LOCUS       NP_001020847             420 aa            linear   ROD 27-APR-2025
DEFINITION  pre-mRNA-splicing factor RBM22 [Rattus norvegicus].
ACCESSION   NP_001020847
VERSION     NP_001020847.1
DBSOURCE    REFSEQ: accession NM_001025676.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 420)
  AUTHORS   Bertram,K., Agafonov,D.E., Liu,W.T., Dybkov,O., Will,C.L.,
            Hartmuth,K., Urlaub,H., Kastner,B., Stark,H. and Luhrmann,R.
  TITLE     Cryo-EM structure of a human spliceosome activated for step 2 of
            splicing
  JOURNAL   Nature 542 (7641), 318-323 (2017)
   PUBMED   28076346
REFERENCE   2  (residues 1 to 420)
  AUTHORS   Chanarat,S. and Strasser,K.
  TITLE     Splicing and beyond: the many faces of the Prp19 complex
  JOURNAL   Biochim Biophys Acta 1833 (10), 2126-2134 (2013)
   PUBMED   23742842
  REMARK    Review article
REFERENCE   3  (residues 1 to 420)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (residues 1 to 420)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (residues 1 to 420)
  AUTHORS   Rasche,N., Dybkov,O., Schmitzova,J., Akyildiz,B., Fabrizio,P. and
            Luhrmann,R.
  TITLE     Cwc2 and its human homologue RBM22 promote an active conformation
            of the spliceosome catalytic centre
  JOURNAL   EMBO J 31 (6), 1591-1604 (2012)
   PUBMED   22246180
REFERENCE   6  (residues 1 to 420)
  AUTHORS   Janowicz,A., Michalak,M. and Krebs,J.
  TITLE     Stress induced subcellular distribution of ALG-2, RBM22 and hSlu7
  JOURNAL   Biochim Biophys Acta 1813 (5), 1045-1049 (2011)
   PUBMED   21122810
REFERENCE   7  (residues 1 to 420)
  AUTHORS   Montaville,P., Dai,Y., Cheung,C.Y., Giller,K., Becker,S.,
            Michalak,M., Webb,S.E., Miller,A.L. and Krebs,J.
  TITLE     Nuclear translocation of the calcium-binding protein ALG-2 induced
            by the RNA-binding protein RBM22
  JOURNAL   Biochim Biophys Acta 1763 (11), 1335-1343 (2006)
   PUBMED   17045351
REFERENCE   8  (residues 1 to 420)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   9  (residues 1 to 420)
  AUTHORS   Kitaura,Y., Matsumoto,S., Satoh,H., Hitomi,K. and Maki,M.
  TITLE     Peflin and ALG-2, members of the penta-EF-hand protein family, form
            a heterodimer that dissociates in a Ca2+-dependent manner
  JOURNAL   J Biol Chem 276 (17), 14053-14058 (2001)
   PUBMED   11278427
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097991.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097991.1, SRR8487227.197734.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00155325, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..420
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     Protein         1..420
                     /product="pre-mRNA-splicing factor RBM22"
                     /calculated_mol_wt=46733
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q9NW64; propagated from
                     UniProtKB/Swiss-Prot (Q4V7D7.1)"
     Site            4
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9NW64; propagated from
                     UniProtKB/Swiss-Prot (Q4V7D7.1)"
     Site            102
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9NW64; propagated from
                     UniProtKB/Swiss-Prot (Q4V7D7.1)"
     Region          159..185
                     /region_name="ZnF_C3H1"
                     /note="zinc finger; smart00356"
                     /db_xref="CDD:214632"
     Site            212
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9NW64; propagated from
                     UniProtKB/Swiss-Prot (Q4V7D7.1)"
     Region          231..304
                     /region_name="RRM_RBM22"
                     /note="RNA recognition motif (RRM) found in
                     Pre-mRNA-splicing factor RBM22 and similar proteins;
                     cd12224"
                     /db_xref="CDD:409671"
     Region          303..343
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4V7D7.1)"
     Region          371..420
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4V7D7.1)"
     CDS             1..420
                     /gene="Rbm22"
                     /coded_by="NM_001025676.1:54..1316"
                     /db_xref="GeneID:307410"
                     /db_xref="RGD:1305770"
ORIGIN      
        1 matslgsnty nrqnwedadf pilcqtclge npyirmtkek ygkeckicar pftvfrwcpg
       61 vrmrfkktev cqtcsklknv cqtclldley glpiqvrdag lsfkddmpks dvnkeyytqn
      121 mereisnsdg trpvgmlgka tstsdmllkl arttpyykrn rphicsfwvk geckrgeecp
      181 yrhekptdpd dpladqnikd ryygindpva dkllkrastm prldppedkt ittlyvgglg
      241 dtitetdlrn hfyqfgeirt vtvvqrqqca fiqfatrqaa evaaeksfnk livngrrlnv
      301 kwgrsqaarg kekekdgttd sgiklepvpg lpgalppppa aeeeasanyf nlppsgppav
      361 vnialppppg iapppppgfg phlfhpmgpp ppfmrapgpi hypsqdpqrm gahagkhssp
//
