LOCUS       NM_019211               3630 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus RAS guanyl releasing protein 1 (Rasgrp1), mRNA.
ACCESSION   NM_019211
VERSION     NM_019211.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3630)
  AUTHORS   Mao,H., Yang,W., Latour,S., Yang,J., Winter,S., Zheng,J., Ni,K.,
            Lv,M., Liu,C., Huang,H., Chan,K.W., Pui-Wah Lee,P., Tu,W.,
            Fischer,A. and Lau,Y.L.
  TITLE     RASGRP1 mutation in autoimmune lymphoproliferative syndrome-like
            disease
  JOURNAL   J Allergy Clin Immunol 142 (2), 595-604 (2018)
   PUBMED   29155103
REFERENCE   2  (bases 1 to 3630)
  AUTHORS   Salzer,E., Cagdas,D., Hons,M., Mace,E.M., Garncarz,W.,
            Petronczki,O.Y., Platzer,R., Pfajfer,L., Bilic,I., Ban,S.A.,
            Willmann,K.L., Mukherjee,M., Supper,V., Hsu,H.T., Banerjee,P.P.,
            Sinha,P., McClanahan,F., Zlabinger,G.J., Pickl,W.F., Gribben,J.G.,
            Stockinger,H., Bennett,K.L., Huppa,J.B., Dupre,L., Sanal,O.,
            Jager,U., Sixt,M., Tezcan,I., Orange,J.S. and Boztug,K.
  TITLE     RASGRP1 deficiency causes immunodeficiency with impaired
            cytoskeletal dynamics
  JOURNAL   Nat Immunol 17 (12), 1352-1360 (2016)
   PUBMED   27776107
REFERENCE   3  (bases 1 to 3630)
  AUTHORS   Iwig,J.S., Vercoulen,Y., Das,R., Barros,T., Limnander,A., Che,Y.,
            Pelton,J.G., Wemmer,D.E., Roose,J.P. and Kuriyan,J.
  TITLE     Structural analysis of autoinhibition in the Ras-specific exchange
            factor RasGRP1
  JOURNAL   Elife 2, e00813 (2013)
   PUBMED   23908768
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3630)
  AUTHORS   Jin,T., Ding,Q., Huang,H., Xu,D., Jiang,Y., Zhou,B., Li,Z.,
            Jiang,X., He,J., Liu,W., Zhang,Y., Pan,Y., Wang,Z., Thomas,W.G. and
            Chen,Y.
  TITLE     PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus
  JOURNAL   Cell Res 22 (4), 661-676 (2012)
   PUBMED   21968647
REFERENCE   5  (bases 1 to 3630)
  AUTHORS   Shen,S., Chen,Y., Gorentla,B.K., Lu,J., Stone,J.C. and Zhong,X.P.
  TITLE     Critical roles of RasGRP1 for invariant NKT cell development
  JOURNAL   J Immunol 187 (9), 4467-4473 (2011)
   PUBMED   21957144
REFERENCE   6  (bases 1 to 3630)
  AUTHORS   Dower,N.A., Stang,S.L., Bottorff,D.A., Ebinu,J.O., Dickie,P.,
            Ostergaard,H.L. and Stone,J.C.
  TITLE     RasGRP is essential for mouse thymocyte differentiation and TCR
            signaling
  JOURNAL   Nat Immunol 1 (4), 317-321 (2000)
   PUBMED   11017103
REFERENCE   7  (bases 1 to 3630)
  AUTHORS   Szpirer,C., Van Vooren,P., Riviere,M., Scohy,S., Collau,G. and
            Szpirer,J.
  TITLE     Localization of 54 rat genes, and definition of new synteny groups
            conserved in the human and the rat
  JOURNAL   Mamm Genome 11 (9), 729-735 (2000)
   PUBMED   10967130
REFERENCE   8  (bases 1 to 3630)
  AUTHORS   Ebinu,J.O., Stang,S.L., Teixeira,C., Bottorff,D.A., Hooton,J.,
            Blumberg,P.M., Barry,M., Bleakley,R.C., Ostergaard,H.L. and
            Stone,J.C.
