LOCUS       NM_001191066            4867 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus RB transcriptional corepressor like 1 (Rbl1),
            mRNA.
ACCESSION   NM_001191066 XM_001055763 XM_039105839
VERSION     NM_001191066.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4867)
  AUTHORS   Wong,P.F., Jamal,J., Tong,K.L., Khor,E.S., Yeap,C.E., Jong,H.L.,
            Lee,S.T., Mustafa,M.R. and Abubakar,S.
  TITLE     Deregulation of hsa-miR-20b expression in TNF-alpha-induced
            premature senescence of human pulmonary microvascular endothelial
            cells
  JOURNAL   Microvasc Res 114, 26-33 (2017)
   PUBMED   28595801
REFERENCE   2  (bases 1 to 4867)
  AUTHORS   Miles,W.O., Korenjak,M., Griffiths,L.M., Dyer,M.A., Provero,P. and
            Dyson,N.J.
  TITLE     Post-transcriptional gene expression control by NANOS is
            up-regulated and functionally important in pRb-deficient cells
  JOURNAL   EMBO J 33 (19), 2201-2215 (2014)
   PUBMED   25100735
REFERENCE   3  (bases 1 to 4867)
  AUTHORS   Kurimchak,A., Haines,D.S., Garriga,J., Wu,S., De Luca,F.,
            Sweredoski,M.J., Deshaies,R.J., Hess,S. and Grana,X.
  TITLE     Activation of p107 by fibroblast growth factor, which is essential
            for chondrocyte cell cycle exit, is mediated by the protein
            phosphatase 2A/B55alpha holoenzyme
  JOURNAL   Mol Cell Biol 33 (16), 3330-3342 (2013)
   PUBMED   23775125
  REMARK    GeneRIF: Fibroblast growth factor 1, which induces maturation and
            cell cycle exit in chondrocytes, triggers rapid accumulation of
            retinoblastoma-like 1 (p107)-PP2A/B55-alpha complexes coinciding
            with retinoblastoma-like 1 (p107) dephosphorylation.
REFERENCE   4  (bases 1 to 4867)
  AUTHORS   Kolupaeva,V., Daempfling,L. and Basilico,C.
  TITLE     The B55alpha regulatory subunit of protein phosphatase 2A mediates
            fibroblast growth factor-induced p107 dephosphorylation and growth
            arrest in chondrocytes
  JOURNAL   Mol Cell Biol 33 (15), 2865-2878 (2013)
   PUBMED   23716589
  REMARK    GeneRIF: Only the B55alpha(55-kDa regulatory subunit, alpha
            isoform) regulatory subunit of PP2A was able to bind
            retinoblastoma-like 1 (p107), and this interaction was induced by
            fibroblast growth factor 1 in chondrocytes but not in other cell
            types.
REFERENCE   5  (bases 1 to 4867)
  AUTHORS   Kolupaeva,V., Laplantine,E. and Basilico,C.
  TITLE     PP2A-mediated dephosphorylation of p107 plays a critical role in
            chondrocyte cell cycle arrest by FGF
  JOURNAL   PLoS One 3 (10), e3447 (2008)
   PUBMED   18927618
REFERENCE   6  (bases 1 to 4867)
  AUTHORS   Batsche,E., Moschopoulos,P., Desroches,J., Bilodeau,S. and
            Drouin,J.
  TITLE     Retinoblastoma and the related pocket protein p107 act as
            coactivators of NeuroD1 to enhance gene transcription
  JOURNAL   J Biol Chem 280 (16), 16088-16095 (2005)
   PUBMED   15701640
REFERENCE   7  (bases 1 to 4867)
  AUTHORS   Sage,J., Miller,A.L., Perez-Mancera,P.A., Wysocki,J.M. and Jacks,T.
  TITLE     Acute mutation of retinoblastoma gene function is sufficient for
            cell cycle re-entry
  JOURNAL   Nature 424 (6945), 223-228 (2003)
   PUBMED   12853964
REFERENCE   8  (bases 1 to 4867)
  AUTHORS   Timchenko,N.A., Wilde,M. and Darlington,G.J.
  TITLE     C/EBPalpha regulates formation of S-phase-specific E2F-p107
            complexes in livers of newborn mice
  JOURNAL   Mol Cell Biol 19 (4), 2936-2945 (1999)
   PUBMED   10082561
REFERENCE   9  (bases 1 to 4867)
  AUTHORS   Beijersbergen,R.L., Carlee,L., Kerkhoven,R.M. and Bernards,R.
