LOCUS       NM_021764               2350 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus RANBP2-type and C3HC4-type zinc finger containing
            1 (Rbck1), mRNA.
ACCESSION   NM_021764
VERSION     NM_021764.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2350)
  AUTHORS   Van Quickelberghe,E., De Sutter,D., van Loo,G., Eyckerman,S. and
            Gevaert,K.
  TITLE     A protein-protein interaction map of the TNF-induced NF-kappaB
            signal transduction pathway
  JOURNAL   Sci Data 5, 180289 (2018)
   PUBMED   30561431
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2350)
  AUTHORS   Damgaard,R.B., Walker,J.A., Marco-Casanova,P., Morgan,N.V.,
            Titheradge,H.L., Elliott,P.R., McHale,D., Maher,E.R.,
            McKenzie,A.N.J. and Komander,D.
  TITLE     The Deubiquitinase OTULIN Is an Essential Negative Regulator of
            Inflammation and Autoimmunity
  JOURNAL   Cell 166 (5), 1215-1230 (2016)
   PUBMED   27523608
REFERENCE   3  (bases 1 to 2350)
  AUTHORS   Elliott,P.R., Nielsen,S.V., Marco-Casanova,P., Fiil,B.K.,
            Keusekotten,K., Mailand,N., Freund,S.M., Gyrd-Hansen,M. and
            Komander,D.
  TITLE     Molecular basis and regulation of OTULIN-LUBAC interaction
  JOURNAL   Mol Cell 54 (3), 335-348 (2014)
   PUBMED   24726323
REFERENCE   4  (bases 1 to 2350)
  AUTHORS   Muller-Rischart,A.K., Pilsl,A., Beaudette,P., Patra,M., Hadian,K.,
            Funke,M., Peis,R., Deinlein,A., Schweimer,C., Kuhn,P.H.,
            Lichtenthaler,S.F., Motori,E., Hrelia,S., Wurst,W., Trumbach,D.,
            Langer,T., Krappmann,D., Dittmar,G., Tatzelt,J. and Winklhofer,K.F.
  TITLE     The E3 ligase parkin maintains mitochondrial integrity by
            increasing linear ubiquitination of NEMO
  JOURNAL   Mol Cell 49 (5), 908-921 (2013)
   PUBMED   23453807
REFERENCE   5  (bases 1 to 2350)
  AUTHORS   Chu,W.M.
  TITLE     Tumor necrosis factor
  JOURNAL   Cancer Lett 328 (2), 222-225 (2013)
   PUBMED   23085193
  REMARK    Review article
REFERENCE   6  (bases 1 to 2350)
  AUTHORS   Kirisako,T., Kamei,K., Murata,S., Kato,M., Fukumoto,H., Kanie,M.,
            Sano,S., Tokunaga,F., Tanaka,K. and Iwai,K.
  TITLE     A ubiquitin ligase complex assembles linear polyubiquitin chains
  JOURNAL   EMBO J 25 (20), 4877-4887 (2006)
   PUBMED   17006537
REFERENCE   7  (bases 1 to 2350)
  AUTHORS   Tatematsu,K., Yoshimoto,N., Koyanagi,T., Tokunaga,C., Tachibana,T.,
            Yoneda,Y., Yoshida,M., Okajima,T., Tanizawa,K. and Kuroda,S.
  TITLE     Nuclear-cytoplasmic shuttling of a RING-IBR protein RBCK1 and its
            functional interaction with nuclear body proteins
  JOURNAL   J Biol Chem 280 (24), 22937-22944 (2005)
   PUBMED   15833741
  REMARK    GeneRIF: RBCK1 (human C20orf18 and rat Pkcbpb15) is involved in
            transcriptional machinery in the nuclear bodies, and its
            transcriptional activity is regulated by nucleocytoplasmic
            shuttling.
REFERENCE   8  (bases 1 to 2350)
  AUTHORS   Yamanaka,K., Ishikawa,H., Megumi,Y., Tokunaga,F., Kanie,M.,
            Rouault,T.A., Morishima,I., Minato,N., Ishimori,K. and Iwai,K.
