LOCUS       NM_031094               4860 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus RB transcriptional corepressor like 2 (Rbl2),
            mRNA.
ACCESSION   NM_031094
VERSION     NM_031094.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4860)
  AUTHORS   Miles,W.O., Korenjak,M., Griffiths,L.M., Dyer,M.A., Provero,P. and
            Dyson,N.J.
  TITLE     Post-transcriptional gene expression control by NANOS is
            up-regulated and functionally important in pRb-deficient cells
  JOURNAL   EMBO J 33 (19), 2201-2215 (2014)
   PUBMED   25100735
REFERENCE   2  (bases 1 to 4860)
  AUTHORS   Calvisi,D.F., Pinna,F., Ladu,S., Muroni,M.R., Frau,M., Demartis,I.,
            Tomasi,M.L., Sini,M., Simile,M.M., Seddaiu,M.A., Feo,F. and
            Pascale,R.M.
  TITLE     The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin
            ligase is genetically controlled in rodent liver cancer and
            contributes to determine the susceptibility to the disease
  JOURNAL   Int J Cancer 126 (5), 1275-1281 (2010)
   PUBMED   19533683
REFERENCE   3  (bases 1 to 4860)
  AUTHORS   Galderisi,U., Helmbold,H., Squillaro,T., Alessio,N., Komm,N.,
            Khadang,B., Cipollaro,M., Bohn,W. and Giordano,A.
  TITLE     In vitro senescence of rat mesenchymal stem cells is accompanied by
            downregulation of stemness-related and DNA damage repair genes
  JOURNAL   Stem Cells Dev 18 (7), 1033-1042 (2009)
   PUBMED   19099372
  REMARK    GeneRIF: RB2/P130 could be a marker of senescence or that it even
            plays a role in triggering the process in MSCs.
REFERENCE   4  (bases 1 to 4860)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 4860)
  AUTHORS   Gizard,F., Nomiyama,T., Zhao,Y., Findeisen,H.M., Heywood,E.B.,
            Jones,K.L., Staels,B. and Bruemmer,D.
  TITLE     The PPARalpha/p16INK4a pathway inhibits vascular smooth muscle cell
            proliferation by repressing cell cycle-dependent telomerase
            activation
  JOURNAL   Circ Res 103 (10), 1155-1163 (2008)
   PUBMED   18818403
  REMARK    GeneRIF: PPARalpha trans-repression involved the recruitment of the
            retinoblastoma (RB) family proteins p107 and p130 to the TERT
            promoter resulting in impaired E2F-1 binding, an effect that was
            dependent on p16.
REFERENCE   6  (bases 1 to 4860)
  AUTHORS   Jori,F.P., Napolitano,M.A., Melone,M.A., Cipollaro,M., Cascino,A.,
            Giordano,A. and Galderisi,U.
  TITLE     Role of RB and RB2/P130 genes in marrow stromal stem cells
            plasticity
  JOURNAL   J Cell Physiol 200 (2), 201-212 (2004)
   PUBMED   15174090
  REMARK    GeneRIF: Rb2 was found to have a role in neural differentiation but
            not in neural determination.
REFERENCE   7  (bases 1 to 4860)
  AUTHORS   Surapureddi,S., Yu,S., Bu,H., Hashimoto,T., Yeldandi,A.V.,
            Kashireddy,P., Cherkaoui-Malki,M., Qi,C., Zhu,Y.J., Rao,M.S. and
            Reddy,J.K.
  TITLE     Identification of a transcriptionally active peroxisome
            proliferator-activated receptor alpha -interacting cofactor complex
            in rat liver and characterization of PRIC285 as a coactivator
  JOURNAL   Proc Natl Acad Sci U S A 99 (18), 11836-11841 (2002)
   PUBMED   12189208
REFERENCE   8  (bases 1 to 4860)
  AUTHORS   Timchenko,N.A., Wilde,M. and Darlington,G.J.
  TITLE     C/EBPalpha regulates formation of S-phase-specific E2F-p107
            complexes in livers of newborn mice
  JOURNAL   Mol Cell Biol 19 (4), 2936-2945 (1999)
   PUBMED   10082561
REFERENCE   9  (bases 1 to 4860)
  AUTHORS   Woitach,J.T., Zhang,M., Niu,C.H. and Thorgeirsson,S.S.
