LOCUS       NM_053721               8170 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus RAS protein-specific guanine nucleotide-releasing
            factor 2 (Rasgrf2), mRNA.
ACCESSION   NM_053721
VERSION     NM_053721.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8170)
  AUTHORS   Wu,R.F., Liao,C., Hatoum,H., Fu,G., Ochoa,C.D. and Terada,L.S.
  TITLE     RasGRF Couples Nox4-Dependent Endoplasmic Reticulum Signaling to
            Ras
  JOURNAL   Arterioscler Thromb Vasc Biol 37 (1), 98-107 (2017)
   PUBMED   27856453
REFERENCE   2  (bases 1 to 8170)
  AUTHORS   Jin,S.X. and Feig,L.A.
  TITLE     Long-term potentiation in the CA1 hippocampus induced by NR2A
            subunit-containing NMDA glutamate receptors is mediated by
            Ras-GRF2/Erk map kinase signaling
  JOURNAL   PLoS One 5 (7), e11732 (2010)
   PUBMED   20661302
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8170)
  AUTHORS   Zhang,G.C., Hoffmann,J., Parelkar,N.K., Liu,X.Y., Mao,L.M.,
            Fibuch,E.E. and Wang,J.Q.
  TITLE     Cocaine increases Ras-guanine nucleotide-releasing factor 1 protein
            expression in the rat striatum in vivo
  JOURNAL   Neurosci Lett 427 (2), 117-121 (2007)
   PUBMED   17931779
  REMARK    GeneRIF: data identify the Ras activator, Ras-GRF1, although not
            Ras-GRF2, as a susceptible target to cocaine stimulation in
            striatal neurons
REFERENCE   4  (bases 1 to 8170)
  AUTHORS   Tian,X., Gotoh,T., Tsuji,K., Lo,E.H., Huang,S. and Feig,L.A.
  TITLE     Developmentally regulated role for Ras-GRFs in coupling NMDA
            glutamate receptors to Ras, Erk and CREB
  JOURNAL   EMBO J 23 (7), 1567-1575 (2004)
   PUBMED   15029245
REFERENCE   5  (bases 1 to 8170)
  AUTHORS   Arozarena,I., Matallanas,D., Berciano,M.T., Sanz-Moreno,V.,
            Calvo,F., Munoz,M.T., Egea,G., Lafarga,M. and Crespo,P.
  TITLE     Activation of H-Ras in the endoplasmic reticulum by the RasGRF
            family guanine nucleotide exchange factors
  JOURNAL   Mol Cell Biol 24 (4), 1516-1530 (2004)
   PUBMED   14749369
  REMARK    GeneRIF: RasGRF family exchange factors, both endogenous and
            ectopically expressed, are present in the endoplasmic reticulum but
            not in the Golgi complex
REFERENCE   6  (bases 1 to 8170)
  AUTHORS   Laes,J.F., Quan,X., Ravoet,M., Stieber,D., Van Vooren,P., Van
            Reeth,T., Szpirer,J. and Szpirer,C.
  TITLE     Analysis of candidate genes included in the mammary cancer
            susceptibility 1 (Mcs1) region
  JOURNAL   Mamm Genome 12 (3), 199-206 (2001)
   PUBMED   11252168
REFERENCE   7  (bases 1 to 8170)
  AUTHORS   Anborgh,P.H., Qian,X., Papageorge,A.G., Vass,W.C., DeClue,J.E. and
            Lowy,D.R.
  TITLE     Ras-specific exchange factor GRF: oligomerization through its Dbl
            homology domain and calcium-dependent activation of Raf
  JOURNAL   Mol Cell Biol 19 (7), 4611-4622 (1999)
   PUBMED   10373510
REFERENCE   8  (bases 1 to 8170)
  AUTHORS   Fan,W.T., Koch,C.A., de Hoog,C.L., Fam,N.P. and Moran,M.F.
  TITLE     The exchange factor Ras-GRF2 activates Ras-dependent and
            Rac-dependent mitogen-activated protein kinase pathways
  JOURNAL   Curr Biol 8 (16), 935-938 (1998)
   PUBMED   9707409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000065.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_053721.3.
