LOCUS       NM_001134417            3135 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus RB binding protein 8, endonuclease (Rbbp8), mRNA.
ACCESSION   NM_001134417 XM_001072535 XM_214620
VERSION     NM_001134417.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3135)
  AUTHORS   Zhang,W., Song,Y., He,X., Liu,X., Zhang,Y., Yang,Z., Yang,P.,
            Wang,J., Hu,K., Liu,W., Zhang,X., Yuan,X. and Jing,H.
  TITLE     Prognosis value of RBBP8 expression in plasma cell myeloma
  JOURNAL   Cancer Gene Ther 27 (1-2), 22-29 (2020)
   PUBMED   30622325
REFERENCE   2  (bases 1 to 3135)
  AUTHORS   Baude,A., Aaes,T.L., Zhai,B., Al-Nakouzi,N., Oo,H.Z., Daugaard,M.,
            Rohde,M. and Jaattela,M.
  TITLE     Hepatoma-derived growth factor-related protein 2 promotes DNA
            repair by homologous recombination
  JOURNAL   Nucleic Acids Res 44 (5), 2214-2226 (2016)
   PUBMED   26721387
REFERENCE   3  (bases 1 to 3135)
  AUTHORS   Davies,O.R., Forment,J.V., Sun,M., Belotserkovskaya,R., Coates,J.,
            Galanty,Y., Demir,M., Morton,C.R., Rzechorzek,N.J., Jackson,S.P.
            and Pellegrini,L.
  TITLE     CtIP tetramer assembly is required for DNA-end resection and repair
  JOURNAL   Nat Struct Mol Biol 22 (2), 150-157 (2015)
   PUBMED   25558984
REFERENCE   4  (bases 1 to 3135)
  AUTHORS   Panier,S. and Boulton,S.J.
  TITLE     Double-strand break repair: 53BP1 comes into focus
  JOURNAL   Nat Rev Mol Cell Biol 15 (1), 7-18 (2014)
   PUBMED   24326623
  REMARK    Review article
REFERENCE   5  (bases 1 to 3135)
  AUTHORS   Rajendran,P., Kidane,A.I., Yu,T.W., Dashwood,W.M., Bisson,W.H.,
            Lohr,C.V., Ho,E., Williams,D.E. and Dashwood,R.H.
  TITLE     HDAC turnover, CtIP acetylation and dysregulated DNA damage
            signaling in colon cancer cells treated with sulforaphane and
            related dietary isothiocyanates
  JOURNAL   Epigenetics 8 (6), 612-623 (2013)
   PUBMED   23770684
REFERENCE   6  (bases 1 to 3135)
  AUTHORS   Huertas,P., Cortes-Ledesma,F., Sartori,A.A., Aguilera,A. and
            Jackson,S.P.
  TITLE     CDK targets Sae2 to control DNA-end resection and homologous
            recombination
  JOURNAL   Nature 455 (7213), 689-692 (2008)
   PUBMED   18716619
REFERENCE   7  (bases 1 to 3135)
  AUTHORS   Oswald,F., Winkler,M., Cao,Y., Astrahantseff,K., Bourteele,S.,
            Knochel,W. and Borggrefe,T.
  TITLE     RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch
            target genes
  JOURNAL   Mol Cell Biol 25 (23), 10379-10390 (2005)
   PUBMED   16287852
REFERENCE   8  (bases 1 to 3135)
  AUTHORS   Chen,P.L., Liu,F., Cai,S., Lin,X., Li,A., Chen,Y., Gu,B., Lee,E.Y.
            and Lee,W.H.
  TITLE     Inactivation of CtIP leads to early embryonic lethality mediated by
            G1 restraint and to tumorigenesis by haploid insufficiency
  JOURNAL   Mol Cell Biol 25 (9), 3535-3542 (2005)
   PUBMED   15831459
REFERENCE   9  (bases 1 to 3135)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   10 (bases 1 to 3135)
  AUTHORS   Rho,J.Y., Wada-Kiyama,Y., Onishi,Y., Kiyama,R. and Sakuma,Y.
