LOCUS       NM_001106974            4153 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Rattus norvegicus RNA binding fox-1 homolog 1 (Rbfox1), mRNA.
ACCESSION   NM_001106974 XM_001076609 XM_220155
VERSION     NM_001106974.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4153)
  AUTHORS   Shen,F., Xu,X., Yu,Z., Li,H., Shen,H., Li,X., Shen,M. and Chen,G.
  TITLE     Rbfox-1 contributes to CaMKIIalpha expression and intracerebral
            hemorrhage-induced secondary brain injury via blocking
            micro-RNA-124
  JOURNAL   J Cereb Blood Flow Metab 41 (3), 530-545 (2021)
   PUBMED   32248729
  REMARK    GeneRIF: Rbfox-1 contributes to CaMKIIalpha expression and
            intracerebral hemorrhage-induced secondary brain injury via
            blocking micro-RNA-124.
REFERENCE   2  (bases 1 to 4153)
  AUTHORS   Vaht,M., Laas,K., Fernandez-Castillo,N., Kurrikoff,T., Kanarik,M.,
            Faraone,S.V., Tooding,L.M., Veidebaum,T., Franke,B., Reif,A.,
            Cormand,B. and Harro,J.
  TITLE     Variants of the Aggression-Related RBFOX1 Gene in a Population
            Representative Birth Cohort Study: Aggressiveness, Personality, and
            Alcohol Use Disorder
  JOURNAL   Front Psychiatry 11, 501847 (2020)
   PUBMED   33329073
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4153)
  AUTHORS   Kucherenko,M.M. and Shcherbata,H.R.
  TITLE     Stress-dependent miR-980 regulation of Rbfox1/A2bp1 promotes
            ribonucleoprotein granule formation and cell survival
  JOURNAL   Nat Commun 9 (1), 312 (2018)
   PUBMED   29358748
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4153)
  AUTHORS   Wang,J., Li,G., Yu,D., Wong,Y.P., Yong,T.F., Liang,M.C., Liao,P.,
            Foo,R., Hoppe,U.C. and Soong,T.W.
  TITLE     Characterization of CaV1.2 exon 33 heterozygous knockout mice and
            negative correlation between Rbfox1 and CaV1.2 exon 33 expressions
            in human heart failure
  JOURNAL   Channels (Austin) 12 (1), 51-57 (2018)
   PUBMED   28949795
  REMARK    Correction to:[Addendum to: Li G, Wang J, Liao P, Bartels P, Zhang
            H, Yu D, Liang MC, Poh KK, Yu CY, Jiang F, et al. Exclusion of
            alternative exon 33 of CaV1.2 calcium channels in heart is
            proarrhythmogenic. Proc Natl Acad Sci U S A. 2017;114:E4288-E4295.
            http://doi: 10.1073/pnas.1617205114.]
REFERENCE   5  (bases 1 to 4153)
  AUTHORS   Kapeli,K., Pratt,G.A., Vu,A.Q., Hutt,K.R., Martinez,F.J.,
            Sundararaman,B., Batra,R., Freese,P., Lambert,N.J., Huelga,S.C.,
            Chun,S.J., Liang,T.Y., Chang,J., Donohue,J.P., Shiue,L., Zhang,J.,
            Zhu,H., Cambi,F., Kasarskis,E., Hoon,S., Ares,M. Jr., Burge,C.B.,
            Ravits,J., Rigo,F. and Yeo,G.W.
  TITLE     Distinct and shared functions of ALS-associated proteins TDP-43,
            FUS and TAF15 revealed by multisystem analyses
  JOURNAL   Nat Commun 7, 12143 (2016)
   PUBMED   27378374
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4153)
  AUTHORS   Pistoni,M., Shiue,L., Cline,M.S., Bortolanza,S., Neguembor,M.V.,
            Xynos,A., Ares,M. Jr. and Gabellini,D.
  TITLE     Rbfox1 downregulation and altered calpain 3 splicing by FRG1 in a
            mouse model of Facioscapulohumeral muscular dystrophy (FSHD)
  JOURNAL   PLoS Genet 9 (1), e1003186 (2013)
   PUBMED   23300487
REFERENCE   7  (bases 1 to 4153)
  AUTHORS   Gehman,L.T., Meera,P., Stoilov,P., Shiue,L., O'Brien,J.E.,
            Meisler,M.H., Ares,M. Jr., Otis,T.S. and Black,D.L.
