LOCUS       NM_001399544            4674 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus RAS guanyl releasing protein 3 (Rasgrp3), mRNA.
ACCESSION   NM_001399544 XM_006239757
VERSION     NM_001399544.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4674)
  AUTHORS   Yang,H.C., Liang,Y.J., Wu,Y.L., Chung,C.M., Chiang,K.M., Ho,H.Y.,
            Ting,C.T., Lin,T.H., Sheu,S.H., Tsai,W.C., Chen,J.H., Leu,H.B.,
            Yin,W.H., Chiu,T.Y., Chen,C.I., Fann,C.S., Wu,J.Y., Lin,T.N.,
            Lin,S.J., Chen,Y.T., Chen,J.W. and Pan,W.H.
  TITLE     Genome-wide association study of young-onset hypertension in the
            Han Chinese population of Taiwan
  JOURNAL   PLoS One 4 (5), e5459 (2009)
   PUBMED   19421330
REFERENCE   2  (bases 1 to 4674)
  AUTHORS   Biou,V., Brinkhaus,H., Malenka,R.C. and Matus,A.
  TITLE     Interactions between drebrin and Ras regulate dendritic spine
            plasticity
  JOURNAL   Eur J Neurosci 27 (11), 2847-2859 (2008)
   PUBMED   18588530
  REMARK    GeneRIF: Together these data demonstrate a novel mechanism in which
            the balance between stability and plasticity in dendritic spines
            depends on binding of drebrin to actin filaments in a manner that
            is regulated by Ras.
REFERENCE   3  (bases 1 to 4674)
  AUTHORS   Regier,D.S., Higbee,J., Lund,K.M., Sakane,F., Prescott,S.M. and
            Topham,M.K.
  TITLE     Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3
            and inhibits Rap1 signaling
  JOURNAL   Proc Natl Acad Sci U S A 102 (21), 7595-7600 (2005)
   PUBMED   15894621
REFERENCE   4  (bases 1 to 4674)
  AUTHORS   Ozaki,N., Miura,Y., Yamada,T., Kato,Y. and Oiso,Y.
  TITLE     RasGRP3 mediates phorbol ester-induced, protein kinase
            C-independent exocytosis
  JOURNAL   Biochem Biophys Res Commun 329 (2), 765-771 (2005)
   PUBMED   15737652
  REMARK    GeneRIF: These results indicate that RasGRP3 is implicated in
            phorbol ester-induced, PKC-independent exocytosis.
REFERENCE   5  (bases 1 to 4674)
  AUTHORS   Aiba,Y., Oh-hora,M., Kiyonaka,S., Kimura,Y., Hijikata,A., Mori,Y.
            and Kurosaki,T.
  TITLE     Activation of RasGRP3 by phosphorylation of Thr-133 is required for
            B cell receptor-mediated Ras activation
  JOURNAL   Proc Natl Acad Sci U S A 101 (47), 16612-16617 (2004)
   PUBMED   15545601
REFERENCE   6  (bases 1 to 4674)
  AUTHORS   Rebhun,J.F., Castro,A.F. and Quilliam,L.A.
