LOCUS       NM_001191100            2611 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus RNA binding motif protein 24 (Rbm24), mRNA.
ACCESSION   NM_001191100 XM_001073426
VERSION     NM_001191100.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2611)
  AUTHORS   Zhang,M., Zhang,Y., Xu,E., Mohibi,S., de Anda,D.M., Jiang,Y.,
            Zhang,J. and Chen,X.
  TITLE     Rbm24, a target of p53, is necessary for proper expression of p53
            and heart development
  JOURNAL   Cell Death Differ 25 (6), 1118-1130 (2018)
   PUBMED   29358667
REFERENCE   2  (bases 1 to 2611)
  AUTHORS   Lin,Y., Tan,K.T., Liu,J., Kong,X., Huang,Z. and Xu,X.Q.
  TITLE     Global profiling of Rbm24 bound RNAs uncovers a multi-tasking RNA
            binding protein
  JOURNAL   Int J Biochem Cell Biol 94, 10-21 (2018)
   PUBMED   29104163
REFERENCE   3  (bases 1 to 2611)
  AUTHORS   Ito,J., Iijima,M., Yoshimoto,N., Niimi,T., Kuroda,S. and
            Maturana,A.D.
  TITLE     RBM20 and RBM24 cooperatively promote the expression of short enh
            splice variants
  JOURNAL   FEBS Lett 590 (14), 2262-2274 (2016)
   PUBMED   27289039
  REMARK    GeneRIF: results suggest that, in healthy conditions, RBM20 and
            RBM24 cooperate to promote the expression of short ENH isoforms.
REFERENCE   4  (bases 1 to 2611)
  AUTHORS   Zhang,T., Lin,Y., Liu,J., Zhang,Z.G., Fu,W., Guo,L.Y., Pan,L.,
            Kong,X., Zhang,M.K., Lu,Y.H., Huang,Z.R., Xie,Q., Li,W.H. and
            Xu,X.Q.
  TITLE     Rbm24 Regulates Alternative Splicing Switch in Embryonic Stem Cell
            Cardiac Lineage Differentiation
  JOURNAL   Stem Cells 34 (7), 1776-1789 (2016)
   PUBMED   26990106
REFERENCE   5  (bases 1 to 2611)
  AUTHORS   Cardinali,B., Cappella,M., Provenzano,C., Garcia-Manteiga,J.M.,
            Lazarevic,D., Cittaro,D., Martelli,F. and Falcone,G.
  TITLE     MicroRNA-222 regulates muscle alternative splicing through Rbm24
            during differentiation of skeletal muscle cells
  JOURNAL   Cell Death Dis 7 (2), e2086 (2016)
   PUBMED   26844700
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2611)
  AUTHORS   Grifone,R., Xie,X., Bourgeois,A., Saquet,A., Duprez,D. and Shi,D.L.
  TITLE     The RNA-binding protein Rbm24 is transiently expressed in myoblasts
            and is required for myogenic differentiation during vertebrate
            development
  JOURNAL   Mech Dev 134, 1-15 (2014)
   PUBMED   25217815
REFERENCE   7  (bases 1 to 2611)
  AUTHORS   Yang,J., Hung,L.H., Licht,T., Kostin,S., Looso,M., Khrameeva,E.,
            Bindereif,A., Schneider,A. and Braun,T.
  TITLE     RBM24 is a major regulator of muscle-specific alternative splicing
  JOURNAL   Dev Cell 31 (1), 87-99 (2014)
   PUBMED   25313962
REFERENCE   8  (bases 1 to 2611)
  AUTHORS   Xu,E., Zhang,J., Zhang,M., Jiang,Y., Cho,S.J. and Chen,X.
  TITLE     RNA-binding protein RBM24 regulates p63 expression via mRNA
            stability
  JOURNAL   Mol Cancer Res 12 (3), 359-369 (2014)
   PUBMED   24375645
REFERENCE   9  (bases 1 to 2611)
  AUTHORS   Jiang,Y., Zhang,M., Qian,Y., Xu,E., Zhang,J. and Chen,X.
  TITLE     Rbm24, an RNA-binding protein and a target of p53, regulates p21
            expression via mRNA stability
  JOURNAL   J Biol Chem 289 (6), 3164-3175 (2014)
   PUBMED   24356969
REFERENCE   10 (bases 1 to 2611)
  AUTHORS   Jin,D., Hidaka,K., Shirai,M. and Morisaki,T.
  TITLE     RNA-binding motif protein 24 regulates myogenin expression and
            promotes myogenic differentiation
  JOURNAL   Genes Cells 15 (11), 1158-1167 (2010)
   PUBMED   20977548
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000017.1.