  TITLE     A retinoblastoma-binding protein that affects cell-cycle control
            and confers transforming ability
  JOURNAL   Nat Genet 19 (4), 371-374 (1998)
   PUBMED   9697699
REFERENCE   10 (bases 1 to 4860)
  AUTHORS   Sawada,Y., Nomura,H., Endo,Y., Umeki,K., Fujita,T., Ohtaki,S. and
            Fujinaga,K.
  TITLE     Cloning and characterization of the rat p130, a member of the
            retinoblastoma gene family
  JOURNAL   Biochim Biophys Acta 1361 (1), 20-27 (1997)
   PUBMED   9247086
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031094.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D55627.1, BC062040.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-297               JAXUCZ010000019.1  32096115-32096411   c
            298-428             JAXUCZ010000019.1  32093378-32093508   c
            429-629             JAXUCZ010000019.1  32091251-32091451   c
            630-694             JAXUCZ010000019.1  32088214-32088278   c
            695-823             JAXUCZ010000019.1  32083799-32083927   c
            824-984             JAXUCZ010000019.1  32081664-32081824   c
            985-1049            JAXUCZ010000019.1  32081494-32081558   c
            1050-1236           JAXUCZ010000019.1  32080151-32080337   c
            1237-1403           JAXUCZ010000019.1  32077044-32077210   c
            1404-1513           JAXUCZ010000019.1  32074198-32074307   c
            1514-1617           JAXUCZ010000019.1  32072830-32072933   c
            1618-1755           JAXUCZ010000019.1  32069883-32070020   c
            1756-1920           JAXUCZ010000019.1  32068632-32068796   c
            1921-2032           JAXUCZ010000019.1  32067752-32067863   c
            2033-2299           JAXUCZ010000019.1  32064464-32064730   c
            2300-2580           JAXUCZ010000019.1  32064026-32064306   c
            2581-2757           JAXUCZ010000019.1  32063637-32063813   c
            2758-2829           JAXUCZ010000019.1  32058690-32058761   c
            2830-2929           JAXUCZ010000019.1  32057436-32057535   c
            2930-3138           JAXUCZ010000019.1  32056289-32056497   c
            3139-3303           JAXUCZ010000019.1  32055678-32055842   c
            3304-4860           JAXUCZ010000019.1  32049691-32051247   c
FEATURES             Location/Qualifiers
     source          1..4860
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..4860
                     /gene="Rbl2"
                     /gene_synonym="Rb2"
                     /note="RB transcriptional corepressor like 2"
                     /db_xref="GeneID:81758"
                     /db_xref="RGD:3541"
     exon            1..297
                     /gene="Rbl2"
                     /gene_synonym="Rb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..3474
                     /gene="Rbl2"
                     /gene_synonym="Rb2"
                     /note="P130; PRB2; RBR-2; PRIC128; 130 kDa
                     retinoblastoma-associated protein; PPAR-alpha-interacting
                     complex protein 128; retinoblastoma-related protein 2;
                     retinoblastoma-like 2"
                     /codon_start=1
                     /product="retinoblastoma-like protein 2"
                     /protein_id="NP_112356.2"
                     /db_xref="GeneID:81758"
                     /db_xref="RGD:3541"
                     /translation="MASGGNQSSPPPPAAAASSEEEEEDGDTADRAQPAGSPSHQIQQ
