LOCUS       NM_017045               4694 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus RB transcriptional corepressor 1 (Rb1), mRNA.
ACCESSION   NM_017045 XM_001071121 XM_344434
VERSION     NM_017045.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4694)
  AUTHORS   Sadek,K., Abouzed,T., Nasr,S. and Shoukry,M.
  TITLE     Licochalcone B Ameliorates Liver Cancer via Targeting of Apoptotic
            Genes, DNA Repair Systems, and Cell Cycle Control
  JOURNAL   Iran J Pharm Res 19 (4), 372-386 (2020)
   PUBMED   33841550
REFERENCE   2  (bases 1 to 4694)
  AUTHORS   Freytsis,M., Baugh,L., Liu,Z., Georgakoudi,I., Hinds,P.W.,
            Black,L.D. and Huggins,G.S.
  TITLE     Conditional deletion of RB1 in the Tie2 lineage leads to aortic
            valve regurgitation
  JOURNAL   PLoS One 13 (1), e0190623 (2018)
   PUBMED   29304157
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4694)
  AUTHORS   Hille,S., Dierck,F., Kuhl,C., Sosna,J., Adam-Klages,S., Adam,D.,
            Lullmann-Rauch,R., Frey,N. and Kuhn,C.
  TITLE     Dyrk1a regulates the cardiomyocyte cell cycle via
            D-cyclin-dependent Rb/E2f-signalling
  JOURNAL   Cardiovasc Res 110 (3), 381-394 (2016)
   PUBMED   27056896
  REMARK    GeneRIF: Identify Dyrk1a as a novel negative regulator of
            D-cyclin-mediated Rb1/E2f-signalling. As dysregulation of this
            pathway with impaired cardiomyocyte proliferation leads to
            cardiomyopathy.
REFERENCE   4  (bases 1 to 4694)
  AUTHORS   Miles,W.O., Korenjak,M., Griffiths,L.M., Dyer,M.A., Provero,P. and
            Dyson,N.J.
  TITLE     Post-transcriptional gene expression control by NANOS is
            up-regulated and functionally important in pRb-deficient cells
  JOURNAL   EMBO J 33 (19), 2201-2215 (2014)
   PUBMED   25100735
REFERENCE   5  (bases 1 to 4694)
  AUTHORS   Reed,C., Hutcheson,J., Mayhew,C.N., Witkiewicz,A.K. and
            Knudsen,E.S.
  TITLE     RB tumor suppressive function in response to xenobiotic
            hepatocarcinogens
  JOURNAL   Am J Pathol 184 (6), 1853-1859 (2014)
   PUBMED   24726645
REFERENCE   6  (bases 1 to 4694)
  AUTHORS   Esumi,M., Idutsu,T., Kinugasa,S., Ohno,M., Nakabayashi,H., Ikeda,T.
            and Shikata,T.
  TITLE     Isolation and sequence polymorphism of a rat retinoblastoma (RB)
            cDNA
  JOURNAL   Gene 161 (2), 231-235 (1995)
   PUBMED   7665085
REFERENCE   7  (bases 1 to 4694)
  AUTHORS   Beijersbergen,R.L., Carlee,L., Kerkhoven,R.M. and Bernards,R.
  TITLE     Regulation of the retinoblastoma protein-related p107 by G1 cyclin
            complexes
  JOURNAL   Genes Dev 9 (11), 1340-1353 (1995)
   PUBMED   7797074
REFERENCE   8  (bases 1 to 4694)
  AUTHORS   Lee,E.Y., Hu,N., Yuan,S.S., Cox,L.A., Bradley,A., Lee,W.H. and
            Herrup,K.
  TITLE     Dual roles of the retinoblastoma protein in cell cycle regulation
            and neuron differentiation
  JOURNAL   Genes Dev 8 (17), 2008-2021 (1994)
   PUBMED   7958874
REFERENCE   9  (bases 1 to 4694)
  AUTHORS   Pahel,G., Aulabaugh,A., Short,S.A., Barnes,J.A., Painter,G.R.,
            Ray,P. and Phelps,W.C.
