LOCUS       NM_019365               3423 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus Ras association domain family member 5 (Rassf5),
            mRNA.
ACCESSION   NM_019365
VERSION     NM_019365.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3423)
  AUTHORS   Nakamura,T., Yasuda,S., Nagai,H., Koinuma,S., Morishita,S.,
            Goto,A., Kinashi,T. and Wada,N.
  TITLE     Longest neurite-specific activation of Rap1B in hippocampal neurons
            contributes to polarity formation through RalA and Nore1A in
            addition to PI3-kinase
  JOURNAL   Genes Cells 18 (11), 1020-1031 (2013)
   PUBMED   24165023
  REMARK    GeneRIF: specific activation of Rap1B contributes to neuronal
            polarization via interaction with RalA and Nore1A in addition to
            PI3-kinase.
REFERENCE   2  (bases 1 to 3423)
  AUTHORS   Lee,D., Park,S.J., Sung,K.S., Park,J., Lee,S.B., Park,S.Y.,
            Lee,H.J., Ahn,J.W., Choi,S.J., Lee,S.G., Kim,S.H., Kim,D.H.,
            Kim,J., Kim,Y. and Choi,C.Y.
  TITLE     Mdm2 associates with Ras effector NORE1 to induce the degradation
            of oncoprotein HIPK1
  JOURNAL   EMBO Rep 13 (2), 163-169 (2012)
   PUBMED   22173032
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3423)
  AUTHORS   Gezginci-Oktayoglu,S. and Bolkent,S.
  TITLE     Ras signaling in NGF reduction and TNF-alpha-related pancreatic
            beta cell apoptosis in hyperglycemic rats
  JOURNAL   Apoptosis 17 (1), 14-24 (2012)
   PUBMED   21938476
  REMARK    GeneRIF: Apoptotic Ras effector molecules RASSF1 and NORE1 play
            important role in NGF reduction and TNF-alpha-related pancreatic
            beta cell apoptosis in hyperglycemic rats.
REFERENCE   4  (bases 1 to 3423)
  AUTHORS   Katagiri,K., Ueda,Y., Tomiyama,T., Yasuda,K., Toda,Y., Ikehara,S.,
            Nakayama,K.I. and Kinashi,T.
  TITLE     Deficiency of Rap1-binding protein RAPL causes lymphoproliferative
            disorders through mislocalization of p27kip1
  JOURNAL   Immunity 34 (1), 24-38 (2011)
   PUBMED   21194982
REFERENCE   5  (bases 1 to 3423)
  AUTHORS   Shinmura,K., Tao,H., Nagura,K., Goto,M., Matsuura,S., Mochizuki,T.,
            Suzuki,K., Tanahashi,M., Niwa,H., Ogawa,H. and Sugimura,H.
  TITLE     Suppression of hydroxyurea-induced centrosome amplification by
            NORE1A and down-regulation of NORE1A mRNA expression in non-small
            cell lung carcinoma
  JOURNAL   Lung Cancer 71 (1), 19-27 (2011)
   PUBMED   20434789
REFERENCE   6  (bases 1 to 3423)
  AUTHORS   Hwang,E., Ryu,K.S., Paakkonen,K., Guntert,P., Cheong,H.K.,
            Lim,D.S., Lee,J.O., Jeon,Y.H. and Cheong,C.
  TITLE     Structural insight into dimeric interaction of the SARAH domains
            from Mst1 and RASSF family proteins in the apoptosis pathway
  JOURNAL   Proc Natl Acad Sci U S A 104 (22), 9236-9241 (2007)
   PUBMED   17517604
REFERENCE   7  (bases 1 to 3423)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   8  (bases 1 to 3423)
  AUTHORS   Vos,M.D., Martinez,A., Ellis,C.A., Vallecorsa,T. and Clark,G.J.
  TITLE     The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated
            tumor suppressor in the lung
  JOURNAL   J Biol Chem 278 (24), 21938-21943 (2003)
   PUBMED   12676952
  REMARK    GeneRIF: Nore1 is a member of a family of Ras effector/tumor
            suppressors that includes RASSF1
REFERENCE   9  (bases 1 to 3423)
  AUTHORS   Yao,R., Wang,Y. and You,M.
