LOCUS       NM_001107174            3852 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus RB binding protein 5, histone lysine
            methyltransferase complex subunit (Rbbp5), mRNA.
ACCESSION   NM_001107174 XM_001060117 XM_222669
VERSION     NM_001107174.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3852)
  AUTHORS   Ravnskjaer,K., Hogan,M.F., Lackey,D., Tora,L., Dent,S.Y.,
            Olefsky,J. and Montminy,M.
  TITLE     Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated
            epigenetic effects
  JOURNAL   J Clin Invest 123 (10), 4318-4328 (2013)
   PUBMED   24051374
REFERENCE   2  (bases 1 to 3852)
  AUTHORS   Shilatifard A.
  TITLE     The COMPASS family of histone H3K4 methylases: mechanisms of
            regulation in development and disease pathogenesis
  JOURNAL   Annu Rev Biochem 81, 65-95 (2012)
   PUBMED   22663077
  REMARK    Review article
REFERENCE   3  (bases 1 to 3852)
  AUTHORS   Patel A, Dharmarajan V, Vought VE and Cosgrove MS.
  TITLE     On the mechanism of multiple lysine methylation by the human mixed
            lineage leukemia protein-1 (MLL1) core complex
  JOURNAL   J Biol Chem 284 (36), 24242-24256 (2009)
   PUBMED   19556245
REFERENCE   4  (bases 1 to 3852)
  AUTHORS   Wu M, Wang PF, Lee JS, Martin-Brown S, Florens L, Washburn M and
            Shilatifard A.
  TITLE     Molecular regulation of H3K4 trimethylation by Wdr82, a component
            of human Set1/COMPASS
  JOURNAL   Mol Cell Biol 28 (24), 7337-7344 (2008)
   PUBMED   18838538
REFERENCE   5  (bases 1 to 3852)
  AUTHORS   Lee JH and Skalnik DG.
  TITLE     Wdr82 is a C-terminal domain-binding protein that recruits the
            Setd1A Histone H3-Lys4 methyltransferase complex to transcription
            start sites of transcribed human genes
  JOURNAL   Mol Cell Biol 28 (2), 609-618 (2008)
   PUBMED   17998332
REFERENCE   6  (bases 1 to 3852)
  AUTHORS   Mo R, Rao SM and Zhu YJ.
  TITLE     Identification of the MLL2 complex as a coactivator for estrogen
            receptor alpha
  JOURNAL   J Biol Chem 281 (23), 15714-15720 (2006)
   PUBMED   16603732
REFERENCE   7  (bases 1 to 3852)
  AUTHORS   Dou Y, Milne TA, Tackett AJ, Smith ER, Fukuda A, Wysocka J, Allis
            CD, Chait BT, Hess JL and Roeder RG.
  TITLE     Physical association and coordinate function of the H3 K4
            methyltransferase MLL1 and the H4 K16 acetyltransferase MOF
  JOURNAL   Cell 121 (6), 873-885 (2005)
   PUBMED   15960975
REFERENCE   8  (bases 1 to 3852)
  AUTHORS   Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I,
            Herr W and Cleary ML.
  TITLE     Leukemia proto-oncoprotein MLL forms a SET1-like histone
            methyltransferase complex with menin to regulate Hox gene
            expression
  JOURNAL   Mol Cell Biol 24 (13), 5639-5649 (2004)
   PUBMED   15199122
REFERENCE   9  (bases 1 to 3852)
  AUTHORS   Hughes CM, Rozenblatt-Rosen O, Milne TA, Copeland TD, Levine SS,
            Lee JC, Hayes DN, Shanmugam KS, Bhattacharjee A, Biondi CA, Kay GF,
            Hayward NK, Hess JL and Meyerson M.
  TITLE     Menin associates with a trithorax family histone methyltransferase
            complex and with the hoxc8 locus
  JOURNAL   Mol Cell 13 (4), 587-597 (2004)
   PUBMED   14992727
REFERENCE   10 (bases 1 to 3852)
  AUTHORS   Ginger MR, Gonzalez-Rimbau MF, Gay JP and Rosen JM.
  TITLE     Persistent changes in gene expression induced by estrogen and
            progesterone in the rat mammary gland
  JOURNAL   Mol Endocrinol 15 (11), 1993-2009 (2001)
   PUBMED   11682629
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473958.2.