  TITLE     Structural and functional characterization of the HPV16 E7 protein
            expressed in bacteria
  JOURNAL   J Biol Chem 268 (34), 26018-26025 (1993)
   PUBMED   8245034
REFERENCE   10 (bases 1 to 4694)
  AUTHORS   Spandidos,D.A., Karaiossifidi,H., Malliri,A., Linardopoulos,S.,
            Vassilaros,S., Tsikkinis,A. and Field,J.K.
  TITLE     Expression of ras Rb1 and p53 proteins in human breast cancer
  JOURNAL   Anticancer Res 12 (1), 81-89 (1992)
   PUBMED   1567185
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Nov 27, 2020 this sequence version replaced NM_017045.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D25233.1, SRR26643429.49154.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-292               JAXUCZ010000015.1  54911566-54911857   c
            293-419             JAXUCZ010000015.1  54908116-54908242   c
            420-535             JAXUCZ010000015.1  54887837-54887952   c
            536-655             JAXUCZ010000015.1  54884749-54884868   c
            656-694             JAXUCZ010000015.1  54878317-54878355   c
            695-762             JAXUCZ010000015.1  54877253-54877320   c
            763-873             JAXUCZ010000015.1  54872086-54872196   c
            874-1016            JAXUCZ010000015.1  54867638-54867780   c
            1017-1094           JAXUCZ010000015.1  54865742-54865819   c
            1095-1204           JAXUCZ010000015.1  54863990-54864099   c
            1205-1282           JAXUCZ010000015.1  54863003-54863080   c
            1283-1370           JAXUCZ010000015.1  54859334-54859421   c
            1371-1487           JAXUCZ010000015.1  54853519-54853635   c
            1488-1544           JAXUCZ010000015.1  54852809-54852865   c
            1545-1576           JAXUCZ010000015.1  54852688-54852719   c
            1577-1653           JAXUCZ010000015.1  54852530-54852606   c
            1654-1850           JAXUCZ010000015.1  54850770-54850966   c
            1851-1966           JAXUCZ010000015.1  54803368-54803483   c
            1967-2112           JAXUCZ010000015.1  54800982-54801127   c
            2113-2258           JAXUCZ010000015.1  54799688-54799833   c
            2259-2363           JAXUCZ010000015.1  54793298-54793402   c
            2364-2477           JAXUCZ010000015.1  54792122-54792235   c
            2478-2641           JAXUCZ010000015.1  54791856-54792019   c
            2642-2672           JAXUCZ010000015.1  54788872-54788902   c
            2673-2815           JAXUCZ010000015.1  54784545-54784687   c
            2816-2865           JAXUCZ010000015.1  54783898-54783947   c
            2866-4694           JAXUCZ010000015.1  54780858-54782686   c
FEATURES             Location/Qualifiers
     source          1..4694
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q11"
     gene            1..4694
                     /gene="Rb1"
                     /note="RB transcriptional corepressor 1"
                     /db_xref="GeneID:24708"
                     /db_xref="RGD:3540"
     exon            1..292
                     /gene="Rb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..2939
                     /gene="Rb1"
                     /note="pRb; pp105; Retinoblastoma 1 (including
                     osteosarcoma); retinoblastoma protein"