                     RFEELCSRLNMDEAARAEAWSSYRSMSESYTLEGNDLHWLACALYVACRKSVPTVSKG
                     TAEGNYVSLTRILRCSEQSLIEFFNKMKKWEDMANLPPHFRERTERLERNFTVSAVIF
                     KKYEPIFQDIFKYPQEEQPRQQRGRKQRRQPCTTSEIFHFCWVLFIYAKGNFPMISDD
                     LVNSYHLLLCALDLVYGNALQCSNRKELVNPNFKGVSEDGHPRDSHPSSDPPCVIEKL
                     CSLHDGLVLEAKGIKQHFWKPYIRKLFEKKLLRGKEENLTGFLEPGNFAESFKAVNKA
                     YEEYVLATGSLDERIFLGEDAEEEVGTLSRCVSAASGTESAERTQMRDILQQHLDKSK
                     TLRVCNPLTGVRYVQENSPCVTPVSTATHSLNRLHTMLAGLRNAPSEKLEQILRSCSR
                     DPTRAIADRLREMYEIYSQHFQPDENVSNCAKEMANKHFRFAEMLYYKVLESVIEQEQ
                     KRLGDMDLSGVLEQDAFHKSLLACCLEVVAFSYKPPGNFPFIAEIFDVPHYHFYKVIE
                     VFIRAEDGLCREVVKHLNQIEEQILDHLAWKTKSPLWDRIRDNENRVPTCEEVTPPHN
                     LERTDEIYIAGSPLTPRRVGEVRTDAGGLGRSVTSPTTLYDRYSSPTVSTTRRRLFES
                     DSPSEGSTAGRIPPQPLVNAVPVQNVSGETVSVTPVPGQTLVTMATATVTANNGQTVT
                     IPVQGIANENGGITFFPVQVNVGGQAQAVTGSIQPLSAQALAGSLSSQQVTGTTLQVP
                     GPVAIQQISPGGQQQNQGQPLTSSSIRPRKTSSLSLFFRKVYYLAGVRLRDLCTKLDI
                     SDELRKKIWTCFEFSIVQCPELMMDRHLDQLLMCAIYVMAKVTKEDKSFQNIMRCYRT
                     QPQARSQVYRSVLIKGKRRNSGSCENRSHQNSPTELNTDRASRDSSPVMRSNSTLPVP
                     QPSSAPPTPTRLTGANSDIEEEERGDLIQFYNNIYRKQIQTFAMKYSQANSQMDTPPL
                     SPYPFVRTGSPRRVQLSQSHPIYISPHKNEAMLSPREKIFYYFSNSPSKRLREINSMI
                     RTGETPTKKRGILLDDGSESPAKRICPENHSALLRRLQDVANDRGSH"
     exon            298..428
                     /gene="Rbl2"
                     /gene_synonym="Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            429..629
                     /gene="Rbl2"
                     /gene_synonym="Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            630..694
                     /gene="Rbl2"
                     /gene_synonym="Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            695..823
                     /gene="Rbl2"
                     /gene_synonym="Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            824..984
                     /gene="Rbl2"
                     /gene_synonym="Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1049
                     /gene="Rbl2"
                     /gene_synonym="Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1236
                     /gene="Rbl2"
                     /gene_synonym="Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1403
                     /gene="Rbl2"
                     /gene_synonym="Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1513
                     /gene="Rbl2"
                     /gene_synonym="Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1617
                     /gene="Rbl2"
                     /gene_synonym="Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1755
                     /gene="Rbl2"
                     /gene_synonym="Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1920
                     /gene="Rbl2"
                     /gene_synonym="Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2032
                     /gene="Rbl2"
                     /gene_synonym="Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2299
                     /gene="Rbl2"
                     /gene_synonym="Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2580
                     /gene="Rbl2"
                     /gene_synonym="Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2581..2757
