LOCUS       NM_053696               1185 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Rattus norvegicus RNA binding motif protein 3 (Rbm3), mRNA.
ACCESSION   NM_053696 XM_001063211 XM_343773
VERSION     NM_053696.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1185)
  AUTHORS   Lin,P., Lin,C. and Diao,L.
  TITLE     RBM3 Ameliorates Acute Brain Injury-induced Inflammation and
            Oxidative Stress by Stabilizing GAS6 mRNA Through Nrf2 Signaling
            Pathway
  JOURNAL   Neuroscience 547, 74-87 (2024)
   PUBMED   38555015
  REMARK    GeneRIF: RBM3 Ameliorates Acute Brain Injury-induced Inflammation
            and Oxidative Stress by Stabilizing GAS6 mRNA Through Nrf2
            Signaling Pathway.
REFERENCE   2  (bases 1 to 1185)
  AUTHORS   Sertel,S.M., von Elling-Tammen,M.S. and Rizzoli,S.O.
  TITLE     The mRNA-Binding Protein RBM3 Regulates Activity Patterns and Local
            Synaptic Translation in Cultured Hippocampal Neurons
  JOURNAL   J Neurosci 41 (6), 1157-1173 (2021)
   PUBMED   33310754
  REMARK    GeneRIF: The mRNA-Binding Protein RBM3 Regulates Activity Patterns
            and Local Synaptic Translation in Cultured Hippocampal Neurons.
REFERENCE   3  (bases 1 to 1185)
  AUTHORS   Van Pelt,D.W., Confides,A.L., Judge,A.R., Vanderklish,P.W. and
            Dupont-Versteegden,E.E.
  TITLE     Cold shock protein RBM3 attenuates atrophy and induces hypertrophy
            in skeletal muscle
  JOURNAL   J Muscle Res Cell Motil 39 (1-2), 35-40 (2018)
   PUBMED   30051360
  REMARK    GeneRIF: Overexpression of RBM3 also attenuated muscle atrophy in
            rat soleus muscle undergoing disuse atrophy. These findings provide
            direct evidence for a novel role of RBM3 in inducing hypertrophy as
            well as attenuating atrophy.
REFERENCE   4  (bases 1 to 1185)
  AUTHORS   Jackson,T.C., Manole,M.D., Kotermanski,S.E., Jackson,E.K.,
            Clark,R.S. and Kochanek,P.M.
  TITLE     Cold stress protein RBM3 responds to temperature change in an
            ultra-sensitive manner in young neurons
  JOURNAL   Neuroscience 305, 268-278 (2015)
   PUBMED   26265550
  REMARK    GeneRIF: This study showed that a 1 degrees C reduction in
            temperature can induce pleiotropic biochemical changes by
            upregulating global protein synthesis in neurons.
REFERENCE   5  (bases 1 to 1185)
  AUTHORS   Cui,Z., Zhang,J., Bao,G., Xu,G., Sun,Y., Wang,L., Chen,J., Jin,H.,
            Liu,J., Yang,L., Feng,G. and Li,W.
  TITLE     Spatiotemporal profile and essential role of RBM3 expression after
            spinal cord injury in adult rats
  JOURNAL   J Mol Neurosci 54 (2), 252-263 (2014)
   PUBMED   24668366
  REMARK    GeneRIF: RBM3 expression was increased in astrocytes after spinal
            cord injury. RBM3 regulated proliferation of astrocytes in vitro.
REFERENCE   6  (bases 1 to 1185)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 1185)
  AUTHORS   Pilotte,J., Cunningham,B.A., Edelman,G.M. and Vanderklish,P.W.
  TITLE     Developmentally regulated expression of the cold-inducible
            RNA-binding motif protein 3 in euthermic rat brain
  JOURNAL   Brain Res 1258, 12-24 (2009)
   PUBMED   19150436
  REMARK    GeneRIF: These results indicate that expression of RBM3 is
            dynamically regulated in the developing brain and suggest that it
            contributes to translation-dependent processes underlying
            proliferation, differentiation, and plasticity.
REFERENCE   8  (bases 1 to 1185)
  AUTHORS   Dupont-Versteegden,E.E., Nagarajan,R., Beggs,M.L., Bearden,E.D.,
            Simpson,P.M. and Peterson,C.A.
  TITLE     Identification of cold-shock protein RBM3 as a possible regulator
            of skeletal muscle size through expression profiling
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 295 (4), R1263-R1273 (2008)
   PUBMED   18753264
  REMARK    GeneRIF: Aa cold-shock response may be part of a compensatory
            mechanism in muscles undergoing atrophy to preserve remaining
            muscle mass. RBM3, which was induced most highly in atrophic muscle
            from old rats, may be a therapeutic target to prevent muscle loss.
REFERENCE   9  (bases 1 to 1185)
  AUTHORS   Smart,F., Aschrafi,A., Atkins,A., Owens,G.C., Pilotte,J.,
            Cunningham,B.A. and Vanderklish,P.W.
