LOCUS       NM_001170484            1444 bp    mRNA    linear   ROD 23-AUG-2024
DEFINITION  Rattus norvegicus RNA binding motif protein 4 (Rbm4), mRNA.
ACCESSION   NM_001170484
VERSION     NM_001170484.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1444)
  AUTHORS   Lin,J.C., Yan,Y.T., Hsieh,W.K., Peng,P.J., Su,C.H. and Tarn,W.Y.
  TITLE     RBM4 promotes pancreas cell differentiation and insulin expression
  JOURNAL   Mol Cell Biol 33 (2), 319-327 (2013)
   PUBMED   23129807
REFERENCE   2  (bases 1 to 1444)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 1444)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 1444)
  AUTHORS   Lin,J.C. and Tarn,W.Y.
  TITLE     RBM4 down-regulates PTB and antagonizes its activity in muscle
            cell-specific alternative splicing
  JOURNAL   J Cell Biol 193 (3), 509-520 (2011)
   PUBMED   21518792
REFERENCE   5  (bases 1 to 1444)
  AUTHORS   Lin,J.C. and Tarn,W.Y.
  TITLE     RNA-binding motif protein 4 translocates to cytoplasmic granules
            and suppresses translation via argonaute2 during muscle cell
            differentiation
  JOURNAL   J Biol Chem 284 (50), 34658-34665 (2009)
   PUBMED   19801630
REFERENCE   6  (bases 1 to 1444)
  AUTHORS   Kar,A., Havlioglu,N., Tarn,W.Y. and Wu,J.Y.
  TITLE     RBM4 interacts with an intronic element and stimulates tau exon 10
            inclusion
  JOURNAL   J Biol Chem 281 (34), 24479-24488 (2006)
   PUBMED   16777844
REFERENCE   7  (bases 1 to 1444)
  AUTHORS   Markus,M.A. and Morris,B.J.
  TITLE     Lark is the splicing factor RBM4 and exhibits unique subnuclear
            localization properties
  JOURNAL   DNA Cell Biol 25 (8), 457-464 (2006)
   PUBMED   16907643
REFERENCE   8  (bases 1 to 1444)
  AUTHORS   Lin,J.C. and Tarn,W.Y.
  TITLE     Exon selection in alpha-tropomyosin mRNA is regulated by the
            antagonistic action of RBM4 and PTB
  JOURNAL   Mol Cell Biol 25 (22), 10111-10121 (2005)
   PUBMED   16260624
REFERENCE   9  (bases 1 to 1444)
  AUTHORS   Diederichs,S., Baumer,N., Ji,P., Metzelder,S.K., Idos,G.E.,
            Cauvet,T., Wang,W., Moller,M., Pierschalski,S., Gromoll,J.,
            Schrader,M.G., Koeffler,H.P., Berdel,W.E., Serve,H. and
            Muller-Tidow,C.
  TITLE     Identification of interaction partners and substrates of the cyclin
            A1-CDK2 complex
  JOURNAL   J Biol Chem 279 (32), 33727-33741 (2004)
   PUBMED   15159402
REFERENCE   10 (bases 1 to 1444)
  AUTHORS   Lai,M.C., Kuo,H.W., Chang,W.C. and Tarn,W.Y.
