LOCUS       NP_690600                852 aa            linear   ROD 30-APR-2025
DEFINITION  RNA-binding protein 10 isoform 1 [Rattus norvegicus].
ACCESSION   NP_690600
VERSION     NP_690600.1
DBSOURCE    REFSEQ: accession NM_152861.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 852)
  AUTHORS   Shang,Y., Li,X., Liu,W., Shi,X., Yuan,S., Huo,R., Fang,G., Han,X.,
            Zhang,J., Wang,K., Dou,Z., Zhang,Y., Zang,A. and Zhang,L.
  TITLE     Comprehensive genomic profile of Chinese lung cancer patients and
            mutation characteristics of individuals resistant to
            icotinib/gefitinib
  JOURNAL   Sci Rep 10 (1), 20243 (2020)
   PUBMED   33219256
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 852)
  AUTHORS   Xu,T., Zhang,Y., Zhang,J., Qi,C., Liu,D., Wang,Z., Li,Y., Ji,C.,
            Li,J., Lin,X., Hou,T., Liu,H., Zhang,L., Han-Zhang,H., Shen,L. and
            Wang,X.
  TITLE     Germline Profiling and Molecular Characterization of Early Onset
            Metastatic Colorectal Cancer
  JOURNAL   Front Oncol 10, 568911 (2020)
   PUBMED   33194656
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 852)
  AUTHORS   Zhao,Z., Li,J. and Shen,F.
  TITLE     Protective effect of the RNA-binding protein RBM10 in
            hepatocellular carcinoma
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (11), 6005-6013 (2020)
   PUBMED   32572914
REFERENCE   4  (residues 1 to 852)
  AUTHORS   Jin,X., Di,X., Wang,R., Ma,H., Tian,C., Zhao,M., Cong,S., Liu,J.,
            Li,R. and Wang,K.
  TITLE     RBM10 inhibits cell proliferation of lung adenocarcinoma via
            RAP1/AKT/CREB signalling pathway
  JOURNAL   J Cell Mol Med 23 (6), 3897-3904 (2019)
   PUBMED   30955253
REFERENCE   5  (residues 1 to 852)
  AUTHORS   Yin,L.L., Wen,X.M., Li,M., Xu,Y.M., Zhao,X.F., Li,J. and Wang,X.W.
  TITLE     A gene mutation in RNA-binding protein 10 is associated with lung
            adenocarcinoma progression and poor prognosis
  JOURNAL   Oncol Lett 16 (5), 6283-6292 (2018)
   PUBMED   30405763
REFERENCE   6  (residues 1 to 852)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (residues 1 to 852)
  AUTHORS   Hegele,A., Kamburov,A., Grossmann,A., Sourlis,C., Wowro,S.,
            Weimann,M., Will,C.L., Pena,V., Luhrmann,R. and Stelzl,U.
  TITLE     Dynamic protein-protein interaction wiring of the human spliceosome
  JOURNAL   Mol Cell 45 (4), 567-580 (2012)
   PUBMED   22365833
REFERENCE   8  (residues 1 to 852)
  AUTHORS   Mueller,C.F., Berger,A., Zimmer,S., Tiyerili,V. and Nickenig,G.
  TITLE     The heterogenous nuclear riboprotein S1-1 regulates AT1 receptor
            gene expression via transcriptional and posttranscriptional
            mechanisms
  JOURNAL   Arch Biochem Biophys 488 (1), 76-82 (2009)
   PUBMED   19508861
  REMARK    GeneRIF: Overexpression of S1-1 sense resulted in VSMC in
            significant stabilization of AT1 receptor mRNA.
REFERENCE   9  (residues 1 to 852)
  AUTHORS   Zhu,P., Zhou,W., Wang,J., Puc,J., Ohgi,K.A., Erdjument-Bromage,H.,
            Tempst,P., Glass,C.K. and Rosenfeld,M.G.
  TITLE     A histone H2A deubiquitinase complex coordinating histone
            acetylation and H1 dissociation in transcriptional regulation
  JOURNAL   Mol Cell 27 (4), 609-621 (2007)
   PUBMED   17707232
REFERENCE   10 (residues 1 to 852)
  AUTHORS   Inoue,A., Takahashi,K.P., Kimura,M., Watanabe,T. and Morisawa,S.