  TITLE     The splicing regulator Rbfox2 is required for both cerebellar
            development and mature motor function
  JOURNAL   Genes Dev 26 (5), 445-460 (2012)
   PUBMED   22357600
REFERENCE   8  (bases 1 to 4153)
  AUTHORS   Kim,K.K., Kim,Y.C., Adelstein,R.S. and Kawamoto,S.
  TITLE     Fox-3 and PSF interact to activate neural cell-specific alternative
            splicing
  JOURNAL   Nucleic Acids Res 39 (8), 3064-3078 (2011)
   PUBMED   21177649
REFERENCE   9  (bases 1 to 4153)
  AUTHORS   Ma,L., Hanson,R.L., Traurig,M.T., Muller,Y.L., Kaur,B.P.,
            Perez,J.M., Meyre,D., Fu,M., Korner,A., Franks,P.W., Kiess,W.,
            Kobes,S., Knowler,W.C., Kovacs,P., Froguel,P., Shuldiner,A.R.,
            Bogardus,C. and Baier,L.J.
  TITLE     Evaluation of A2BP1 as an obesity gene
  JOURNAL   Diabetes 59 (11), 2837-2845 (2010)
   PUBMED   20724578
  REMARK    GeneRIF: Association analysis suggests that variation in A2BP1
            influences obesity.
REFERENCE   10 (bases 1 to 4153)
  AUTHORS   Shibata,H., Huynh,D.P. and Pulst,S.M.
  TITLE     A novel protein with RNA-binding motifs interacts with ataxin-2
  JOURNAL   Hum Mol Genet 9 (9), 1303-1313 (2000)
   PUBMED   10814712
  REMARK    Erratum:[Hum Mol Genet 2000 Jul 22;9(12):1903]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Jan 10, 2008 this sequence version replaced NM_001106974.1.
            
            Summary: The Fox-1 family of RNA-binding proteins is evolutionarily
            conserved, and regulates tissue-specific alternative splicing in
            metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or
            in flanking introns. [provided by RefSeq, Nov 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-316               JAXUCZ010000010.1  8999076-8999391     c
            317-556             JAXUCZ010000010.1  8838527-8838766     c
            557-700             JAXUCZ010000010.1  8788196-8788339     c
            701-754             JAXUCZ010000010.1  8780448-8780501     c
            755-847             JAXUCZ010000010.1  8774121-8774213     c
            848-908             JAXUCZ010000010.1  8772245-8772305     c
            909-962             JAXUCZ010000010.1  8762799-8762852     c
            963-1043            JAXUCZ010000010.1  8740612-8740692     c
            1044-1176           JAXUCZ010000010.1  8717026-8717158     c
            1177-1216           JAXUCZ010000010.1  8706723-8706762     c
            1217-1281           JAXUCZ010000010.1  8693796-8693860     c
            1282-1357           JAXUCZ010000010.1  8663293-8663368     c
            1358-4153           JAXUCZ010000010.1  8658809-8661604     c
FEATURES             Location/Qualifiers
     source          1..4153
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..4153
                     /gene="Rbfox1"
                     /gene_synonym="A2bp1"
                     /note="RNA binding fox-1 homolog 1"
                     /db_xref="GeneID:302920"
                     /db_xref="RGD:1311210"
     exon            1..316
                     /gene="Rbfox1"
                     /gene_synonym="A2bp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..1480
                     /gene="Rbfox1"
                     /gene_synonym="A2bp1"
                     /note="fox-1 homolog A; ataxin 2 binding protein 1; RNA
                     binding protein, fox-1 homolog 1"
                     /codon_start=1
                     /product="RNA binding protein fox-1 homolog 1"
                     /protein_id="NP_001100444.2"
                     /db_xref="GeneID:302920"
                     /db_xref="RGD:1311210"
                     /translation="MLASQGVLLHSYGVPMVVPAAPFFPGLMQGNQEAAAAPDTMAQP
