LOCUS       NM_130824               2164 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus RAS guanyl releasing protein 4 (Rasgrp4), mRNA.
ACCESSION   NM_130824
VERSION     NM_130824.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2164)
  AUTHORS   Kono,M., Yasuda,S., Stevens,R.L., Koide,H., Kurita,T., Shimizu,Y.,
            Kanetsuka,Y., Oku,K., Bohgaki,T., Amengual,O., Horita,T.,
            Shimizu,T., Majima,T., Koike,T. and Atsumi,T.
  TITLE     Ras guanine nucleotide-releasing protein 4 is aberrantly expressed
            in the fibroblast-like synoviocytes of patients with rheumatoid
            arthritis and controls their proliferation
  JOURNAL   Arthritis Rheumatol 67 (2), 396-407 (2015)
   PUBMED   25330932
  REMARK    GeneRIF: RasGRP-4 is aberrantly expressed in fibroblast-like
            synoviocytes and helps regulate their growth.
REFERENCE   2  (bases 1 to 2164)
  AUTHORS   Li,L., Yang,Y. and Stevens,R.L.
  TITLE     RasGRP4 regulates the expression of prostaglandin D2 in human and
            rat mast cell lines
  JOURNAL   J Biol Chem 278 (7), 4725-4729 (2003)
   PUBMED   12493770
  REMARK    GeneRIF: RasGRP4 regulates the expression of prostaglandin D2 in
            mast cell
REFERENCE   3  (bases 1 to 2164)
  AUTHORS   Li,L., Yang,Y. and Stevens,R.L.
  TITLE     Cloning of rat Ras guanine nucleotide releasing protein 4, and
            evaluation of its expression in rat mast cells and their bone
            marrow progenitors
  JOURNAL   Mol Immunol 38 (16-18), 1283-1288 (2002)
   PUBMED   12217396
  REMARK    GeneRIF: Cloning of Ras guanine nucleotide releasing protein 4, and
            evaluation of its expression in mast cells and their bone marrow
            progenitors.
            Review article
REFERENCE   4  (bases 1 to 2164)
  AUTHORS   Reuther,G.W., Lambert,Q.T., Rebhun,J.F., Caligiuri,M.A.,
            Quilliam,L.A. and Der,C.J.
  TITLE     RasGRP4 is a novel Ras activator isolated from acute myeloid
            leukemia
  JOURNAL   J Biol Chem 277 (34), 30508-30514 (2002)
   PUBMED   11880369
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF465263.1.
            
            On Mar 15, 2007 this sequence version replaced NM_130824.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF465263.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2164
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2164
                     /gene="Rasgrp4"
                     /note="RAS guanyl releasing protein 4"
                     /db_xref="GeneID:170668"
                     /db_xref="RGD:620476"
     CDS             1..2037
                     /gene="Rasgrp4"
                     /codon_start=1
                     /product="RAS guanyl-releasing protein 4"
                     /protein_id="NP_570837.2"
                     /db_xref="GeneID:170668"
                     /db_xref="RGD:620476"
                     /translation="MNRKDIKRKSHQECSGKAGGHGRPRQARRHKTCPTPREISKVMA
                     SLNLGVLSESSCSVDELLEECIRCFDSAGSLHRGDHILKMVLTMHSWVLPSSDLAARL
                     LTSYQKAAKDARELRQLQICYLVRYWLTHHPEVVHQEPQLEAIINRFWTTVAQEGNMA
                     QRSLGDASNLLSPGGPGPPPLMSSPGLGKKRKVSLLFDHLETEELAQHLTYLEFRSFQ
                     AITPQDLRGYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPAQRAQVLDKFIR
                     VAQRLRQMQNFNTLMAVTGGLCHSAISRLKDSHVHLSPDSTKALLELTELLSSHNNYA
                     YYRRTWASCTDFRLPVLGVHLKDLVSLYEAHPDRLPDGRLHLPKLNSLYLRLQELAAL
                     QRQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPLSPFKAPVVVEW
                     AHGVTPKPDSATLGQHVEQLVESVFKNYDPEGHGSISLEDFEKLSANFPFACHGLHPP
                     PRHGSGSFSREELTKYLLHASAICSKLGLAFLHAFQEVTFRKPTFCHSCNGFVSTGPL
                     WGVTKRGYRCQDCGLCCHRHCRDQVRVECKKRPETKGDPGPPGAPGPATPLPPTGCGS
                     EEGLSYTLSPHLESGCHLHHAWTQTESSHSSWEPEMVPCPAPVLPSKASSKSSV"
     exon            1..23
                     /gene="Rasgrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            24..208
                     /gene="Rasgrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            209..314