            
            [WARNING] On May 2, 2024 this sequence was replaced by
            NM_001107174.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_222669.4, XM_001060117.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132263 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3852
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..3852
                     /gene="Rbbp5"
                     /note="RB binding protein 5, histone lysine
                     methyltransferase complex subunit"
                     /db_xref="GeneID:304794"
                     /db_xref="RGD:1305532"
     exon            1..388
                     /gene="Rbbp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             370..1986
                     /gene="Rbbp5"
                     /codon_start=1
                     /product="retinoblastoma-binding protein 5"
                     /protein_id="NP_001100644.1"
                     /db_xref="GeneID:304794"
                     /db_xref="RGD:1305532"
                     /translation="MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCN
                     DGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQ
                     RFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFD
                     RRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTA
                     DRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHAL
                     YIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAP
                     DFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEE
                     LEDSKALLYLPIAPEVEDPEENPYGPPPDAVPTSLMDEGASSEKKRQSSADGSQPPKK
                     KPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDR
                     GLPLEGSTKGKVQAGLSQPLAAGGAISELL"
     exon            389..414
                     /gene="Rbbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            415..587
                     /gene="Rbbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            588..728
                     /gene="Rbbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            729..891
                     /gene="Rbbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1001
                     /gene="Rbbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1121
                     /gene="Rbbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1275
                     /gene="Rbbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1347
                     /gene="Rbbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1465
                     /gene="Rbbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1535
                     /gene="Rbbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1765
                     /gene="Rbbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1957
                     /gene="Rbbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..3852
                     /gene="Rbbp5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgggttagt gatatgcctg aaatttcttt ctcacttaca tggtcccgga gagaaaagct
       61 tcccattctt gaactttctg gagttctgaa tgactatgat atttttcata tctcaataat
      121 attacaattg attgatttaa agagcgttta atcttttttt aaattaggga taaatgtgga
      181 cagctacgta aaacgaacaa ggaaggcggg ggaggaaagc ggaagccgcg gggccttcta
      241 aatacgaaag tctccggagc ttgcgccagg ctcttcgcgg cgccccccac ttagacgcgg
      301 ggcttctgag cgggtggggg agaaggaact gttgccggtg cggagaccag gcggccagcg
      361 tctgcaggga tgaacctcga gttgctggag tcctttggac agaactatcc agaggaagct
      421 gatggaactt tggattgcat cagcatggcc ctgacttgca cctttaacag gtggggcaca
      481 ctgcttgctg ttggctgtaa cgatggccga attgttattt gggatttctt gacaagaggc
      541 attgctaaaa taattagtgc acacatccat ccagtctgtt ctttgtgttg gagtcgagat
      601 ggtcataagc tcgtgagtgc ttctacagat aacatagtgt cacagtggga tgttctttct
      661 ggagattgcg accagaggtt tcgattccct tcacccatct taaaagtcca atatcatcct
