LOCUS       NM_001414967            6881 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus RNA binding fox-1 homolog 2 (Rbfox2), transcript
            variant 1, mRNA.
ACCESSION   NM_001414967 XM_006241836
VERSION     NM_001414967.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6881)
  AUTHORS   Yang,Y., Lee,G.C., Nakagaki-Silva,E., Huang,Y., Peacey,M.,
            Partridge,R., Gooding,C. and Smith,C.W.J.
  TITLE     Cell-type specific regulator RBPMS switches alternative splicing
            via higher-order oligomerization and heterotypic interactions with
            other splicing regulators
  JOURNAL   Nucleic Acids Res 51 (18), 9961-9982 (2023)
   PUBMED   37548402
REFERENCE   2  (bases 1 to 6881)
  AUTHORS   Li,P., Qin,D., Chen,T., Hou,W., Song,X., Yin,S., Song,M.,
            Fernando,W.C.H.A., Chen,X., Sun,Y. and Wang,J.
  TITLE     Dysregulated Rbfox2 produces aberrant splicing of CaV1.2 calcium
            channel in diabetes-induced cardiac hypertrophy
  JOURNAL   Cardiovasc Diabetol 22 (1), 168 (2023)
   PUBMED   37415128
  REMARK    GeneRIF: Dysregulated Rbfox2 produces aberrant splicing of CaV1.2
            calcium channel in diabetes-induced cardiac hypertrophy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6881)
  AUTHORS   He,X., Zhang,J., Guo,Y., Yang,X., Huang,Y. and Hao,D.
  TITLE     LncRNA MIAT Promotes Spinal Cord Injury Recovery in Rats by
            Regulating RBFOX2-Mediated Alternative Splicing of MCL-1
  JOURNAL   Mol Neurobiol 59 (8), 4854-4868 (2022)
   PUBMED   35641779
REFERENCE   4  (bases 1 to 6881)
  AUTHORS   Cao,J., Verma,S.K., Jaworski,E., Mohan,S., Nagasawa,C.K.,
            Rayavara,K., Sooter,A., Miller,S.N., Holcomb,R.J., Powell,M.J.,
            Ji,P., Elrod,N.D., Yildirim,E., Wagner,E.J., Popov,V., Garg,N.J.,
            Routh,A.L. and Kuyumcu-Martinez,M.N.
  TITLE     RBFOX2 is critical for maintaining alternative polyadenylation
            patterns and mitochondrial health in rat myoblasts
  JOURNAL   Cell Rep 37 (5), 109910 (2021)
   PUBMED   34731606
  REMARK    GeneRIF: RBFOX2 is critical for maintaining alternative
            polyadenylation patterns and mitochondrial health in rat myoblasts.
REFERENCE   5  (bases 1 to 6881)
  AUTHORS   Nakura,T., Ozoe,A., Narita,Y., Matsuo,M., Hakuno,F., Kataoka,N. and
            Takahashi,S.I.
  TITLE     Rbfox2 mediates exon 11 inclusion in insulin receptor pre-mRNA
            splicing in hepatoma cells
  JOURNAL   Biochimie 187, 25-32 (2021)
   PUBMED   34022289
  REMARK    GeneRIF: Rbfox2 mediates exon 11 inclusion in insulin receptor
            pre-mRNA splicing in hepatoma cells.
REFERENCE   6  (bases 1 to 6881)
  AUTHORS   Wolfrum,C., Howell,J.J., Ndungo,E. and Stoffel,M.
  TITLE     Foxa2 activity increases plasma high density lipoprotein levels by
            regulating apolipoprotein M
  JOURNAL   J Biol Chem 283 (24), 16940-16949 (2008)
   PUBMED   18381283
REFERENCE   7  (bases 1 to 6881)
  AUTHORS   Yang,G., Huang,S.C., Wu,J.Y. and Benz,E.J. Jr.
  TITLE     Regulated Fox-2 isoform expression mediates protein 4.1R splicing
            during erythroid differentiation
  JOURNAL   Blood 111 (1), 392-401 (2008)
   PUBMED   17715393
REFERENCE   8  (bases 1 to 6881)
  AUTHORS   Zhou,H.L., Baraniak,A.P. and Lou,H.
  TITLE     Role for Fox-1/Fox-2 in mediating the neuronal pathway of
            calcitonin/calcitonin gene-related peptide alternative RNA
            processing
  JOURNAL   Mol Cell Biol 27 (3), 830-841 (2007)
   PUBMED   17101796
REFERENCE   9  (bases 1 to 6881)
  AUTHORS   Norris,J.D., Fan,D., Sherk,A. and McDonnell,D.P.
