LOCUS       NM_001399561            4630 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus RNA binding motif protein 15 (Rbm15), mRNA.
ACCESSION   NM_001399561 XM_003749380
VERSION     NM_001399561.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4630)
  AUTHORS   Patil,D.P., Chen,C.K., Pickering,B.F., Chow,A., Jackson,C.,
            Guttman,M. and Jaffrey,S.R.
  TITLE     m(6)A RNA methylation promotes XIST-mediated transcriptional
            repression
  JOURNAL   Nature 537 (7620), 369-373 (2016)
   PUBMED   27602518
REFERENCE   2  (bases 1 to 4630)
  AUTHORS   Zhang,L., Tran,N.T., Su,H., Wang,R., Lu,Y., Tang,H., Aoyagi,S.,
            Guo,A., Khodadadi-Jamayran,A., Zhou,D., Qian,K., Hricik,T.,
            Cote,J., Han,X., Zhou,W., Laha,S., Abdel-Wahab,O., Levine,R.L.,
            Raffel,G., Liu,Y., Chen,D., Li,H., Townes,T., Wang,H., Deng,H.,
            Zheng,Y.G., Leslie,C., Luo,M. and Zhao,X.
  TITLE     Cross-talk between PRMT1-mediated methylation and ubiquitylation on
            RBM15 controls RNA splicing
  JOURNAL   Elife 4, e07938 (2015)
   PUBMED   26575292
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4630)
  AUTHORS   Xiao,N., Laha,S., Das,S.P., Morlock,K., Jesneck,J.L. and
            Raffel,G.D.
  TITLE     Ott1 (Rbm15) regulates thrombopoietin response in hematopoietic
            stem cells through alternative splicing of c-Mpl
  JOURNAL   Blood 125 (6), 941-948 (2015)
   PUBMED   25468569
REFERENCE   4  (bases 1 to 4630)
  AUTHORS   Horiuchi,K., Kawamura,T., Iwanari,H., Ohashi,R., Naito,M.,
            Kodama,T. and Hamakubo,T.
  TITLE     Identification of Wilms' tumor 1-associating protein complex and
            its role in alternative splicing and the cell cycle
  JOURNAL   J Biol Chem 288 (46), 33292-33302 (2013)
   PUBMED   24100041
REFERENCE   5  (bases 1 to 4630)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 4630)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 4630)
  AUTHORS   Raffel,G.D., Chu,G.C., Jesneck,J.L., Cullen,D.E., Bronson,R.T.,
            Bernard,O.A. and Gilliland,D.G.
  TITLE     Ott1 (Rbm15) is essential for placental vascular branching
            morphogenesis and embryonic development of the heart and spleen
  JOURNAL   Mol Cell Biol 29 (2), 333-341 (2009)
   PUBMED   18981216
REFERENCE   8  (bases 1 to 4630)
  AUTHORS   Ma,X., Renda,M.J., Wang,L., Cheng,E.C., Niu,C., Morris,S.W.,
            Chi,A.S. and Krause,D.S.
  TITLE     Rbm15 modulates Notch-induced transcriptional activation and
            affects myeloid differentiation
  JOURNAL   Mol Cell Biol 27 (8), 3056-3064 (2007)
   PUBMED   17283045
REFERENCE   9  (bases 1 to 4630)
  AUTHORS   Hiriart,E., Gruffat,H., Buisson,M., Mikaelian,I., Keppler,S.,
            Meresse,P., Mercher,T., Bernard,O.A., Sergeant,A. and Manet,E.