      721 cgagatcaga acaaggttct cgtgtgtccc atgaaatctg ctcctgtcat gttgaccctt
      781 tcagattcca aacatgttgt tctgccggta gacgatgact cggatttgaa cgtggtggca
      841 tcttttgata ggcgagggga atatatttat acaggaaatg caaaaggcaa gatcttggtc
      901 ctaaaaacag actctcagga tcttgttgct tccttcagag taacaacggg aacaagcaat
      961 accacagcca ttaagtctat tgagtttgcc cgaaagggga gttgcttcct gattaacaca
     1021 gcagatcgaa taatcagagt ttatgacggc agagagattt taacgtgtgg acgggacgga
     1081 gagcctgagc ctatgcagaa actgcaggac ttggtgaaca ggactccatg gaaaaaatgt
     1141 tgcttctctg gggatgggga gtacatagtg gcaggctcag cgaggcagca tgcgctgtat
     1201 atctgggaaa agagcattgg caatctggtg aagatcttgc atgggaccag aggggagctc
     1261 ctgctggacg tggcttggca tccagttcga cccatcatag cttctatttc tagtggagtg
     1321 gtgtccattt gggcccaaaa tcaagtagaa aattggagtg catttgcacc agatttcaaa
     1381 gagttggatg aaaatgtaga atatgaggaa agagaatcag aatttgatat tgaggacgaa
     1441 gataagagtg agcctgagca aacaggggct gatgctgctg aagatgagga agtggatgtc
     1501 accagtgtgg atcccattgc tgccttctgt agcagtgatg aagagctgga agattcaaag
     1561 gctctattgt atttacccat tgcccctgag gtagaagacc ctgaagagaa tccgtatggc
     1621 cccccaccgg atgcagtccc aacctccttg atggatgaag gggctagctc agagaagaag
     1681 aggcagtctt cagcagacgg gtcccagcct ccaaagaaga aacctaaaac gaccaatata
     1741 gagctccaag gagtgccgaa tgacgaagtc catccactgc tgggtgtgaa gggggatggc
     1801 aaatccaaga agaagcaagc aggccggcct aaaggatcaa aaggtaaaga gaaagattct
     1861 ccatttaaac cgaaactcta caaaggggac agaggtttac ctctggaagg atcaacgaag
     1921 ggtaaagtgc aggcgggact cagccagccc ttggcagcag gaggagcaat ctcagaactg
     1981 ctatgaagac cgggaaactc ttggttctcc tcactctgtc gtcaggtagc ctttggacag
     2041 tatggccaat catctgagat tggccttagt tgaaaacaaa ggcctctgcc tcccacccag
     2101 gaggtgaagg agtggatcct atgtttgaat gaagaagtga attatggaag aagagcacac
     2161 gtccccgcct tccctttcaa gcataagtcc aaataggctc tcaggaacga ggatgcatgc
     2221 agacatcggg agatttgacc cgcttccacc tacacgaggt ggtgttgctg gtgaagaatg
     2281 ccgtgttttg ttcacctaac tgttgaagtc acatctttgg acatgtcctt tcccacctcc
     2341 tgtttgcctt ccatcctcag tgcatgtcct caagtgactt gttcttttct caaaatttgc
     2401 taccagtacc taggaagact gacacatttt ctgtttcttt catttataac tttcccctcc
     2461 cagatgcttc ctgtatttct atattgtgta taaaggttgg gcagagaagc aagtgctcaa
     2521 aagatttcaa gctgacagga aggaagatcg aaggccccat cactctgtct taccgtaacc
     2581 tttgctcagg aggctgggct ctagagaatc aggggtttcc cttgcattgc atgttttcca
     2641 ggatcagatg tttgaataat catggctttt ggatatgatt agttttatcc atctccagct
     2701 aagactcatc agtagtttgt gtgttacttt acctgtgttg acttccagag ttggaaacaa
     2761 agcaaggtgt gtttctccac aaggttcttt ctgtgggtgt ggggtactgt gcaagggctg
     2821 acttgaggcc ccaaatcaaa gcaacagcag ctcacttcag tcaggttcgt gcgtgtgcgt
     2881 gcgtgtgtta aatcattgcc tgtggagagc ttgtccccgg cagccatggt gtggtctttc
     2941 ctggagccac gtccccttta ctgtcttttc actcacttcc tttctgtgaa aggttgctta
     3001 gctttttacc cttctctttc tcactctggc tctctctgta tttgctgttc ttttaataaa
     3061 aatagcaaat taaatggatt tgtacaataa gtgtttgaaa ttttctgaaa atccaaagtc
     3121 aggaagccaa gtgtgcaaag ggttagtggc ctctggcgat agctttgact tgccctgggt
     3181 catactctct cagcactgaa aggaggtttg aatactgtgc taattgtgaa atctctatca
     3241 gttggtggag gctccttcag atagccaaac ccgtcgatta catttactgt ggggtagagg
     3301 tggcagggga cacggccgga agtctccagt gtcgtgctgg tgctgcttcc tcaagtgagt
     3361 gagaccaatg gttgtgattg gtaagtggct cacaggacat gttttaattt gtagacatta
     3421 tatccatgtc atgtctcttt acagcacacc acagtggtgt gcacaccgat acaggggttt
     3481 ctgccttgtg tgtgtgtgaa gtggcttgat ttcctccatc gggatgctaa tgctgtgtcc
     3541 atttccacta aggagctacc gagtaaatcg gctcaaaccc tgccaggtcg tctctggcag
     3601 cagctcctaa taactatttg tgcttttgga atcttttcgt cagcttctag aaccttccat
     3661 ccactttcag ctcggatttc tcatttgtgt aatatatgta tatttccttc ttgccgtcat
     3721 cctccccgcc tctccatttt atttcttaaa aatgttctgt agttttgtac aagatgagac
     3781 ttagccttgg gtaacttctt gctaaagctt taatgctttg taaataaaat tggatgttta
     3841 tcaaaccaca ag
//