  TITLE     Identification of the ubiquitin-protein ligase that recognizes
            oxidized IRP2
  JOURNAL   Nat Cell Biol 5 (4), 336-340 (2003)
   PUBMED   12629548
REFERENCE   9  (bases 1 to 2350)
  AUTHORS   Tokunaga,C., Tatematsu,K., Kuroda,S., Nakagawa,N. and Kikkawa,U.
  TITLE     Molecular cloning and characterization of RBCK2, a splicing variant
            of a RBCC family protein, RBCK1
  JOURNAL   FEBS Lett 435 (1), 11-15 (1998)
   PUBMED   9755849
REFERENCE   10 (bases 1 to 2350)
  AUTHORS   Tokunaga,C., Kuroda,S., Tatematsu,K., Nakagawa,N., Ono,Y. and
            Kikkawa,U.
  TITLE     Molecular cloning and characterization of a novel protein kinase
            C-interacting protein with structural motifs related to RBCC family
            proteins
  JOURNAL   Biochem Biophys Res Commun 244 (2), 353-359 (1998)
   PUBMED   9514928
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U48248.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U48248.1, BC061723.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676811 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2350
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..2350
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; Pkcbpb15"
                     /note="RANBP2-type and C3HC4-type zinc finger containing
                     1"
                     /db_xref="GeneID:60383"
                     /db_xref="RGD:708404"
     exon            1..317
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; Pkcbpb15"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..1822
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; Pkcbpb15"
                     /EC_number="2.3.2.31"
                     /note="protein kinase C-binding protein beta-15;
                     ubiquitin-conjugating enzyme 7-interacting protein 3;
                     heme-oxidized IRP2 ubiquitin ligase 1 homolog; RBCC
                     protein interacting with PKC 1; protein kinase C-binding
                     protein Beta15; RanBP-type and C3HC4-type zinc finger
                     containing 1; RING-type E3 ubiquitin transferase HOIL-1"
                     /codon_start=1
                     /product="ranBP-type and C3HC4-type zinc finger-containing
                     protein 1"
                     /protein_id="NP_068532.2"
                     /db_xref="GeneID:60383"
                     /db_xref="RGD:708404"
                     /translation="MDEKTKKAEEMALSLARAVTGGDEQAAIKYATWLAEQKVPLRVQ
                     VKPEVSPTQDIRLCVSVEDAYMHTVTIWLTVRPDMTVASLKDMVFLDYGFPPSLQQWV
                     VGQRLARDQETLHSHGIRRNGDSAYLYLLSARNTSLNPQELQRQRQLRMLEDLGFKDL
                     TLQPRGPLEPVLPKPRTHQETGQPDAAPESPPVGWQCPGCTFINKPTRPGCEMCCRAR
                     PEAYQIPASYQPDEEERARLAGEEEALRQYEQRKQQQQEGNYLQHVQLEQRSLVLNTE
                     PAECPVCYSVLAPGEAVVLRECLHTFCRECLQGTIRNSQEAEVSCPFIDNTYSCPGKL
                     LEREIRALLSPEDYQRFLDLGVSIAENRSTLSYHCKTPDCRGWCFFEDDVNEFTCPVC
                     TRVNCLLCKAIHERMNCREYQDDLAHRARNDVAAQQTTEMLRVMLQQGEAMYCPQCRI
                     VVQKKDGCDWIRCTVCHTEICWVTKGPRWGPGGPGDTSGGCRCRVNGIPCHPSCQNCH
                     "
     exon            318..462
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; Pkcbpb15"
                     /inference="alignment:Splign:2.1.0"
     exon            463..556
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; Pkcbpb15"
                     /inference="alignment:Splign:2.1.0"
     exon            557..755
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; Pkcbpb15"
                     /inference="alignment:Splign:2.1.0"
     exon            756..871
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; Pkcbpb15"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1045