  TITLE     Expressional regulation of neuronal and cancer-related genes by
            estrogen in adult female rats
  JOURNAL   Endocr Res 30 (2), 257-267 (2004)
   PUBMED   15473135
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC162012.1.
            
            On or before Aug 29, 2008 this sequence version replaced
            XM_001072535.1, XM_214620.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC162012.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3135
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p13"
     gene            1..3135
                     /gene="Rbbp8"
                     /gene_synonym="CtIP; RBBP-8; RGD1308872; RIM; SAE2"
                     /note="RB binding protein 8, endonuclease"
                     /db_xref="GeneID:291787"
                     /db_xref="RGD:1308872"
     exon            1..167
                     /gene="Rbbp8"
                     /gene_synonym="CtIP; RBBP-8; RGD1308872; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            168..371
                     /gene="Rbbp8"
                     /gene_synonym="CtIP; RBBP-8; RGD1308872; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..2944
                     /gene="Rbbp8"
                     /gene_synonym="CtIP; RBBP-8; RGD1308872; RIM; SAE2"
                     /note="ctBP-interacting protein; sporulation in the
                     absence of SPO11 protein 2 homolog; retinoblastoma binding
                     protein 8"
                     /codon_start=1
                     /product="DNA endonuclease RBBP8"
                     /protein_id="NP_001127889.1"
                     /db_xref="GeneID:291787"
                     /db_xref="RGD:1308872"
                     /translation="MSISGSSCGSPNSTDISSDFKELWTKLKEYHDKEVQGLQIKVTK
                     LKKERILDAQRLEEFFTKNQQLRDQQKVLQETIKILEDRLRAGLCDRCAVTEEHMHKK
                     QQEFENIRQQNLRLITELMNEKSALQEENKKLSEQLQQKMESGQQDQVAELECEENII
                     PDSPITSFSFSGINRLRRKENLHVRYVEQTHTKLEHSACTSELRKFSKGSTPAPVNSE
                     EHEILVADTCDQSHSPLSKICGTSSYPADKLSSNLDAVVAETLGLDGQEESEPQGPVS
                     PLGNELYHCLKEDHKKQPFMESAIRNEDNVRFSDSASKAPPRELTTRGSSPVFGPTST
                     VKTHLGLKTSFSPSLLDSGKKNLLSTAPFSSISVSRSEKVRSKSEDNALFTQQSAGSE
                     VKVISQSFPSKQILTSKNVSDSVDEQGGADHMKDAVSDKHLVPLKSLGGKASKRKRTE
                     EEGEHAVHCPQTCFDKENALPFPMENQFPVNGDHVMDKPLDLSDRFAANQRQEKNHGD
                     ETCKHKLKQVTIYEALKPVPKGSSSGRKALSGACTLAQDSAETYCLQQRTLQCSSKFS
                     PDHNTQLQIKEENPVFKTPPRSQESLETENLFGDVKGIGSLVPIKVKGRSAHGGCELA
                     SVLQLNPCRVAKTKSLPSNHDMSFENIQWSVDPGADLSQYKMDVTVIDTKDSSHSRLG
                     GETVDMDCTLVSETMLLKMKKQEQREKSPNGDIKMNDSLEDMFDRTTHEEYESCLADN
                     FSQVPDEEELSDTTKKPNIHGDKQDGIKQKAFVEPYFKDKERETSIQNFPHIEVVRKK
                     EERRKLLGHTCKECEIYYADLPAEEREKKLASCSRHRFRYIPTNTPENFWEVGFPSTQ
                     TCLERGYIKEDLDPCPRPKRRQPYNAVFSPKGKEQRT"
     exon            372..414
                     /gene="Rbbp8"
                     /gene_synonym="CtIP; RBBP-8; RGD1308872; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            415..510
                     /gene="Rbbp8"