                     YASAQFAPPQNGIPAEYTAPHPHPAPEYTGQTTVPDHTLNLYPPTQTHSEQSADTSAQ
                     TVSGTATQTDDAAPTDGQPQTQPSENTENKSQPKRLHVSNIPFRFRDPDLRQMFGQFG
                     KILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNK
                     KAVNPYTNGWKLNPVVGAVYSPDFYAGTVLLCQANQEGSSMYSGPSSLVYTSAMPGFP
                     YPAATAAAAYRGAHLRGRGRTVYNTFRAAAPPPPIPAYGGVVYQDGFYGADIYGGYAA
                     YRYAQPTPATAAAYSDSYGRVYAADPYHHTLAPAPTYGVGAMNAFAPLTDAKTRSHAD
                     DVGLVLSSLQASIYRGGYNRFAPY"
     exon            317..556
                     /gene="Rbfox1"
                     /gene_synonym="A2bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            557..700
                     /gene="Rbfox1"
                     /gene_synonym="A2bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..754
                     /gene="Rbfox1"
                     /gene_synonym="A2bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            755..847
                     /gene="Rbfox1"
                     /gene_synonym="A2bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            848..908
                     /gene="Rbfox1"
                     /gene_synonym="A2bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            909..962
                     /gene="Rbfox1"
                     /gene_synonym="A2bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1043
                     /gene="Rbfox1"
                     /gene_synonym="A2bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1176
                     /gene="Rbfox1"
                     /gene_synonym="A2bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1216
                     /gene="Rbfox1"
                     /gene_synonym="A2bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1281
                     /gene="Rbfox1"
                     /gene_synonym="A2bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1357
                     /gene="Rbfox1"
                     /gene_synonym="A2bp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..4153
                     /gene="Rbfox1"
                     /gene_synonym="A2bp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgtcccttc cttgtctgtg aagaaaactt tcacattaag agttgctgat gcaggatttt
       61 ctttcctttc ccctctccgc cgcctgtgga tgagcacttg gctcctgaca gaagcgattt
      121 ggctctcggc tttgtagttg agaagaagtt gggtctatag atttctttcc ccctctaact
      181 ctctattgat gtgttcagcc ttggagggaa taaagcctcc atttaaagca tgttggcgtc
      241 gcaaggagtc cttctgcatt cttatggcgt gcctatggtt gtgcctgctg cccccttctt
      301 cccgggactg atgcagggta atcaggaagc agcggccgcc cctgacacaa tggctcagcc
      361 ttatgcctca gcgcagttcg ctccacccca gaatggcatc cctgcagaat acacggcccc
      421 tcatccccat cccgcgccag agtacaccgg ccagaccact gtccccgacc acacattaaa
      481 cctgtatcct cctacacaga cgcactcgga gcagagcgct gatacaagcg cacagaccgt
      541 ctccggcacc gccacacaga cagatgatgc cgccccgacc gacggccagc cccagacaca
      601 accttctgaa aacacagaaa acaagtccca gcccaagcgg ctgcatgtgt ccaacatccc
      661 cttccggttc cgggatccag acctccgaca aatgtttggc caatttggta aaatattaga
      721 tgttgaaatt atttttaatg agcggggctc gaagggattt ggtttcgtaa ctttcgaaaa
      781 tagtgcggat gcggacaggg cgagggagaa attgcacggt accgtggtag agggccgtaa
      841 aatcgaggtt aataatgcga cagcacgcgt gatgactaat aaaaaggccg tgaaccccta
      901 caccaatggc tggaaattaa atccagttgt gggcgcggtc tacagccccg acttctatgc
      961 aggcacggtg ctgttgtgcc aggccaacca ggagggatct tccatgtaca gtggccccag
     1021 ttcacttgta tatacttctg caatgcctgg ctttccatat ccggccgcca ctgctgcagc
     1081 tgcataccga ggggctcacc ttcgaggccg tggtcgcacc gtgtacaaca ccttcagagc
     1141 tgcggcgccc ccacccccaa tcccggccta tggcggtgtt gtttaccagg atggatttta