  TITLE     Regulation of the retinoblastoma protein-related p107 by G1 cyclin
            complexes
  JOURNAL   Genes Dev 9 (11), 1340-1353 (1995)
   PUBMED   7797074
REFERENCE   10 (bases 1 to 4867)
  AUTHORS   Pahel,G., Aulabaugh,A., Short,S.A., Barnes,J.A., Painter,G.R.,
            Ray,P. and Phelps,W.C.
  TITLE     Structural and functional characterization of the HPV16 E7 protein
            expressed in bacteria
  JOURNAL   J Biol Chem 268 (34), 26018-26025 (1993)
   PUBMED   8245034
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Nov 8, 2022 this sequence version replaced
            XM_039105839.1, NM_001191066.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.823146.1,
                                           SRR26360186.38871.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               JAXUCZ010000003.1  166289145-166289376 c
            233-366             JAXUCZ010000003.1  166284616-166284749 c
            367-567             JAXUCZ010000003.1  166280893-166281093 c
            568-632             JAXUCZ010000003.1  166280491-166280555 c
            633-761             JAXUCZ010000003.1  166280266-166280394 c
            762-922             JAXUCZ010000003.1  166280001-166280161 c
            923-972             JAXUCZ010000003.1  166275826-166275875 c
            973-1159            JAXUCZ010000003.1  166274919-166275105 c
            1160-1326           JAXUCZ010000003.1  166273770-166273936 c
            1327-1439           JAXUCZ010000003.1  166269382-166269494 c
            1440-1543           JAXUCZ010000003.1  166269119-166269222 c
            1544-1681           JAXUCZ010000003.1  166260389-166260526 c
            1682-1846           JAXUCZ010000003.1  166258258-166258422 c
            1847-1979           JAXUCZ010000003.1  166257330-166257462 c
            1980-2243           JAXUCZ010000003.1  166252048-166252311 c
            2244-2455           JAXUCZ010000003.1  166250434-166250645 c
            2456-2632           JAXUCZ010000003.1  166246452-166246628 c
            2633-2704           JAXUCZ010000003.1  166244759-166244830 c
            2705-2783           JAXUCZ010000003.1  166242847-166242925 c
            2784-2932           JAXUCZ010000003.1  166238763-166238911 c
            2933-3097           JAXUCZ010000003.1  166231089-166231253 c
            3098-4867           JAXUCZ010000003.1  166226187-166227956 c
FEATURES             Location/Qualifiers
     source          1..4867
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..4867
                     /gene="Rbl1"
                     /gene_synonym="p107; pRb1"
                     /note="RB transcriptional corepressor like 1"
                     /db_xref="GeneID:680111"
                     /db_xref="RGD:1595511"
     exon            1..232
                     /gene="Rbl1"
                     /gene_synonym="p107; pRb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..3268
                     /gene="Rbl1"
                     /gene_synonym="p107; pRb1"
                     /note="retinoblastoma-like 1 (p107); 107 kDa
                     retinoblastoma-associated protein"
                     /codon_start=1
                     /product="retinoblastoma-like protein 1"
                     /protein_id="NP_001177995.2"
                     /db_xref="GeneID:680111"
                     /db_xref="RGD:1595511"
                     /translation="MFEDEPHAEGAAAVAAAREALQALCQELNLDEGSAAEALDDFTA
                     IRGNYSLEGEVIHWLACSLYVACRKSIIPTVGKGVMEGNCVSLTRILRSAKLSLIQFF