                     /gene_synonym="CtIP; RBBP-8; RGD1308872; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            511..623
                     /gene="Rbbp8"
                     /gene_synonym="CtIP; RBBP-8; RGD1308872; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            624..690
                     /gene="Rbbp8"
                     /gene_synonym="CtIP; RBBP-8; RGD1308872; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            691..866
                     /gene="Rbbp8"
                     /gene_synonym="CtIP; RBBP-8; RGD1308872; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            867..971
                     /gene="Rbbp8"
                     /gene_synonym="CtIP; RBBP-8; RGD1308872; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1069
                     /gene="Rbbp8"
                     /gene_synonym="CtIP; RBBP-8; RGD1308872; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1182
                     /gene="Rbbp8"
                     /gene_synonym="CtIP; RBBP-8; RGD1308872; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..2068
                     /gene="Rbbp8"
                     /gene_synonym="CtIP; RBBP-8; RGD1308872; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2195
                     /gene="Rbbp8"
                     /gene_synonym="CtIP; RBBP-8; RGD1308872; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2284
                     /gene="Rbbp8"
                     /gene_synonym="CtIP; RBBP-8; RGD1308872; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2396
                     /gene="Rbbp8"
                     /gene_synonym="CtIP; RBBP-8; RGD1308872; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2537
                     /gene="Rbbp8"
                     /gene_synonym="CtIP; RBBP-8; RGD1308872; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2538..2607
                     /gene="Rbbp8"
                     /gene_synonym="CtIP; RBBP-8; RGD1308872; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2704
                     /gene="Rbbp8"
                     /gene_synonym="CtIP; RBBP-8; RGD1308872; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2846
                     /gene="Rbbp8"
                     /gene_synonym="CtIP; RBBP-8; RGD1308872; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..3113
                     /gene="Rbbp8"
                     /gene_synonym="CtIP; RBBP-8; RGD1308872; RIM; SAE2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcactagcc tttgtgtcca cagagacccg ggagacaaga tgagtgttgt gagagagaag
       61 ggctcagtgc gcagcgaata acggttcaga gcaaaaagat tggctgcaaa gtgctgagcg
      121 agcgtactag atggaaagga tgctgtgagc cgaaatttgc aaacatggta tttcaacaat
      181 ccaaagacaa cgtcacacct atgtaaggac acaaaggtca ggcgagcatc aacaaaaaga
      241 agtgtggagc cgggtaagca agatgagcat ttcaggaagc agctgtggaa gccctaattc
      301 cacagatata tccagtgact tcaaggagct ctggacaaaa ctaaaagaat atcatgataa
      361 ggaagtacaa ggtttacaaa tcaaagtaac caaactgaaa aaggaaagaa ttttagatgc
      421 acagagacta gaagaattct tcaccaaaaa tcaacagctg agagaccagc aaaaagttct
      481 tcaggaaacc attaaaattt tagaagatag gttaagagca ggactgtgtg atcgctgtgc
      541 agtaactgaa gagcatatgc acaaaaagca gcaggagttt gaaaacatcc gacagcagaa
