LOCUS       NM_053678               1457 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus retina and anterior neural fold homeobox (Rax),
            mRNA.
ACCESSION   NM_053678
VERSION     NM_053678.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1457)
  AUTHORS   Rohde,K., Klein,D.C., Moller,M. and Rath,M.F.
  TITLE     Rax : developmental and daily expression patterns in the rat pineal
            gland and retina
  JOURNAL   J Neurochem 118 (6), 999-1007 (2011)
   PUBMED   21749377
  REMARK    GeneRIF: These findings are consistent with the evidence that Rax
            is of functional importance in eye development and suggest a role
            of Rax in the developing pineal gland
REFERENCE   2  (bases 1 to 1457)
  AUTHORS   Silva,V.A., Polesskaya,A., Sousa,T.A., Correa,V.M., Andre,N.D.,
            Reis,R.I., Kettelhut,I.C., Harel-Bellan,A. and De Lucca,F.L.
  TITLE     Expression and cellular localization of microRNA-29b and RAX, an
            activator of the RNA-dependent protein kinase (PKR), in the retina
            of streptozotocin-induced diabetic rats
  JOURNAL   Mol Vis 17, 2228-2240 (2011)
   PUBMED   21897745
  REMARK    GeneRIF: RAX expression in the retina of diabetic rats may be
            indirectly regulated by miR-29b.
REFERENCE   3  (bases 1 to 1457)
  AUTHORS   Voronina,V.A., Kozlov,S., Mathers,P.H. and Lewandoski,M.
  TITLE     Conditional alleles for activation and inactivation of the mouse Rx
            homeobox gene
  JOURNAL   Genesis 41 (4), 160-164 (2005)
   PUBMED   15789424
REFERENCE   4  (bases 1 to 1457)
  AUTHORS   Zhang,L., Mathers,P.H. and Jamrich,M.
  TITLE     Function of Rx, but not Pax6, is essential for the formation of
            retinal progenitor cells in mice
  JOURNAL   Genesis 28 (3-4), 135-142 (2000)
   PUBMED   11105055
REFERENCE   5  (bases 1 to 1457)
  AUTHORS   Furukawa,T., Mukherjee,S., Bao,Z.Z., Morrow,E.M. and Cepko,C.L.
  TITLE     rax, Hes1, and notch1 promote the formation of Muller glia by
            postnatal retinal progenitor cells
  JOURNAL   Neuron 26 (2), 383-394 (2000)
   PUBMED   10839357
REFERENCE   6  (bases 1 to 1457)
  AUTHORS   Kimura,A., Singh,D., Wawrousek,E.F., Kikuchi,M., Nakamura,M. and
            Shinohara,T.
  TITLE     Both PCE-1/RX and OTX/CRX interactions are necessary for
            photoreceptor-specific gene expression
  JOURNAL   J Biol Chem 275 (2), 1152-1160 (2000)
   PUBMED   10625658
REFERENCE   7  (bases 1 to 1457)
  AUTHORS   Harch,C., Chase,H.B. and Gonsalves,N.I.
  TITLE     Studies on an anophthalmic strain of mice. VI. Lens and cup
            interaction
  JOURNAL   Dev Biol 63 (2), 352-357 (1978)
   PUBMED   640224
REFERENCE   8  (bases 1 to 1457)
  AUTHORS   Silver,J.
  TITLE     Abnormal development of the suprachiasmatic nuclei of the
            hypothalamus in a strain of genetically anophthalmic mice
  JOURNAL   J Comp Neurol 176 (4), 589-606 (1977)
   PUBMED   925203
REFERENCE   9  (bases 1 to 1457)
  AUTHORS   BECK,S.L.
  TITLE     The anophthalmic mutant of the mouse. II. An association of
            anophthalmia and polydactyly
  JOURNAL   J Hered 54, 79-83 (1963)
   PUBMED   13970082
REFERENCE   10 (bases 1 to 1457)
  AUTHORS   Chase,H.B.
