LOCUS       NM_001134498            4632 bp    mRNA    linear   ROD 14-JUN-2023
DEFINITION  Rattus norvegicus RNA binding fox-1 homolog 3 (Rbfox3), transcript
            variant 2, mRNA.
ACCESSION   NM_001134498 XM_001081777 XM_039085680 XM_213535
VERSION     NM_001134498.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4632)
  AUTHORS   Anderson MB, Das S and Miller KE.
  TITLE     Subcellular localization of neuronal nuclei (NeuN) antigen in size
            and calcitonin gene-related peptide (CGRP) populations of dorsal
            root ganglion (DRG) neurons during acute peripheral inflammation
  JOURNAL   Neurosci Lett 760, 135974 (2021)
   PUBMED   34146639
  REMARK    GeneRIF: Subcellular localization of neuronal nuclei (NeuN) antigen
            in size and calcitonin gene-related peptide (CGRP) populations of
            dorsal root ganglion (DRG) neurons during acute peripheral
            inflammation.
REFERENCE   2  (bases 1 to 4632)
  AUTHORS   Du Z, Zhang H, Chen Q, Gao Y and Sun B.
  TITLE     Intranasal Calcitonin Gene-Related Peptide Protects Against Focal
            Cerebral Ischemic Injury in Rats Through the Wnt/beta-Catenin
            Pathway
  JOURNAL   Med Sci Monit 24, 8860-8869 (2018)
   PUBMED   30531687
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4632)
  AUTHORS   Zimatkin,S.M. and Karniushko,O.A.
  TITLE     [EXPRESSION OF DOUBLECORTIN AND NeuN IN THE DEVELOPING CEREBELLAR
            NEURONS IN RAT]
  JOURNAL   Morfologiia 149 (1), 38-42 (2016)
   PUBMED   27487661
  REMARK    GeneRIF: EXPRESSION OF DOUBLECORTIN AND NeuN IN THE DEVELOPING
            CEREBELLAR NEURONS IN RAT
REFERENCE   4  (bases 1 to 4632)
  AUTHORS   Jakovcevski M, Ruan H, Shen EY, Dincer A, Javidfar B, Ma Q, Peter
            CJ, Cheung I, Mitchell AC, Jiang Y, Lin CL, Pothula V, Stewart AF,
            Ernst P, Yao WD and Akbarian S.
  TITLE     Neuronal Kmt2a/Mll1 histone methyltransferase is essential for
            prefrontal synaptic plasticity and working memory
  JOURNAL   J Neurosci 35 (13), 5097-5108 (2015)
   PUBMED   25834037
REFERENCE   5  (bases 1 to 4632)
  AUTHORS   Korzhevskiy,D.E., Beznin,G.V., Kolos,Y.A. and Kirik,V.
  TITLE     [CYTOPLASMIC LOCALIZATION OF NEUN/Fox-3 NUCLEAR PROTEIN IN THE
            PANCREATIC CELLS]
  JOURNAL   Morfologiia 148 (5), 88-90 (2015)
   PUBMED   26987225
  REMARK    GeneRIF: the presence of NeuN protein in the secretory epithelial
            cells of the exocrine part of this organ. The protein was located
            in the apical part of the cytoplasm slightly below the zone of
            zymogen granules.
REFERENCE   6  (bases 1 to 4632)
  AUTHORS   Marcal N, Patel H, Dong Z, Belanger-Jasmin S, Hoffman B, Helgason
            CD, Dang J and Stifani S.
  TITLE     Antagonistic effects of Grg6 and Groucho/TLE on the transcription
            repression activity of brain factor 1/FoxG1 and cortical neuron
            differentiation
  JOURNAL   Mol Cell Biol 25 (24), 10916-10929 (2005)
   PUBMED   16314515
REFERENCE   7  (bases 1 to 4632)
  AUTHORS   Franke H, Klimke K, Brinckmann U, Grosche J, Francke M, Sperlagh B,
            Reichenbach A, Liebert UG and Illes P.
  TITLE     P2X(7) receptor-mRNA and -protein in the mouse retina; changes
            during retinal degeneration in BALBCrds mice
  JOURNAL   Neurochem Int 47 (4), 235-242 (2005)
   PUBMED   15964665
REFERENCE   8  (bases 1 to 4632)
  AUTHORS   Feng R, Wang H, Wang J, Shrom D, Zeng X and Tsien JZ.
  TITLE     Forebrain degeneration and ventricle enlargement caused by double
            knockout of Alzheimer's presenilin-1 and presenilin-2
  JOURNAL   Proc Natl Acad Sci U S A 101 (21), 8162-8167 (2004)
   PUBMED   15148382
REFERENCE   9  (bases 1 to 4632)
  AUTHORS   Arvidsson A, Collin T, Kirik D, Kokaia Z and Lindvall O.