  TITLE     Interaction of the Epstein-Barr virus mRNA export factor EB2 with
            human Spen proteins SHARP, OTT1, and a novel member of the family,
            OTT3, links Spen proteins with splicing regulation and mRNA export
  JOURNAL   J Biol Chem 280 (44), 36935-36945 (2005)
   PUBMED   16129689
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jan 12, 2022 this sequence version replaced XM_003749380.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.7252.1,
                                           SRR26643289.7400.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3734              JAXUCZ010000002.1  197638964-197642697 c
            3735-4630           JAXUCZ010000002.1  197634174-197635069 c
FEATURES             Location/Qualifiers
     source          1..4630
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..4630
                     /gene="Rbm15"
                     /note="RNA binding motif protein 15"
                     /db_xref="GeneID:684233"
                     /db_xref="RGD:1592713"
     exon            1..3734
                     /gene="Rbm15"
                     /inference="alignment:Splign:2.1.0"
     CDS             869..3757
                     /gene="Rbm15"
                     /note="putative RNA-binding protein 15"
                     /codon_start=1
                     /product="RNA-binding protein 15"
                     /protein_id="NP_001386490.1"
                     /db_xref="GeneID:684233"
                     /db_xref="RGD:1592713"
                     /translation="MRSAGREPLPRRSPRWRRASPLCETSAGWRVSQLRRDDLRRPST
                     MKGKERSPVKPKRSRGGEDSSSRGERSKKLGGSGGSNGSSSGKTDSGGSRRSLHLDKS
                     SSRGGSREYDTGGGSSSSRLHSYSSPSTKNSSGGGESRSSSRGGGGESRSSGAASSAP
                     GGGDGVEYKTLKISELGSQLSDEAVEDGLFHEFKRFGDVSVKISHLSGSGSGDERVAF
                     VNFRRPEDARAAKHARGRLVLYDRPLKIEAVYVSRRRSRSPLDKDTYAPSSSVVGSSV
                     GSHRHAPGGGGGQRSLSPGGAALGYRDYRLQQLALGRLPPPPPPPLPRELERERDYPF
                     YDRVRPAYSLEPRVGAGAGAAPFREVDEISPEDDQRANRTLFLGNLDITVTENDLRRA
                     FDRFGVITEVDIKRPSRGQTSTYGFLKFENLDMSHRAKIAMSGKIIIRNPIKIGYGKA
                     TPTTRLWVGGLGPWVPLAALAREFDRFGTIRTIDYRKGDSWAYIQYESLDAAHAAWTH
                     MRGFPLGGPDRRLRVDFADTEHRYQQQYLQPLPLTHYELVTDTFGHRAPDPLRSARDR
                     TPPLLYRDRDRDLYPDSDWVPPPPPVRERSARAATSAVTAYEPLDSLDRRRDGWSLDR
                     DRGDRDLPSSRDQPRKRRLPEESGGRHLDRSPESDRPRKQRHCTPSPDRSPELSSNRD
                     RYNSDNDRSSRLLLLERPSPVRDRRGSLEKSQSDKRDRKNSASAERDRKHRTAAPTEG
                     KTPLKKEDRSDGNTPSASTSSSKQKPPSQKQDGGTAPVAASSPKLCLAWQGMLLLKNS
                     NFPSNMHLLQGDLQVASSLLVEGSTGGKVAQLKITQRLRLDQPKLDEVTRRIKVAGPN
                     GYAILLAVPGSSDSRSSSSSATSDTAASTQRPLRNLVSYLKQKQAAGVISLPVGGNKD
                     KENTGVLHAFPPCEFSQQFLDSPAKALAKSEEDYLVMIIVRAKLVNIG"
     exon            3735..4630
