LOCUS       NM_001013207            2699 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus RNA binding motif protein 39 (Rbm39), mRNA.
ACCESSION   NM_001013207 XM_342557
VERSION     NM_001013207.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2699)
  AUTHORS   Uehara T, Minoshima Y, Sagane K, Sugi NH, Mitsuhashi KO, Yamamoto
            N, Kamiyama H, Takahashi K, Kotake Y, Uesugi M, Yokoi A, Inoue A,
            Yoshida T, Mabuchi M, Tanaka A and Owa T.
  TITLE     Selective degradation of splicing factor CAPERalpha by anticancer
            sulfonamides
  JOURNAL   Nat Chem Biol 13 (6), 675-680 (2017)
   PUBMED   28437394
REFERENCE   2  (bases 1 to 2699)
  AUTHORS   Han T, Goralski M, Gaskill N, Capota E, Kim J, Ting TC, Xie Y,
            Williams NS and Nijhawan D.
  TITLE     Anticancer sulfonamides target splicing by inducing RBM39
            degradation via recruitment to DCAF15
  JOURNAL   Science 356 (6336) (2017)
   PUBMED   28302793
  REMARK    Erratum:[Science. 2017 May 26;356(6340):null. PMID: 28546157]
REFERENCE   3  (bases 1 to 2699)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 2699)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 2699)
  AUTHORS   Dowhan DH, Hong EP, Auboeuf D, Dennis AP, Wilson MM, Berget SM and
            O'Malley BW.
  TITLE     Steroid hormone receptor coactivation and alternative RNA splicing
            by U2AF65-related proteins CAPERalpha and CAPERbeta
  JOURNAL   Mol Cell 17 (3), 429-439 (2005)
   PUBMED   15694343
REFERENCE   6  (bases 1 to 2699)
  AUTHORS   Gao G and Goff SP.
  TITLE     Isolation of suppressor genes that restore retrovirus
            susceptibility to a virus-resistant cell line
  JOURNAL   Retrovirology 1, 30 (2004)
   PUBMED   15453907
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC078917.1 and BC091394.1.
            
            On Nov 28, 2013 this sequence version replaced NM_001013207.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091394.1, SRR8487231.28742.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN16676787
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BC078917.1         1-11
            12-1990             BC091394.1         1-1979
            1991-2699           BC078917.1         2082-2790
FEATURES             Location/Qualifiers
     source          1..2699
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..2699
                     /gene="Rbm39"
                     /gene_synonym="Rnp1; Rnpc2; Rrm"
                     /note="RNA binding motif protein 39"
                     /db_xref="GeneID:362251"
                     /db_xref="RGD:1310071"
     exon            1..250
                     /gene="Rbm39"
                     /gene_synonym="Rnp1; Rnpc2; Rrm"
                     /inference="alignment:Splign:2.1.0"
     exon            251..314
                     /gene="Rbm39"
                     /gene_synonym="Rnp1; Rnpc2; Rrm"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..1838
                     /gene="Rbm39"
                     /gene_synonym="Rnp1; Rnpc2; Rrm"
                     /note="RNA-binding protein 39-like; RNA-binding
                     region-containing 2; RNA-binding region (RNP1, RRM)
                     containing 2"
                     /codon_start=1
                     /product="RNA-binding protein 39"