  TITLE     Identification of guanine nucleotide exchange factors (GEFs) for
            the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction
  JOURNAL   J Biol Chem 275 (45), 34901-34908 (2000)
   PUBMED   10934204
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Jan 12, 2022 this sequence version replaced XM_006239757.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.17545.1,
                                           SRR26643284.8502.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760475,
                                           SAMN12840115 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               JAXUCZ010000006.1  25710459-25710591   c
            134-266             JAXUCZ010000006.1  25687225-25687357   c
            267-470             JAXUCZ010000006.1  25684192-25684395   c
            471-573             JAXUCZ010000006.1  25682726-25682828   c
            574-636             JAXUCZ010000006.1  25680545-25680607   c
            637-768             JAXUCZ010000006.1  25679929-25680060   c
            769-916             JAXUCZ010000006.1  25678468-25678615   c
            917-1090            JAXUCZ010000006.1  25677030-25677203   c
            1091-1207           JAXUCZ010000006.1  25676511-25676627   c
            1208-1483           JAXUCZ010000006.1  25673849-25674124   c
            1484-1561           JAXUCZ010000006.1  25667601-25667678   c
            1562-1678           JAXUCZ010000006.1  25666379-25666495   c
            1679-1794           JAXUCZ010000006.1  25663937-25664052   c
            1795-1942           JAXUCZ010000006.1  25661776-25661923   c
            1943-1979           JAXUCZ010000006.1  25652443-25652479   c
            1980-2105           JAXUCZ010000006.1  25652001-25652126   c
            2106-2467           JAXUCZ010000006.1  25651303-25651664   c
            2468-4674           JAXUCZ010000006.1  25647386-25649592   c
FEATURES             Location/Qualifiers
     source          1..4674
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12-q13"
     gene            1..4674
                     /gene="Rasgrp3"
                     /note="RAS guanyl releasing protein 3"
                     /db_xref="GeneID:313874"
                     /db_xref="RGD:1304612"
     exon            1..133
                     /gene="Rasgrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            134..266
                     /gene="Rasgrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            267..470
                     /gene="Rasgrp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             401..2476
                     /gene="Rasgrp3"
                     /note="RAS guanyl releasing protein 3 (calcium and
                     DAG-regulated)"
                     /codon_start=1
                     /product="ras guanyl-releasing protein 3"
                     /protein_id="NP_001386473.1"
                     /db_xref="GeneID:313874"
                     /db_xref="RGD:1304612"
                     /translation="MGSNGLGKAATLDELLSTCIEMFDDNGELNDSYLPRIMLLMHRW
                     YLSSTELAGKLLCMYRNASGESCDEFRLKICYFMRYWITKFPAEFNLDLGLIRMTEEF
                     REVASQLGYEKHSNLMDISSIPSYDWMRRVTQRKKVSKRGKACLLFDHLEPIELAEHL
                     TFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPSAQQR
                     AEVITKFINVAQKLLQLKNFNTLMAVVGGLSHSSISRLKDTHSHLSSEVTKNWNEMTE
                     LVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWMEENKVNVVKMHQLS
                     VTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSP
                     TTPNKPVVPLEWASEVVPKPDPTIINKHIRKLVESVFRNYDHDHDGYISQEDFESIAA
                     NFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMNYLKPTFC
                     EHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRLARAPSLSSNPESLPGSPAL
                     PPVQDEVFEFPGVTARHRDLDSRDITLVTGSSRKISVRVQRATTSQATQTEPVWSEAV
                     WGDSGSHTFPKMKSKLHDKAAKDKGFAKWENEKPTLHAGVDVVDRGTAFEPDQDDEQD
                     EAQQGVEDG"
     exon            471..573
                     /gene="Rasgrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            574..636
                     /gene="Rasgrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            637..768
                     /gene="Rasgrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            769..916
                     /gene="Rasgrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1090
                     /gene="Rasgrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1207
                     /gene="Rasgrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1483
                     /gene="Rasgrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1561
                     /gene="Rasgrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1678
                     /gene="Rasgrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1794
                     /gene="Rasgrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1942
                     /gene="Rasgrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..1979
                     /gene="Rasgrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2105
                     /gene="Rasgrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2467
                     /gene="Rasgrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..4674
                     /gene="Rasgrp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgtttatc aggaggtgca tatgactggt taagacacac agcctggctg gaaggaaaca
       61 gctgctactg cctgctccac acttggcagc tagacaggcc aagcgcttgt gtgaggaaga
      121 caaaattacc ccagttttcc agagccctta tcatttgagt tgaatgaacc agttcttcag
      181 tctgcttccc ccatgccctt cccagggatg acaactgccc ttggcatctt ttcagacctg
      241 gatctctatc aatatgaaaa tagattagca ttcttggggc ataattagga agtaacatta
      301 agctatcaaa gggcgagaga accactgact tgtacagata tggaggtaat gtgtctgctg
      361 ctggaaatgt ctccagattt ttgacaacgg ctaaagcacc atggggtcca acggcctcgg
      421 gaaagcggcg acactagatg aacttctcag cacatgcatt gagatgtttg atgacaatgg
      481 agaactgaat gacagctact tgcccagaat catgctactg atgcatcgat ggtatttatc
      541 ctccactgaa ctggcaggaa aactcctatg catgtatcgg aatgccagcg gagaaagttg
      601 tgatgagttc cgactgaaga tctgctattt catgaggtac tggattacaa aatttcctgc
      661 agagtttaat ttggatcttg gtttgattcg catgactgag gagttccggg aagtagctag
      721 tcaactagga tatgagaaac acagcaacct catggacata tccagcattc cttcctatga
      781 ctggatgagg agagtcacgc agaggaaaaa agtatcaaaa aggggaaagg cctgtctctt
      841 atttgaccat ctggagccca ttgaattggc tgagcacctc acttttctgg agcataaatc
      901 ttttagaagg atctcgttca cagattatca gagctacgtc attcatggct gcctggagaa
      961 taacccgaca ttggagagat ctattgcctt atttaatgga atctctaagt gggtccaatt
     1021 gatggttctt agcaaaccaa gtgctcaaca aagggcggaa gtcatcacaa agttcatcaa
     1081 tgtagcacag aaactccttc aactaaaaaa ttttaacacc ttgatggctg tggttggtgg
     1141 ccttagtcac agctccattt cccgactcaa agatacccat tctcacctct cttctgaagt
     1201 tacaaagaac tggaatgaga tgacagagtt ggtctcctcc aacggcaatt actgcaatta
     1261 ccgcaaggcc tttgctgact gtgatggctt caaaatcccc atccttggcg tgcacttgaa
     1321 agacttgata gcagtccatg tcattttccc agactggatg gaagagaaca aagtgaacgt
     1381 tgtgaaaatg caccagcttt ctgttaccct gagtgaactg gtctccctgc agaatgcctc
     1441 tcaccacttg gagcctaaca tggatttgat caacctcctc actctctctc tggacctcta
     1501 ccacacagaa gacgatattt ataaactatc actggtgctg gagcctagga attccaaatc
     1561 acagccaact tcccccacaa cacctaataa gcctgtggta cccctggagt gggcttcaga
     1621 agtggtacca aagccagacc ccacaatcat caacaaacac ataaggaagt tggttgagtc