  TITLE     A novel splicing regulator shares a nuclear import pathway with SR
            proteins
  JOURNAL   EMBO J 22 (6), 1359-1369 (2003)
   PUBMED   12628928
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.4702.1,
                                           SRR26643296.3463.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                JAXUCZ010000001.1  211516823-211516907 c
            86-508              JAXUCZ010000001.1  211515412-211515834 c
            509-1202            JAXUCZ010000001.1  211510014-211510707 c
            1203-1444           JAXUCZ010000001.1  211507845-211508086 c
FEATURES             Location/Qualifiers
     source          1..1444
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1444
                     /gene="Rbm4"
                     /note="RNA binding motif protein 4"
                     /db_xref="GeneID:293663"
                     /db_xref="RGD:1306891"
     exon            1..85
                     /gene="Rbm4"
                     /inference="alignment:Splign:2.1.0"
     exon            86..508
                     /gene="Rbm4"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1194
                     /gene="Rbm4"
                     /codon_start=1
                     /product="RNA binding motif protein 4"
                     /protein_id="NP_001163955.1"
                     /db_xref="GeneID:293663"
                     /db_xref="RGD:1306891"
                     /translation="MVKLFIGNLPREATEQEIRSLFEQYGKVLECDIIKNYGFVHIED
                     KTAAEDAIRNLHHYKLHGVNINVEASKNKSKASTKLHVGNISPTCTNQELRAKFEEYG
                     PVIECDIVKDYAFVHMERAEDAVEAIRGLDNTEFQGKRMHVQLSTSRLRTAPGMGDQS
                     GCYRCGKEGHWSKECPIDRSGRVADLTEQYNEQYGAVRTPYTMSYGDSLYYNNTYGAL
                     DAYYKRCRAARSYEAVAAAAASAYNNYAEQTLSQLPQVQNTAMASHLTSTSLDPYNRH
                     LLPPSGAAAAAAAAAAAAAACTAASTPYYGRDRSPLRRATGPVPTVGEGYGYGHDSEL
                     SQASAAARNSLYDMARYEREQYADRARYSAF"
     exon            509..1202
                     /gene="Rbm4"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1444
                     /gene="Rbm4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtcactgc tgtggccgcc gccattttag cgttttgtca gagccgtcta cgctgcgagg
       61 aggaggacct gcagatttcc atgcggctgt gtggagatgg tgaaactgtt catcggaaat
      121 ctgccccggg aggccacaga gcaggagatc cgctcactct tcgagcagta cgggaaggtg
      181 ctggaatgtg acatcattaa gaactatggc tttgtgcaca tagaggacaa gacggccgct
      241 gaggatgcca tacgcaacct gcaccactac aaactgcacg gagtgaacat caatgtggaa
      301 gccagcaaga ataagagcaa agcttcaacc aaattacatg tgggcaacat cagtcccact
      361 tgtaccaacc aagagcttcg ggccaagttt gaggagtacg gcccagtcat cgaatgtgac
      421 atcgtgaaag attatgcctt tgtacacatg gagcgggcag aagatgcggt ggaggccatc
      481 aggggccttg acaacacaga gtttcaaggc aaacgaatgc acgtgcagtt gtccaccagc
      541 cggcttagga ccgcgcccgg gatgggagac cagagcggct gctatcggtg cgggaaagag
      601 gggcactggt ccaaagagtg tccgatagac cgttcgggcc gtgtggcaga cttgaccgag
      661 caatataatg agcaatatgg agcagtgcgt acgccttaca ccatgagtta tggggattca
      721 ttgtattaca acaacacgta cggagcgctc gatgcctact acaagcgctg ccgtgctgcc
      781 cggtcctatg aggcagtggc agctgcagct gcctctgcat ataataacta tgcagagcag
      841 actttgtccc agctgccaca agtccagaac acagccatgg ccagtcacct cacctccacc
      901 tctcttgatc cctacaatag acatctgttg ccgccttcag gagctgctgc agcagcagct
      961 gctgctgctg ctgctgctgc tgcttgtact gcagcttcta ctccatatta cgggcgggat
     1021 cggagccccc tgcgtcgcgc tacaggccca gttcccactg ttggagaggg ctacggttac
     1081 gggcatgaca gtgagttgtc ccaagcttca gcagctgctc ggaattccct gtacgacatg
     1141 gcccggtatg agcgggagca gtatgcggat cgggcgcggt actcagcctt ttaaagtttg
     1201 aggtgggatg tgtgtgggct gaaattccga gctgcggttg tgcatgagaa tacacccttc
     1261 gtggtacccc atctccggga cgttctcggc tctgtgcatt cagtccctca ggaaccatgg
     1321 accttaattt accttgttaa gttctttctc tttcctattc tctttcctgc tcaatttcct
     1381 gttctcctgt ttattcttct gtaacttccc attcgagttc tgttctccca gcatgcctcc
     1441 tatg
//