            
            On Mar 10, 2021 this sequence version replaced NM_053721.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ276774.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-870               JACYVU010000065.1  15865938-15866807   c
            871-977             JACYVU010000065.1  15796092-15796198   c
            978-1125            JACYVU010000065.1  15776909-15777056   c
            1126-1215           JACYVU010000065.1  15774783-15774872   c
            1216-1469           JACYVU010000065.1  15771100-15771353   c
            1470-1549           JACYVU010000065.1  15769420-15769499   c
            1550-1743           JACYVU010000065.1  15768910-15769103   c
            1744-1853           JACYVU010000065.1  15764171-15764280   c
            1854-1972           JACYVU010000065.1  15763333-15763451   c
            1973-2133           JACYVU010000065.1  15758082-15758242   c
            2134-2200           JACYVU010000065.1  15756948-15757014   c
            2201-2337           JACYVU010000065.1  15756227-15756363   c
            2338-2420           JACYVU010000065.1  15741655-15741737   c
            2421-2669           JACYVU010000065.1  15737120-15737368   c
            2670-2929           JACYVU010000065.1  15736286-15736545   c
            2930-3037           JACYVU010000065.1  15728006-15728113   c
            3038-3127           JACYVU010000065.1  15724660-15724749   c
            3128-3231           JACYVU010000065.1  15680267-15680370   c
            3232-3344           JACYVU010000065.1  15656676-15656788   c
            3345-3405           JACYVU010000065.1  15642414-15642474   c
            3406-3509           JACYVU010000065.1  15642063-15642166   c
            3510-3594           JACYVU010000065.1  15639380-15639464   c
            3595-3792           JACYVU010000065.1  15636153-15636350   c
            3793-3872           JACYVU010000065.1  15626289-15626368   c
            3873-3990           JACYVU010000065.1  15624943-15625060   c
            3991-4059           JACYVU010000065.1  15624324-15624392   c
            4060-8170           JACYVU010000065.1  15618883-15622993   c
FEATURES             Location/Qualifiers
     source          1..8170
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..8170
                     /gene="Rasgrf2"
                     /note="RAS protein-specific guanine nucleotide-releasing
                     factor 2"
                     /db_xref="GeneID:114513"
                     /db_xref="RGD:69413"
     exon            1..870
                     /gene="Rasgrf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             583..4152
                     /gene="Rasgrf2"
                     /note="ras-GRF2; guanine nucleotide-releasing factor 2;
                     ras guanine nucleotide exchange factor 2"
                     /codon_start=1
                     /product="ras-specific guanine nucleotide-releasing factor
                     2"
                     /protein_id="NP_446173.2"
                     /db_xref="GeneID:114513"
                     /db_xref="RGD:69413"
                     /translation="MQKSVRYNEGHALYLAFLARKEGTKRGFLSKKAAEASRWHEKWF
                     ALYQNVLFYFEGEQSGRPAGMYLLEGCSCERTPAPPRTNAGPAGARDALDKQYYFTVL
                     FGHEGQKPLELRCEEEQAGKEWMEAIHQASYADILIEREVLMQKYIHLVQIVETEKIA
                     ANQLRHQLEDQDTEIERLKSEIVALNKTKERMRPYHTHQEEEDPDIKKIKKVQSFMRG
                     WLCRRKWKTIVQDYICSPHAESMRKRNQIVFTMVEAESEYVHQLYILVNGFLRPLRMA