                     SKMKKWMDMSNLPQEFRERIERLERNFEVSTVIFKKFEPIFLDIFQNPYEELPKLPRS
                     RKQRRIPCSVKDLFNFCWTLFVYTKGNFRMIGDDLVNSYHLLLCCLDLIFANAIMCPN
                     RRDLLNPSFKGLPSDFHAVNFKAAEEPPCIIAVLCDLHDGLLVEAKGIKEHYFKPYIS
                     KLFDKKILKGECLLDLSSFTDNSKAVNKEYEEYVLTVGDFDERIFLGADAEEEIGTPR
                     KFAADTQFGKLTSQASVDCNLQQHFEKKRSFAPSTPLTGRRYLQEKEAVTTPVASATQ
                     SVSRLQSIVAGLKSAPSEQLLTIFESCMRNPMGNIVKIVKGIGETFCQHYTQSTDKQP
                     GSHIDFAVNRLKLAEILYYKILETIMVQETRRLHGMDMSVLLEQDIFHRSLLACCLEI
                     VLFAYSSPRTFPWIIDVLGLQPFYFYKVIEVVIRSEEGLSRDMVKHLNSIEEQILESL
                     AWTNNSALWEALRASANKVPSCEEVIFPNNFEIGNGGSVQGHLPMMPMSPIIHPRVKE
                     VRTDSGSLRKDMQPLSPISVHERYSSPAAGSAKRRLFGDDPPKETLMEKIMAEGTQLK
                     IAPSSVTAESLSISPGQALLTMATTTVTGTTGRKVTVPLHGIANDAGEITLVPISMNT
                     TQDSTAESLVSLTAQSLIGASPKQTHLTKTQDAPLTGISKPKRTGSLALFYRKVYHLA
                     SVRLRDLCLKLDVSNELRRKIWTCFEFTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKE
                     ERTFQEIMKSYRNQPQANSHVYRSVLLKSIPGEVVAYNGDYEMTDGDIEDATKTPNCS
                     SEPVKEERGDLIKFYNAIYVGRVKSFALKYDLSNQDHIMDAPPLSPFPHIKQQPGSPR
                     RISQQHSIYVSPHKNASGLTPRSALLYKFNGSPSKSLKDINNMIRQGEQKAKKRVIAI
                     SGDAESPAKRLCQENDDVLLKRLQDVVSERANH"
     exon            233..366
                     /gene="Rbl1"
                     /gene_synonym="p107; pRb1"
                     /inference="alignment:Splign:2.1.0"
     exon            367..567
                     /gene="Rbl1"
                     /gene_synonym="p107; pRb1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..632
                     /gene="Rbl1"
                     /gene_synonym="p107; pRb1"
                     /inference="alignment:Splign:2.1.0"
     exon            633..761
                     /gene="Rbl1"
                     /gene_synonym="p107; pRb1"
                     /inference="alignment:Splign:2.1.0"
     exon            762..922
                     /gene="Rbl1"
                     /gene_synonym="p107; pRb1"
                     /inference="alignment:Splign:2.1.0"
     exon            923..972
                     /gene="Rbl1"
                     /gene_synonym="p107; pRb1"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1159
                     /gene="Rbl1"
                     /gene_synonym="p107; pRb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1326
                     /gene="Rbl1"
                     /gene_synonym="p107; pRb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1439
                     /gene="Rbl1"
                     /gene_synonym="p107; pRb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1543
                     /gene="Rbl1"
                     /gene_synonym="p107; pRb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1681
                     /gene="Rbl1"
                     /gene_synonym="p107; pRb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1846
                     /gene="Rbl1"
                     /gene_synonym="p107; pRb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1979
                     /gene="Rbl1"
                     /gene_synonym="p107; pRb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2243
                     /gene="Rbl1"
                     /gene_synonym="p107; pRb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2455
                     /gene="Rbl1"
                     /gene_synonym="p107; pRb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2632