  TITLE     Neuronal replacement from endogenous precursors in the adult brain
            after stroke
  JOURNAL   Nat Med 8 (9), 963-970 (2002)
   PUBMED   12161747
REFERENCE   10 (bases 1 to 4632)
  AUTHORS   Mullen RJ, Buck CR and Smith AM.
  TITLE     NeuN, a neuronal specific nuclear protein in vertebrates
  JOURNAL   Development 116 (1), 201-211 (1992)
   PUBMED   1483388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000220.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001134498.4.
            
            On or before Oct 27, 2022 this sequence version replaced
            XM_039085680.1, NM_001134498.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132287, SAMEA5756307
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               JACYVU010000220.1  60981555-60981823   c
            270-402             JACYVU010000220.1  60878098-60878230   c
            403-508             JACYVU010000220.1  60737497-60737602   c
            509-548             JACYVU010000220.1  60670584-60670623   c
            549-803             JACYVU010000220.1  60569168-60569422   c
            804-941             JACYVU010000220.1  60561810-60561947   c
            942-995             JACYVU010000220.1  60559942-60559995   c
            996-1088            JACYVU010000220.1  60559019-60559111   c
            1089-1149           JACYVU010000220.1  60557750-60557810   c
            1150-1203           JACYVU010000220.1  60553657-60553710   c
            1204-1336           JACYVU010000220.1  60553407-60553539   c
            1337-1517           JACYVU010000220.1  60552812-60552992   c
            1518-1585           JACYVU010000220.1  60550883-60550950   c
            1586-1664           JACYVU010000220.1  60549757-60549835   c
            1665-4632           JACYVU010000220.1  60545213-60548180   c
FEATURES             Location/Qualifiers
     source          1..4632
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..4632
                     /gene="Rbfox3"
                     /gene_synonym="Hrnbp3; Neun; RGD1560070"
                     /note="RNA binding fox-1 homolog 3"
                     /db_xref="GeneID:287847"
                     /db_xref="RGD:1560070"
     exon            1..269
                     /gene="Rbfox3"
                     /gene_synonym="Hrnbp3; Neun; RGD1560070"
                     /inference="alignment:Splign:2.1.0"
     exon            270..402
                     /gene="Rbfox3"
                     /gene_synonym="Hrnbp3; Neun; RGD1560070"
                     /inference="alignment:Splign:2.1.0"
     exon            403..508
                     /gene="Rbfox3"
                     /gene_synonym="Hrnbp3; Neun; RGD1560070"
                     /inference="alignment:Splign:2.1.0"
     exon            509..548
                     /gene="Rbfox3"
                     /gene_synonym="Hrnbp3; Neun; RGD1560070"
                     /inference="alignment:Splign:2.1.0"
     exon            549..803
                     /gene="Rbfox3"
                     /gene_synonym="Hrnbp3; Neun; RGD1560070"
                     /inference="alignment:Splign:2.1.0"
     CDS             582..1709
                     /gene="Rbfox3"
                     /gene_synonym="Hrnbp3; Neun; RGD1560070"
                     /note="isoform 2 is encoded by transcript variant 2; fox-1
                     homolog C; neuronal nuclei; hexaribonucleotide binding
                     protein 3; RNA binding protein, fox-1 homolog 3"
                     /codon_start=1
                     /product="RNA binding protein fox-1 homolog 3 isoform 2"
                     /protein_id="NP_001127970.1"
                     /db_xref="GeneID:287847"
                     /db_xref="RGD:1560070"
                     /translation="MAQPYPPAQYPPPPQNGIPAEYAPPPPHPTQDYSGQTPVPPEHG
                     MTLYTPAQTHPEQPGTEASTQPIAGTQTVPQADEAAQTDSQQLHPSDPTEKQQPKRLH
