LOCUS       NP_570837                678 aa            linear   ROD 29-JUL-2024
DEFINITION  RAS guanyl-releasing protein 4 [Rattus norvegicus].
ACCESSION   NP_570837
VERSION     NP_570837.2
DBSOURCE    REFSEQ: accession NM_130824.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 678)
  AUTHORS   Kono,M., Yasuda,S., Stevens,R.L., Koide,H., Kurita,T., Shimizu,Y.,
            Kanetsuka,Y., Oku,K., Bohgaki,T., Amengual,O., Horita,T.,
            Shimizu,T., Majima,T., Koike,T. and Atsumi,T.
  TITLE     Ras guanine nucleotide-releasing protein 4 is aberrantly expressed
            in the fibroblast-like synoviocytes of patients with rheumatoid
            arthritis and controls their proliferation
  JOURNAL   Arthritis Rheumatol 67 (2), 396-407 (2015)
   PUBMED   25330932
  REMARK    GeneRIF: RasGRP-4 is aberrantly expressed in fibroblast-like
            synoviocytes and helps regulate their growth.
REFERENCE   2  (residues 1 to 678)
  AUTHORS   Li,L., Yang,Y. and Stevens,R.L.
  TITLE     RasGRP4 regulates the expression of prostaglandin D2 in human and
            rat mast cell lines
  JOURNAL   J Biol Chem 278 (7), 4725-4729 (2003)
   PUBMED   12493770
  REMARK    GeneRIF: RasGRP4 regulates the expression of prostaglandin D2 in
            mast cell
REFERENCE   3  (residues 1 to 678)
  AUTHORS   Li,L., Yang,Y. and Stevens,R.L.
  TITLE     Cloning of rat Ras guanine nucleotide releasing protein 4, and
            evaluation of its expression in rat mast cells and their bone
            marrow progenitors
  JOURNAL   Mol Immunol 38 (16-18), 1283-1288 (2002)
   PUBMED   12217396
  REMARK    GeneRIF: Cloning of Ras guanine nucleotide releasing protein 4, and
            evaluation of its expression in mast cells and their bone marrow
            progenitors.
            Review article
REFERENCE   4  (residues 1 to 678)
  AUTHORS   Reuther,G.W., Lambert,Q.T., Rebhun,J.F., Caligiuri,M.A.,
            Quilliam,L.A. and Der,C.J.
  TITLE     RasGRP4 is a novel Ras activator isolated from acute myeloid
            leukemia
  JOURNAL   J Biol Chem 277 (34), 30508-30514 (2002)
   PUBMED   11880369
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF465263.1.
            
            On Mar 15, 2007 this sequence version replaced NP_570837.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF465263.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN06680412
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..678
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     Protein         1..678
                     /product="RAS guanyl-releasing protein 4"
                     /calculated_mol_wt=75274
     Region          1..33
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R5I4.1)"
     Region          57..172
                     /region_name="REM"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal domain (RasGef_N), also called REM
                     domain (Ras exchanger motif). This domain is common in
                     nucleotide exchange factors for Ras-like small GTPases and
                     is typically found immediately...; cd06224"
                     /db_xref="CDD:100121"
     Site            order(68,115,119..120,123,126..127,162..163,166)
                     /site_type="other"
                     /note="GTPase interaction site [polypeptide binding]"
                     /db_xref="CDD:100121"
     Region          165..185
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R5I4.1)"
     Region          197..432
                     /region_name="RasGEF"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases; smart00147"
                     /db_xref="CDD:214539"
     Site            order(230..232,240..241,243..245,247..248,251..252,255,
                     288,291..292,294..296,298..301,303..304,324,327,332..334,
                     337,350..352,355..357,359..361,363..366,381,385,420,
                     423..424)
                     /site_type="other"
                     /note="Ras interaction site [polypeptide binding]"
                     /db_xref="CDD:238087"
     Region          538..599
                     /region_name="C1"
                     /note="protein kinase C conserved region 1 (C1 domain)
                     superfamily; cl00040"
                     /db_xref="CDD:412127"
     Region          598..620
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R5I4.1)"
     Region          651..678
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R5I4.1)"
     CDS             1..678
                     /gene="Rasgrp4"
                     /coded_by="NM_130824.2:1..2037"
                     /db_xref="GeneID:170668"
                     /db_xref="RGD:620476"
ORIGIN      
        1 mnrkdikrks hqecsgkagg hgrprqarrh ktcptpreis kvmaslnlgv lsesscsvde
       61 lleecircfd sagslhrgdh ilkmvltmhs wvlpssdlaa rlltsyqkaa kdarelrqlq
      121 icylvrywlt hhpevvhqep qleaiinrfw ttvaqegnma qrslgdasnl lspggpgppp
      181 lmsspglgkk rkvsllfdhl eteelaqhlt ylefrsfqai tpqdlrgyvl qgsvrgcpal
      241 egsvglsnsv srwvqvmvls rpgpaqraqv ldkfirvaqr lrqmqnfntl mavtgglchs
      301 aisrlkdshv hlspdstkal leltellssh nnyayyrrtw asctdfrlpv lgvhlkdlvs
      361 lyeahpdrlp dgrlhlpkln slylrlqela alqrqhppcs anedllhllt lsldlfyted
      421 eiyelsyare prcpkslpls pfkapvvvew ahgvtpkpds atlgqhveql vesvfknydp
      481 eghgsisled feklsanfpf achglhpppr hgsgsfsree ltkyllhasa icsklglafl
      541 hafqevtfrk ptfchscngf vstgplwgvt krgyrcqdcg lcchrhcrdq vrveckkrpe
      601 tkgdpgppga pgpatplppt gcgseeglsy tlsphlesgc hlhhawtqte sshsswepem
      661 vpcpapvlps kasskssv
//