                     /gene="Rbm15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggctgctaa ctaagatggt gtcggctgga cttcccggga cagctgccta agcggatcga
       61 gggccagcag ccggaaggac caccgagccc attgtcccgc ccagacagga cagtgcggag
      121 cccgcaagtt ccagactcga aggaccgaag cacaggcaag tacgccgtag gacctaacaa
      181 atgtttaaga gaacgccgaa agcgcgggga ggcgggcctg actcactgtc accgtctcgc
      241 gacagctaag tgacgtcgca cagcaagcgc gtggtagagt ctttcacctt cagactcctc
      301 agtttatggg cctactcctt taagtgagtg atggacagcg cttttatcca atcattttcc
      361 tcgtcaacat ccaatcagat ttaaacttta ttcagccgcc ggagaagttg gaagactggg
      421 gttgaaagag agcgagcgag tgagcgagcg agctctttgt ctctcgcgag atccgagaga
      481 gccaagttct cagggaaaaa cgcctgaact gatgtccaga cttcccaagt agtgatttaa
      541 aggacgtggc cataaaccaa tgaaagggaa gagaaggtgg gatcgctgct ttcgccgtgc
      601 tagaagtacc gttacagggc agactttttg tccaatcaac gcttctaggc tttgggtcag
      661 gtgaccatga agtgcgaggg gcggagctac agcctggcgc gaggaaccgt taagatagac
      721 aacgaatata accaatgagg tactgcgatt agggcgttgg gaacccaata acagcgtcgg
      781 ggcgggcgcc ttcccggagc gcggggagat gtaaagacgg acaaatagtt tttccaatga
      841 gaaagctgaa gagtgaatta attgaccaat gaggtctgcg gggcgggagc ctttgccgcg
      901 gcggagtcca agatggcggc gtgcgagtcc gctgtgtgaa acgagcgcgg ggtggcgggt
      961 tagtcagctc cgcagagacg acctccggcg accctcaaca atgaaaggaa aggagcgctc
     1021 gccagtcaag cccaaacgct cccgtggcgg tgaggactcc agttctcgtg gggaacggag
     1081 caagaagtta gggggctctg gcggcagcaa tgggagcagc agcgggaaga cggacagcgg
     1141 cgggtcgcgg cggagccttc atctggacaa gtccagcagc cgaggcggca gccgcgagta
     1201 tgataccggt gggggcagct ccagtagccg cttgcatagt tacagctccc caagcaccaa
     1261 aaattcctca ggcgggggcg agtcgcgcag cagctcccgg ggtggaggcg gggagtcacg
     1321 ttcctctggg gccgcctcct cagcgcctgg cggcggggac ggcgtggagt acaagaccct
     1381 gaagataagc gaattggggt cccagctgag tgacgaagcg gtggaggacg gactgtttca
     1441 cgagttcaaa cgcttcggtg atgtaagtgt caaaatcagt catctctcag gttctggcag
     1501 cggggatgag cgggtagcct ttgtgaactt ccggaggcca gaggacgcga gggcggccaa
     1561 gcatgccaga ggccgcctgg tgctctatga ccggcctctg aagatagaag ccgtgtatgt
     1621 gagccggcgc cgcagccgct ccccgttaga caaagatact tacgccccgt cgtccagcgt
     1681 ggtcggaagc tctgtaggta gccacaggca cgcccctgga ggaggtggag gtcagagatc
     1741 gctttctcct ggcggtgctg ctttgggata cagagactac cggttgcagc agttggctct
     1801 tggccgcctg cctcctccac ccccgccacc attgccccga gagctggaaa gagaacgaga
     1861 ctatccgttc tatgacagag tgcggccagc atatagtctt gagccgaggg tgggagctgg
     1921 agcaggtgct gctccattcc gagaagtgga tgagatatca cctgaggatg atcagcgtgc
     1981 caaccggaca cttttcttgg gcaacttaga tatcactgtg acagaaaatg atctgagaag
     2041 ggcttttgat cgttttggag tcatcacaga agtggacatt aagaggcctt ctcgtggcca
     2101 gaccagtact tacggctttc tcaaatttga gaacctagac atgtctcaca gggccaaaat
     2161 agcaatgtct ggcaaaatta taattcggaa tccaatcaag attggttatg ggaaagccac
     2221 acccactacc cgactttggg tgggtggtct gggaccttgg gtgcctcttg ctgccctggc