                     /codon_start=1
                     /product="retinoblastoma-associated protein"
                     /protein_id="NP_058741.2"
                     /db_xref="GeneID:24708"
                     /db_xref="RGD:3540"
                     /translation="MPPKAPRRTAAAEPPPPPPPPPEDDPAQDSDPEELPLIRLEFEK
                     IEEPEFIALCQKLKVPDHVRERAWLTWEKVSSVDGILEGYIQKKKELWGICIFIAAVD
                     LDEMPFTFTELQKSIETSVYKFFDLLKEIDTSTKVDNAVSRLLKKYNVLCALYSKLER
                     TCGLIYLTQPSSGLSTEINSMLVLKVSWITFLLAKGEVVQMEDDLVISFQLMLCVLDY
                     FIKLSPPALLREPYKTAATPINGSPRTPRRGQNRSARIAKQLESDTRTIEVLCKEHEC
                     NVDEVKNVYFKNFIPFISSLGIVSSNGLPELESLSKRYEEVYLKSKDLDARLFLDHDK
                     TLQTDTIDSFETERTPRKSNPDEEANMVTPHTPVRTVMNTIQQLMVILNSASDQPSEN
                     LISYFSNCTVNPKENILKRVKDVGHIFKEKFASAVGQGCIDIGAQRYKLGVRLYYRVM
                     ESMLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYSRSMLQNLDSGTDLSFP
                     WILNVLNLKAFDFYKVIESFIKVEANLTREMIKHLERCEHRIMESLAWLSDSPLFDLI
                     KQSKDGEGPDHLESACSLSLPLQSNHTAADMYLSPIRSPKKRTSTTRVNSAANTETQA
                     ASAFHTQKPLKSTSLSLFYKKVYRLAYLRLNTLCARLLSDHPELEHIIWTLFQHTLEN
                     EYELMKDRHLDQIMMCSMYGICKVKNIDLKFKIIVTAYKDLPHAAQETFKRVLIREEE
                     FDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFSSSPLRIPGGNIYI
                     SPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAE
                     GGNPPKPLKKLRFDIEGSDEADGSKHLPAESKFQQKLAEMTSTRTRMQKQKLNDSMEI
                     SNKEEK"
     exon            293..419
                     /gene="Rb1"
                     /inference="alignment:Splign:2.1.0"
     exon            420..535
                     /gene="Rb1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..655
                     /gene="Rb1"
                     /inference="alignment:Splign:2.1.0"
     exon            656..694
                     /gene="Rb1"
                     /inference="alignment:Splign:2.1.0"
     exon            695..762
                     /gene="Rb1"
                     /inference="alignment:Splign:2.1.0"
     exon            763..873
                     /gene="Rb1"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1016
                     /gene="Rb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1094
                     /gene="Rb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1204
                     /gene="Rb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1282
                     /gene="Rb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1370
                     /gene="Rb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1487
                     /gene="Rb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1544
                     /gene="Rb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1576
                     /gene="Rb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1653
                     /gene="Rb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1850
                     /gene="Rb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1966
                     /gene="Rb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2112
                     /gene="Rb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2258