  TITLE     Chromosome mapping and sequence variation of the murine Ras
            effector gene Nore1
  JOURNAL   Cytogenet Cell Genet 95 (1-2), 126-128 (2001)
   PUBMED   11978988
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Nov 27, 2020 this sequence version replaced NM_019365.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF002251.2, SRR26643295.46274.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-570               JAXUCZ010000013.1  45254708-45255277   c
            571-692             JAXUCZ010000013.1  45225973-45226094   c
            693-803             JAXUCZ010000013.1  45195013-45195123   c
            804-1101            JAXUCZ010000013.1  45193898-45194195   c
            1102-1217           JAXUCZ010000013.1  45193296-45193411   c
            1218-3423           JAXUCZ010000013.1  45189805-45192010   c
FEATURES             Location/Qualifiers
     source          1..3423
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..3423
                     /gene="Rassf5"
                     /gene_synonym="Maxp1; Nore1"
                     /note="Ras association domain family member 5"
                     /db_xref="GeneID:54355"
                     /db_xref="RGD:621694"
     exon            1..570
                     /gene="Rassf5"
                     /gene_synonym="Maxp1; Nore1"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1370
                     /gene="Rassf5"
                     /gene_synonym="Maxp1; Nore1"
                     /note="novel ras effector 1; new ras effector 1; protein
                     interacting with guanine nucleotide exchange factor; Ras
                     association (RalGDS/AF-6) domain family member 5"
                     /codon_start=1
                     /product="ras association domain-containing protein 5"
                     /protein_id="NP_062238.1"
                     /db_xref="GeneID:54355"
                     /db_xref="RGD:621694"
                     /translation="MASPAIGQRPYPLLLDPEPPRYLQSLGGTEPPPPARPRRCIPTA
                     LISASGASEGRGSRRNARGDPEPTPRDCRHARPVRPGLQQRLRRRPGSHRPRDVRSIF
                     EQPQDPRVLAERGEGHRFAELALRGGPGWCDLCGREVLRQALRCANCKFTCHPECRSL
                     IQLDCRQKEGPALDRQSPESTLTPTFNKNVCKAVEETQHPPTIQEIKQKIDSYNSREK
                     HCLGMKLSEDGTYTGFIKVHLKLRRPVTVPAGIRPQSIYDAIKEVNPAATTDKRTSFY
                     LPLDAIKQLHISSSTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKLSIAD
                     CPLYLRLLAGPDTDVLSFVLKENETGDVEWDAFSIPELQNFLTILEKEEQDKIHQLQK
                     KYNKFRQKLEEALRESQGKPG"
     exon            571..692
                     /gene="Rassf5"
                     /gene_synonym="Maxp1; Nore1"
                     /inference="alignment:Splign:2.1.0"
     exon            693..803
                     /gene="Rassf5"
                     /gene_synonym="Maxp1; Nore1"
                     /inference="alignment:Splign:2.1.0"
     exon            804..1101
                     /gene="Rassf5"
                     /gene_synonym="Maxp1; Nore1"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1217
                     /gene="Rassf5"
                     /gene_synonym="Maxp1; Nore1"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..3423
                     /gene="Rassf5"
                     /gene_synonym="Maxp1; Nore1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctctccgt gggctccgcc ccgccccgcc ccgcccgcgg gctgcgggcc ctttaaaagc
       61 gcgctcggcc ggagccgccc cttctgttgg ccaggctctg gagctgctgc cgcctgcggg
      121 ccttggccat ggcgtccccg gccattgggc agcgtcccta cccgctgctg ctagaccccg
      181 agccgccgcg gtatctgcag agcctgggtg gcaccgagcc gccaccgccc gcccggccgc
      241 gtcgctgtat ccccacggcc ctgatctccg cgtccggggc gtcagagggt cgcggtagca
      301 ggaggaatgc ccggggggac ccggagccca cgccccggga ctgccgacac gctcgccctg