      601 ccttaggctt atcacagagc tcatgaatga aaagagcgct cttcaggaag aaaacaaaaa
      661 gctttctgag caactgcaac agaaaatgga aagtggtcaa caggatcaag tagctgagct
      721 tgaatgtgag gaaaacatta ttccagactc accgataact tccttttcct tttctggcat
      781 taaccgccta cgaagaaagg agaatctcca tgtccgatac gttgaacaaa cgcacactaa
      841 attggagcac tctgcatgta caagtgaatt aagaaagttt tccaagggtt caactcctgc
      901 accagttaac tctgaggaac atgaaattct agtagccgac acttgtgatc agagtcattc
      961 tccactgtct aaaatatgtg gaacaagcag ttaccccgct gacaagttat cttctaactt
     1021 agatgctgtt gttgctgaga cgcttggact tgatggtcaa gaagaatctg aaccccaagg
     1081 tcctgtgagc cctcttggaa atgagctcta ccactgtctc aaagaagatc acaaaaaaca
     1141 gccttttatg gaatctgcaa taaggaacga agataacgta aggttttcag actctgcttc
     1201 aaaggcccct ccccgagaac tcactactcg ggggtcatct cccgtgtttg gacctacctc
     1261 taccgtgaaa actcatttgg gtttgaaaac aagtttctcc ccttcactct tagacagtgg
     1321 gaaaaaaaac cttctgagca cagctccctt tagcagcatt tctgtttcta gatcagagaa
     1381 agttagatcc aaatcagagg ataatgccct tttcacacaa caaagtgctg ggtctgaggt
     1441 aaaggtcatc agccagtcat ttcctagtaa gcagattctt acaagtaaaa acgttagtga
     1501 ctctgtcgac gagcagggtg gtgctgatca catgaaagat gctgttagtg ataaacacct
     1561 ggtgcctttg aaatcactgg gaggcaaagc gtccaaaagg aagaggactg aggaagaggg
     1621 tgagcacgca gtacactgcc cgcagacctg ttttgataag gaaaatgccc ttccttttcc
     1681 aatggagaat cagttccctg tgaatggaga ccatgtgatg gataaacctc tggacctgtc
     1741 agatcggttt gcagctaatc agcgtcaaga gaagaaccac ggggatgaaa cttgcaaaca
     1801 caaacttaag caagtgacta tttatgaggc tctgaagccc gttcccaagg gctcctcctc
     1861 aggccgcaag gccttgagtg gggcctgcac actagcccaa gactctgcag agacatactg
     1921 cttacagcag cgcaccctcc agtgctctag taaattctct ccagaccata acactcaatt
     1981 acagataaaa gaagaaaatc ctgttttcaa aacacctcca cgttcacagg aaagtttgga
     2041 gacagagaat ctttttggtg atgtgaaggg tattgggtct cttgtgccaa taaaagtaaa
     2101 aggcagatca gcccatggag gatgtgagct tgcatcagtt cttcagttaa acccctgcag
     2161 agttgctaag acaaagtctc tgcccagcaa ccacgatatg tcatttgaaa atatccagtg
     2221 gagtgtagat ccgggagcag acctttctca atataaaatg gatgttactg tgatagatac
     2281 aaaggacagc agtcactcac gactgggagg agagacagtg gacatggact gtacattggt
     2341 cagtgaaacc atgcttttaa aaatgaagaa acaagaacaa agagagaaaa gtccaaatgg
     2401 agacataaaa atgaatgata gcttggaaga tatgtttgat cggacaacac atgaagaata
     2461 tgaatcctgc ttggcagata acttctccca ggtaccagat gaggaagaat tgtctgatac
     2521 cacaaagaaa cctaacatac acggtgataa acaagatgga atcaagcaga aagcatttgt
     2581 ggagccatat tttaaagata aggagagaga aactagcata cagaattttc ctcatattga
     2641 ggtagttcgg aaaaaagaag aaagaaggaa attgcttggg cacacatgta aagaatgtga
     2701 aatttattac gcagatttgc cagcagaaga aagagaaaag aagttggctt cctgctcaag
     2761 acaccgattt cgctacattc caaccaacac accagagaat ttctgggaag ttggttttcc
     2821 ttctactcag acgtgtctgg aaaggggtta tatcaaggaa gatctcgatc cttgtcctcg
     2881 tcccaaaaga cggcagcctt acaacgcagt cttttctcca aagggcaaag aacagaggac
     2941 ctagacactg cagtgagggc aggggagcag gcctttttgt gtttcattta gttatttata
     3001 gttaaagttg gaacaaacat tgatctttga tttttcttct ataaattgat ttataaatgt
     3061 tttctattaa aaatgttcta aatggcaaat actaaacata caaataacta aaaaaaaaaa
     3121 aaaaaaaaaa aaaaa
//