                     /gene="Rbl1"
                     /gene_synonym="p107; pRb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2704
                     /gene="Rbl1"
                     /gene_synonym="p107; pRb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2783
                     /gene="Rbl1"
                     /gene_synonym="p107; pRb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..2932
                     /gene="Rbl1"
                     /gene_synonym="p107; pRb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2933..3097
                     /gene="Rbl1"
                     /gene_synonym="p107; pRb1"
                     /inference="alignment:Splign:2.1.0"
     exon            3098..4867
                     /gene="Rbl1"
                     /gene_synonym="p107; pRb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggggttgt gggtagctcg ccgggaggga aaagaaaacc ccgaagccgg tcgcgccgcc
       61 cgtcgggccg gaggggatgt tcgaggacga gccccacgcc gagggggcgg cagccgtcgc
      121 cgcggccagg gaggcgctgc aggccctgtg ccaggagctg aacctggacg aggggagcgc
      181 cgccgaagcc ctggacgact tcaccgccat ccgcggcaac tacagcctag agggggaagt
      241 tatacactgg ctggcatgct ctttgtacgt cgcttgccgc aagagcatca ttcctaccgt
      301 gggaaagggc gtcatggaag gaaactgtgt ttcgctgacc agaatactac gctcagctaa
      361 gttaagctta attcagtttt ttagtaaaat gaagaagtgg atggacatgt caaacctacc
      421 acaagaattc cgggagcgta tagaaaggct agaaagaaat tttgaagtat ctacagtaat
      481 ttttaaaaaa tttgagccca tttttttaga tatctttcaa aatccatatg aagagctacc
      541 aaagttgcca cgaagcagaa agcagaggag gattccttgc agtgttaagg atctctttaa
      601 tttctgctgg acgctcttcg tttacactaa gggtaatttt cgtatgattg gtgatgattt
      661 agtaaactca tatcatttac ttctgtgctg cttggacctg atttttgcca atgctataat
      721 gtgtccaaat agacgagact tgttaaatcc atcatttaaa ggtttaccat cggatttcca
      781 tgctgtgaac ttcaaagctg cagaagaacc accctgtatc attgctgtac tttgcgatct
      841 gcacgatgga cttttagtag aagcaaaagg aataaaggag cactacttca aaccatatat
      901 ttcaaaactc tttgacaaga agattttaaa aggtgaatgt ctcttggatc tttccagttt
      961 tactgataat agcaaagcag tgaacaagga gtatgaagag tatgttctaa ctgttgggga
     1021 ctttgacgag aggatctttt tgggagcaga tgcagaggag gagatcggaa cacctcgaaa
     1081 gttcgctgct gacacccaat ttgggaaact gacatcacag gccagtgtgg actgcaacct
     1141 tcaacaacac tttgaaaaaa aacggtcatt tgcaccttct accccactta ctggacggcg
     1201 ctatttacaa gaaaaagagg cagttaccac acctgttgct tcagctactc agagtgtaag
     1261 ccgattacag agcattgtag ccggattgaa aagtgccccg agcgagcagc ttctgactat
     1321 ttttgaatct tgtatgcgga atccgatggg aaacattgta aaaatagtga aaggaatagg
     1381 agagactttc tgccagcact atacccagtc cacagataaa cagccaggat ctcacataga
     1441 ctttgctgta aacagactga aactggcaga aattttgtat tataaaatac tagagactat
     1501 aatggtccag gaaacacgac gacttcatgg aatggacatg tcagttcttt tagaacaaga
     1561 catatttcac aggtccttgc tggcttgttg tttggaaatt gtgctctttg cctatagctc
     1621 accccgtact ttcccttgga tcattgacgt tctcggtttg cagccgtttt acttctataa
     1681 ggttattgag gtggtgatcc gctcagagga ggggctctcc agagacatgg tgaaacacct
     1741 aaacagcatt gaagagcaga ttttggagag tttagcttgg actaataatt ctgcactgtg
     1801 ggaagctctc cgtgcttctg caaataaagt tccttcctgt gaagaagtta tattcccaaa
     1861 taactttgaa ataggaaatg gaggaagtgt gcaaggccat cttcccatga tgccaatgtc
     1921 tccaataata catccaagag tcaaggaagt tcgcactgac agtgggagcc ttcgaaaaga
     1981 tatgcagcca ctgtctccca tctccgtcca tgagcgctac agctcccctg ccgcaggaag
     2041 tgctaagagg agactctttg gtgatgaccc accaaaggag acattgatgg aaaagattat
