LOCUS       NP_001401896             445 aa            linear   ROD 01-APR-2024
DEFINITION  RNA binding protein fox-1 homolog 2 isoform 1 [Rattus norvegicus].
ACCESSION   NP_001401896 XP_006241898
VERSION     NP_001401896.1
DBSOURCE    REFSEQ: accession NM_001414967.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 445)
  AUTHORS   Yang,Y., Lee,G.C., Nakagaki-Silva,E., Huang,Y., Peacey,M.,
            Partridge,R., Gooding,C. and Smith,C.W.J.
  TITLE     Cell-type specific regulator RBPMS switches alternative splicing
            via higher-order oligomerization and heterotypic interactions with
            other splicing regulators
  JOURNAL   Nucleic Acids Res 51 (18), 9961-9982 (2023)
   PUBMED   37548402
REFERENCE   2  (residues 1 to 445)
  AUTHORS   Li,P., Qin,D., Chen,T., Hou,W., Song,X., Yin,S., Song,M.,
            Fernando,W.C.H.A., Chen,X., Sun,Y. and Wang,J.
  TITLE     Dysregulated Rbfox2 produces aberrant splicing of CaV1.2 calcium
            channel in diabetes-induced cardiac hypertrophy
  JOURNAL   Cardiovasc Diabetol 22 (1), 168 (2023)
   PUBMED   37415128
  REMARK    GeneRIF: Dysregulated Rbfox2 produces aberrant splicing of CaV1.2
            calcium channel in diabetes-induced cardiac hypertrophy.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 445)
  AUTHORS   He,X., Zhang,J., Guo,Y., Yang,X., Huang,Y. and Hao,D.
  TITLE     LncRNA MIAT Promotes Spinal Cord Injury Recovery in Rats by
            Regulating RBFOX2-Mediated Alternative Splicing of MCL-1
  JOURNAL   Mol Neurobiol 59 (8), 4854-4868 (2022)
   PUBMED   35641779
REFERENCE   4  (residues 1 to 445)
  AUTHORS   Cao,J., Verma,S.K., Jaworski,E., Mohan,S., Nagasawa,C.K.,
            Rayavara,K., Sooter,A., Miller,S.N., Holcomb,R.J., Powell,M.J.,
            Ji,P., Elrod,N.D., Yildirim,E., Wagner,E.J., Popov,V., Garg,N.J.,
            Routh,A.L. and Kuyumcu-Martinez,M.N.
  TITLE     RBFOX2 is critical for maintaining alternative polyadenylation
            patterns and mitochondrial health in rat myoblasts
  JOURNAL   Cell Rep 37 (5), 109910 (2021)
   PUBMED   34731606
  REMARK    GeneRIF: RBFOX2 is critical for maintaining alternative
            polyadenylation patterns and mitochondrial health in rat myoblasts.
REFERENCE   5  (residues 1 to 445)
  AUTHORS   Nakura,T., Ozoe,A., Narita,Y., Matsuo,M., Hakuno,F., Kataoka,N. and
            Takahashi,S.I.
  TITLE     Rbfox2 mediates exon 11 inclusion in insulin receptor pre-mRNA
            splicing in hepatoma cells
  JOURNAL   Biochimie 187, 25-32 (2021)
   PUBMED   34022289
  REMARK    GeneRIF: Rbfox2 mediates exon 11 inclusion in insulin receptor
            pre-mRNA splicing in hepatoma cells.
REFERENCE   6  (residues 1 to 445)
  AUTHORS   Wolfrum,C., Howell,J.J., Ndungo,E. and Stoffel,M.
  TITLE     Foxa2 activity increases plasma high density lipoprotein levels by
            regulating apolipoprotein M
  JOURNAL   J Biol Chem 283 (24), 16940-16949 (2008)
   PUBMED   18381283
REFERENCE   7  (residues 1 to 445)
  AUTHORS   Yang,G., Huang,S.C., Wu,J.Y. and Benz,E.J. Jr.
  TITLE     Regulated Fox-2 isoform expression mediates protein 4.1R splicing
            during erythroid differentiation
  JOURNAL   Blood 111 (1), 392-401 (2008)
   PUBMED   17715393
REFERENCE   8  (residues 1 to 445)
  AUTHORS   Zhou,H.L., Baraniak,A.P. and Lou,H.
  TITLE     Role for Fox-1/Fox-2 in mediating the neuronal pathway of
            calcitonin/calcitonin gene-related peptide alternative RNA
            processing
  JOURNAL   Mol Cell Biol 27 (3), 830-841 (2007)
   PUBMED   17101796
REFERENCE   9  (residues 1 to 445)
  AUTHORS   Norris,J.D., Fan,D., Sherk,A. and McDonnell,D.P.
  TITLE     A negative coregulator for the human ER
  JOURNAL   Mol Endocrinol 16 (3), 459-468 (2002)
   PUBMED   11875103
REFERENCE   10 (residues 1 to 445)
  AUTHORS   Lieberman,A.P., Friedlich,D.L., Harmison,G., Howell,B.W.,
            Jordan,C.L., Breedlove,S.M. and Fischbeck,K.H.
  TITLE     Androgens regulate the mammalian homologues of invertebrate sex
            determination genes tra-2 and fox-1
  JOURNAL   Biochem Biophys Res Commun 282 (2), 499-506 (2001)
   PUBMED   11401487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Dec 16, 2022 this sequence version replaced XP_006241898.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.321080.1,
                                           SRR22582424.498185.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..445
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     Protein         1..445
                     /product="RNA binding protein fox-1 homolog 2 isoform 1"
                     /note="RNA-binding protein 9; fox-1 homolog B; RNA-binding
                     motif protein 9; RNA-binding protein FOX2; RNA binding
                     protein, fox-1 homolog 2"
                     /calculated_mol_wt=46861
     Region          <37..251
                     /region_name="ELAV_HUD_SF"
                     /note="ELAV/HuD family splicing factor; TIGR01661"
                     /db_xref="CDD:273741"
     Region          180..255
                     /region_name="RRM_FOX1_like"
                     /note="RNA recognition motif (RRM) found in vertebrate RNA
                     binding protein fox-1 homologs and similar proteins;
                     cd12407"
                     /db_xref="CDD:409841"
     Site            order(181,183,185..190,210..214,216..221,223,247,252..255)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:409841"
     Region          320..417
                     /region_name="Fox-1_C"
                     /note="Calcitonin gene-related peptide regulator C
                     terminal; pfam12414"
                     /db_xref="CDD:463568"
     CDS             1..445
                     /gene="Rbfox2"
                     /gene_synonym="Rbm9"
                     /coded_by="NM_001414967.1:386..1723"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:362950"
                     /db_xref="RGD:1311838"
ORIGIN      
        1 maeggqaqqq ppqlgpgaaa rgmkreseve lpvpgagadg pepglskrpr teeaadegmq
       61 nepltpgyhg fpardgqgnq eptttpdamv qpfttipfpp ppqngiptey gvphtqdyag
      121 qtsehnltly gssqphgeqs snspsnqngs ltqteggaqt dgqqsqtqss enseskstpk
      181 rlhvsnipfr frdpdlrqmf gqfgkildve iifnergskg fgfvtfensa dadrareklh
      241 gtvvegrkie vnnatarvmt nkkmvtpyan gwklspvvga vygpelyaas sfqadvslgn
      301 eaavplsgrg gintyiplii pgfpyptaat taaafrgahl rgrgrtvyga vravpptaip
      361 aypgvvyqdg fygadlyggy aayryaqpat ataataaaaa aaaysdgygr vytadpyhal
      421 apaasygvga vaslyrggys rfapy
//
