LOCUS       NP_001094018             815 aa            linear   ROD 09-AUG-2024
DEFINITION  RNA-binding protein 5 isoform 1 [Rattus norvegicus].
ACCESSION   NP_001094018 XP_001073543 XP_217263
VERSION     NP_001094018.1
DBSOURCE    REFSEQ: accession NM_001100548.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 815)
  AUTHORS   Jackson,T.C., Kotermanski,S.E. and Kochanek,P.M.
  TITLE     Whole-transcriptome microarray analysis reveals regulation of Rab4
            by RBM5 in neurons
  JOURNAL   Neuroscience 361, 93-107 (2017)
   PUBMED   28818525
  REMARK    GeneRIF: RBM5 regulates Rab4a in rat neurons
REFERENCE   2  (residues 1 to 815)
  AUTHORS   Zhang,J., Cui,Z., Feng,G., Bao,G., Xu,G., Sun,Y., Wang,L., Chen,J.,
            Jin,H., Liu,J., Yang,L. and Li,W.
  TITLE     RBM5 and p53 expression after rat spinal cord injury: implications
            for neuronal apoptosis
  JOURNAL   Int J Biochem Cell Biol 60, 43-52 (2015)
   PUBMED   25578565
  REMARK    GeneRIF: findings indicate that RBM5 promotes neuronal apoptosis
            through modulating p53 signaling pathway following SCI.
REFERENCE   3  (residues 1 to 815)
  AUTHORS   Loiselle,J.J. and Sutherland,L.C.
  TITLE     Differential downregulation of Rbm5 and Rbm10 during skeletal and
            cardiac differentiation
  JOURNAL   In Vitro Cell Dev Biol Anim 50 (4), 331-339 (2014)
   PUBMED   24178303
  REMARK    GeneRIF: This work establishes myoblast differentiation as a
            relevant model in which to conduct functional studies regarding
            Rbm5 and Rbm10.
REFERENCE   4  (residues 1 to 815)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (residues 1 to 815)
  AUTHORS   Kotlajich,M.V. and Hertel,K.J.
  TITLE     Death by splicing: tumor suppressor RBM5 freezes splice-site
            pairing
  JOURNAL   Mol Cell 32 (2), 162-164 (2008)
   PUBMED   18951082
REFERENCE   6  (residues 1 to 815)
  AUTHORS   Fushimi,K., Ray,P., Kar,A., Wang,L., Sutherland,L.C. and Wu,J.Y.
  TITLE     Up-regulation of the proapoptotic caspase 2 splicing isoform by a
            candidate tumor suppressor, RBM5
  JOURNAL   Proc Natl Acad Sci U S A 105 (41), 15708-15713 (2008)
   PUBMED   18840686
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Sep 4, 2008 this sequence version replaced
            XP_217263.3, XP_001073543.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166477.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..815
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     Protein         1..815
                     /product="RNA-binding protein 5 isoform 1"
                     /note="RNA-binding protein 5"
                     /calculated_mol_wt=92221
     Region          1..93
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (B2GV05.1)"
     Site            18
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P52756; propagated from
                     UniProtKB/Swiss-Prot (B2GV05.1)"
     Site            59
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (B2GV05.1)"
     Site            69
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P52756; propagated from
                     UniProtKB/Swiss-Prot (B2GV05.1)"
     Site            72
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P52756; propagated from
                     UniProtKB/Swiss-Prot (B2GV05.1)"
     Site            78
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (B2GV05.1)"
     Region          93..179
                     /region_name="RRM1_RBM5"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     RNA-binding protein 5 (RBM5); cd12752"
                     /db_xref="CDD:410146"
     Region          181..210
                     /region_name="zf-RanBP"
                     /note="Zn-finger in Ran binding protein and others;
                     pfam00641"
                     /db_xref="CDD:395516"
     Region          185..204