                     ASSKKPPISHDDVSSIFLNSETIMFLHEIFHQGLKARLANWPTLVLADLFDILLPMLN
                     IYQEFVRNHQYSLQVLANCKQNRDFDKLLKQYEGNPACEGRMLETFLTYPMFQIPRYI
                     ITLHELLAHTPHEHVERKSLEFAKSKLEELSRVMHDEVSDTENIRKNLAIERMIVEGC
                     DILLDTSQTFIRQGSLIQVPSVERGKLSKVRLGSLSLKKEGERQCFLFTKHFLICTRS
                     SGGKLHLLKTGGVLSLIQCTLIEEPDTSDDDTKGPGHMFGHLDFKIVVEPPDAAPFTV
                     VLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIVFEENSKVTVPHMIKSDARLHKDDTD
                     ICFSKTLNSCKVPQIRYASVERLLERLTDLRFLSIDFLNTFLHTYRIFTTAAVVLGKL
                     SDIYKRPFTSIPVRSLELFFATSQNNREHLVDGKSPRLCRKFSSPPPLAVSRTSSPVR
                     ARKLSLTSSLNSRIGALDLTTSSSSSSPTTVHSPAASPPPHTAVPESAPADRAGDSTD
                     MSPCRSPSTTPRHLRYRQPGGQVADSTHCAVSPASAFAIATAAAGHGSPPGFNNERTC
                     DKEFIIRRTATNRVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERK
                     ATANILRALSQDDQDDIHLKLEDIIQMTDCPKAECFETLSAMELAEQITLLDHIVFRS
                     IPYEEFLGQGWMKLDKNERTPYIMKTSQHFNEMSNLVASQIMNYADISSRANAIEKWV
                     AVADICRCLHNYNGVLEITSALNRSAIYRLKKTWTKVSKQTKALMDKLQKTVSSEGRF
                     KNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQ
                     FQQTAYRIDQQPKVIQYLLDKALVIDEDTLYELSLKIEPRLPA"
     exon            871..977
                     /gene="Rasgrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1125
                     /gene="Rasgrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1215
                     /gene="Rasgrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1469
                     /gene="Rasgrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1549
                     /gene="Rasgrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1743
                     /gene="Rasgrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1853
                     /gene="Rasgrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1972
                     /gene="Rasgrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2133
                     /gene="Rasgrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2200
                     /gene="Rasgrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2337
                     /gene="Rasgrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2420
                     /gene="Rasgrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2669
                     /gene="Rasgrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..2929
                     /gene="Rasgrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3037
                     /gene="Rasgrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3038..3127
                     /gene="Rasgrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3128..3231
                     /gene="Rasgrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3232..3344
                     /gene="Rasgrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3345..3405
                     /gene="Rasgrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3406..3509
                     /gene="Rasgrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3510..3594
                     /gene="Rasgrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3595..3792
                     /gene="Rasgrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3793..3872
                     /gene="Rasgrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3873..3990
                     /gene="Rasgrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            3991..4059