  TITLE     A negative coregulator for the human ER
  JOURNAL   Mol Endocrinol 16 (3), 459-468 (2002)
   PUBMED   11875103
REFERENCE   10 (bases 1 to 6881)
  AUTHORS   Lieberman,A.P., Friedlich,D.L., Harmison,G., Howell,B.W.,
            Jordan,C.L., Breedlove,S.M. and Fischbeck,K.H.
  TITLE     Androgens regulate the mammalian homologues of invertebrate sex
            determination genes tra-2 and fox-1
  JOURNAL   Biochem Biophys Res Commun 282 (2), 499-506 (2001)
   PUBMED   11401487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Dec 16, 2022 this sequence version replaced XM_006241836.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.321080.1,
                                           SRR22582424.498185.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-565               JAXUCZ010000007.1  110934337-110934901 c
            566-616             JAXUCZ010000007.1  110852156-110852206 c
            617-841             JAXUCZ010000007.1  110747352-110747576 c
            842-988             JAXUCZ010000007.1  110729867-110730013 c
            989-1042            JAXUCZ010000007.1  110726662-110726715 c
            1043-1135           JAXUCZ010000007.1  110717987-110718079 c
            1136-1196           JAXUCZ010000007.1  110715285-110715345 c
            1197-1250           JAXUCZ010000007.1  110712432-110712485 c
            1251-1343           JAXUCZ010000007.1  110712223-110712315 c
            1344-1476           JAXUCZ010000007.1  110710924-110711056 c
            1477-1516           JAXUCZ010000007.1  110707425-110707464 c
            1517-1605           JAXUCZ010000007.1  110698230-110698318 c
            1606-1678           JAXUCZ010000007.1  110697773-110697845 c
            1679-6881           JAXUCZ010000007.1  110691230-110696432 c
FEATURES             Location/Qualifiers
     source          1..6881
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..6881
                     /gene="Rbfox2"
                     /gene_synonym="Rbm9"
                     /note="RNA binding fox-1 homolog 2"
                     /db_xref="GeneID:362950"
                     /db_xref="RGD:1311838"
     exon            1..565
                     /gene="Rbfox2"
                     /gene_synonym="Rbm9"
                     /inference="alignment:Splign:2.1.0"
     CDS             386..1723
                     /gene="Rbfox2"
                     /gene_synonym="Rbm9"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RNA-binding protein 9; fox-1 homolog B; RNA-binding motif
                     protein 9; RNA-binding protein FOX2; RNA binding protein,
                     fox-1 homolog 2"
                     /codon_start=1
                     /product="RNA binding protein fox-1 homolog 2 isoform 1"
                     /protein_id="NP_001401896.1"
                     /db_xref="GeneID:362950"
                     /db_xref="RGD:1311838"
                     /translation="MAEGGQAQQQPPQLGPGAAARGMKRESEVELPVPGAGADGPEPG
                     LSKRPRTEEAADEGMQNEPLTPGYHGFPARDGQGNQEPTTTPDAMVQPFTTIPFPPPP
                     QNGIPTEYGVPHTQDYAGQTSEHNLTLYGSSQPHGEQSSNSPSNQNGSLTQTEGGAQT
                     DGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGS
                     KGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGWKLSP
                     VVGAVYGPELYAASSFQADVSLGNEAAVPLSGRGGINTYIPLIIPGFPYPTAATTAAA
                     FRGAHLRGRGRTVYGAVRAVPPTAIPAYPGVVYQDGFYGADLYGGYAAYRYAQPATAT
                     AATAAAAAAAAYSDGYGRVYTADPYHALAPAASYGVGAVASLYRGGYSRFAPY"