                     /gene="Rb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2363
                     /gene="Rb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2477
                     /gene="Rb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..2641
                     /gene="Rb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2672
                     /gene="Rb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..2815
                     /gene="Rb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..2865
                     /gene="Rb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..4694
                     /gene="Rb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttttcccgc ggttggcccg gcgctcggtt gccgggcgcg tccggttttc ctcaggggac
       61 gttcccatta tttttgtaac gggagtcggg tgaggacggg gcgtgcccgg cgtgcgcgcg
      121 cgcccgcctc cccgcgcgcc tccctcgcct gctcgcgccg gcccgcgcag cgcgtcatgc
      181 cgcccaaagc cccgcgcaga accgcggccg ccgagccccc gccgccgccg ccgccgcctc
      241 cggaggacga ccccgcgcag gacagtgacc ccgaagagct gcccctgatc aggcttgagt
      301 ttgaaaaaat tgaagaacct gaatttattg cattatgtca gaagttaaag gtgcccgatc
      361 atgtcagaga gagagcttgg ctaacgtggg agaaagtttc atctgtggat ggaatcctgg
      421 aaggatatat tcagaagaag aaggaactct ggggcatctg catcttcatt gcagcagttg
      481 acctggatga gatgccattc acttttactg agcttcagaa aagcatagaa accagtgtct
      541 ataaattctt tgacttatta aaagaaattg ataccagtac caaagttgat aatgctgtgt
      601 caaggctatt gaagaagtac aatgtgttat gtgcactcta cagcaaatta gaacggacat
      661 gtggacttat atatttgaca cagcccagca gtgggttatc tactgaaata aattctatgt
      721 tggtgctaaa agtttcttgg atcacctttt tactagctaa aggagaagta gtacagatgg
      781 aagatgatct ggtgatctca tttcagttaa tgttgtgtgt acttgactat tttatcaagc
      841 tctcgcctcc tgcgctgctc agagagccgt acaaaacagc tgcaacaccc attaatggtt
      901 cacctcggac acccagaaga ggtcagaaca ggagtgctcg gatagcaaaa caactagaaa
      961 gtgatacaag aactattgaa gttctctgta aggagcacga gtgtaatgta gatgaggtga
     1021 aaaatgttta tttcaaaaat tttatccctt ttataagttc acttggaatt gtatcatcta
     1081 atggacttcc agagcttgaa agtctttcta aacgctacga agaagtttat cttaaaagca
     1141 aagatttaga tgcaagacta tttttggatc atgacaaaac acttcagact gatactatag
     1201 acagttttga aacagagaga actccacgaa aaagcaaccc tgatgaagag gcaaacatgg
     1261 ttactccaca cactccagtt aggactgtta tgaatactat tcaacagtta atggtgattt
     1321 taaattctgc aagtgatcag ccatcagaaa atctgatttc ctacttcagt aattgcacag
     1381 tgaatccaaa agaaaatatc ctaaaaagag taaaggatgt tggacacatc tttaaagaga
     1441 agtttgctag cgctgtgggg cagggatgta ttgacattgg agcacagcga tataaacttg
     1501 gggttcgatt gtattatcgt gtgatggaat cgatgcttaa atcagaagaa gaacgtttgt
     1561 ccattcagaa ttttagcaaa ctcctaaatg acaacatctt tcatatgtct ttattggcct
     1621 gtgctcttga agttgtaatg gctacatata gcaggagtat gttacagaat cttgattctg
     1681 gaacagattt gtccttcccg tggattctga atgtacttaa tttaaaagcc tttgattttt
     1741 acaaagtgat tgaaagtttt atcaaagtgg aagccaactt gacaagagaa atgataaaac
     1801 atttagaaag atgtgagcat cgaatcatgg aatcccttgc atggctttct gattcacctt
     1861 tgtttgatct cataaagcag tccaaggatg gggaaggacc tgatcacctt gagtctgctt
     1921 gttctctcag cctccctctc cagagtaacc acactgcagc agatatgtat ctttctccta
     1981 taagatctcc aaagaaaaga acttctacta cacgtgtaaa ttctgcggca aatacagaga
     2041 cgcaagcagc ctcagccttc catactcaga agccattgaa atctacctcc ctttccctgt