                     /gene="Rasgrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            4060..8170
                     /gene="Rasgrf2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcggctgg gtgctaccac gctcctgccc ttcctgggcg atctactcca tccaggcttg
       61 gtctgggcag aggaggaggc cagggacctg gcaggcgagt ggagagtgga gggtgtgcgc
      121 tggtgcgagc aggcagcgcc tccgcggccg ccaccgcgct ggctttaccc tttaaatcgg
      181 tctccaagcc gattactgct gatctcccac gtgacgtttt accttctgtc tcccagagcg
      241 cgttgcccga ggacagtcct ctagctgccg cgcgccacac agcatagctc agcccgccgc
      301 agaggcaggg ctcccgcaac acttcgggtg gagcgacacc ggtccgggcg ccctcggagg
      361 gtcactcggc accgggcttc cggggatcgg gaggtgtcaa gggccggaga gggcgcggtc
      421 ggggaggaga ccgtgcccca gcctggatag gagccctagg tctgggcggc aagcggggtg
      481 ccctgtggca ggcgaactgg ggtgcgtcct ttcagagggc actctgcgat gaccccgccg
      541 cggagctgag gctgcgaccc gaaagccctc cgcgccctcg ccatgcagaa aagtgtgcgc
      601 tacaacgagg ggcacgccct gtacctggcc ttcctggcgc gcaaggaggg caccaagcgc
      661 ggtttcctga gcaaaaaggc tgccgaggcg agccgctggc acgagaagtg gttcgctctc
      721 tatcagaatg tgctctttta cttcgaaggc gaacagagcg gccgcccagc gggcatgtac
      781 ctcctagagg gctgcagctg tgagcggacg cccgccccac caaggaccaa cgcaggaccc
      841 gcaggcgccc gggacgcgct ggacaaacag tattacttca ctgtcctttt tggtcacgaa
      901 ggtcagaaac cactggagct gcgctgtgag gaggagcaag cagggaaaga gtggatggag
      961 gccattcacc aagccagtta cgcagacatt ttgattgaga gggaagtgtt aatgcaaaag
     1021 tacattcatc tagttcagat tgtggagaca gaaaaaattg ctgctaacca actccgacat
     1081 caactcgaag atcaagatac cgaaattgaa agacttaaat cagagattgt tgctcttaat
     1141 aagaccaagg aacggatgcg cccgtatcat acccatcaag aggaggagga tccagacatc
     1201 aagaagatca agaaggttca gagcttcatg agagggtggc tgtgcaggag gaagtggaag
     1261 accatcgttc aggactacat ttgttccccc catgctgaga gcatgaggaa gaggaaccag
     1321 attgtcttca cgatggtgga ggccgagtca gaatatgtgc accagctcta catcctggtg
     1381 aacggtttcc tcaggcctct gcgcatggca gccagctcca agaagccccc cattagccat
     1441 gatgatgtca gcagcatttt cctcaacagt gaaacaatca tgtttcttca tgaaatattc
     1501 catcaaggtc taaaggcaag gctggcaaat tggcccactt tggttttagc tgatctcttt
     1561 gatattttgc tgcctatgct caacatttat caagaatttg tgcgtaatca tcagtacagc
     1621 ctccaagtac ttgccaactg taagcaaaat agagattttg acaagctctt aaagcagtat
     1681 gaaggcaacc ctgcctgtga gggaaggatg ctggagacat tcttgactta cccaatgttt
     1741 cagatcccca ggtatatcat cacgctgcac gaactcctgg ctcacacccc ccatgaacac
     1801 gtggagagga aaagtctgga gttcgctaag tcaaagctgg aggaactgtc cagagtgatg
     1861 cacgacgaag tcagtgacac cgaaaacata cggaaaaatc tcgccattga gaggatgatc
     1921 gtggagggct gcgacatttt gctagacacc agtcaaactt tcatccgaca aggttctctt
     1981 atccaagtac cttctgtgga gagggggaaa ctcagtaaag tccgcctggg ctccctgtct
     2041 ttgaaaaagg aaggcgagag acaatgtttc ttattcacga agcactttct gatctgtacc
     2101 cgaagttcag gaggaaagct tcatttgctc aagacaggtg gggttctctc cctcattcag
     2161 tgtacgttga tcgaggagcc ggacacaagt gatgatgaca ccaaaggtcc tggtcacatg
     2221 ttcggacatc tggattttaa aattgtcgtg gagcctcctg atgctgcccc gttcactgtg
     2281 gtcttgctag caccttcgcg ccaggagaag gctgcctgga tgagcgacat cagccagtgc
     2341 gtggacaata tccgatgcaa tggattgatg actatagtct tcgaagagaa ttctaaagtt
     2401 actgtgcccc atatgataaa gtctgatgcc cgtcttcata aagacgacac tgacatctgt
     2461 ttcagtaaaa cactcaattc ctgcaaagtg ccccagatcc gctacgccag cgtggagcgc
     2521 ctcttggagc ggttgacgga tttgcggttt ctgagcatcg atttcctcaa caccttcctg
     2581 cacacctacc gcattttcac cacggctgcc gtagtgctgg ggaagctctc cgacatctac