     exon            566..616
                     /gene="Rbfox2"
                     /gene_synonym="Rbm9"
                     /inference="alignment:Splign:2.1.0"
     exon            617..841
                     /gene="Rbfox2"
                     /gene_synonym="Rbm9"
                     /inference="alignment:Splign:2.1.0"
     exon            842..988
                     /gene="Rbfox2"
                     /gene_synonym="Rbm9"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1042
                     /gene="Rbfox2"
                     /gene_synonym="Rbm9"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1135
                     /gene="Rbfox2"
                     /gene_synonym="Rbm9"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1196
                     /gene="Rbfox2"
                     /gene_synonym="Rbm9"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1250
                     /gene="Rbfox2"
                     /gene_synonym="Rbm9"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1343
                     /gene="Rbfox2"
                     /gene_synonym="Rbm9"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1476
                     /gene="Rbfox2"
                     /gene_synonym="Rbm9"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1516
                     /gene="Rbfox2"
                     /gene_synonym="Rbm9"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1605
                     /gene="Rbfox2"
                     /gene_synonym="Rbm9"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1678
                     /gene="Rbfox2"
                     /gene_synonym="Rbm9"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..6881
                     /gene="Rbfox2"
                     /gene_synonym="Rbm9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggccgtccc cttcttcgca cagccggcga gtggtgaggg agcgcgggac cgaaggacca
       61 agggacagag ggatcggcgc acgcgcgtgc gagcgagcga gcgagcgagt gagtgagtga
      121 gcgagcgagc gagcgagcga gcgagcggcc ggcgcgaagc cggagcagaa gccagagtcg
      181 gggccgaagc cggagccata acctgagtcg gagcggtagt gaagccgaag ccgaagcccg
      241 gctccggacc ggcgcgcacg cacacacgca cgcggggggc ggggccggcg cgcgcccgcc
      301 tgtcgcgact gtccgcaccg aggcccaggg ggaggtggcc tgtcgcgggt cgcccggctc
      361 ccggtggcga agggggcgcg ggcggatggc ggaaggcggc caggcacagc agcagccgcc
      421 tcagctcggg cccggcgctg ccgcccgggg catgaagcgg gagtcggagg tggagctgcc
      481 ggtgcccgga gcgggggcag acggacccga gcccggcctg agcaagcggc cacgcacaga
      541 ggaggcggcc gacgaaggga tgcagaacga gccactgacc ccgggttatc atggattccc
      601 agcaagggac ggccagggta accaggagcc aacaacaact cctgacgcaa tggttcagcc
      661 ttttactacc atcccattcc caccacctcc acagaacgga attcccacag aatatggagt
      721 gccacacact caggactatg ccggccagac cagtgaacat aacctgacac tctacgggag
      781 ttcacagccc catggagaac agagtagcaa ttcacccagc aaccagaatg gatctctcac
      841 gcagacagaa ggtggagcac agacagacgg acaacagtca cagacacaaa gtagtgaaaa
      901 ttcagagagt aaatccacgc ccaagcgact acatgtctct aatattccct tccgcttccg
      961 ggaccctgac ctccggcaga tgtttgggca gtttggcaaa atcctagatg tggaaataat
     1021 ctttaatgag cgcggttcca agggattcgg gttcgtaact ttcgagaata gtgctgatgc
     1081 agacagggcc agggagaaat tgcacggcac cgtggtagag ggccgtaaaa tcgaggtgaa
     1141 taatgctacc gcacgggtca tgaccaacaa gaagatggtc acaccatatg caaatggctg
     1201 gaagttaagc ccagtagttg gagctgtgta cggccctgag ttatatgcag catccagctt
     1261 tcaagctgat gtgtccctag gcaatgaggc ggctgtgccc ttgtcaggaa gagggggcat
