LOCUS       NM_001037555            1149 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus Ras association domain family member 1 (Rassf1),
            transcript variant 1, mRNA.
ACCESSION   NM_001037555
VERSION     NM_001037555.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1149)
  AUTHORS   Xiaochuan,B., Qianfeng,J., Min,X. and Xiao,L.
  TITLE     RASSF1 promotes cardiomyocyte apoptosis after acute myocardial
            infarction and is regulated by miR-125b
  JOURNAL   J Cell Biochem 121 (1), 489-496 (2020)
   PUBMED   31595551
  REMARK    GeneRIF: RASSF1 promotes cardiomyocyte apoptosis after acute
            myocardial infarction and is regulated by miR-125b.
REFERENCE   2  (bases 1 to 1149)
  AUTHORS   Tao,H., Yang,J.J., Hu,W., Shi,K.H. and Li,J.
  TITLE     HDAC6 Promotes Cardiac Fibrosis Progression through Suppressing
            RASSF1A Expression
  JOURNAL   Cardiology 133 (1), 18-26 (2016)
   PUBMED   26401643
  REMARK    GeneRIF: The results suggest a previously unknown mechanism of
            HDAC6 inactivation of RASSF1A controls cardiac fibroblast
            proliferation and fibrosis.
REFERENCE   3  (bases 1 to 1149)
  AUTHORS   Tao,H., Yang,J.J., Chen,Z.W., Xu,S.S., Zhou,X., Zhan,H.Y. and
            Shi,K.H.
  TITLE     DNMT3A silencing RASSF1A promotes cardiac fibrosis through
            upregulation of ERK1/2
  JOURNAL   Toxicology 323, 42-50 (2014)
   PUBMED   24945829
  REMARK    GeneRIF: DNMT3A and RASSF1A may serve as a new mechanism for
            cardiac fibrosis.
REFERENCE   4  (bases 1 to 1149)
  AUTHORS   Gezginci-Oktayoglu,S. and Bolkent,S.
  TITLE     Ras signaling in NGF reduction and TNF-alpha-related pancreatic
            beta cell apoptosis in hyperglycemic rats
  JOURNAL   Apoptosis 17 (1), 14-24 (2012)
   PUBMED   21938476
  REMARK    GeneRIF: Apoptotic Ras effector molecules RASSF1 and NORE1 play
            important role in NGF reduction and TNF-alpha-related pancreatic
            beta cell apoptosis in hyperglycemic rats.
REFERENCE   5  (bases 1 to 1149)
  AUTHORS   Zhang,J., Zhang,J., Li,M., Wu,Y., Fan,Y., Zhou,Y., Tan,L., Shao,Z.
            and Shi,H.
  TITLE     Methylation of RAR-beta2, RASSF1A, and CDKN2A genes induced by
            nickel subsulfide and nickel-carcinogenesis in rats
  JOURNAL   Biomed Environ Sci 24 (2), 163-171 (2011)
   PUBMED   21565688
  REMARK    GeneRIF: These findings suggest that loss of function or decrease
            of RAR-beta2, RASSF1A, and CDKN2A, as well as the hypermethylation
            of 5' region of these genes, are related with nickel exposure.
REFERENCE   6  (bases 1 to 1149)
  AUTHORS   Praskova,M., Khoklatchev,A., Ortiz-Vega,S. and Avruch,J.
  TITLE     Regulation of the MST1 kinase by autophosphorylation, by the growth
            inhibitory proteins, RASSF1 and NORE1, and by Ras
  JOURNAL   Biochem J 381 (Pt 2), 453-462 (2004)
   PUBMED   15109305
REFERENCE   7  (bases 1 to 1149)
  AUTHORS   Song,M.S., Song,S.J., Ayad,N.G., Chang,J.S., Lee,J.H., Hong,H.K.,
            Lee,H., Choi,N., Kim,J., Kim,H., Kim,J.W., Choi,E.J.,
            Kirschner,M.W. and Lim,D.S.
  TITLE     The tumour suppressor RASSF1A regulates mitosis by inhibiting the
            APC-Cdc20 complex
  JOURNAL   Nat Cell Biol 6 (2), 129-137 (2004)
   PUBMED   14743218
REFERENCE   8  (bases 1 to 1149)
  AUTHORS   Pfeifer,G.P., Yoon,J.H., Liu,L., Tommasi,S., Wilczynski,S.P. and
            Dammann,R.
  TITLE     Methylation of the RASSF1A gene in human cancers
  JOURNAL   Biol Chem 383 (6), 907-914 (2002)
   PUBMED   12222680
  REMARK    Review article
REFERENCE   9  (bases 1 to 1149)
  AUTHORS   Shivakumar,L., Minna,J., Sakamaki,T., Pestell,R. and White,M.A.
  TITLE     The RASSF1A tumor suppressor blocks cell cycle progression and
            inhibits cyclin D1 accumulation
  JOURNAL   Mol Cell Biol 22 (12), 4309-4318 (2002)
   PUBMED   12024041
REFERENCE   10 (bases 1 to 1149)
  AUTHORS   Ortiz-Vega,S., Khokhlatchev,A., Nedwidek,M., Zhang,X.F.,
            Dammann,R., Pfeifer,G.P. and Avruch,J.