     2281 acgagaattt gatcgatttg gcaccattcg aaccatagac taccgaaaag gtgacagttg
     2341 ggcatatata cagtatgaaa gcttggatgc agctcatgct gcctggaccc atatgcgtgg
     2401 attcccactt ggtggcccag atcgtcgcct tagggtagac tttgcagaca cagaacatcg
     2461 ttaccagcag cagtatcttc agcctctgcc cttaacccat tatgaactag tgacagatac
     2521 ttttggacat cgagcacctg accctttgag gagtgctcgg gaccggacac cacccttact
     2581 atacagagat cgtgataggg acctttatcc cgattctgat tgggtgccac ccccgccacc
     2641 ggttcgggaa cgcagtgctc gggctgcaac tagtgccgtc actgcttatg agccactgga
     2701 tagcttggat cgaaggaggg atggctggtc actggacagg gacagaggtg accgggattt
     2761 gcctagcagc agggaccagc caaggaagcg aaggctgcct gaggaaagtg gaggacggca
     2821 tcttgataga tcacccgaga gtgaccggcc tcgaaaacag cgtcactgca ctccttctcc
     2881 tgaccgaagt ccagaactga gcagtaacag agatcgttac aacagtgaca atgatcgatc
     2941 atctcgtctt ctactcttgg aaaggccttc cccagtcaga gatagacggg gcagtttgga
     3001 gaagagccag agtgacaaac gagaccgtaa aaactctgca tcagctgaac gggataggaa
     3061 gcaccggaca gctgctccca cagagggaaa aacccctctg aaaaaggaag accgatctga
     3121 tggcaataca cccagtgcca gcacttcttc atcaaagcag aagccacctt cccagaaaca
     3181 ggatggaggg acagctcctg tggcagcatc ctctcccaaa ctctgtttgg cttggcaggg
     3241 catgcttcta ctgaagaaca gcaacttccc ttccaacatg catctattgc agggtgacct
     3301 ccaagttgct agcagtctac ttgtggaggg ttccactgga ggcaaagtag cccagctcaa
     3361 gatcactcag cggctccgtt tggaccagcc caagttggat gaagtaactc gacgcatcaa
     3421 agtggcaggg cctaatggtt atgccattct cctagctgta cctggaagtt ctgacagccg
     3481 atcctcctct tcctcagcca catcagacac tgccgcctct actcagaggc cacttaggaa
     3541 ccttgtgtcc tatttaaagc aaaagcaggc agctggggtg atcagcctcc ctgtgggagg
     3601 caataaagac aaggaaaaca ccggggttct tcatgccttc ccaccttgtg agttctctca
     3661 gcagttcctg gattcccctg ccaaggcact ggccaaatct gaagaagatt acctggtcat
     3721 gatcattgtc cgtgcaaaac tggtgaacat cggatgaaga tacggaattc aaagctctaa
     3781 tggacctttt tgaagagaag tggcttatgt ggagtttaca tgggcctctg atggaagaaa
     3841 gctaatctgt ttagtatttt gtgcatttta ctaaaatggc agcttaacat tgtgtatctg
     3901 ctattgtgat gccaatgccg gtgttttaag tggaaaaatg acctctttgc tttgtgctgt
     3961 gtacacaaga tttctggaaa agtaaagaaa aacccttttt atggctcaca cagcttaaaa
     4021 gtagctgtca ctcaaacatg ggctcacagt tgagctgctt ttgttttatt ctaaataaat
     4081 tgtttctttt gaggaaaatg tttttctgcc tggaagtgaa ttgacggcaa accttgaccc
     4141 ctttgtttgc agcggagggg gtacttgctg ctgctcagat cttgtatgtc ttgagcaaga
     4201 agcagggaga tcatcaattt cattttgact atcacggtgt gtcaattctg aaggatcata
     4261 gtgttacagt gacccccttt gtttgcagtg aaggggatcc tttgcttctc ggtcctcaac
     4321 acacgatgag ggtgctgttt gctggcatgc aagaagcggg gcaagcactc taagcctccc
     4381 accacagtgc acgagtcggg ggctttgctg gttgaagagc cggagttcct gaaatttaag
     4441 ttttgattta ttttgttcac ccatcacgtt tggctttagt ttcatttttt aatttgaaga
     4501 aaagtttgaa gttgcattat cttgcacttt taacatttgc accaaattgc caaaagaagg
     4561 agaaatgctc cggttgcttt ttaaatgtta atgatgatgt taataaagcc tttcctgaca
     4621 catttgagga
//