     1321 caacacttac attcctctaa tcattcctgg cttcccttac ccaactgcag ccaccacagc
     1381 agccgctttc agaggagccc atctgagggg cagagggcgg acagtgtatg gtgcagtgcg
     1441 agcggtacct ccaacagcca tccccgccta tccaggtgtg gtttaccagg acggatttta
     1501 cggtgctgac ctctatggtg gatatgcagc ctacagatat gcacagcctg ctactgcaac
     1561 cgcagccaca gctgctgcag ccgctgcagc cgcttacagc gacggttacg gcagggtgta
     1621 cacagctgac ccctaccatg ccctcgcccc tgccgccagc tatggagttg gcgctgtggc
     1681 gagtttgtac cgaggtggct acagccgatt tgccccctac tgaagtgacg tgagacccct
     1741 gcaaatggga cagcccccag ttcatgaggc ctggctattg caatatttac tagtagagga
     1801 ctctatagca agatgaagag gaaaacaaac aaaaaagaga gaatactttt tatacctcac
     1861 tgtgttcttt gaatatgtat ttttccttta aatttctgcc tttaattctt ttgttccaaa
     1921 gattgtgctt tttttggttt tgtttttgtt tttgaatttt tgtttttgtt tggagggggg
     1981 gttgttttgg ggtttttttg ttttgttttt tgttttgggg ttttttgttc ttatttttgc
     2041 ttttttttaa aactgtggtt aaaaaaaaaa aaaagatagt gcatttccac gtctgtatgt
     2101 ccacgctcag cttattctgt cggtcacaga agaggcagtg gaggaggaag gagctgatac
     2161 atgcatttga ccagaagcca gcagacagaa ttaccaaagt ggatctggtg ctgatggctg
     2221 gggggacaag cagagtgggg gccagctctg cagcagtgtg cccttctggc ctgactctgg
     2281 ctggaggctc tgactggctg tggctggaat ccacatgcct ttcggtagga gtttgtgctt
     2341 acaaagcaag agaatttaaa agatgctttt ctctcctcta acctcctgcc tttctattcg
     2401 ttttacaatc attgacaggt acagcctgag agtgttgtca tggcttttgg aattacagtg
     2461 ctggtattcc caagcatgct ctcagactgt ggatgagaaa cacctcagta caaaaatgat
     2521 cttgaagtga gctcccaaat aggaaaacac ttgtttcttt tcctttcaga aatctcagca
     2581 tccttgctgg gctgttgccc ctttaattga gccactgtgc tgcaactcct ctgttctttt
     2641 attaacatgc tactcccatg tcctcaagat tcaggaatcg ggatctggga atggaagaat
     2701 gaatagtcag tggccagatt tccccccaga tatctgggca cagtatgagg attaaaagta
     2761 caaattgttc agagccatta aagagtgtgt agaagaggaa agggggatgt tcaatctgat
     2821 atcccttcat ttttcttgta gcacgaagtc agtacagagt aagaaaggca tcggaaagcc
     2881 tctgctgggg caggataagg aaccaagccc taggctggct gtcctaacaa gtgtgctgat
     2941 gaggaccagt aagggcaggc agaggcagtt tgtcctcact ccaaagccat aggaatttcc
     3001 atcctccaga gcctctgagc ctccagccct tgtggccact gcatccagct tcacagtgtc
     3061 ctccagagtc acagccaagc acctggaccc cttggggaac actaagaaga cgggccgtgg
     3121 actttaagcc tacctttgaa ggaggatgta aaatttcaag ggtcctcctg cacgggccat
     3181 ggcagtgaaa cctggcttca gttttgtttc caaaggactt ctttctcccc cagatctgag
     3241 atgtattcga aaggcaaggg tcccacagag gctccaaaat gaaggcatta ggaaaccgga
     3301 gtgtcaacgg gctccctggt cagttcacct gagggatcgc tgctaagggg agtagttcag
     3361 agacatgagc ttgggttttg ttagggtctg ttttagggtt attttattgg ggtttggttc
     3421 tgttgttgtt gttgttgttg ttgttgttgt tgttgttgtc gtcgtcgttg cctctgcctc
     3481 tacacatttt tgagtgataa atgattcatg tccctgaatt aaagtggctg acgtttgact
     3541 gcatcaagca tccttttgta agcagggagg ccttggccta cggctgacac gtaccgtctt
     3601 gctctcagat cctatctccc attatatctg aagagacaac gtggaagctg gagagctcag
     3661 tgtagtcatt gattctggga caacgtgtga aataggaaac gagacagact gcctgccact
     3721 ggccacttat ggagtccctt ccccgaagcc aaagtttggt ttgttgttgc tgttatgaca
     3781 gtcttcattg tatgtgcata aatattttag ttaggggaag ggataggctg gggcctcttg
     3841 gagttctaga gaatgggggc agagggattt tcctttattt tgtttctttt tgagaaaatt
     3901 tactggctaa aggaacagac attttgggtc tttgtttaat aagggccatt ctcacaaaaa
     3961 ggcaagcccc ttcacctggt ggagactagg ccagtccctc gacaattgta tccacaaagg
     4021 gcagaaaggg aggaagaatt gaagaaggca tctttcttcc tggacaggag taagggtggt