                     /gene="Rbl2"
                     /gene_synonym="Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2758..2829
                     /gene="Rbl2"
                     /gene_synonym="Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..2929
                     /gene="Rbl2"
                     /gene_synonym="Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3138
                     /gene="Rbl2"
                     /gene_synonym="Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            3139..3303
                     /gene="Rbl2"
                     /gene_synonym="Rb2"
                     /inference="alignment:Splign:2.1.0"
     exon            3304..4860
                     /gene="Rbl2"
                     /gene_synonym="Rb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggtttgaa tggctgtggg cccgggccct aagctcatct gaagagccgc ggcctccggg
       61 tgtgccatgg catctggagg caaccagtcg tcacctcccc ctcctgctgc tgcagccagc
      121 tcagaggaag aggaggagga tggcgacacc gcggaccggg cgcagcccgc agggtcccca
      181 agccatcaga tccaacagcg gttcgaagag ctgtgcagcc gccttaacat ggacgaggcg
      241 gcacgcgccg aggcctggag cagctaccgc agcatgagcg agagctacac gctggaggga
      301 aatgatctcc attggttagc atgtgcctta tatgtggctt gcagaaaatc tgttcctact
      361 gtgagcaaag ggactgctga aggaaactat gtgtctttaa ctagaatcct tcgatgttct
      421 gagcaaagcc taattgaatt ttttaacaag atgaagaagt gggaagatat ggcaaattta
      481 cccccacact tccgagaacg aaccgaaaga ttagaaagaa acttcactgt ctccgctgtg
      541 atctttaaga aatatgaacc catttttcaa gacattttta aatatcccca agaagaacaa
      601 cctcgccagc aaagaggaag aaagcagagg cgacagccct gtaccacatc tgaaattttc
      661 catttttgtt gggtgctttt tatatacgca aaaggaaact tccccatgat cagtgatgat
      721 ctggtcaatt cctaccatct tctgctgtgt gcactagatt tagtttatgg aaatgcccta
      781 caatgctcta accggaaaga acttgtgaac cctaatttta aaggcgtgtc cgaggacggc
      841 caccccaggg actctcaccc gtcctctgat ccaccgtgtg tcattgagaa gctctgctcc
      901 ttacacgacg gcctagtgct ggaggcaaag gggataaagc agcatttctg gaaaccctac
      961 attaggaagc tttttgaaaa gaagctcctc agggggaagg aagaaaatct cactggcttc
     1021 ctggagcccg ggaacttcgc agagagcttt aaggctgtta ataaggcgta tgaagaatac
     1081 gtgttagcca ctgggagtct ggatgagcgg atatttcttg gcgaggatgc ggaggaggaa
     1141 gttggaactc tctcacggtg tgtaagtgct gcctcgggca cagagagtgc cgaacgaacg
     1201 cagatgagag acatcttgca gcagcatctt gacaagtcta aaacacttag agtctgcaac
     1261 ccactgactg gcgtgcggta tgttcaggag aacagccctt gtgtgactcc cgtctccaca
     1321 gcaacacaca gcctgaaccg tcttcacacc atgctggccg gcctcaggaa tgcacccagt
     1381 gagaagctag aacagatact caggtcatgt tcccgagatc cgactcgggc tatcgctgac
     1441 aggttgagag agatgtatga aatatattct cagcatttcc agccagacga gaatgttagt
     1501 aattgtgcta aagaaatggc caacaaacac tttcgttttg cagaaatgct ttactataaa
     1561 gtattagagt ctgttattga gcaagaacag aagagattgg gagacatgga cttatctggt
     1621 gttctggagc aagatgcatt ccataagtca ctcctggcct gctgccttga ggtggtcgct
     1681 ttttcctata agcctcctgg aaatttccca tttattgctg aaatatttga tgtaccacat
     1741 tatcattttt ataaggtaat agaagtattt attagagcag aagacggtct ttgcagagaa
     1801 gtggtcaaac acctcaatca gattgaagaa caaattttag accacttggc atggaaaacc
     1861 aagtccccac tgtgggatag aattagagat aatgaaaaca gagtccctac atgtgaagag
     1921 gttacaccac ctcacaacct agagagaaca gatgaaatct atattgctgg ctctccctta
     1981 actccgagaa gggtgggtga agttcgcact gatgctggag gacttggaag aagtgtgaca
     2041 tctccaacca cattgtatga caggtacagt tccccaacag tcagtactac tagaaggcgg