  TITLE     Molecular cloning of a RNA binding protein, S1-1
  JOURNAL   Nucleic Acids Res 24 (15), 2990-2997 (1996)
   PUBMED   8760884
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D83948.1, SRR26643292.64831.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..852
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq11"
     Protein         1..852
                     /product="RNA-binding protein 10 isoform 1"
                     /function="RNA metabolism"
                     /note="RNA-binding protein 10; RNA-binding protein S1-1;
                     S1-1 protein from liver"
                     /calculated_mol_wt=94257
     Region          1..78
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70501.1)"
     Site            61
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P98175; propagated from
                     UniProtKB/Swiss-Prot (P70501.1)"
     Region          67..134
                     /region_name="RRM_SF"
                     /note="RNA recognition motif (RRM) superfamily; cl17169"
                     /db_xref="CDD:473069"
     Region          138..162
                     /region_name="ZnF_RBZ"
                     /note="Zinc finger domain; smart00547"
                     /db_xref="CDD:197784"
     Region          140..159
                     /region_name="RanBP2-type Zn finger"
                     /note="RanBP2-type Zn finger [structural motif]"
                     /db_xref="CDD:275376"
     Region          221..307
                     /region_name="RRM2_RBM10"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     RNA-binding protein 10 (RBM10); cd12754"
                     /db_xref="CDD:410148"
     Site            306
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P98175; propagated from
                     UniProtKB/Swiss-Prot (P70501.1)"
     Region          343..365
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70501.1)"
     Region          386..410
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70501.1)"
     Region          426..446
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70501.1)"
     Region          459..489
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70501.1)"
     Region          486..549
                     /region_name="OCRE_RBM10"
                     /note="OCRE domain found in RNA-binding protein 10 (RBM10)
                     and similar proteins; cd16167"
                     /db_xref="CDD:293886"
     Region          492..499
                     /region_name="OCRE repeat 1"
                     /note="OCRE repeat 1 [structural motif]"
                     /db_xref="CDD:293886"
     Region          500..507
                     /region_name="OCRE repeat 2"
                     /note="OCRE repeat 2 [structural motif]"
                     /db_xref="CDD:293886"
     Region          508..515
                     /region_name="OCRE repeat 3"
                     /note="OCRE repeat 3 [structural motif]"
                     /db_xref="CDD:293886"
     Region          516..523
                     /region_name="OCRE repeat 4"
                     /note="OCRE repeat 4 [structural motif]"
                     /db_xref="CDD:293886"
     Region          525..532
                     /region_name="OCRE repeat 5"
                     /note="OCRE repeat 5 [structural motif]"
                     /db_xref="CDD:293886"
     Region          542..568
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70501.1)"
     Region          634..675
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70501.1)"
     Site            640
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P98175; propagated from
                     UniProtKB/Swiss-Prot (P70501.1)"
     Site            645
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P70501.1)"
     Site            655
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P70501.1)"
     Site            658
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P70501.1)"
     Site            660
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P70501.1)"
     Site            703
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P98175; propagated from
                     UniProtKB/Swiss-Prot (P70501.1)"
     Site            719
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P70501.1)"
     Region          740..783
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70501.1)"
     Site            767
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P98175; propagated from
                     UniProtKB/Swiss-Prot (P70501.1)"
     Region          780..824
                     /region_name="G-patch"
                     /note="G-patch domain; pfam01585"
                     /db_xref="CDD:396249"
     Site            824
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:P98175; propagated from
                     UniProtKB/Swiss-Prot (P70501.1)"
     CDS             1..852
                     /gene="Rbm10"
                     /coded_by="NM_152861.5:328..2886"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:64510"
                     /db_xref="RGD:631366"
ORIGIN      
        1 meyerrggrg drtgrygatd rsqddggenr srdhdyrdmd yrsypreygs qegkheydds
       61 seeqsaeirg qlqshgvqar evrlmrnkss gqsrgfafve fshlqdatrw meanqhslni
      121 lgqkvsmhys dpkpkinedw lcnkcgvqnf krrekcfkcg vpkseaeqkl plgtrldqqa
      181 lplggrelsq gllplpqpyq aqgvltsqal sqgsepssen andtiilrnl nphstmdsil
      241 galapyavls ssnvrvikdk qtqlnrgfaf iqlstiveaa qllqilqalh ppltidgkti
      301 nvefakgskr dmasnegsri naasvastai aaaqwaisqa sqggestwaa peeppvdysy
      361 yqqdegygss qgtdslyahg ylkntkgpgm tgtkgdtsga gpetsleggt dsvslqafsr
      421 aqpgaapgly qqsaegssgq gtatnsqsyt imspavlkse lqspthpssa lppatsptap
      481 esysqypvpd vstyqydets gyyydpqtgl yydpnsqyyy naqsqqylyw dgerrtyipa
      541 leqsadghkd tgasskegke kkekhktkta qqiakdmerw arslnkqken fknsfqpisa
      601 lrdderresa tadagyaile kkgalaerqh tsmdlpklas ddrpspprgl vaaysgesds
      661 eeeqerggpe reekltdwqk lacllcrrqf pskealirhq qlsglhkqnl eihrrahlse
      721 nelealeknd meqmkyrdra aerrekygip eppepkrrky ggistasvdf eqptrdglgs
      781 dnigsrmlqa mgwkegsglg rkkqgivtpi eaqtrvrgsg lgargssygv tstesyketl
      841 hktmvtrfne aq
//