            
            On Jul 17, 2010 this sequence version replaced XM_001073426.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.60458.1,
                                           SRR26643298.68874.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840110, SAMN12840129
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               JAXUCZ010000017.1  18493376-18493628   c
            254-377             JAXUCZ010000017.1  18492162-18492285   c
            378-432             JAXUCZ010000017.1  18490726-18490780   c
            433-2611            JAXUCZ010000017.1  18481893-18484071   c
FEATURES             Location/Qualifiers
     source          1..2611
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..2611
                     /gene="Rbm24"
                     /note="RNA binding motif protein 24"
                     /db_xref="GeneID:690139"
                     /db_xref="RGD:1584029"
     exon            1..253
                     /gene="Rbm24"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..796
                     /gene="Rbm24"
                     /codon_start=1
                     /product="RNA-binding protein 24"
                     /protein_id="NP_001178029.1"
                     /db_xref="GeneID:690139"
                     /db_xref="RGD:1584029"
                     /translation="MHTTQKDTTYTKIFVGGLPYHTTDASLRKYFEVFGDIEEAVVIT
                     DRQTGKSRGYGFVTMADRAAAERACKDPNPIIDGRKANVNLAYLGAKPRIMQPGFAFG
                     VQQLHPALIQRPFGIPAHYVYPQAFVQPGVVIPHVQPTAAAASTTPYIDYTGAAYAQY
                     SAAAAAAAAAAAYDQYPYAASPAATGYVTTGGYSYAVQQPITAAAPGTAAAAAAAAAA
                     AAAFGQYQPQQLQTDRMQ"
     exon            254..377
                     /gene="Rbm24"
                     /inference="alignment:Splign:2.1.0"
     exon            378..432
                     /gene="Rbm24"
                     /inference="alignment:Splign:2.1.0"
     exon            433..2611
                     /gene="Rbm24"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcgcgctg cgggagacgc ggagcccgag gaccaggcgc agccgcagcc gcagccggag
       61 cccgagccgc ggggcgggcg cgaagatgca caccacccag aaggacacga cgtacaccaa
      121 gatcttcgtg ggagggctgc cctaccacac caccgacgcc agcctgcgca agtacttcga
      181 ggtcttcgga gacatcgagg aggctgtggt catcaccgac cggcagacgg gcaagtcccg
      241 gggctacgga tttgtcacca tggctgaccg cgctgctgct gaaagagcct gtaaggatcc
      301 taaccccatc atcgatggta ggaaggccaa tgtgaatctg gcgtacttgg gagccaaacc
      361 aagaatcatg cagccaggtt ttgcctttgg cgttcaacaa cttcacccgg cccttatcca
      421 gagacctttt gggatccccg cccactacgt ctacccgcag gcttttgtgc agcctggagt
      481 ggtcattccc cacgtccagc ccacggcagc tgcggcttcc accacaccgt acatagatta
      541 cactggagcc gcctacgcac agtactcggc ggcggcggct gcagccgcgg cggctgctgc
      601 ctatgaccag tacccatatg cagcatcgcc agctgccaca ggctatgtga ccactggggg
      661 ctacagctat gccgtccagc agcccatcac cgctgctgcg cccggaacgg ctgctgctgc
      721 ggctgcggcc gctgcagccg cagcagcctt cggccagtat cagcctcaac agctgcagac
      781 agaccgaatg cagtagacca gccgtctgat ccaagtcaaa ggggtttctc tttccctccc
      841 agtttcccag tttttagtag ctgatgagag agttaacgtt cacctgatgg ctttgaaggg
      901 acaaggcaaa ggtagtgtga gacagaggtg ttccttttct cggtactgct gcagatggaa
      961 aggggaggaa caggagggcg agaaacagtt tttgaagtca atcccaaaga gcctgagtta
     1021 cacagaatag ccactaggac acgatggcag gggtacccat gggacttcac ttttgtatgg
     1081 ggatttttat tttttttgct cttttttata gtatcaggga agcaaactgc cttttccaag
     1141 ttagaaaacg ctacgtgaat ctagctgaac cagggaatac ggagtgcaca atatgtagct
     1201 tgaattacgt gtaaaagtag atttttgaag aaagaaacac cacagcggaa agcactggtt
     1261 gtccttcctt tgcagtggtg actgcggcct gcagaactct gtcgaggcgg gaggtagtgt
     1321 ttgcgctacc tcaaaaatgg gcatcgaaca atcagtttag gggcgtgatg gcgggtatgg
     1381 tggcggacag gtaccaaagc tattttctca tctgtccctg tggacgagtg gggttgtgga
     1441 gccattgata ctgcaccagc cgctcagaca atcgatagca cacaccgttc gcaggaagag
     1501 tccatcactt gtactcgtgg gaggagcttg tgacattata attcccctcc ccatcccctg
     1561 tcactcgggg atgatctctt ctgccagtcg ggctttcacc acaccacttg tctttctatt
     1621 tattatctag actagaggat tatgggtaaa ggcaggcgga gtttgcagat gctcacccct
     1681 tcgggactgt ctgaaggacc tttgttttct tcccgccccg cccccactcc ccccttttaa
     1741 aataatttta cactttttcg tatctatttc agagtcctat ttaaaactat ttattagtga
     1801 ctacagtacc taagacagca aggttcttga cattacagtt cttcgacggt tgatggtctt
     1861 gtactttata atgtgcctta ataataatcc tatttaagat atttattttt taagttttac
     1921 tatgctgcac tctaaaggaa ggaactttag aagtgacact gtaaaattat gtattcatct
     1981 catggcataa gttattcagt aggtctagat gtagcatatt aaatattaac ctattcaact
     2041 aaagatgttg gctttggatt tatttaaatt cttatgtgca ctgttcaggt gggtgctctt
     2101 acctgaacga atttgagttt agtttagtct tgagttgttt tttgttttgt tctttttttt
     2161 cttttctttc tttctttctt tttttttttt tttttaaaca agctacgtcg ccggttctgt
     2221 gcttcctcga atgttttccc cctgcagatc tcatctgccg ggaacagatg ttcccacttt
     2281 ccttgtgtag tgtatgtagt tttaaaagac ggctttatat tttttccttc tgaaagtgtg
     2341 atacttgcaa tttttactct taaactaaat tgaatactat tttacactgt attggacttt
     2401 tatacttgaa gaacttcata caagggacaa caggttagca tttttatgga ctctccattg
     2461 tcactggatt taagtattcc cgtaccagac agtggtatgc aatggaggcg tggctctcct
     2521 gtgcaaacta tttatttgtt gtgtatctcg ctttataatg tttcggatct tctcatctat
     2581 tcacttgtat taaatataat ttttaaaaac t
//