     1681 tgtgtttcga aactatgacc atgaccatga tggatacatc tctcaagagg actttgagag
     1741 catagcggcc aattttccct tcctggattc cttctgtgtg ctagacaaag accaggacgg
     1801 cttaattagc aaagacgaaa tgatggctta tttcctgaga gccaaatctc agctacactg
     1861 caagatggga ccaggcttta tccataattt tcaggaaatg aactatctca agcccacttt
     1921 ctgcgaacac tgtgcgggat ttctctgggg cataatcaaa caaggctaca aatgcaaaga
     1981 ctgtggagcc aactgtcaca aacagtgcaa agacctcttg gttctggcct gtaggagact
     2041 tgccagggca ccctccttga gcagcaaccc tgagtcactg cctggaagcc cagccttgcc
     2101 cccagtgcag gatgaggtgt ttgagtttcc tggcgtcact gctagacacc gagacctgga
     2161 cagcagagac atcacgctgg ttacaggatc ttcccgtaag atctccgtga gagtgcagag
     2221 agccaccact agtcaagcca cgcaaaccga acctgtgtgg tcagaggctg tctggggaga
     2281 ctctgggtcc cataccttcc ccaaaatgaa atccaagctc catgacaaag cagcaaagga
     2341 caaaggcttt gccaagtggg aaaatgaaaa gcccacgcta cacgctggtg tggatgttgt
     2401 agatcgaggc actgcattcg aacctgacca ggacgatgag caagatgaag cccaacaggg
     2461 tgtcgaggat ggctgaggtc aagctgggga aaccgaaggc aatcaagtcg gctttggaag
     2521 gagagagaag agctctgaaa ggcactgtcc tctcagaaca gtctggaaaa gagatttgaa
     2581 tatgctcatg gcctccagtc atcctgggag ccccatgact ggactacggg atagagaatt
     2641 taccctgact ctgaactatt tatttcctgt actctgcccc tactcaggtg ccacgaaacc
     2701 tagttacata gtcagcagct tctcgcgtct ctctaaagcc atttgtaccc aggggaatga
     2761 aagctttggt gcatgtgcat gatagccctt ctctaaaatc aagacttagc tcctttggac
     2821 aatattattt ttataaagtg tgtgcatgtg tgtagggttg tctcataagt tgagtttgag
     2881 ctccttttgt gtgtctttta gatgggactg gggcctgaag ttttactgag ggacaaagac
     2941 attctttaga ccctggaagg cagtgagccc ttggctgatg attctctgta aggaatgttt
     3001 gtagtgtcct accacacagt ggctgtgctg ggcaatgtca tgccgtgtgt gtgtgtgtgt
     3061 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gcgtgtcacc taggtcttac caatcctgga
     3121 ttgctaaggg gaatcatatc cccaaagatc ccttaatact catgctagat atggtaaaaa
     3181 aaaaatgcat atacctgact acctaattgg attccccact ctttctgaaa attctcaaaa
     3241 taaaatgtta attaagaaat caaattccaa gggagaaaat ttagtagaaa aacccactga
     3301 atcactaggt taaaaaaaca acaaacaggg gctggggatt tagctcagtg gtagagcgct
     3361 tacctaggaa gcgcaaggcc ctgggttcgg tccccagctc cgaaaaaaaa gaaccaaaaa
     3421 aaaaaaaaaa acaacaaaca aacaaacaaa caaacaaaac caactagttt ggaagctgaa
     3481 agtaatcctg tggtttttat tttagataat ttttggatgg aaagggtaac ttaattttct
     3541 cctaagaaat tctcatccac agttaagaaa tattcacaaa aaggaaaatc accataaacc
     3601 tcaactatgg attgatattc catttagacc tttaaaatat taataattta aatgtctttc
     3661 tttgggtgtg tatcttatgc aatagattca agatgctcag aaatagagac actgccaggc
     3721 tggtgtttaa atacctataa tctctggact tgggatgtga ggtaggaaga ccccaagtct
     3781 caagtcaaca tggggaactt agcaagaatc taagaaaaaa tgtaggggct ggagagatgg
     3841 ctcagaggtt aagaccactg tctgcctttc cagaggtcct gagttcaatc cccaggaacc
     3901 acacagtggc tcagaaccat ctgcaatgag atcctatgtc ctctactggt gagtctgaaa
     3961 acagccgtag tgcactcaag aaaagttgag gtgattgagt ttgtctgtca ttgagggcac
     4021 catctcatat caaatgaccg gttaggaaat attccacaga ggtaccaggt ccacatttga
     4081 gggctaactt gtatatccca tgtaaaacag attgtggtgt tatttgcgga cgtcacttcc
     4141 atatagctca actgataatt gtgctctggc ccttagaaac tgagaggagg acaaaactgc
     4201 taagggtctc aagacaacct tggtagagct gacatgatgt gcccgacagt cctggagtgg
     4261 ggcatgattc agattgggga tactgaagac taagcgaagt tctcaattga aggagctgtg
     4321 attaatctag atgagagctc acttcagtgt cgagcgcctt gggcagtgct gttggatcta
     4381 tgtatataga ctgtctgtta ctattcataa atacagcaga gtacatgtta atgaattcaa
     4441 accagaaact gacaagtcga gtacaggcaa actctctaaa aacatccaga aagaaaccta
     4501 ttaaggaatg ttggtggttt tgtatttctt ttcaaaggag ttatctcacc tgccatttgg
     4561 tttagaaatt tatgagtttt catatataca aggaattttg tatctttggt cttcctgtga
     4621 tatggaaaaa aatgtacctt cgatgaaaaa ataaatgaac aaacagaaat acaa
//