                     /gene="Rasgrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            315..377
                     /gene="Rasgrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            378..509
                     /gene="Rasgrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            510..663
                     /gene="Rasgrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            664..837
                     /gene="Rasgrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            838..954
                     /gene="Rasgrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1230
                     /gene="Rasgrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1311
                     /gene="Rasgrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1416
                     /gene="Rasgrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1535
                     /gene="Rasgrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1695
                     /gene="Rasgrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1732
                     /gene="Rasgrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1867
                     /gene="Rasgrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1980
                     /gene="Rasgrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2153
                     /gene="Rasgrp4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaaccgga aagacatcaa aaggaagtct catcaggaat gctctgggaa ggcaggaggg
       61 catggtcggc cgagacaggc ccgccgccac aagacgtgtc ccaccccccg ggaaatcagc
      121 aaggtcatgg cttccctgaa cctgggcgtg ctgagtgaga gcagctgcag tgtggatgag
      181 ctactggagg aatgcatccg gtgctttgat tcagctggca gcttacaccg aggggaccac
      241 attctcaaga tggtgcttac catgcacagc tgggtgctgc catcctcaga ccttgccgcc
      301 cgcctgctga cttcgtatca gaaggctgcc aaagatgccc gggagctaag acagctacag
      361 atctgttacc tggtcaggta ctggctgacc catcaccccg aggtagtgca ccaggaaccc
      421 cagctggaag caatcataaa ccggttttgg accactgtag ctcaggaggg caacatggcc
      481 caaaggagcc taggagatgc ctccaatctg ctgagtcctg gagggcccgg tcccccacct
      541 ctcatgagca gcccaggcct gggcaaaaag cggaaagtgt ccttgctgtt cgatcacctg
      601 gagacagagg agctggcaca gcaccttact tacctggagt tccggtcctt ccaggccatc
      661 acgccccaag acctgcgggg ctatgttttg cagggctcgg tgagaggttg tcctgctctg
      721 gaaggttctg tgggtctgag caacagtgtg tcccgctggg tacaggtcat ggtgctgagt
      781 cgtcctgggc ctgcgcagcg tgcccaggta ctggacaaat tcattcgtgt ggcacagagg
      841 cttcgccaga tgcagaattt caacacgctg atggcggtca cggggggtct gtgtcatagc
      901 gccatctcca gactcaagga ctcccacgtc catctgagcc ctgacagcac taaggccctg
      961 ctggagctga cagagcttct ctcttcccac aacaactatg cctactaccg ccgcacctgg
     1021 gccagctgca ctgacttccg gctgccagta ctgggtgttc acctcaagga cctggtatct
     1081 ctgtatgagg cccatccaga caggttgcca gatggccgcc tgcacctacc caagctgaat
     1141 agcctctatc tacggctgca ggagctggca gcactccaga gacagcatcc cccgtgcagt
     1201 gccaatgagg acctgctaca cctgctgacg ctctccctgg atctcttcta cacggaagat
     1261 gagatctacg agctttctta tgcccgggag ccacgttgtc ccaagagtct gcccctatcc
     1321 cccttcaaag cgcctgtggt ggtagagtgg gcccatggtg tgacgccaaa gccagacagt
     1381 gcgactctgg gtcagcatgt ggaacagcta gtggagtccg tgttcaagaa ctatgaccca
     1441 gaaggccatg gctctatttc tctggaggac tttgagaagc tgtcagccaa cttccccttt
     1501 gcctgccatg ggcttcaccc acctccccgc cacgggagtg gctccttcag cagagaggag
     1561 ctgaccaagt atctgctcca tgccagcgcc atctgctcca agctgggcct ggctttcctg
     1621 cacgccttcc aggaggtcac cttccgcaag cccaccttct gtcacagctg caacggcttc
     1681 gtgagcactg gccctctctg gggcgtcacc aagcgaggct atcgctgtca ggactgtggg
     1741 ctgtgttgtc acagacactg cagggatcaa gtgagagtgg agtgtaagaa gaggccagag
     1801 actaaaggtg acccgggtcc ccctggcgca cccgggccag ccacaccact tcctcctacc
     1861 ggctgtggct ccgaggaagg tctctcctat acactctccc cgcatctgga gtctggttgc
     1921 caccttcacc atgcttggac tcagacggag tcctcacact cttcctggga gccagagatg
     1981 gtgccctgcc cagcaccagt tttaccatcc aaagcttcct caaagtccag tgtctgaaca
     2041 gcatctgggc ctcttccctt actcccctac ccaatgcctc ttccacatct gcgctgcctc
     2101 tgacgaggta cctgccatct ttccccctaa aaaaatgttc tgttggcagt gcaaaaaaaa
     2161 aaaa
//