     2641 aagaggcctt tcacctccat tcctgtcaga tcactagagt tattttttgc cacgagccag
     2701 aacaacagag aacatttggt cgatggaaaa tccccacgtc tttgtcgcaa gttctcttcc
     2761 ccacctcccc tggctgtatc cagaacgtcc tccccagtga gggccagaaa gctgtctttg
     2821 acatcttcct tgaactcaag gatcggagcc ttggacctga ctacatcctc atcttccagt
     2881 agtcccacca ctgtccacag tcctgctgcg tccccaccac ctcacactgc tgtcccagag
     2941 tctgcaccag ccgaccgagc aggagactcc acagacatgt caccttgtag atctccctca
     3001 accactcccc ggcacctccg atatcgccag cctggaggac aggtagctga cagcacccac
     3061 tgcgctgttt cacctgcttc tgcctttgcg atcgccacag cagcagcagg acatgggagt
     3121 ccgccaggat ttaacaacga gaggacatgt gacaaggagt tcatcatacg gagaacagcc
     3181 accaatcgag tcctgaatgt cctccgccac tgggtttcaa agcatgcaca ggattttgaa
     3241 ctcaataatg aactcaaaat gaatgttctg aacttgctag aagaagttct acgagacccg
     3301 gaccttcttc ctcaagaaag gaaagccacg gcgaacatcc tgagggctct ttcacaagat
     3361 gatcaagatg acatccacct aaaattagag gatataattc aaatgacaga ctgtccaaag
     3421 gccgagtgct ttgagacatt gtcagccatg gagctggctg agcagatcac tctcctggac
     3481 cacattgttt tcagaagcat cccctatgaa gagtttcttg ggcagggctg gatgaagctg
     3541 gataaaaacg aaaggactcc ttatatcatg aaaaccagcc agcacttcaa tgagatgagt
     3601 aacctggtgg cctcccagat aatgaattat gctgacatca gttcccgtgc caatgccatt
     3661 gagaagtggg tagcagtggc ggacatctgc cgatgtctac acaactacaa tggtgtgctg
     3721 gagatcacct cggccttaaa cagaagtgcc atctacaggc tgaagaaaac ctggaccaag
     3781 gtgtccaagc agacaaaagc tctgatggac aaacttcaga agactgtctc gtctgaagga
     3841 agatttaaaa acctcagaga aactctcaaa aactgtaacc ccccagctgt cccttacctt
     3901 gggatgtact tgacagacct ggcattcatt gaagaaggga caccgaactt taccgaagaa
     3961 ggccttgtca atttctccaa aatgcgaatg atatcacaca tcattcgtga gatacgccag
     4021 ttccagcaga ccgcttaccg catagaccag cagccaaagg tcatacaata cctgcttgac
     4081 aaagcccttg tcatagatga agatacactc tatgagctgt cactcaagat tgaacctcga
     4141 ctccctgcct gaagatctgg ccctgtcccc gagaccactg gaattccgtg gaaagtgggt
     4201 cacgcatggc acagggggga accagaggga caacgcctgc ctcctttcac caccaaagac
     4261 ggaacctaac tgtaattctg tctccagcaa gagtgaagcc ctgctgcatg ggccaaaggc
     4321 agatgctcca ggcttgggtg ggaaggtgta aacggtgaag cctggggaag ctgatggcac
     4381 agtttgcgta aggggtacag tacggagacg ctggtagcaa ttgtaatgaa gtggaatgaa
     4441 actaaacctt ccctgccctg tgctctgtta gaactcaggg acgaggtccc acagagaagg
     4501 cctgcaatgt ttctttgtca ctctaccagc ctgggcacac ctctaccaac gccctaggac
     4561 tcaattgctt ctgtcacagc ttctttatgc caagcatcat ggccaggctg aagcttcctc
     4621 tctaggccca gcacaaaagc agtttcagca cgcagcatgt gcatggctct cagtgcgttc
     4681 tacgtgcatg gagtggtgtc ctctcaaaat ggccgttttt accctttagg caataggaca
     4741 ggaaataaaa gattaaaaat gcagtggatt tgtgggtagc atttccttaa tgacaagtat
     4801 ccagtgtccc ataggctcga gtgggggctt cactgagaga ttggtggccc caagaagctg
     4861 cccccttgga gaaccaagca tggaggtctc agtaagatgc atgcccatgt cagtcacctg
     4921 accaaactgt ggaatgtgct gtgaagagaa atgactttta ctaaggaaac gtaggcctaa
     4981 aaatcacctt cgctggtttc acttattttc ctttccccca aattacccca gaaccttttt
     5041 ctgttgtgta caaacccatt ggggttcatt gtgagcactg gctatacttt gaaaaagagc
     5101 attttgtggg cttttctttt ttctttcttt ttctgttgga gagctcacac ttgcttgtgc
     5161 tgttggcaga cagtcctttc tcctgtctca gacatctttg tttaaaatga ttttgagatc
     5221 attctgcata aaagaaaaaa aaactctaag tgcaggggta atggcccgga gcacaccaca
     5281 gctcttaccg cataaaaacc aaatgaaggg ggtttccttg caccccaagc ctggataagt
     5341 ggccttggtc tcctcacaat ggttcgttgt taaaggaatg ggggtctcct cgactgcctc
