LOCUS       NM_001025676            1725 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus RNA binding motif protein 22 (Rbm22), mRNA.
ACCESSION   NM_001025676
VERSION     NM_001025676.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1725)
  AUTHORS   Bertram,K., Agafonov,D.E., Liu,W.T., Dybkov,O., Will,C.L.,
            Hartmuth,K., Urlaub,H., Kastner,B., Stark,H. and Luhrmann,R.
  TITLE     Cryo-EM structure of a human spliceosome activated for step 2 of
            splicing
  JOURNAL   Nature 542 (7641), 318-323 (2017)
   PUBMED   28076346
REFERENCE   2  (bases 1 to 1725)
  AUTHORS   Chanarat,S. and Strasser,K.
  TITLE     Splicing and beyond: the many faces of the Prp19 complex
  JOURNAL   Biochim Biophys Acta 1833 (10), 2126-2134 (2013)
   PUBMED   23742842
  REMARK    Review article
REFERENCE   3  (bases 1 to 1725)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 1725)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 1725)
  AUTHORS   Rasche,N., Dybkov,O., Schmitzova,J., Akyildiz,B., Fabrizio,P. and
            Luhrmann,R.
  TITLE     Cwc2 and its human homologue RBM22 promote an active conformation
            of the spliceosome catalytic centre
  JOURNAL   EMBO J 31 (6), 1591-1604 (2012)
   PUBMED   22246180
REFERENCE   6  (bases 1 to 1725)
  AUTHORS   Janowicz,A., Michalak,M. and Krebs,J.
  TITLE     Stress induced subcellular distribution of ALG-2, RBM22 and hSlu7
  JOURNAL   Biochim Biophys Acta 1813 (5), 1045-1049 (2011)
   PUBMED   21122810
REFERENCE   7  (bases 1 to 1725)
  AUTHORS   Montaville,P., Dai,Y., Cheung,C.Y., Giller,K., Becker,S.,
            Michalak,M., Webb,S.E., Miller,A.L. and Krebs,J.
  TITLE     Nuclear translocation of the calcium-binding protein ALG-2 induced
            by the RNA-binding protein RBM22
  JOURNAL   Biochim Biophys Acta 1763 (11), 1335-1343 (2006)
   PUBMED   17045351
REFERENCE   8  (bases 1 to 1725)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   9  (bases 1 to 1725)
  AUTHORS   Kitaura,Y., Matsumoto,S., Satoh,H., Hitomi,K. and Maki,M.
  TITLE     Peflin and ALG-2, members of the penta-EF-hand protein family, form
            a heterodimer that dissociates in a Ca2+-dependent manner
  JOURNAL   J Biol Chem 276 (17), 14053-14058 (2001)
   PUBMED   11278427
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097991.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097991.1, SRR8487227.197734.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00155325, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1725
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..1725
                     /gene="Rbm22"
                     /note="RNA binding motif protein 22"
                     /db_xref="GeneID:307410"
                     /db_xref="RGD:1305770"
     exon            1..107
                     /gene="Rbm22"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1316
                     /gene="Rbm22"
                     /codon_start=1
                     /product="pre-mRNA-splicing factor RBM22"
                     /protein_id="NP_001020847.1"
                     /db_xref="GeneID:307410"
                     /db_xref="RGD:1305770"
                     /translation="MATSLGSNTYNRQNWEDADFPILCQTCLGENPYIRMTKEKYGKE
                     CKICARPFTVFRWCPGVRMRFKKTEVCQTCSKLKNVCQTCLLDLEYGLPIQVRDAGLS
                     FKDDMPKSDVNKEYYTQNMEREISNSDGTRPVGMLGKATSTSDMLLKLARTTPYYKRN
                     RPHICSFWVKGECKRGEECPYRHEKPTDPDDPLADQNIKDRYYGINDPVADKLLKRAS
                     TMPRLDPPEDKTITTLYVGGLGDTITETDLRNHFYQFGEIRTVTVVQRQQCAFIQFAT