                     /protein_id="NP_001013225.1"
                     /db_xref="GeneID:362251"
                     /db_xref="RGD:1310071"
                     /translation="MADDIDIEAMLEAPYKKDENKLNSANGHEERSKKRKKSKSRSRS
                     HERKRSKSKERKRSRDRERKKSKSRERKRSRSKERRRSRSRSRDRRFRGRYRSPYSGP
                     KFNSAIRGKIGLPHSIKLSRRRSRSKSPFRKDKSPVREPIDNLTPEERDARTVFCMQL
                     AARIRPRDLEEFFSTVGKVRDVRMISDRNSRRSKGIAYVEFVDVSSVPLAIGLTGQRV
                     LGVPIIVQASQAEKNRAAAMANNLQKGSAGPMRLYVGSLHFNITEDMLRGIFEPFGRI
                     ESIQLMMDSETGRSKGYGFITFSDSECAKKALEQLNGFELAGRPMKVGHVTERTDASS
                     ASSFLDSDELERTGIDLGTTGRLQLMARLAEGTGLQIPPAAQQALQMSGSLAFGAVAD
                     LQTRLSQQTEASALAAAASVQPLATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNK
                     HGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNL
                     FPDSMTATQLLVPSRR"
     exon            315..364
                     /gene="Rbm39"
                     /gene_synonym="Rnp1; Rnpc2; Rrm"
                     /inference="alignment:Splign:2.1.0"
     exon            365..559
                     /gene="Rbm39"
                     /gene_synonym="Rnp1; Rnpc2; Rrm"
                     /inference="alignment:Splign:2.1.0"
     exon            560..625
                     /gene="Rbm39"
                     /gene_synonym="Rnp1; Rnpc2; Rrm"
                     /inference="alignment:Splign:2.1.0"
     exon            626..679
                     /gene="Rbm39"
                     /gene_synonym="Rnp1; Rnpc2; Rrm"
                     /inference="alignment:Splign:2.1.0"
     exon            680..797
                     /gene="Rbm39"
                     /gene_synonym="Rnp1; Rnpc2; Rrm"
                     /inference="alignment:Splign:2.1.0"
     exon            798..950
                     /gene="Rbm39"
                     /gene_synonym="Rnp1; Rnpc2; Rrm"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1088
                     /gene="Rbm39"
                     /gene_synonym="Rnp1; Rnpc2; Rrm"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1154
                     /gene="Rbm39"
                     /gene_synonym="Rnp1; Rnpc2; Rrm"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1359
                     /gene="Rbm39"
                     /gene_synonym="Rnp1; Rnpc2; Rrm"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1437
                     /gene="Rbm39"
                     /gene_synonym="Rnp1; Rnpc2; Rrm"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1470
                     /gene="Rbm39"
                     /gene_synonym="Rnp1; Rnpc2; Rrm"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1552
                     /gene="Rbm39"
                     /gene_synonym="Rnp1; Rnpc2; Rrm"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1658
                     /gene="Rbm39"
                     /gene_synonym="Rnp1; Rnpc2; Rrm"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1737
                     /gene="Rbm39"
                     /gene_synonym="Rnp1; Rnpc2; Rrm"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..2677
                     /gene="Rbm39"
                     /gene_synonym="Rnp1; Rnpc2; Rrm"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagggagcta gccgacgctg tcgcaggggt ggatcctgag ctgccgaagc cgctgccctg