     1201 tggtgcagac atttatggtg gttacgctgc ataccgctac gcccagccca cccctgccac
     1261 tgctgctgcc tacagtgaca gttacggacg agtttatgct gccgacccct accaccacac
     1321 acttgctcca gcccccacct acggcgttgg tgccatgaat gcttttgcgc ccttgaccga
     1381 tgccaagact aggagccatg ctgatgatgt gggtctcgtt ctttcttcat tgcaggctag
     1441 tatataccga gggggataca accgttttgc tccatattaa atgataaaac cattaaacaa
     1501 acaaacaaaa aacaaaacaa aaacaaaaaa accaaccttc caatgtgggg agagaggaag
     1561 ctttccgagg cccgagtgtt gcgacacatg cagtaggaca tcactttagc aactcaaaga
     1621 aacaactaaa aaaaaaaaaa atcaaaaaaa agaggaaaaa ttacattttt tatcttatac
     1681 ctcagatatt ttgttctgtg tattttaata ttgtgggtct ttggtttatg aaggtttttg
     1741 tagttcagtt gctggctgta ggagtttttg tggttgatct agagagaggc tagatataaa
     1801 taaaaaccga tttagggcca tatccagagt gctatattat gtaaatggat tatatatgcc
     1861 gaacatgaag ctactggggt tacgctgttt gggaagactg taagtggcaa gtcattcttt
     1921 ctgcatctat attattttat tctgtgaaag gggaggccgg gaggggctta ggggtttggg
     1981 actggggttt ggctgaaagg aaaaaaaaag aaaatatata tatatataaa tacatatata
     2041 tagtaactga tgaatctaaa tgacccactg caccaactat cataaatcta tggttcgaag
     2101 ttactcctgg caaaggcaag ccaaaggctg tgttaagaat ctgcttctta tagcacggag
     2161 attgcagttg aacgaagctg tgacggtccg ccctcttatc attccaccgc agtacgcagc
     2221 ttcttaccta cccactagtt atttaagcca aggctactag ttaggccatc aataagcatt
     2281 ctttttatat ttcttccagt atgagaaatt attgatatca ctgctgactt ttatattacg
     2341 ggagggaaaa ttaacattaa taaaaggtga taaaaagcac tgtttctatt tttttctttt
     2401 tttccaaaaa agaaagtaat aaaaacttaa attctttgta ccagttaaaa atatgtataa
     2461 aatttacatc tgtgcagtgg agttatgttc tagaaacagt ctctgaggct ttagttttag
     2521 cttagtagat taactgttag agacagacgt ataattttta tggaattaca tgataatcat
     2581 atctggattt atagtcgcat tttacaagta tcgcaatcat tgaatagaga taatcacggt
     2641 attttcatca gcttgatact ttttgaaaac atgactgcgc tgtgagcaac ttgcaatttt
     2701 tcagtctgtg agagcctgcc cttccttctc cccagtgccc cagggttatg ttaaactggt
     2761 gtctttactt ctatcgccaa ggcccaagac aattgtcaga aggaagcaaa aacaagacaa
     2821 aaaacaaaac tagaaccatg ccctccttcc ccaaagagca gtgtctgccg catccttttc
     2881 cggagcaggg ccagagcaac acagccgaaa aattgcagct tgtgaatttc ttctgtttga
     2941 atccccccat gttgtcctgt ttacaagtta acctaagttg gggtatctgt catgggtctt
     3001 cctgtttttg tatttaaatt ctaaaatatc agcaagctgt tccctgagta gtgtttttgc
     3061 ctgtgtgtgc agtgccggcc ccacggcacg cactttagta agttatcaac tcacgctgtg
     3121 aacctgccaa tctgctgtaa caactctgct ttaaaatcaa aaccaaacaa aactttaaaa
     3181 agaaaaaaaa aagtgtttgt gatccagctt ttcctcatca tcctacgtgc atgcccgtaa
     3241 gatcggttgg atattaaacc atcaataaag tttcatgaga tttgaaaaca aagttttcgt
     3301 agcttcgata tctaagacag aggatcatgg tttgggagag gaagaaaagc aaggggcgag
     3361 gaggggaagg gagagagact gctgaactgg tgagaagagg aaaaaaaatc taggaactgg
     3421 tcttctttca ccagacctct ttgagtaggg agagatgggg ccagaggggg acaggttgac
     3481 aacatcacgt tcccactccc ctggcctgct acagtgcgca cctggttgat gttacccaag
     3541 gcaacaattt atcatgatgc tgtagcattc gaccccagat ggggtcaagg tagtaaaagg
     3601 aaggggctgc acaaaggtca acagactcct cccagtcgcc ccagctttcc aagcctagaa
     3661 cctgcattgt gtatgaaatc acaaacatgg aattcttact gtgctggcta aagtaaaact
     3721 catttgcggt tttgatttcc atcaacgaac tgtactttcc cccacgaccg tatgtagttt
     3781 taataaaaat catttagagc aagtgggtgc caaccgatgt cgcagaacct tttgtctagg
     3841 cactccgctg agctgccgat aagtcgtttt aaactgtcat gtcagaggtg taaacaaaca
     3901 ttttggattt tttaaaacaa cagtatttat ttggaatgtt ttcatttatc taaataacta
     3961 ttgctattat gaattatgga aaaaagatta atgtggcata tagtgacttc ttaacacaca
     4021 tcactcaatc tgcaaaccca gaaaatgtgt atatctgtct ttagaaatta gtgtttatat
     4081 cacttacagt ggtttgtgaa taaagaaaac tggtttgtaa tatcaaaaaa taaaagctta
     4141 gtctgaaaag gta
//