                     VSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFETSSDADRAREKLNG
                     TIVEGRKIEVNNATARVMTNKKPGNPYANGWKLNPVVGAVYGPEFYAVTSFPYPTTGT
                     AVAYRGAHLRGRGRAVYNTFRAAPPPPPIPTYGAALEQTLVKMPVPWAGLAPCPLPPQ
                     QTPEPAYPTSPAFPPLSCPFASRVVYQDGFYGAEIYGGYAAYRYAQPAAAAAAAAYSD
                     SYGRVYAAADPYHHTIGPTATYSIGTMASLCRGGYSRFTPY"
     exon            804..941
                     /gene="Rbfox3"
                     /gene_synonym="Hrnbp3; Neun; RGD1560070"
                     /inference="alignment:Splign:2.1.0"
     exon            942..995
                     /gene="Rbfox3"
                     /gene_synonym="Hrnbp3; Neun; RGD1560070"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1088
                     /gene="Rbfox3"
                     /gene_synonym="Hrnbp3; Neun; RGD1560070"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1149
                     /gene="Rbfox3"
                     /gene_synonym="Hrnbp3; Neun; RGD1560070"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1203
                     /gene="Rbfox3"
                     /gene_synonym="Hrnbp3; Neun; RGD1560070"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1336
                     /gene="Rbfox3"
                     /gene_synonym="Hrnbp3; Neun; RGD1560070"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1517
                     /gene="Rbfox3"
                     /gene_synonym="Hrnbp3; Neun; RGD1560070"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1585
                     /gene="Rbfox3"
                     /gene_synonym="Hrnbp3; Neun; RGD1560070"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1664
                     /gene="Rbfox3"
                     /gene_synonym="Hrnbp3; Neun; RGD1560070"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..4632
                     /gene="Rbfox3"
                     /gene_synonym="Hrnbp3; Neun; RGD1560070"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagagagaga gagagagaga gagagtgtgt cggcgaggca agcggagcgg ggacacggag
       61 ccgttgctcc ggaaccagcg gaaacctcct ccgagagcag tcgggagcct gccccagcag
      121 ctcgcgtgat cgccggagac gctgcggccg ccaccgccgc tccaacccgg cctctcgcgc
      181 tccttgccgc cggctcgcct gggcggccgg gatgcagccg gggcatggcc gccagggccc
      241 cgtcacctgc cgcggggaac gctgaacccg ttgaaaagct gcctgtgaga acctagcctt
      301 cttttgtgat cccgctctgt ctgggcgcac acacaccata ctaaggaagc ctcatcaggt
      361 cctgcacggg cccctggcag aaagtagaca gcactccaac agcgtgacat cagaaggacc
      421 agggggaatt ctgctgcctt ccccagagct ggcccacagg cctaccttgg cgggaaccta
      481 tccaaggagt ggcccgatct gcaaacagag agcccagagc gcctcgggga aaattggctg
      541 aataaaaggg caatcaggac gccacggctc cgcctgaagc gatggcccag ccctaccccc
      601 ctgcccagta ccctcctcca cctcagaatg gaatcccagc tgaatatgcc ccacctccgc
      661 cacatcccac acaggactac tccggccaga cccccgtccc cccagagcac ggcatgaccc
      721 tctacacgcc agcacagacg catcctgagc agccgggcac tgaggccagc acacagccca
      781 tcgctgggac ccagacggtg ccgcaggcag atgaagcagc acagacagat agccagcaac
      841 tccacccttc cgaccccacg gagaagcagc agcccaaacg actacatgtc tccaacatcc
      901 ccttccggtt cagggacccc gacctgcggc aaatgttcgg gcaattcggg aaaattttag
      961 acgtggagat catttttaac gagcggggct ccaagggttt tgggtttgta acttttgaaa
     1021 ctagctcaga tgctgaccga gcccgggaga agctgaatgg gacgatcgta gagggacgga
     1081 aaattgaggt caataatgcc acggcccggg tcatgaccaa taagaagcct gggaacccat
     1141 atgccaatgg ctggaagcta aaccctgtgg taggagcagt ctatgggccc gaattctatg
     1201 cagtgaccag tttcccctac cccaccacgg gcaccgccgt cgcctatcgg ggtgcgcacc
     1261 tgcggggccg gggccgtgct gtgtataata catttcgagc tgcaccacct ccgcccccca
     1321 ttccaactta cggagcggca ctggagcaaa cgcttgttaa aatgccagtc ccgtgggcgg
     1381 ggctggcacc gtgccccctc cctcctcagc agacaccgga gccggcctac cccacctctc
     1441 cagcgttccc accactctct tgtccgtttg cttccagggt cgtgtatcag gatggatttt
     1501 atggtgctga gatttatgga ggctatgcag cttacagata tgctcagcca gcagcagcag