     2101 tttacaaaaa agtgtaccgt ctagcatatc tccgactaaa tacactgtgt gcgcgccttc
     2161 tgtctgatca cccagagcta gaacacatca tctggactct gtttcagcat acattggaaa
     2221 atgagtatga gctcatgaaa gaccgacatt tggaccagat tatgatgtgt tctatgtatg
     2281 gcatctgcaa ggtgaaaaac attgacctta aattcaaaat catcgtaact gcgtataagg
     2341 atcttcctca cgctgcccag gagaccttta aacgtgtttt gatcagagaa gaggagtttg
     2401 attccattat agtgttctac aactcagttt tcatgcagag actaaaaaca aatattttac
     2461 agtatgcctc caccaggcct cctaccttgt caccaatacc tcacattcct cgaagccctt
     2521 acaagttctc tagttcaccc ttgcggattc ctggaggtaa catctatata tcacccctaa
     2581 agagtcctta taaaatttca gaaggtctgc caacacccac aaaaatgact ccaagatcaa
     2641 gaatcttggt ctcaatcggt gaatcatttg ggacatccga gaagttccag aaaataaacc
     2701 agatggtgtg taacagtgac agagtgctca aaagaagtgc tgaaggcggc aatcccccca
     2761 aacccctgaa gaagctgcgc tttgacatcg aaggatccga tgaagcagac gggagtaaac
     2821 atctcccagc ggagtccaaa ttccaacaga aactggcaga aatgacttct actcgaacac
     2881 gaatgcaaaa gcagaaactg aatgatagca tggaaatctc aaacaaggag gaaaagtgat
     2941 gatctcagga ccctaacact gtagaccctc gggacacctg actcgtgtct catggatgtg
     3001 actatagttc ccaggttctg ctcatgttat agatataaaa tgtgcaggta caagctgaat
     3061 atttatgtgg gtgatttgta agccacttca atgttgtaat caatggtata gaattgacag
     3121 tacacaggat tgagaatctt gtgcagatca tgccatttaa aatatgaaag cagattgttg
     3181 gcatttccaa caggagcctg ctgccctcag aagtgaggct gcctctggag ggagtcctag
     3241 caactccctt acatctggct gactactttg cctttccttg tggcacatgt gtgatgtttg
     3301 ctcttggttt tattaattta tatgtatttt ttaatttaac gtgaatatcc ttagaaaatg
     3361 tgtcttgtct tccaaatgca agttgattga ttgtccacat tcaaccaaat tatcttgaat
     3421 cctctactga aacagattgt tacaaactgg ggaaaagtac taatttgtac acattggact
     3481 tgttttaata ctagaatcta atgtgccata tgtttgtttc acacatttta cctttgaaat
     3541 agaagcaaaa aaagtataaa catatgatac tgtcttacta ctgacacaga tttcatacct
     3601 cagaccctct aagaaccaat tcttttattc atccaactca tactttaaac tgaagactat
     3661 tgataatact ccaggtttgt tttttctttt aatctttcag atcactgaat ctttaagtac
     3721 ccatgtagta cttgaaaatc aagtctggcc acaactgtac ttcagaggac cctagtacag
     3781 tacaacccaa gtgcactttc taatgtctct gggtcctgag gaatcaagat acaaattaac
     3841 tatgttctgt aagcagaccg ttaactatag gagccttcgg tttaactatg ttctgtaagc
     3901 agaccgttaa ctataggagc cttcggtttt ccctcataca agtgtctaac cacatctcaa
     3961 cagttcactc tgctcttctg catccagggc tgatgtgttc cctctggaat ggtacatgtc
     4021 ttccagggtc ttttgaactg gcaggtatct atttttttaa gccaatctgg tctaataaca
     4081 ctggcttctt caaagccaca gcatttctaa tccagctgtg ccgaagcttc agactaaaac
     4141 agctgcattg aaagaagagg cactcccttc accccccccc cacctaaagg tgtttacatt
     4201 atcttgtggg attaacttat ttagagatgc tataatttaa aataggcggt atttaaggta
     4261 gcgtcagcta gcatttaaga aaatcatttt ttctaaactc catacttttt gaaaagaaat
     4321 ctggtcttgt tagaaaacaa atttctactt tgtcctcaat ttagtttcag ttttactagg
     4381 ttgatagtta tctcgatgac aaaggccgta gacagctccc cccatttctt cattgagttt
     4441 tgcatggcca tcacacaggt tagttaggtt taggtcaagg gctgaccata cttctaggtc
     4501 ttttgctagt aagttcaagt tagaattagt gacagaatca taggaatttt cagagatcct
     4561 ctattaagat ttcttaaaac tgcagaccct gcttttgttt ttgtactggt taaaactata
     4621 cattcagatt gctatgttcc tattttctat aatagtttgt ctattttaca ataaactagt
     4681 tgttaagagc ctta
//