                     /region_name="RanBP2-type Zn finger"
                     /note="RanBP2-type Zn finger [structural motif]"
                     /db_xref="CDD:275375"
     Region          229..314
                     /region_name="RRM2_RBM5"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 5 (RBM5); cd12755"
                     /db_xref="CDD:410149"
     Region          321..809
                     /region_name="Required for interaction with U2AF2.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (B2GV05.1)"
     Region          407..468
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (B2GV05.1)"
     Site            444
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P52756; propagated from
                     UniProtKB/Swiss-Prot (B2GV05.1)"
     Region          452..535
                     /region_name="Sufficient for interaction with ACIN1,
                     PRPF8, SFRS3, SNRPB, SNRPN, SNRNP70 and SNRNP200.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (B2GV05.1)"
     Region          455..510
                     /region_name="OCRE_RBM5"
                     /note="OCRE domain found in RNA-binding protein 5 (RBM5)
                     and similar proteins; cd16168"
                     /db_xref="CDD:293887"
     Region          460..467
                     /region_name="OCRE repeat 1"
                     /note="OCRE repeat 1 [structural motif]"
                     /db_xref="CDD:293887"
     Region          468..475
                     /region_name="OCRE repeat 2"
                     /note="OCRE repeat 2 [structural motif]"
                     /db_xref="CDD:293887"
     Region          476..483
                     /region_name="OCRE repeat 3"
                     /note="OCRE repeat 3 [structural motif]"
                     /db_xref="CDD:293887"
     Region          484..491
                     /region_name="OCRE repeat 4"
                     /note="OCRE repeat 4 [structural motif]"
                     /db_xref="CDD:293887"
     Region          493..500
                     /region_name="OCRE repeat 5"
                     /note="OCRE repeat 5 [structural motif]"
                     /db_xref="CDD:293887"
     Region          508..540
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (B2GV05.1)"
     Site            621
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (B2GV05.1)"
     Site            624
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (B2GV05.1)"
     Region          743..787
                     /region_name="G-patch"
                     /note="G-patch domain; pfam01585"
                     /db_xref="CDD:396249"
     CDS             1..815
                     /gene="Rbm5"
                     /coded_by="NM_001100548.2:670..3117"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:300996"
                     /db_xref="RGD:1305059"
ORIGIN      
        1 mgsdkrvsrt ersgrygsii drddrderes rsrrrdsdyk rssddrrgdr yddyrdydsp
       61 erererrnsd rsedgyhsdg dygehdyrhd isdereskti mlrglpitit esdiremmes
      121 fegpqpadvr lmkrktgvsr gfafvefyhl qdatswmean qkklviqgkh iamhysnprp
      181 kfedwlcnkc clnnfrkrlk cfrcgadkfd seqevppgtt esvqsvdyyc dtiilrniap
      241 htvvdsimta lspyaslavn nirlikdkqt qqnrgfafvq lssamdasql lqilqslhpp
      301 lkidgktigv dfaksarkdl vlpdgnrvsa fsvastaiaa aqwsstqsqs geggnvdysy
      361 mqpgqdgytq ytqysqdyqq fyqqqtggle sdasatsgtt vtttsaavvs qspqlynqts
      421 nppgspteea qpstststqa paasptgvvp gtkyavpdts tyqydessgy yydpttglyy
      481 dpnsqyyyns ltqqylywdg eketyvpaae sssnqqaglp stkegkekke kpksktaqqi
      541 akdmerwaks lnkqkenfkn sfqpvnslre eerresaaad agfalfekkg alaerqqlip
      601 elvrngdeen plkrglvaay sgdsdneeel verleseeek ladwkkmacl lcrrqfpnrd
      661 alvrhqqlsd lhkqnmdiyr rsrlseqele alelreremk yrdraaerre kygipeppep
      721 krkkqfdagt vnyeqptkdg idhsnignkm lqamgwregs glgrkcqgit apieaqvrlk
      781 gaglgakgsa yglsgadsyk davrkamfar fteme
//