     1561 ctgccgccgc agcctacagt gacagttatg gtagagtcta tgcggctgct gatccctacc
     1621 atcataccat cggccccaca gcaacctaca gcatcggaac catggctagc ctctgccgag
     1681 gagggtacag ccgcttcacc ccctactagc aagagacccc cctcacagca ttcacaccac
     1741 agcttattcc aaaccaaacc ctacagtccc aacaccaggc acaaccgccc ggaggacagt
     1801 gcgcccctcc cagtcagcga ccagcaagct gaccctctgc gactctataa agtccataga
     1861 tttttacctc cagccagctg gtctccccac cccacccatg ctggtgtgtg tgtctctgac
     1921 cctggttttc ctgtatgtct gaaccttggt ttcctatctt gacgttgttg tacaagccac
     1981 ttcaggtatg gtatgcatac agcgggagcc aggccggggg gacggcatgg tgccctgtca
     2041 gggccgtgcc cacgcctcag ggcagcatgg gccctcgggg ctccagaagt gccaggccaa
     2101 gcctccctca gagtcacctc agccagcccc tgcaggcctg gccaccccgg gtttgatggc
     2161 tgacagagga gctccaggcc tagccagtag gatcccccct aatgggaggg gcttctgccc
     2221 acctttcaca aggagtagct gcatccccaa tccaggcttc cactcaactg aagttaacat
     2281 ttctattaaa gcttactaat gatccttcct ctccaagtag tcacacgcac actgttctgt
     2341 gtgcagtact gccgtggtca ccctggctct gggattcctt acatacatga acatgcccct
     2401 gtcccaaggt ttaccctgca ttgcctgtgg atctggagac cctccctgag tctgaccacc
     2461 tccttgggct cctgttgctg atggctctga atatttttcc ttgacctaca gagccacccc
     2521 acccatcccc aagacccaac agacggttta tggaggtcca ttccaggaaa gagaagggtt
     2581 cagtggtcag gccagggaca cagtatcggc ttccttcctc tggcctccct gcagccaccc
     2641 aagcctcggt tagcatgtgt gtgcctctgt ggcctgtggg ggcctaccta gccccactgc
     2701 ccagagtccc aggctgaagt caggctgaaa ccctagaaaa ctagcagatg ctaatccctc
     2761 cactctgggg gttcagggcc acaaggtgac ccaagctgta agccccatct agctcctttg
     2821 tgaatagagc cctgctctct tgcctccacg tttgcagctc tcctccgcca taccctgccc
     2881 tctactagat ccagacatta tctgccccag ctctgcccat cgctaagata tggtcctact
     2941 ttagatctgg cttgtagtgt ggttccagaa gctgtggtgg ggatatgggc aggtttgggg
     3001 ggtgtgtggc ctcggggcag gtttaggggg aggtgtggct tcaggtcgga ccccagacca
     3061 cagtcacgtc ccccccccca agcccccccc ccccagcacg ctgcagccac ccctcggaaa
     3121 ctgcaagccc tcctttctgt ttctgttgta gtgaaacctt ccaccgtctc cttctcggat
     3181 catgaagggc aaaaacaaaa aaacaaaaaa aatcacaaaa caaaaaacaa aacaaaaaaa
     3241 gatgttaaga tccaagcaac aacaacaaca aaaaaaaaaa taccaaccaa accaagaggc
     3301 atccaaccaa gtccaagtcc acgtctggcg tacacccgca ccgagggagc tcgtccccca
     3361 gggggcgccg gagagtggct ttgcctggct ggcggtgcag tggggacgcg gccaggcact
     3421 ggggaagacc tgaaggggaa acgtggccag tgggtgtggg gcgggggggc tccggtatct
     3481 atccagtctt cctttcccac cctgctcccc agataggggg ttcctagggt ggaccaggcc
     3541 cctgagaagg aacggccagc tgacttgggc tgctgagccc tgaaggggct ggagcagtta
     3601 ggggccagcg gcttatcact catcccaggt ctccagcctg gcctcattga atgtgctgcc
     3661 agtgccgtca gctatccaac cagccgccct gggttccaac tcccgatgca aagggctgac
     3721 acggctccag aattctgggg caccccatgc tccgctcccc tatgtgagaa agcttccggc
     3781 tacagagaac aaagaaagcc cagccagtgg ggacgcagtc ctcacgctgt gaacgtggac
     3841 aggtgggccc tcgggcacag tgttgtttgt tgtggcagcc tcccagaagg aggcgctgtg
     3901 ggctcgaagg ccagcctccg ctgtctgcta ggacccagcc cttctttcca ctccatctgt
     3961 aggctcggtt ctgctgggga gtggggaatg agacgggcca gccccaggct gcacctcgag
     4021 gttgggagcc aaggtgctat gggtctggag ggccacagtc agagcaggac ccatgggaaa
     4081 gacaagggat ggggaaggtc tgggctggcc ctgccacaat ggaggccggc tgggctgcag
     4141 cccatttgct ccctgagcag gtgaagtaag ggagtcagag gaaagcagca ggcccagagg
     4201 atggaacagg gaagaggtat cgagaagccc ctgggcaagg cagggatagg tggagtaggg
     4261 ttaacagcaa aaaattaaca gaaaccaagg ctcccgacgc ggcaccactg tctcatgaca
     4321 cctcgaaata aatcacctca ctttctatcc agcatcagcc acagaagcta tggaaacgga
     4381 accctccttt tctattcctg ttgtacatag ccccgcgcct gcctccggct ctgtcctctg
     4441 tacagagccc cttgccttct gctgtttcgg acccttttcc cgcagcagct cggacccctc
     4501 ctcccagccc ctcccaggac tgcagccgag ccccaggctt cctttcttac cattctgtat
     4561 gcttccacgg tgtgaccatt caaattaaca gtattattat taagattaat aaagatttct
     4621 ttcttcaaac ca
//