     2101 ctatttgaga gtgacagtcc ctctgaagga agcacggctg ggcgcatccc cccacaaccc
     2161 ctagtcaatg ctgtccctgt gcagaatgta tctggggaga ctgtttctgt cacaccagtt
     2221 cctggacaga ccttggtcac catggcaaca gccactgtca cagccaacaa tggacaaaca
     2281 gtgaccattc cagtacaagg tattgccaac gaaaatggag ggataacatt cttcccagtc
     2341 caagtgaatg ttgggggcca ggcacaggct gtgactggct ctatccagcc cctcagtgct
     2401 caagcgctgg ctggaagtct gagttcccaa caggtgacag gaacaacttt gcaagtcccc
     2461 ggtccggtgg ccattcaaca aatttcccct ggaggacaac agcagaacca aggccagccg
     2521 ttaaccagca gcagtatcag gcctcggaag actagctcct tatcactttt ctttagaaag
     2581 gtttactact tagctggtgt ccgccttcga gacctttgca caaaactaga tatttcagat
     2641 gaactgagga aaaaaatttg gacctgcttt gaattctcta tagtccagtg tcctgaactt
     2701 atgatggaca gacatctgga ccagttgtta atgtgtgcca tttacgtgat ggcaaaggtc
     2761 acaaaagaag acaagtcctt ccagaatatc atgcgctgtt acaggactca gccacaggcc
     2821 cggagccagg tatacagaag tgtcttgata aaagggaaaa gaagaaattc tggcagctgt
     2881 gagaacagaa gccatcagaa ttctccaaca gaactaaata cagacagagc cagtagagac
     2941 tccagtccag ttatgaggtc aaacagcacc ttaccagttc cacagcccag cagtgcccct
     3001 cctacaccaa ctcgactcac aggtgccaac agtgacattg aagaggagga aagaggagac
     3061 ctcattcagt tctacaacaa catctacagg aaacaaatcc aaacgtttgc catgaagtac
     3121 tcacaggcaa actcccaaat ggacacccct cccctgtctc cctatccgtt tgtaagaacg
     3181 ggctcccctc gccgagtaca gttatctcaa agtcacccta tctacatttc cccacataaa
     3241 aacgaagcaa tgctttctcc tcgagagaag attttttact acttcagcaa cagcccatca
     3301 aagagactga gagaaattaa cagtatgata cggacaggag agactccaac taaaaagaga
     3361 gggattctct tggacgatgg aagtgaatcg cctgcaaaaa gaatttgccc agaaaatcat
     3421 tctgctctgt tacgtcgtct ccaagatgta gctaatgacc gaggttcaca ctgaggttag
     3481 tgtccaggag gaaactatct tcacatgaac tctttggcag gacttaatgc atgcagaatt
     3541 atggaacctt gctccgtaat ccagcaactg attagaggcg ggtataaagg ggagcacctc
     3601 tgactcagtg tggcagtaaa cgcctgctat ctcatcaccc aaggggtgga gggtaagagg
     3661 accaggagtt taaggccaac ctgacttaca gagcatgtct gaggccaact tggactacat
     3721 gtaaccctta ctcaaaacaa aaaatggaag ggacattttg gtaagaaaga agacttattc
     3781 catgtcctta gagtatttta ttcatcccac ttgcctctac ctctacttag tgcttgcctt
     3841 caacactgct cagaatccac acatgaattt tttttttaac tctgatagac ttttacaatc
     3901 actgcagaaa gcaaatcttt agaggccttt ataggtcgag ccagtagagg aactgtattt
     3961 aaagtcattc ccgcttggca tgtggctagg tccaaccatg tgttttagga tgaaaacacc
     4021 cgagaagttt acaatcagaa cacaggatgg ccaacctgga agtgtccggg cactggccta
     4081 aggctcctat gcctttgagc attatcccgt cccaaggagg tgcggacagt gtgaaagccg
     4141 tgcatgtctg agtgaacctg tgtacttggt ggcactttag agctgtgaga tgcatagcat
     4201 tgtgacccag attttgctgt atatttatgg tggcactttc tacagtgtga actttagcca
     4261 gtacaagcct tctaggctta gattaaacag ctaatctttt ctttcatgct tttctaaagg
     4321 actgctgatg tagctacacg ttctgggcac gtgtaggact ctcccattta tggtagtggc
     4381 attacatagg gatcatttag ctaaataaag atttttaaat caagttgaat tgataagtat
     4441 ttgaaaaatt atgacccctt cctttcggaa gtagctatcc agaagaaagt atctttgagg
     4501 gtactcctgg cagttaaaag aataggttgg agaatttagg tttttattag tacatggtac
     4561 cattgacaca aattagaaga tttaatagct attgattatc tacacatatc tttattaatc
     4621 attattatca agtaattttt taagttggat taataatcct aaggagaaaa ttcaatttaa
     4681 attggatcac tgtaaacaaa gttactaggt gacttcatac cgctccaaag acccagctga
     4741 caacctacag cctggcactg gccaccagag tgctgtgcaa agtacgtaga aacctcttcg
     4801 taccgctact gtaattttat atgaaaatat gtgtattttt caataaagca cttataaatt
//