  TITLE     Studies on an Anophthalmic Strain of Mice. IV. a Second Major Gene
            for Anophthalmia
  JOURNAL   Genetics 29 (3), 264-269 (1944)
   PUBMED   17247120
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Sep 29, 2022 this sequence version replaced NM_053678.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF135839.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN17050756
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-327               JAXUCZ010000018.1  61737118-61737444   c
            328-584             JAXUCZ010000018.1  61736617-61736873   c
            585-1457            JAXUCZ010000018.1  61733322-61734194   c
FEATURES             Location/Qualifiers
     source          1..1457
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..1457
                     /gene="Rax"
                     /gene_synonym="Rx"
                     /note="retina and anterior neural fold homeobox"
                     /db_xref="GeneID:114213"
                     /db_xref="RGD:620371"
     exon            1..327
                     /gene="Rax"
                     /gene_synonym="Rx"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1067
                     /gene="Rax"
                     /gene_synonym="Rx"
                     /note="retina and anterior neural fold homeobox protein;
                     retinal homeobox transcription factor Rx/rax"
                     /codon_start=1
                     /product="retinal homeobox protein Rx"
                     /protein_id="NP_446130.1"
                     /db_xref="GeneID:114213"
                     /db_xref="RGD:620371"
                     /translation="MHLPGCPPAMADGSFSLAGHLLRSPGGSTSRLHSIEAILGFTKE
                     DGILDTFPAERSSRGSKERDPRLGARSACPKAPAGGSESSPPAAPGLVPEFEATRPCY
                     PKEQGEARPSPGLPVGPAAGDSKLSEEEEPPKKKHRRNRTTFTTYQLHELERAFEKSH
                     YPDVYSREELAGKVNLPEVRVQVWFQNRRAKWRRQEKLEVSSMKLQDSPLLSFSRSPP
                     SSALAPLGGPGSGSGPPGSALPLEPWLGPPLPGGGATALQSLPGFGPPGQGLPASYTP
                     PPPFLNSAPLGPGLQQLGPPPAYPCAPAFGDKFSLEEAYPRNSSIAALRLKAKEHIQA
                     IGKPWQAL"
     exon            328..584
                     /gene="Rax"
                     /gene_synonym="Rx"
                     /inference="alignment:Splign:2.1.0"
     exon            585..1457
                     /gene="Rax"
                     /gene_synonym="Rx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcgagctcc agtttgccaa gtacactccc gcctccccat gcacctgccg ggctgcccgc
       61 cagccatggc cgacgggagc ttctcgctcg ctggccacct gctccgcagc ccgggcggga
      121 gcacgtcgcg tttgcacagc atcgaagcca tcctgggctt taccaaggaa gacgggatcc
      181 tagacacctt tcctgcagag aggagctcca ggggctcgaa ggagcgggat cccagactgg
      241 gtgcgcggtc cgcctgcccc aaagctccag ccggaggctc ggagtcttcc ccaccagcag
      301 ccccggggct cgtcccggag ttcgaagcta ctcgcccctg ctatcccaag gagcaaggag
      361 aggcacggcc gagccccgga ctgccggttg ggccagcagc gggcgattcg aagctgtcgg
      421 aggaggagga acctcccaag aagaaacaca ggcgcaaccg cacgaccttc accacgtatc
      481 aactgcacga gctggaacgt gcctttgaga agtcccacta ccccgacgtg tacagccgcg
      541 aagagttggc cggcaaggtt aacctacccg aggttcgggt ccaggtgtgg ttccagaacc
      601 gtcgggccaa gtggagacgc caggagaaac tagaagtgtc gtccatgaag ctgcaggact
      661 cgcccctcct ctccttcagc cggtccccac cttcctcggc actggctccg ctaggcggcc
      721 cgggcagcgg tagcggacct ccggggagcg ccctgccgct ggagccttgg ctcgggccac
      781 cgctgcccgg cggaggtgcc acagcgctgc agagcctgcc aggtttcggg ccgccggggc
      841 agggtctccc ggccagctac acgccgccac cgcccttcct caactccgcg cccctgggtc
      901 ccggtctgca gcagctcggg ccaccacccg cgtacccgtg cgcgccggcc ttcggggaca
      961 agttctcgct ggaagaggcg tacccacgca acagcagcat cgccgcgctg cgcctgaagg
     1021 ccaaagagca catccaggcc atcgggaagc cctggcaagc cctctagagg cgctgcggag
     1081 ttgctgcgag ccctgtgtgc acccagcccg gtggtcgcac tttctttgct aaccctgctg
     1141 caagccggcc gccagccttg ggcaggacac tcgcgcctac ttctttctga ttcttcgaga
     1201 aaggccaaac ttgaggccag cagaacttca gcctcgctgc cagaggaacg tgctgtgggt
     1261 cccgctggcc acactgctcc tagctgctcc cataaagcaa tcagcgtcta ccatcgggag
     1321 ggaccaaaga tcttgacctg ggatgttccc gacggaagga atggggagtg agaaaaatag
     1381 agttgaagaa actgtttgta aagttagtgt aaagtatttt gggggagaaa ttaaagattt
     1441 gtttgttgcc cggctaa
//