      361 tccggcccgg tctgcagcag agactgcggc ggcgacctgg gtcgcaccga ccccgcgacg
      421 tgaggagcat cttcgagcaa ccgcaggatc cccgcgtctt agccgagaga ggagagggac
      481 accgtttcgc ggaattggcg ctccggggtg gcccgggctg gtgtgacctg tgcggacgag
      541 aggtgctgcg gcaggcgctg cgctgcgcta attgtaaatt cacctgccac ccagagtgcc
      601 gcagcctgat ccagctggac tgcagacaga aggagggccc tgccctggac agacagtctc
      661 cagaaagcac cctcacccca accttcaaca agaatgtctg taaggctgtg gaggagacac
      721 agcacccgcc caccatacag gagatcaagc agaagattga cagctataac agccgggaga
      781 agcactgcct gggcatgaag ttgagtgaag atggcaccta cacaggtttc atcaaagtgc
      841 atttgaaact ccgccggcca gtgacggtgc ctgctgggat tcggccccag tccatctatg
      901 atgccattaa ggaagtgaac cctgcagcta ccacagacaa gcggacatcc ttctacctgc
      961 cacttgacgc catcaagcag ctacacatta gcagcagcac cactgtcagt gaggtcatcc
     1021 aggggctgct caagaaattc atggttgtgg acaacccaca gaagtttgcc ctttttaagc
     1081 ggatacacaa agatggacaa gtgctcttcc agaaactctc catcgctgac tgccctctct
     1141 accttcgtct gctcgctggt cctgacaccg acgtgctcag ctttgtgctc aaggagaatg
     1201 aaaccggaga cgtagagtgg gatgcctttt ccattcctga actccagaac ttcttaacta
     1261 tcctggaaaa agaggagcag gacaagatcc atcaactgca gaagaagtac aacaaattcc
     1321 ggcagaaact ggaggaggcc ttacgagagt cccaagggaa gcctgggtaa ccagcttact
     1381 tcctgtcctc tcagtgccct ccaatttatt ttgttaatta ttttgcaatg aacagttatt
     1441 ctcaaggcac ctctgatgtg tccacctgtg cctgcccagc agttaacaga tgtggcacaa
     1501 agtctcttcc acgaagtgtc tgtgcagggt ttgattcctg ctaacccacc acaccatggc
     1561 tctggagatt ttccgtctgg gatcagaact cctgtggaat gaccagtatt tcccctgttc
     1621 aatctgctgg cttttcggaa accaaatggt tgcctctctg ctcaccaaac tccaaccaat
     1681 caccagctgg caaaaaggaa tgaaaggttt tagagcctgg gttttttctc tggatttagt
     1741 tctgttcctt tttctttttt ctgccacaca gagtatattt atgggtcaaa tgtggcatat
     1801 tcattttagc taagtccttg aaagcaggaa aatgctcgtg aaaggactgt cgtccttgcc
     1861 cccaaggtgc ctcctcttct cttgtgctag accctcggtc agcctgagat tccagaagcg
     1921 acatctctca ctgcccagca ggccgcatgc tgcaaacaca gacacacaca cacacatctg
     1981 tgtgggactt cggcatgtct cttccagtgt tgctatgctg aaatcttaac ttaatgttgc
     2041 cattcttatg ggtttctacc aaagagaaac cagccattga cttatcaatt ttagtttcct
     2101 gctgagtcgc cagaagtatt acagcaaagc acatccaagc cgctcgtggc ctgtgcctgc
     2161 agtgggggcc tctccttggc cttcagttcc acctccgtcc tccaacttgg gctttagggt
     2221 ctccagctgt tgcctgagta gtagctttga ttacagtggt aaggtcctcc aacttgggag
     2281 tcctttctgg tgggaagcat ggtctgctca cacagcatgg gcaaacctgt gggcctgact
     2341 ttcctggtga cttcagtgcc tttttgtttt cagagaaaag agcagggcat gtttgcttgt
     2401 agctctcctg ctggcttgcc ccagcaggaa gtaggtgcta tagagcaagg acaggaggtt
     2461 tctcagagca cagggcgacg atcacacacc tctttcccat caaacttcct gatcaggctt
     2521 tgactttgaa gattcgaaat tattagactg cactgacagc atcagattag gactccaact
     2581 cttgactaat tcaaacttaa aacaaattag ccagactata ccacccagta gccaggacac
     2641 aaagacgctc aatatggagg gagaaaaact tgtcctttta gaagaaggcc agtgttccaa
     2701 tcgagcctcc agaggagacc gctttcatgt tgtgcttgcc tttccacacc cctcgggttg
     2761 ttttaagccc aagcttctct gtgtagccta aaaagttccc tcccagccca ggctgaggcc
     2821 acattgctcc tgtcccagaa gaatgccaaa tccctgtcat tccaagtttt cagagctgca
     2881 aaagcaccat gagctagcga ctctgaggct gtgcatgcca tagcccctgg ctccctgccg
     2941 cctcaggctc agccttacac tcccctccct tgagaagtcc cctttctgct gtgtattaca
     3001 gggacatacg gaaactcatt cccttcatcc tgcatgtgtg tagcattagg agaaggcatg
     3061 gctcctgctg caaacactgt gaatgctgct cagacctccc tccatggatg gctattttat
     3121 ttttgacaag aaaaaaaatt catgtatata taaaatgtat atacatatat atgtatatac
     3181 acatagaggc atatagctat atataaagaa aaggtgttta ttcagaaagg gatgatcaga
     3241 ttcagacttt aaagcacagt tagacccagg acctctactg aggttgagcc gctggaaacg
     3301 tggagttcct taagtctcag aggggtctaa ctgctggtag tgccttctat ggttgtatgg
     3361 ctctgtggtt ggttgttttg agaatatttt ctttctaaat gtttttctta tacatggttt
     3421 ttt
//
