LOCUS       NM_001082977            2226 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus RAS guanyl releasing protein 2 (Rasgrp2), mRNA.
ACCESSION   NM_001082977 XM_342003
VERSION     NM_001082977.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2226)
  AUTHORS   Canault,M., Ghalloussi,D., Grosdidier,C., Guinier,M., Perret,C.,
            Chelghoum,N., Germain,M., Raslova,H., Peiretti,F., Morange,P.E.,
            Saut,N., Pillois,X., Nurden,A.T., Cambien,F., Pierres,A., van den
            Berg,T.K., Kuijpers,T.W., Alessi,M.C. and Tregouet,D.A.
  TITLE     Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function
            and causes severe bleeding
  JOURNAL   J Exp Med 211 (7), 1349-1362 (2014)
   PUBMED   24958846
REFERENCE   2  (bases 1 to 2226)
  AUTHORS   Clyde-Smith,J., Silins,G., Gartside,M., Grimmond,S., Etheridge,M.,
            Apolloni,A., Hayward,N. and Hancock,J.F.
  TITLE     Characterization of RasGRP2, a plasma membrane-targeted, dual
            specificity Ras/Rap exchange factor
  JOURNAL   J Biol Chem 275 (41), 32260-32267 (2000)
   PUBMED   10918068
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jun 30, 2017 this sequence version replaced NM_001082977.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.5000.1,
                                           SRR26360194.501300.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                JAXUCZ010000001.1  213136734-213136823
            91-238              JAXUCZ010000001.1  213137906-213138053
            239-341             JAXUCZ010000001.1  213138667-213138769
            342-404             JAXUCZ010000001.1  213139229-213139291
            405-536             JAXUCZ010000001.1  213139658-213139789
            537-687             JAXUCZ010000001.1  213140534-213140684
            688-861             JAXUCZ010000001.1  213140917-213141090
            862-978             JAXUCZ010000001.1  213141186-213141302
            979-1260            JAXUCZ010000001.1  213143834-213144115
            1261-1338           JAXUCZ010000001.1  213145021-213145098
            1339-1461           JAXUCZ010000001.1  213145304-213145426
            1462-1577           JAXUCZ010000001.1  213145698-213145813
            1578-1719           JAXUCZ010000001.1  213150047-213150188
            1720-1756           JAXUCZ010000001.1  213150390-213150426
            1757-1933           JAXUCZ010000001.1  213150808-213150984
            1934-1996           JAXUCZ010000001.1  213151822-213151884
            1997-2226           JAXUCZ010000001.1  213152017-213152246
FEATURES             Location/Qualifiers
     source          1..2226
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2226
                     /gene="Rasgrp2"
                     /note="RAS guanyl releasing protein 2"
                     /db_xref="GeneID:361714"
                     /db_xref="RGD:1311630"
     exon            1..90
                     /gene="Rasgrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            91..238
                     /gene="Rasgrp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1992
                     /gene="Rasgrp2"
                     /note="calDAG-GEFI; calcium and DAG-regulated guanine
                     nucleotide exchange factor I; RAS guanyl releasing protein
                     2 (calcium and DAG-regulated)"
                     /codon_start=1
                     /product="RAS guanyl-releasing protein 2"
                     /protein_id="NP_001076446.2"
                     /db_xref="GeneID:361714"
                     /db_xref="RGD:1311630"
                     /translation="MASTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHP
                     WYIPSSQLASKLLHFYQQSRKDNSNSLQVKTCHLVRYWVSAFPAEFDLNPELAEQIKE
                     LKALLDQEGNRRHSSLIDIESVPTYKWKRQVTQRNPVEQKKRKMSLLFDHLEPMELAE
                     HLTYLEYRSFCKILFQDYHSFVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAT
                     QRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPDTIKLWEGL
                     TELVTATGNYSNYRRRLAACVGFRFPILGVHLKDLVALQLALPDWLDPGRTRLNGAKM
                     RQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRSKSSP
                     TSPTSCTPPPRPPVLEEWTSVAKPKLDQALVAEHIEKMVESVFRNFDVDGDGHISQEE
                     FQIIRGNFPYLSAFGDLDQNQDGCISREEMISYFLRSSSVLGGRMGFVHNFQESNSLR
