag gactggagtc tgatgcatca gctacatcag gtaccacggt gactaccacc
     1501 tcagcagctg tagtatccca gagtcctcaa ctctataatc agacctccaa tccacctggc
     1561 tctccgactg aggaagcaca gcctagcact agcacaagta cacaggcccc agctgcttcc
     1621 cctactggtg tagttcctgg taccaagtat gcggtacctg acacgtctac ttatcaatat
     1681 gatgaatctt caggatatta ttatgatcct acaacagggc tctactatga ccctaactca
     1741 cagtactact ataattcctt aacacagcag tacttgtact gggatggaga gaaggagacc
     1801 tacgtgccag ctgcagagtc tagctctaac caacaagctg gcctaccttc cacaaaagag
     1861 ggaaaggaga agaaagaaaa gcccaagagc aaaactgctc aacagattgc caaagacatg
     1921 gaacgctggg ctaagagttt aaataagcag aaagaaaatt ttaaaaacag ctttcaacct
     1981 gtcaattcat tgagagaaga agaaaggaga gaatctgctg cagcagatgc tggctttgct
     2041 ctttttgaga agaagggagc cttagctgaa aggcagcaac tcatccctga attggtgcga
     2101 aatggagatg aggaaaatcc cctcaaaaga ggtctggttg cagcttacag tggtgacagt
     2161 gacaatgagg aagagctggt agagagactt gagagtgagg aagagaaact agctgactgg
     2221 aagaagatgg cctgcctgct gtgccgacgg cagttcccaa acagagatgc cctggtcagg
     2281 caccagcagc tctctgattt acacaagcaa aatatggaca tctaccgaag atccaggctg
     2341 agcgagcagg agttggaagc cctggagctg agagagagag agatgaaata ccgagatcga
     2401 gcagcagaaa gacgagagaa atatggaatt ccagagcccc cagagcccaa gcgcaagaaa
     2461 cagttcgatg ctggcactgt gaattacgag cagcccacca aagatggcat tgaccacagt
     2521 aacattggca acaagatgct gcaggctatg ggctggcggg aaggctcagg cttaggaaga
     2581 aagtgtcaag gcatcacggc tcccattgag gctcaagtcc ggctaaaagg agctggctta
     2641 ggagccaaag gcagtgcata tgggttgtca ggtgccgatt cctacaaaga tgctgttcgg
     2701 aaagccatgt ttgcccggtt cactgagatg gagtgagact ggcgaagcca tgctgagcac
     2761 agggagcaag ccatctcctc agttgctctt actgcctgtc tctagggcat gccttgtgct
     2821 gttaatagtt ttaggatgaa ccacttcatt ctgaggggtt ctcctacctt aaatgagctc
     2881 ccttatgtgg gttacctggt aaacaacctt tcttcccacc taaggatttg tgaacagagg
     2941 ggacaatggg ctttttatac aaggtgtata tagtgtaaat ataatgtgtt ttacaaaaaa
     3001 aaaaaaaaaa aaaaaaaa
//