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; Pkcbpb15"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1206
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; Pkcbpb15"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1318
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; Pkcbpb15"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1498
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; Pkcbpb15"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1597
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; Pkcbpb15"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1741
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; Pkcbpb15"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..2331
                     /gene="Rbck1"
                     /gene_synonym="HOIL-1; Pkcbpb15"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcccgcccg cctccctccg tctcttgctt ttgggtcgtg gttacccatc gccctttgcg
       61 gccttggccc tgtgtctcct tcgctttctg tgttcctcgc agggccctac tgggtcccaa
      121 tgccagactt tggcccttcg gcagtgtgat gctgcccgag tgtagaccgg gacacacgca
      181 caaggccgac taggactgag ttgcttctgc cctccctccc tctcccaggt taccccaagg
      241 tagcgtttcc cggaagcagc agccctttct gaggggatgg gcgcagccag gccagatgga
      301 cgagaagacc aagaaagcag aggagatggc cctgagcctt gcccgggcag tgactggcgg
      361 agatgaacag gctgcaatca agtatgccac ctggctggca gagcagaagg tacccctcag
      421 ggtgcaagta aaacccgagg tttccccaac acaagacatc aggctttgtg tgagtgtgga
      481 agatgcttac atgcacactg tcaccatttg gctcacagta cgccctgata tgacagtggc
      541 ctcccttaag gacatggtat tcctggacta tggctttcca cccagcctgc agcagtgggt
      601 ggttggacag aggctggcac gagaccagga gaccttgcat tcacatggca ttcgacggaa
      661 tggagacagt gcttatctct acctgctgtc agcccgcaac acatcactca accctcaaga
      721 gctgcagcgg cagcggcagc tgcgcatgtt ggaagatttg ggcttcaagg acctcaccct
      781 gcagccacgg ggtcccttgg aacctgtcct tcccaagccc aggacccacc aggagacggg
      841 gcagccagat gcagccccag agtcaccacc ggtgggctgg cagtgccctg gctgcacgtt
      901 catcaacaaa cccacacggc ctgggtgtga gatgtgctgc cgtgcaaggc ctgaggccta
      961 ccagatccct gcctcgtacc agcctgatga ggaggagcga gcacgcctgg ctggtgagga
     1021 ggaggcgctg cgccagtatg agcagcggaa acagcagcag caggagggga actacctgca
     1081 gcacgtgcag ctggagcaga ggagcctggt gctgaacacc gaacctgctg agtgccctgt
     1141 gtgctactca gtgctggcac ccggtgaggc cgtggtgctg cgtgagtgtc tgcacacctt
     1201 ctgcagggag tgcctgcagg gtaccatccg aaacagccag gaggcggagg tatcctgccc
     1261 cttcattgac aacacctact catgccctgg caagctgctg gagagggaga tccgggcgct
     1321 cctgtcccct gaggactacc agcgtttcct ggacctgggt gtgtccatcg cagagaatcg
     1381 aagcaccttg agctaccact gcaagacccc cgactgcagg ggctggtgct tctttgagga
     1441 tgacgtcaac gagttcacct gtcctgtgtg cacccgcgtc aactgtctgc tctgcaaggc
     1501 catccacgag cgcatgaatt gcagagagta ccaggatgac ctggcccatc gggctcggaa
     1561 tgatgtggct gcccagcaga caactgagat gctgagggtg atgctgcagc aaggcgaggc
     1621 catgtactgc ccacagtgcc ggattgtggt gcagaagaag gatggctgtg actggatccg
     1681 ctgtactgtc tgccacactg agatctgctg ggtcaccaag ggtccacgct ggggccctgg
     1741 gggcccaggg gacaccagtg gtggctgccg ctgccgggtc aatgggattc catgccatcc
     1801 aagctgtcaa aactgccact aagtcaaaga tggtggctct cagactgacc cagccgcaca
     1861 tgtatagcag tgaacatcag ggccaggcca agggctttag ctctggtttg gccacaatac
     1921 cttcaagctt ggtaagggag aaagactgag ctgtactgca gtctgattgc tgtgttacaa
     1981 gaacccagct gagctgatgt cagccgcact gcctctgttg cttcaagggc ttgctgacca
     2041 gacctcatgg ccctgagcta gcttccctac ccttactagc caccagcctt aaacacagcc
     2101 ttggcctaag gcctggcggc tagtgctctg agcctcctgg tgactctatt tcccctcagc
     2161 ttgctccctg aggacccaca gccgcatctg ttgccttgct ggctttctgg gtacttttta
     2221 aagctgatgt gaatccatcc agggcccagg tagactggta ggtcaggaaa cagcccatgg
     2281 ggtccagctc tgcatccccc tctctaagtg aattaaagtg tttttccagg aaaaaaaaaa
     2341 aaaaaaaaaa
//