       61 ctctccgtcg cgggctcctt taatcccatt gtttctttta gattcgtttg ggcctagacg
      121 ccctcggggc ccgatattcg ggttgggcgg taccgcggcc tgggcctagt gacttaacag
      181 tagcaacagc agcggcggcg gcggcagccg acttcccgat tcgagcacag gcgcgcgaaa
      241 atccgcacag gcgagtagag aaaatggcag acgatattga tattgaagca atgcttgagg
      301 ccccttacaa gaaggatgag aacaagttga acagtgctaa cggccatgaa gaacgtagca
      361 aaaagagaaa aaaaagcaag agcagaagcc gtagtcatga gagaaaaaga agcaaaagta
      421 aagaacggaa acgaagtaga gatagagaaa ggaaaaagag caaaagtcga gagaggaaac
      481 gaagtagaag caaagaaagg agacgaagcc gctcacgaag tcgagataga agattccgag
      541 gccgctacag aagtccctac tccggaccaa aatttaacag tgccatccga ggaaagattg
      601 ggttgcctca tagcatcaaa ttaagcagaa gacgttcccg aagcaaaagt ccattcagga
      661 aagacaagag ccctgtgagg gaacctattg ataatctcac tcctgaggaa agggatgcaa
      721 ggacagtttt ctgcatgcag ctggcagcaa gaattcgacc aagagatttg gaagaatttt
      781 tctctacagt aggaaaggtt cgagatgtga gaatgatttc tgatagaaat tcaagacgtt
      841 ccaaaggaat cgcctatgtg gagtttgttg atgtcagttc agtgcctcta gcaattggat
      901 taactggtca acgagtttta ggagtgccaa tcatagtcca ggcatcacag gcagaaaaaa
      961 acagagctgc tgcaatggcg aacaatttac aaaagggaag tgctggacct atgaggctct
     1021 atgtgggatc attacacttt aacataactg aagatatgct tcggggaatc tttgaacctt
     1081 ttggaaggat tgaaagtatt cagctcatga tggatagtga aaccggtcga tctaagggat
     1141 atggattcat taccttttct gactcagaat gtgccaaaaa ggctttggaa cagcttaatg
     1201 gattcgagtt agcagggaga ccaatgaaag ttggtcatgt tactgaacga actgatgcat
     1261 ctagcgctag ttcatttttg gacagtgatg aattagaaag gactggaatt gacttgggaa
     1321 caacaggtcg tctccagttg atggcaagac ttgcagaggg taccggtttg cagattccac
     1381 cagcagcaca acaagcttta caaatgagtg gctctctggc atttggtgct gtggcagatt
     1441 tgcaaacacg actttcccaa cagactgaag cctcagcttt agctgcagct gcgtctgttc
     1501 aacctcttgc aacacagtgt ttccaacttt ctaacatgtt taatcctcaa acagaagaag
     1561 aagttggatg ggatacagag attaaagatg atgtcattga agaatgtaat aaacatggtg
     1621 gagtcattca tatttatgtt gacaaaaatt cagctcaggg caatgtgtat gtgaagtgcc
     1681 catcgattgc tgcggctatt gctgctgtca atgcgttgca tggcaggtgg tttgctggta
     1741 aaatgataac agcagcgtat gtacctcttc caacatacca caacctcttt cctgattcca
     1801 tgacagcaac acaactactg gttccaagta gacgatgaag gagatgcagt ccctgatgta
     1861 tatagctttt ttttctcttg agaattcatc ttgagttatc ttttatttag ataaaaaata
     1921 aagaggcaag ggtctactgt catttgtata caactcctgt tatctggaaa aataaaaatg
     1981 ttaacaggaa tgcagtgtgc tcattctccc taactagcaa atcctacttt atgcaaaact
     2041 gttctcttgt tctgctgttt taaatgtcca tgtagaaaat tacattaagg atctatagaa
     2101 tagctctagg ggaacaaatg tgctttctgt acaaaggcag acaggtaatg ttttaatgtt
     2161 tcagaaactt aactttttac acagcagtta catttcacat tcatgtattc ggctcatggt
     2221 tcagcaaagg tttccagaat acacttttgg agtgtgaaaa gtctaagttg ctaaatggct
     2281 gcttagcatt tgaccttgac catttggaaa gtgggggatt tcaaaatatt tcttgatggt
     2341 aaatttttca attactgtat ctgtaaaagt ttctttgtaa atactatgtg ttttagtgtg
     2401 tcttaagatt ccaaacaaaa tgatccctgc atttcctcaa ggtggttgat gtaacagatt
     2461 gagtaaaaca gtcttgggca agagatagga aatgtggaaa taggttttgt ctggttgcat
     2521 ataatctttg ctctttttaa gctctgtgag ctctgaaata tatttttggg ttacttcagt
     2581 gtgtttgaca agacagcttg atatttctat caaacaaatg actttcatat tgcaacaatc
     2641 tttgtaagaa ccactcaaat aaaattctct gaaaaagaaa aaaaaaaaaa aaaaaaaaa
//