  TITLE     RasGRP links T-cell receptor signaling to Ras
  JOURNAL   Blood 95 (10), 3199-3203 (2000)
   PUBMED   10807788
REFERENCE   9  (bases 1 to 3630)
  AUTHORS   Kawasaki,H., Springett,G.M., Toki,S., Canales,J.J., Harlan,P.,
            Blumenstiel,J.P., Chen,E.J., Bany,I.A., Mochizuki,N., Ashbacher,A.,
            Matsuda,M., Housman,D.E. and Graybiel,A.M.
  TITLE     A Rap guanine nucleotide exchange factor enriched highly in the
            basal ganglia
  JOURNAL   Proc Natl Acad Sci U S A 95 (22), 13278-13283 (1998)
   PUBMED   9789079
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Jan 5;96(1):318]
REFERENCE   10 (bases 1 to 3630)
  AUTHORS   Ebinu,J.O., Bottorff,D.A., Chan,E.Y., Stang,S.L., Dunn,R.J. and
            Stone,J.C.
  TITLE     RasGRP, a Ras guanyl nucleotide- releasing protein with calcium-
            and diacylglycerol-binding motifs
  JOURNAL   Science 280 (5366), 1082-1086 (1998)
   PUBMED   9582122
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000118.1.
            
            [WARNING] On Mar 31, 2024 this sequence was replaced by
            NM_019211.4.
            
            On Nov 27, 2020 this sequence version replaced NM_019211.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF081196.1, AF060819.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               JACYVU010000118.1  28096943-28097121   c
            180-364             JACYVU010000118.1  28092551-28092735   c
            365-470             JACYVU010000118.1  28063208-28063313   c
            471-533             JACYVU010000118.1  28059468-28059530   c
            534-665             JACYVU010000118.1  28057957-28058088   c
            666-819             JACYVU010000118.1  28055977-28056130   c
            820-993             JACYVU010000118.1  28051376-28051549   c
            994-1110            JACYVU010000118.1  28050338-28050454   c
            1111-1386           JACYVU010000118.1  28048342-28048617   c
            1387-1467           JACYVU010000118.1  28046118-28046198   c
            1468-1572           JACYVU010000118.1  28045147-28045251   c
            1573-1682           JACYVU010000118.1  28044264-28044373   c
            1683-1827           JACYVU010000118.1  28043483-28043627   c
            1828-1864           JACYVU010000118.1  28042457-28042493   c
            1865-2017           JACYVU010000118.1  28041683-28041835   c
            2018-2397           JACYVU010000118.1  28040455-28040834   c
            2398-3630           JACYVU010000118.1  28037078-28038310   c
FEATURES             Location/Qualifiers
     source          1..3630
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..3630
                     /gene="Rasgrp1"
                     /gene_synonym="Rasgrp"
                     /note="RAS guanyl releasing protein 1"
                     /db_xref="GeneID:29434"
                     /db_xref="RGD:3539"
     exon            1..179
                     /gene="Rasgrp1"
                     /gene_synonym="Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..2532
                     /gene="Rasgrp1"
                     /gene_synonym="Rasgrp"
                     /note="calDAG-GEFII; CalDAG-GEF1; calcium and
                     DAG-regulated guanine nucleotide exchange factor II; RAS
                     guanyl releasing protein 1 (calcium and DAG-regulated)"
                     /codon_start=1
                     /product="RAS guanyl-releasing protein 1"
                     /protein_id="NP_062084.2"
                     /db_xref="GeneID:29434"
                     /db_xref="RGD:3539"
                     /translation="MGTLGKAREAPRKPCHGSRAGPKGRLEAKSTNSPLPAQPSLAQI
                     TQFRMMVSLGHLAKGASLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIIISSAEL
                     LQKLMNLYKDALEKNSPGICLKICYFVRYWITEFWIMFKMDASLTSTMEEFQDLVKAN
                     GEESHCHLIDTTQINSRDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEF
                     KSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFI
                     KFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSC
                     RNYDNYRRAYGECTHFKIPILGVHLKDLISLYEAMPDYLEDGKVNVQKLLALYNHINE
                     LVQLQDVAPPLDANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKPPV
                     VVDWASGVSPKPDPKTISKHVQRMVDSVFKNYDLDQDGYISQEEFEKIAASFPFSFCV
                     MDKDREGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVI
                     KQGYRCKDCGMNCHKQCKDLVVFECKKRSKSPAVSTENISSVVPMSTLCPLGTKDLLH
                     APEEGSFIFQNGEVVDHSEESKDRTIMLLGVSSQKISVRLKRTVAHKTTQTESFPWVG
                     GEMPPGHFVLTSPRKSAQGALYVHSPASPCPSPALVRKRAFVKWENKESLIKPKPELH
                     LRLRTYQELEQEVNTLRADNDALKIQLKYAQKQIESLQLGKSNHVLAQMDHGDGT"
     exon            180..364
                     /gene="Rasgrp1"
                     /gene_synonym="Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            365..470
                     /gene="Rasgrp1"
                     /gene_synonym="Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            471..533
                     /gene="Rasgrp1"
                     /gene_synonym="Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            534..665
                     /gene="Rasgrp1"
                     /gene_synonym="Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            666..819
                     /gene="Rasgrp1"
                     /gene_synonym="Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            820..993
                     /gene="Rasgrp1"
                     /gene_synonym="Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1110
                     /gene="Rasgrp1"
                     /gene_synonym="Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1386
                     /gene="Rasgrp1"
                     /gene_synonym="Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1467
                     /gene="Rasgrp1"
                     /gene_synonym="Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1572
                     /gene="Rasgrp1"
                     /gene_synonym="Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1682
                     /gene="Rasgrp1"
                     /gene_synonym="Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1827
                     /gene="Rasgrp1"
                     /gene_synonym="Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1864
                     /gene="Rasgrp1"
                     /gene_synonym="Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..2017
                     /gene="Rasgrp1"
                     /gene_synonym="Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2397
                     /gene="Rasgrp1"
                     /gene_synonym="Rasgrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..3630
                     /gene="Rasgrp1"
                     /gene_synonym="Rasgrp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcctgggt cggctcgccg ggctccgaga gtggccggct ccgggctgcg agggccggcg
       61 gcggccgagg gatgcgccgc tcccggccga gccgatccca ccgctccagg tgagacggct
      121 ccaggggcgc agagagccgc ggccatggga accctgggca aggcgagaga ggctccgcgg
      181 aaaccttgcc atggctccag agctggcccc aaaggaagac tagaggccaa atcaaccaac
      241 agtcctctcc ctgcccagcc cagcttggcc cagatcaccc agttccgaat gatggtgtcc
      301 ctgggacatc tggccaaagg agccagcctg gatgatctta ttgacagctg cattcaatct
      361 ttcgatgcag atggaaacct gtgtcgaagt aaccagctgt tacaagtcat gctaaccatg
      421 caccgaatca tcatctcctc ggctgagctg ctgcaaaaac tcatgaatct atataaggac
      481 gccctggaaa agaattctcc aggaatttgc ttgaagatct gctattttgt caggtattgg
      541 ataacagaat tctggatcat gttcaaaatg gatgccagct tgaccagcac catggaagag