                     RQAAEVAAEKSFNKLIVNGRRLNVKWGRSQAARGKEKEKDGTTDSGIKLEPVPGLPGA
                     LPPPPAAEEEASANYFNLPPSGPPAVVNIALPPPPGIAPPPPPGFGPHLFHPMGPPPP
                     FMRAPGPIHYPSQDPQRMGAHAGKHSSP"
     exon            108..161
                     /gene="Rbm22"
                     /inference="alignment:Splign:2.1.0"
     exon            162..191
                     /gene="Rbm22"
                     /inference="alignment:Splign:2.1.0"
     exon            192..324
                     /gene="Rbm22"
                     /inference="alignment:Splign:2.1.0"
     exon            325..425
                     /gene="Rbm22"
                     /inference="alignment:Splign:2.1.0"
     exon            426..598
                     /gene="Rbm22"
                     /inference="alignment:Splign:2.1.0"
     exon            599..799
                     /gene="Rbm22"
                     /inference="alignment:Splign:2.1.0"
     exon            800..964
                     /gene="Rbm22"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1053
                     /gene="Rbm22"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1185
                     /gene="Rbm22"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1696
                     /gene="Rbm22"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtggcggtc ggtctctcga gtcggaagcc agagctgccc cgggactccc gatatggcga
       61 cttctctggg ttccaacact tacaacaggc agaactggga ggacgcggac ttccccattc
      121 tgtgtcagac gtgtcttgga gaaaaccctt atatacgaat gaccaaagaa aaatatggaa
      181 aagaatgcaa aatctgtgcc aggccattca cagtatttcg atggtgccct ggggtccgca
      241 tgcgcttcaa gaagactgaa gtgtgccaga cctgcagtaa attgaagaat gtttgtcaga
      301 cctgcctgtt agacctagag tacggcctac ccatccaggt ccgtgatgca gggttatcat
      361 ttaaagatga catgcctaaa tcagatgtca ataaagaata ttacacccaa aatatggaaa
      421 gagaaatttc taactctgat ggaacacggc cagtcggaat gctgggaaaa gcaacatcca
      481 ctagtgacat gctactcaaa ttggcccgga ccacacctta ctacaaaagg aatcggcccc
      541 acatttgttc cttctgggtg aaaggagagt gtaagagggg agaggagtgt ccctacagac
      601 atgagaagcc taccgatcca gatgaccctc ttgctgatca gaatataaaa gaccggtact
      661 atggaattaa cgaccctgtg gctgataagc ttctcaagcg ggcttcaacc atgcctcgtc
      721 ttgacccacc ggaggataag acgatcacca cactgtatgt gggtggtctg ggagacacca
      781 tcactgaaac agacctcagg aatcatttct accagttcgg agagattcgc acagtcactg
      841 ttgtgcagag gcagcagtgt gccttcatcc agttcgccac caggcaagct gccgaggtgg
      901 ctgccgagaa gtctttcaac aagctgattg tgaacggccg acgactcaat gtcaaatggg
      961 gacgatccca agcagccaga ggaaaagaaa aagagaagga tggaactaca gactctggga
     1021 tcaagttaga acctgtacca ggactgcctg gagctctgcc tccacctcct gccgcagaag
     1081 aggaagcgtc tgccaactac ttcaacctgc ccccaagtgg gcctccagcc gtagtgaaca
     1141 ttgccctgcc cccaccccct gggatcgccc cacccccacc cccaggtttt ggaccacact
     1201 tgttccaccc aatgggaccg ccccctcctt tcatgagagc tccaggacca atccactacc
     1261 cgtctcagga ccctcagaga atgggagctc atgctggaaa gcacagcagc ccctagcacc
     1321 acgtcaccac ctggcctctg aggaagaaag ggcactcaaa tcccagtaaa cgagtcctgg
     1381 gataagtata atttcccttg ctttgtagtt tccatggtag ctgaatgtgt cccgatgtgg
     1441 gcagagaaca cagctatgct tccccacatg tattcagagg atcggcgggc ctaaaacaag
     1501 aagctgtcct gaacatagct gcttaccacc acagcagtac taagagcctt atgtctgttc
     1561 ccttcccacc ctgtgggaac acgcacatgg tgaactggaa taaccagcgg agtccccatc
     1621 ctagtgtgtt cattttgtat ctttttggga gggaggcaaa aattgacctg cagtttaaaa
     1681 aaatattttg accattaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