     4081 catagcaggg tgaaaaggac agtccccatg gcccatgccg gaggggccag aggggccttc
     4141 gtgcacttca gttcagctgg ttctggctga ggcctccaag gccagtctgt ttgccagcac
     4201 gtctctgctg catgtacagg gacactctcc ggtgggtgcc acttcctcaa gctccttcca
     4261 aggaacacta gatggagttg gctttttatg caagggtctt tggatttcag ggtgagcact
     4321 gagagtttgg ctcccccaag tgtctgggtt tcactgtatt ggcctcatgg ttggtcctca
     4381 aggccactgt gttggtgtgt tggactgatt taggaagcag caggctagag gagaaaggca
     4441 ttttgtgact ctgttagagg attctggctg atgatttcaa aaagatggct gacgctgaat
     4501 cgcagtgaga agggtgtttt cagtttcaaa ggcttctgca gcctggactt ttctatgctg
     4561 caaatcttac tagaagctgg gctcctttaa ggagacttgt agtgaaaacg tttgtctggc
     4621 tgttcccctt tcagcccgga gagctgcctt aggtctttac tagaatttct gtgttactta
     4681 gttcaacctc agcccagaag caccttgcta ctacttgtca ttttagggct ctcaggtttc
     4741 caggaacctc tgtcaccgtc accctgcagc agccgatgtc tgaactgagc ctgcgttctt
     4801 ccttcccttg gaaaccgcct ggagctcagc tcatagttta aggagagctt gtggctgttc
     4861 ctcaaacatg gactcctcag gggctgaact gtttagttta ggctgtgctt tcttagagat
     4921 gcagccagca ggagtggcca cctgcatcct gcacctagtc atgtagcttc cagacacgag
     4981 ggctgtaaaa tgagaagggc acgaggctat gcaagaagag catgatgtgc ccctccctcc
     5041 ctgtgccagg taaatgaggc cagccagggg cagtctggac ctcgggtgtc ggaaggcggg
     5101 aagctgcctg gcgatccttc ccctttggcc agccagttct ccactactca aaatctagca
     5161 tggcagtgtc tgcaaaatcg caggctttcc cccggctgtt aggagcaaag ggactttggg
     5221 gggtggggac ggggttgtgg tgttttaaag cataagttac ctgtttgcac tgttttcaga
     5281 taggaaacaa tagtgggcac ggtgaacatc taatgtaaac gtgtgtttta ttttgtcatg
     5341 ctcttgagaa tgtctgatca tttgtagtat acaccagtaa cacttgattc tctgttgcat
     5401 aaaacactat atttttggaa atgttgctgt cccacccttc cctctcctgt gtacctcctt
     5461 tacccttgct tcctcatcag ccaggcagtt gccatccctg ggctagagcg ggaaacaggg
     5521 ccccacccca agcgggctct gggtgtccta agccagcatg tgccctctag gttactgagt
     5581 gcaggacagt cccttggcag ctttcctttt gaaaggctca ccaactacca caggttgcca
     5641 aactcttcag caaggcacta gaaatgagcc agggggcacg ggtccctgaa gtcttgtggt
     5701 tggctgtgga agccatgttc ttatgcaagt taccaaaact gtagccagtt acagtgtact
     5761 caggaaaaac ggtggatgag ctcagccatg gcggtgctgg ctggcaggga tgggaactga
     5821 ggactgccca tcagccaaga cctcccaccc agggggcagc cctctgtaca tgccagcgct
     5881 ggggggtggg gagggctgca ttcaccctgg caggcaaaaa gggaacagcg atgctctttc
     5941 cttccctccc tcttccggtt accaatgcca gattcccagg ggcacgcaag tttttgagtt
     6001 tttcaaaaaa tgcttttggt ttggtttttc cggggactga tgtgctttaa tcgctgtctg
     6061 tccccatcag gacgcctagc ttagctcttt tctcgtattt tctgttcaca gtatttttgt
     6121 gtgcctgctt gttgggcagc tcattttggc tgcattatat atggagtgat gaactgatcc
     6181 ttttctttcc ctaagagaca tgactttccc tgtgtcagca ttcagcttgt gaatagctag
     6241 agacaccctg gggctgacac gtgtaagtta gagctgcaga gcgaactgag gcgctctctc
     6301 agtttttgag tctccatctt ctcaaggctc aaagtaccac agaacctcgc tctcctccac
     6361 acctctgtgg cagggagtgg cctgcctagc acgtgtggtt tccctgtggc aggacaggta
     6421 ccactgggac atgggggcat actcggatgc ttgtccaatt gaccacccag ctgtgtctcc
     6481 ttccttccca tcctctccca gagtcacctc ctagggcacc cgagctgctt gcccagggtc
     6541 ctgtttccct gctaactcca gagaagcacc cagggctttg tgacagtctc taactccctc
     6601 tctccctctc tccctcctcc tcaagaatca tattgtatag tagctttcag accatacagt
     6661 attcattggg ttactcctat tattatcaag tagctggaat tgtgaaggtt ggagtagtta
     6721 gatctttagc ttttattcat tattttttgt attactctcc atgtgtataa attattgatc
     6781 atgttgctgg cttttataaa ctcttagcaa aggaggggcc ctgcctcagc ctttgcaaat
     6841 ggtaacgaag cactgttttt aaataaaaga gagaaacacc a
//