      601 tttcaggacc tggtgaaagc caatggtgag gagtcccact gccacctcat cgacacgaca
      661 caaattaatt ctcgagactg gtccaggaaa ctgactcaga ggataaaatc aaataccagc
      721 aagaagcgga aagtgtccct gctgtttgac catcttgaac ctgaagaact gtctgaacac
      781 ctcacctacc ttgagttcaa gtccttccga cggatatctt tctctgatta tcagaattac
      841 cttgtaaaca gctgcgtaaa ggagaacccc accatggagc ggtccattgc cctgtgcaat
      901 ggcatctccc agtgggtaca actgatggtt ctcagccgtc ccaccccaca gctccgggca
      961 gaggtcttca tcaagttcat ccatgtggct cagaagctcc accagctaca gaacttcaac
     1021 acgctaatgg ctgtgatcgg gggactgtgt cacagctcca tctccaggct caaggagaca
     1081 agttcacatg tcccacatga gatcaataag gttctgggtg agatgactga actgctgtcc
     1141 tcctgcagaa actatgacaa ctacaggcga gcctatggtg agtgcaccca cttcaaaatc
     1201 cccatactgg gtgtgcacct caaggacctc atatccctat atgaagccat gcctgactac
     1261 ctggaagacg ggaaggtgaa tgtccaaaag ctcctggccc tttacaatca catcaatgag
     1321 ttggtccagc tgcaggacgt ggccccacca ttggatgcca acaaggacct ggtgcacctg
     1381 ctgacgttat ccctggatct atactacacc gaagatgaaa tctatgagct ttcctacgcc
     1441 cgtgaaccaa ggaaccacag ggccccgcca ctgacacctt cgaagccacc agttgtagtg
     1501 gactgggcct ctggagtgtc tcccaaacct gacccgaaga ccatcagcaa acacgtccaa
     1561 aggatggtgg attctgtctt taagaactat gatctcgacc aggatggata tatctctcag
     1621 gaggagtttg aaaagattgc tgcgagcttt ccattttcct tctgtgtgat ggacaaagat
     1681 agggagggcc tcatcagcag agacgagatc acagcctact tcatgagggc cagctccatc
     1741 tattccaagc tgggcctagg ctttccacac aactttcaag agaccactta cctgaagccc
     1801 accttctgtg acaactgtgc tggctttctc tggggtgtga tcaagcaagg ctatcgctgt
     1861 aaagactgtg ggatgaactg ccacaaacag tgcaaagacc tggtagtgtt tgagtgcaag
     1921 aaacgatcca agagcccggc ggtatccaca gaaaacatca gctctgtggt gccaatgtcc
     1981 actctttgtc cactgggaac caaagatctg ctccatgcac ccgaagaagg atctttcatt
     2041 ttccagaatg gagaggttgt ggaccacagt gaggagagca aggataggac catcatgctc
     2101 ttgggcgtat cctcacagaa aatttcagtt cggctgaaga ggactgttgc ccacaagacc
     2161 acccagacag aatcatttcc ttgggttggc ggcgagatgc cccctggtca ctttgtgctg
     2221 acttctccaa gaaagtcagc acaaggtgct ctttatgtgc acagtccagc atctccgtgc
     2281 cccagcccag cactggtccg gaagcgggca ttcgtcaagt gggagaacaa agagtccctt
     2341 atcaaaccaa aaccagagct tcacctcagg ctccggacct accaagaact ggaacaggag
     2401 gtaaataccc tgagggcaga taacgatgct ctgaagatcc agctgaagta tgcacagaaa
     2461 caaatagaat ccctgcagct tggcaaaagc aatcacgtct tagcacagat ggaccacggt
     2521 gatggtactt aatccagaaa ttcaaggaac agattctgca gatgggttta ctgggatctc
     2581 acttcaaaac tgattgcaga ggttcagcaa ctttagactg attgactttt aaagggcaga
     2641 gatagccact gttattggtg tccttggttt tttccctaac tgtctttaat gtgagtcgtg
     2701 ggttttcagt cagttgagtc aaagggaaga aaagttccag catgtaaaac actgagcagt
     2761 catattctaa ccttttcttt cttttactga aaccaatacc aaacatgtgc taaaataaga
     2821 gtatagtttc ctgacagtgt ctcaggcagc ctgctttact gattcgcact tagataaaga
     2881 gcccctggtg aatcaatttg ctgccttccc cagggtttct gcaaactggg agttactttg
     2941 ttctacccga aaacctgctc ataatggaaa caatacccta aaagtggtga ctttgacatg
     3001 cctgcattgt ttgtgaagct gatccctacc ttattcacta cctcagatct caagagcctc
     3061 tttccctgtc ctttacttgc cccctatttc ctcccttgct tgtaggcaca tcagcatatc
     3121 tacctagaag tgacctccta gagatgtagc ctgtgtttaa atccagagct tcttaattga
     3181 acttgacatt gtctgattgc aggccaactt atagctctag gtcttagtca ttatgaaata
     3241 caaaataaaa ctacccataa tcatcaatta ccatgtcata cacagaactc attatcgaag
     3301 tcaaacgacg taaacatgcc tgtccagata gtctttcttt agtggataga attaacaatc
     3361 tgtgaccttt taaaagacat ggtctgtgaa cagtgtttag ttcttcacgt tctagtctct
     3421 ctctctctct ctctctctct ctctctctct ctctctctct ctctctctct caagtaaact
     3481 atcgtaaggt tctcttttga actgaatctg tgcttaaaat tgtcttcact tttattatct
     3541 acaaataagc tatgggaggc gatggcttta acagctgaca gcatttacct atgtgtagaa
     3601 tatgtgtata tagtatcagg catgcatgga
//