  TITLE     Two isoforms of the cold-inducible mRNA-binding protein RBM3
            localize to dendrites and promote translation
  JOURNAL   J Neurochem 101 (5), 1367-1379 (2007)
   PUBMED   17403028
REFERENCE   10 (bases 1 to 1185)
  AUTHORS   Dresios,J., Aschrafi,A., Owens,G.C., Vanderklish,P.W., Edelman,G.M.
            and Mauro,V.P.
  TITLE     Cold stress-induced protein Rbm3 binds 60S ribosomal subunits,
            alters microRNA levels, and enhances global protein synthesis
  JOURNAL   Proc Natl Acad Sci U S A 102 (6), 1865-1870 (2005)
   PUBMED   15684048
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DY319481.1, AF355190.1, DN933310.1 and CA340698.1.
            
            On or before Jun 5, 2008 this sequence version replaced
            XM_343773.3, XM_001063211.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ235187.1, FQ232482.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               DY319481.1         1-100
            101-481             AF355190.1         65-445
            482-871             DN933310.1         347-736
            872-1185            CA340698.1         287-600
FEATURES             Location/Qualifiers
     source          1..1185
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..1185
                     /gene="Rbm3"
                     /note="RNA binding motif protein 3"
                     /db_xref="GeneID:114488"
                     /db_xref="RGD:620145"
     exon            1..85
                     /gene="Rbm3"
                     /inference="alignment:Splign:2.1.0"
     exon            86..203
                     /gene="Rbm3"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..571
                     /gene="Rbm3"
                     /note="putative RNA-binding protein 3; RNA binding motif
                     (RNP1, RRM) protein 3"
                     /codon_start=1
                     /product="RNA-binding protein 3"
                     /protein_id="NP_446148.1"
                     /db_xref="GeneID:114488"
                     /db_xref="RGD:620145"
                     /translation="MSSEEGKLFVGGLNFNTDEQALEDHFSSFGPISEVVVVKDRETQ
                     RSRGFGFITFTNPEHASDAMRAMNGESLDGRQIRVDHAGKSARGTRGGAFGAHGRGRS
                     YSRGGGDQGYGSGRYDSRPGGYGYGYGRSRDYSGRSQGGYDRYSGGNYRDNYDN"
     exon            204..310
                     /gene="Rbm3"
                     /inference="alignment:Splign:2.1.0"
     exon            311..416
                     /gene="Rbm3"
                     /inference="alignment:Splign:2.1.0"
     exon            417..510
                     /gene="Rbm3"
                     /inference="alignment:Splign:2.1.0"
     exon            511..590
                     /gene="Rbm3"
                     /inference="alignment:Splign:2.1.0"
     exon            591..1185
                     /gene="Rbm3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgtcttcc cgcgccgcag tctctctgtt ctcccggttc cttagagctc gtcgtctctg
       61 cagtcttctg acttttaatt tccaggactt ggattctgcc atgtcttctg aagaaggaaa
      121 actcttcgtg ggagggctca acttcaacac tgatgagcag gcacttgaag accacttcag
      181 cagcttcggg cctatctctg aggtggttgt tgtcaaggac cgggagactc aaagatcccg
      241 gggttttggc ttcatcacct tcacaaaccc agagcatgcc tccgatgcca tgagagccat
      301 gaatggagag tccctggatg ggcgccaaat ccgtgtggac catgcaggca agtctgccag
      361 gggaaccaga gggggtgcct ttggggccca tgggcgtggt cgcagctact ctagaggtgg
      421 tggagaccag ggatatggaa gtggaagata cgacagccga cctggaggct atggatatgg
      481 gtatgggcgg tctagagact acagtggcag aagccagggt ggctatgacc gctactcagg
      541 aggaaattac agagacaatt atgacaactg agatggggca tgcacacaat atacacaagg
      601 aataacactt ctgatccagg atcgtccttg caaattgctg tatttataaa gatttttgga
      661 gctgcgctga aacgtctgtt ttagtacatc aagttctatt tttgaattga gctcccaagg
      721 tagtttgtta aagaacttta agaaagctcc atgtgttctt taaacacttt tccccctttt
      781 aaagacaaat tttaagacat ttgttaacgg tcccaatatt tttcctttta tcagaatttt
      841 tgttgaggca ctcaggatta ttgttgctgg ccaagagaaa aaagtggcca ggataaatca
      901 agttttttaa attaatgtgt attttgggac attaaaaatt tgtaaatgat gttttctcat
      961 ggccagaaag tgatttctga atgtacctat gaacaatcta catcaagatc atgattacta
     1021 gagatgtttt ttattaaaga tcactgtcct gattatatag aagagcttct ttaaaatgtt
     1081 tgtgaatgtc attttttaat actggaagaa aaagtattct gttgtgtctg atgtgtttag
     1141 gatgtccttt atggagctaa ttaaaagatg aaacctgaac acaaa
//