     5401 cctctcctag tctcaggaag accactgctt taaaagaagg cagcgaagtg ggtaattatt
     5461 ctttgagcct agtggactgg gcatttttcc cttagaggaa tgatgcttat tgatgctgac
     5521 agtggtgact gacctgcctg ctatttctcc tcttcccttg cattttaatt gcgtggtaga
     5581 gctaacaacg agctggtgct ttccacttgt tggcttaagc gctagcatcg gtgatgtacc
     5641 acagagctag caaaggcaca tttactgcaa gcattggcca tccttgtata taactgcata
     5701 gagaaataca aactgagtga aaaatattta cagtatatga actccactcc aaaagtcttt
     5761 tcgctggttc ctattagccg acagtgtagc actaagtccc acggggggca cttacagacg
     5821 cgttctcctt tttgttcatt tatttcctga gttgcttgtt tgtcctcttc ggtttcggag
     5881 aagagatcat tgcatcgtgg tgcatgatga cagcatagga tgttggacgc taactgtgca
     5941 taccttgtga cttgtttctc cgtgttcgga ggccaaacaa gatcgtagag agaaaaaagc
     6001 aaaggtcagc attcttgaga ggaccacagc ataccaactt catgaaaaac accactggga
     6061 aaggagtacc cccatcgact ccgacccacc ctgcttccgc tccaccccgt ccctgccctt
     6121 caggggatgg ctctgtgtgc acattgctca ggagtttggg ctcctatttc cccaatgttg
     6181 tattccagag gccagtgcag ccattcttag tttaaaaaaa ataagaggaa ggaatttcta
     6241 atgcccctca tctgttgaaa cgcagctttt ctggggagct tgttcacagt agaatgttgg
     6301 gagtgccccc agtggtcatt gtgggtactg ccatcgcttt ttactccatt tcttcacctt
     6361 gttagagcta aagatcgtat gtgggttagc caaggcagga atgcacattt agaaacaaaa
     6421 cacctccact tggtcacatt taaaactcac cagagcaatt tgtgattttt cctgtgattg
     6481 ttgaaagccc ctgttctttg aagctttcta tgtacttgta ggatgcgacg catgtgctcc
     6541 agtctgtgtc tgccaacact ctgctttaga agacagattc ctaagagcac tgggagtccg
     6601 gcttccaaag atgaagaagt gaacacgtgt actgaaacat taacaggaaa tcaacctgct
     6661 ttcatgcttt caaatgagtg catcatctcg ctagtcggtg gcgtggctgt gaggaaggat
     6721 ttgggggacg cccaagacat ctccacactt agtacagaaa caaatctctt accgaagccc
     6781 tctaccatat gtgacagttg caggcttgaa gtataatcct gtcagttttt gttagcaatt
     6841 taacagggga atataaagag ggggttttaa gctgctgtgg aaatattttg gagtgtccct
     6901 gacacaaagt cccctttgct gtctgtttct gcatctcaaa gtactacaca caaacatgaa
     6961 actcacagac gccggatcat ccgctgtgag ccgttcaatg tgagcatggg cccttcccct
     7021 ttctttcacg ttaggtgaga ccaaacggtg ggcgagcaga cattgcatct tacctaaaga
     7081 ggagcgcaat acagcggtcg ttcccaaatc tgtcagcttt cacattaaaa aaaaaaaaaa
     7141 aaggatgttt tagcttttct tttcaacttt aatgtcattc cccaacaaaa acatctcttg
     7201 ttttaaatgt ttccttgaaa tttaaactgc aagcattacc attcctactg tggttggaat
     7261 ggcatgagag ataatatacc atacaatgat tttagcccag ctgatgtccg cagctggagg
     7321 agactcctga acggaattca ttcatttcca tctctgtgag aaataagact gtaaggctgg
     7381 tgacttttac acgcacctct acggttcctg gaaatccgac tctagtcggt ggaatgtaat
     7441 gggtattctt tccttacctt aaagtgggag agaacagaaa tagagaagaa ccttttgttg
     7501 taggtgctga catgtgagcg atctaacaaa gtttccactt ctgctgacat ttcatttggg
     7561 ggcatggcat taaggttact gttgattgtc cttgatccgg tctgctctag gacaacactc
     7621 accctgtttc acaatgtcga acccttgtct ctgcacattt cagtttgaac cagaaagtcg
     7681 gtgatgaaat agcactgggc cagacatgag cctcagcaca gctctgcact gcccaccgaa
     7741 aagtataagc cagtgtttac acctctgagt ctcgcttttc acatctgcaa aatgggatta
     7801 atcataattc ctgtgctgtc tacctcactg ggctgtcctg aggatcaaag gggtcagaat
     7861 gtaaactgta aagtgctgta cggttgtgag gtgaccgact gccattctca gctctctttt
     7921 gcagaggaat taaatgtact tattatttgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     7981 gtgtgtgtgt gtgtgtgtct atgtgcgaac acatgtgatg gtcagtgaaa cgcattgttt
     8041 gtgtctggct actttgcaca tctgctgtca tttgtaactc taaagggtgg atctgtgttg
     8101 tgtccaagca cttgccaagt gaggtgtagg ttatgccgat atgcaaatta aacgtcgcct
     8161 ttcttcagta
//