     2101 ggcagaagga acacagctga aaattgctcc ttcaagtgtg actgctgaaa gcttgtcaat
     2161 ttcccctggg caagctcttc tcacaatggc cacgaccaca gtcacaggga cgacgggacg
     2221 gaaggttacc gttcctttgc atggtattgc caatgatgct ggagaaatca cactggttcc
     2281 tatttccatg aatacaactc aggactccac agctgagagc cttgtatcac taactgcaca
     2341 gtcattaatt ggtgcttctc caaaacagac ccatctgact aaaacgcaag acgctcctct
     2401 gaccggaata agcaaaccaa agagaactgg gtccttagca ctgttttata gaaaggtcta
     2461 tcatttggca agtgtacgct tacgtgattt atgtttaaaa cttgatgttt cgaatgagtt
     2521 acgaaggaag atctggacat gttttgaatt cactttagtt cactgccctg atttaatgaa
     2581 agataggcat ttggatcagc tccttctgtg tgccttttac atcatggcca aagtaacaaa
     2641 agaagaaaga acttttcaag aaataatgaa aagttacaga aatcagccac aagctaatag
     2701 tcacgtatac aggagtgttc tcttgaaaag tattccagga gaagttgtgg catacaatgg
     2761 tgactatgag atgactgatg gtgacataga agatgccaca aaaactccca actgttccag
     2821 tgaaccagtg aaagaggaaa gaggtgatct tatcaaattc tacaatgcga tatatgtagg
     2881 aagagtgaag tcatttgcat tgaagtatga tttgtccaat caggaccata taatggatgc
     2941 tccaccgctc tctcctttcc cacatattaa gcagcagccg ggctccccac gccgcatttc
     3001 tcagcagcat tccatttatg tctctccgca caagaacgca tcaggcctca cccccaggag
     3061 cgcactactc tacaagttca acggcagccc ctctaagagt ttgaaagaca tcaacaacat
     3121 gataaggcaa ggtgagcaga aggccaagaa gcgtgtgatc gccatcagcg gagatgcaga
     3181 gtcacctgcc aaacgtctct gccaggagaa cgatgatgtt ttacttaaac gactgcagga
     3241 tgttgtcagt gaaagagcga atcattgatg ttgccctttg tctggtcaaa gcacttttgg
     3301 gttgttctgg agaaagttgg ggcttcaccc ttcacatttt tttatcactg ggttatacaa
     3361 aacttgcatc aaaagtaagc tcctttttaa aagcatttat tcaccctgta tatctgacag
     3421 acagacattt tgaggtagat tagaaaagaa tgtgttaggt gccttcataa atagtaataa
     3481 gatttttttt tagtgttcgt tcctaggttt gctttttagg atgaattaag gagaaactat
     3541 tttttaactg tcttttcaaa cggatcaaat gtctcctgtg cgtcttacta tgtggtcagt
     3601 gagtctctga gatacttgtg ctgtctgctt gtgttgaagg taggcttaac tcccacgatt
     3661 tgagcattca ctgatggacc agcctgcctt gggcctggtg gagcaactgc acctcaggta
     3721 gccccagcac gtggggcagt ctgtgccctt ctctttcctc tcagttagta caagcagctt
     3781 cgcaccttat agcttgatgt tatagcccca caacagggat actcagttta aaactacgac
     3841 tttcatgata ttgccttaat tattatatgt gattgtattc agtcatgtag ttctcaaaat
     3901 aaactgtttc ttaactagga ggataaaatt cagataaatg agaagtgaca tttctttagt
     3961 agagtagcat catggtaaga tcattcattc atccgtgtta ggctcagtaa ctccagtgcc
     4021 tgtaactcca gtgcacagga gggctgctgg gaatgtcagg ccagcgcatc cctagcagga
     4081 ccctgactca aatctaagtt attcattctc attgtctatt taatttcctg aaaatatttg
     4141 aagcttttac attagtcact tcatgcttgt aagtgaaatg tttcaagttt aagagctgct
     4201 ttttctttct attttgtgtc accctttgtt ccagtaatta tgctttctct ggattcccct
     4261 ggggtgtaac tcctggatcc ccttgaagac ctttccacac tggaggttta gccttctaaa
     4321 gaatcaggtc gctagtgttt gccttttctt ctctgtgtct agcgttggaa aggatgtgaa
     4381 taagccattt aaattaataa ttagatgatg tatcagtata aaggttttta gctgcaaacc
     4441 ttatttttta aaatataaag tgttgacttg gcagtctatc tcagcgtgtc aaacatatcc
     4501 atcacttgct aatttgaatt agtctaagat ttggctgcca attaatgatg gatggtaacc
     4561 aaaggtttat ttttaaattt taaaaagagg tttgggttat gttttgcttt tctgaaaatt
     4621 gtgttcttgt gttttgtgta gtatctacac atgttgtaat aaaccaaata atagtctgtc
     4681 ttgagtcctt gtacatattt ctgtgtagct ataactactg tatcactttc attattaatg
     4741 tacaaaatat aaatgtagat ttattcaatg actgttaaaa acttaagaca tgaatttacc
     4801 aattttcagg actttgtatt aatgtatata aaatagttaa taaaaattag aattttaaaa
     4861 acataaa
//