                     PVACRHCKALILGIYKQGLKCRACGVNCHKQCKDRLSVECRRRAQSVSLEGSAPSPSP
                     THTHHRAFSFSLPRPGRRSSRPPEIREEEVQTVEDGVFDIHL"
     exon            239..341
                     /gene="Rasgrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            342..404
                     /gene="Rasgrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            405..536
                     /gene="Rasgrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            537..687
                     /gene="Rasgrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            688..861
                     /gene="Rasgrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            862..978
                     /gene="Rasgrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1260
                     /gene="Rasgrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1338
                     /gene="Rasgrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1461
                     /gene="Rasgrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1577
                     /gene="Rasgrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1719
                     /gene="Rasgrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1756
                     /gene="Rasgrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1933
                     /gene="Rasgrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..1996
                     /gene="Rasgrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2226
                     /gene="Rasgrp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgaaggatca gaggctgagc tggttcaagt gaacagaagg tctgggaggt gaactgcatt
       61 cgggtttgca ttctgaagta aaggacttgg gacaggggta cgaatcgagc actgtgggag
      121 gctctgagag tgtaacttgg gtctagccca ctggcaccgg cagccatggc gagcactctg
      181 gacctggaca agggttgcac cgtggaggag ctgctccgtg gctgtatcga agcctttgat
      241 gactctggaa aggtgcgaga tccacagcta gtgcgcatgt ttctcatgat gcacccctgg
      301 tacatacctt cctctcagct ggcttcgaaa ctgctccact tctatcagca atcccggaag
      361 gacaactcca attccctaca ggtgaaaacc tgtcacctgg tcaggtactg ggtctcagcc
      421 ttcccagcag agttcgactt gaacccagag ctggctgaac agatcaagga gctgaaggct
      481 ctgttagacc aagaaggaaa ccgcaggcac agcagcctca tcgacatcga gagtgtcccc
      541 acctacaagt ggaagcggca ggtgacccag cggaaccctg tggaacagaa aaagcgcaag
      601 atgtccctgt tgtttgatca cttggagcct atggaactgg cagaacatct cacctacttg
      661 gagtatcggt ccttctgcaa gatcctgttc caggactatc acagctttgt gactcatggc
      721 tgcactgtag acaatccggt cctggagcga ttcatctccc tcttcaacag tgtctctcag
      781 tgggtccaac tcatgatcct cagcaagccc acagccacgc agcgggcgct ggtcatcaca
      841 catttcgtgc atgtggcaga gaagctgctg cagctgcaga acttcaacac gttgatggcc
      901 gtcgtgggag gcctgagcca cagctccatc tcacgcctca aggagaccca cagccatgtc
      961 agccctgaca ccatcaagct ctgggaaggt ctgacagaac tagtgacagc tactggcaac
     1021 tacagcaact accggcgaag gctggcggcc tgcgtgggct tccgctttcc tatcctgggt
     1081 gtgcacctca aggatctagt ggctctgcag ctggctctgc ctgactggct ggacccaggt
     1141 cggacccggc tcaatggagc caagatgagg cagcttttca gcattctgga ggagttggct
     1201 atggtgacca gtcttcgacc accagtgcaa gccaaccccg acctgctgag tctgctcacg
     1261 gtgtccctgg accagtatca gacggaggat gagctgtatc agctctctct gcagcgagag
     1321 ccacgttcca agtcatcgcc caccagcccc accagctgca ccccgcctcc ccggccgcct
     1381 gtgctggaag agtggacctc agttgccaag cctaagctgg accaagcctt ggtggccgag
     1441 cacattgaga agatggtgga gtctgtgttc cggaactttg acgttgatgg ggacggtcac
     1501 atctcccagg aggagttcca gatcatccgg ggcaacttcc cttatctcag cgcctttggg
     1561 gacttggacc agaaccagga tggctgcatc agccgcgagg agatgatctc ctacttcctg
     1621 cgctccagct cggtgctggg aggccgcatg ggcttcgtac acaacttcca ggagagtaac
     1681 tcgctaaggc cggtcgcctg ccgacactgc aaagctctga tcctgggcat ctacaagcag
     1741 ggcctcaaat gtagagcttg tggtgtgaac tgccacaagc agtgcaaaga ccgactgtca
     1801 gtggaatgtc gccgccgcgc ccagagtgtg agcctggagg gctctgcacc ctctccctca
     1861 cccacacata cccaccatcg ggccttcagc ttctccctgc ctcgcccagg caggcgcagc
     1921 tctcggcctc cagagatccg tgaagaggag gtgcagactg tggaagatgg tgtgttcgac
     1981 atccacttat aagacgctgt gactatcaag gactcattcc tgccttggag aaaagacttg
     2041 gagcagagca gggagccagg gattctgggg caggaggttg gggctgaggg tgggggaggt
     2101 tgagggtggc atgcactgag aagagggcca gggctggtgt ccctaaggtt gtacagactt
     2161 ctgtgaatat ttgtattttc cagatggaat aaaaaggccc gaataattaa cctcgaccat
     2221 cagcct
//