  TITLE     The putative tumor suppressor RASSF1A homodimerizes and
            heterodimerizes with the Ras-GTP binding protein Nore1
  JOURNAL   Oncogene 21 (9), 1381-1390 (2002)
   PUBMED   11857081
  REMARK    Erratum:[Oncogene 2002 Mar 14;21(12):1943]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001037555.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB202124.1, SRR26643292.35347.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               JAXUCZ010000008.1  117103665-117103929
            266-372             JAXUCZ010000008.1  117106952-117107058
            373-477             JAXUCZ010000008.1  117110162-117110266
            478-775             JAXUCZ010000008.1  117110472-117110769
            776-891             JAXUCZ010000008.1  117110903-117111018
            892-1149            JAXUCZ010000008.1  117113929-117114186
FEATURES             Location/Qualifiers
     source          1..1149
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1149
                     /gene="Rassf1"
                     /note="Ras association domain family member 1"
                     /db_xref="GeneID:363140"
                     /db_xref="RGD:1359383"
     exon            1..265
                     /gene="Rassf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1038
                     /gene="Rassf1"
                     /note="isoform 1 is encoded by transcript variant 1; Ras
                     association (RalGDS/AF-6) domain family 1; ras association
                     domain-containing protein 1; Ras association domain family
                     1; Ras association (RalGDS/AF-6) domain family member 1"
                     /codon_start=1
                     /product="ras association domain-containing protein 1
                     isoform 1"
                     /protein_id="NP_001032644.1"
                     /db_xref="GeneID:363140"
                     /db_xref="RGD:1359383"
                     /translation="MSAEPELIELRELAPSGRIGPGRTRLERANALRIAPGTTRNPSQ
                     QHVPGRGHRFQPAGPTTHTWCDLCGDFIWGVVRKGLQCAHCKFTCHYRCRALVCLDCC
                     GPRDLGWDPALERDTNVDEAVERETPDLSQAETEQKIKDYNGQINSNLFMSLNKDGSY
                     TGFIKVQLKLVRPVSVPSSKKPPSLQDARRGTGRSSAVKRRTSFYLPKDAVKHLHVLS
                     RTRAREVIEALLRKFMVVDDPRKFALFERTERHGQIYFRKLSDEEQPLKLRLLAGPSE
                     KALSFVLKENDSGEVNWDAFSMPELHNFLRILQREEEEHLRQILQKYSRCRQKIQEAL
                     HACPLG"
     exon            266..372
                     /gene="Rassf1"
                     /inference="alignment:Splign:2.1.0"
     exon            373..477
                     /gene="Rassf1"
                     /inference="alignment:Splign:2.1.0"
     exon            478..775
                     /gene="Rassf1"
                     /inference="alignment:Splign:2.1.0"
     exon            776..891
                     /gene="Rassf1"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1149
                     /gene="Rassf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcctgacc gggccatgtc ggcggagcca gaactcattg aactacgaga gttggcaccg
       61 tccgggcgca tcggtccagg ccgtacccgg ctggagcgtg ccaacgctct gcgcatcgcg
      121 ccgggcacaa cacgcaatcc gtcacagcag cacgtcccgg gtcgtggcca ccgcttccag
      181 cctgcagggc ccaccacgca cacgtggtgc gacctctgtg gagacttcat ctggggcgtc
      241 gtgcgcaaag gcctacagtg cgcgcactgt aagttcacct gccattaccg atgtcgtgcg
      301 ctcgtctgcc tggactgctg cgggccccga gacctgggct gggaccctgc actggagcgg
      361 gacacgaacg tggatgaggc tgtggagcgg gagacacctg atctttccca agctgagact
      421 gagcagaaaa tcaaggatta caatggccag atcaacagca acctcttcat gagcctgaat
      481 aaggatggct cctacaccgg cttcatcaag gttcagctga aactggtacg ccctgtttca
      541 gtgccttcca gcaagaaacc gccttccttg caggatgccc ggaggggcac ggggcggagc
      601 tcagctgtga agcgccgcac ctctttttac ttgcctaagg atgctgttaa gcatctgcac
      661 gttctgtcac gaacacgcgc gcgtgaggtc attgaggccc tgcttcgaaa attcatggta
      721 gtagatgatc ctcgcaagtt tgcactcttt gaacgaactg aacgccatgg ccaaatatac
      781 ttccggaaac tgtcagatga ggagcagccc ttgaagctac ggcttcttgc agggcccagt
      841 gaaaaagccc tgagctttgt cctgaaggag aatgactctg gggaggtgaa ttgggatgcc
      901 ttcagcatgc ctgagctgca caatttcttg cgcatcctgc agcgtgaaga agaggaacac
      961 cttcgccaga tcctgcagaa gtattctcgg tgtcgccaga agatccagga ggccttgcac
     1021 gcctgtcctt tggggtgacc ttgtgtggcc ctgggtgaca ggaggagaac aggcagtgcg
     1081 aagagcgtgc cgtgtgagtg tgacagggcc cgtggggcct gaggagtgcg tgtgcgtgaa
     1141 ggtcctcct
//
