LOCUS       NM_001277334            2405 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus RAS and EF hand domain containing (Rasef), mRNA.
ACCESSION   NM_001277334 XM_003749964 XM_003754049
VERSION     NM_001277334.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2405)
  AUTHORS   Li,Q., Wu,J., Xu,Y., Liu,L. and Xie,J.
  TITLE     Role of RASEF hypermethylation in cigarette smoke-induced pulmonary
            arterial smooth muscle remodeling
  JOURNAL   Respir Res 20 (1), 52 (2019)
   PUBMED   30845941
  REMARK    GeneRIF: Cigarette smoke caused pulmonary artery remodeling in
            pulmonary hypertensive rats related to RASEF hypermethylation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2405)
  AUTHORS   Tian,L., McClafferty,H., Knaus,H.G., Ruth,P. and Shipston,M.J.
  TITLE     Distinct acyl protein transferases and thioesterases control
            surface expression of calcium-activated potassium channels
  JOURNAL   J Biol Chem 287 (18), 14718-14725 (2012)
   PUBMED   22399288
REFERENCE   3  (bases 1 to 2405)
  AUTHORS   Shintani,M., Tada,M., Kobayashi,T., Kajiho,H., Kontani,K. and
            Katada,T.
  TITLE     Characterization of Rab45/RASEF containing EF-hand domain and a
            coiled-coil motif as a self-associating GTPase
  JOURNAL   Biochem Biophys Res Commun 357 (3), 661-667 (2007)
   PUBMED   17448446
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Apr 4, 2013 this sequence version replaced
            XM_003754049.1, XM_003749964.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.19805.1,
                                           SRR26643299.23149.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-341               JAXUCZ010000005.1  92664653-92664993   c
            342-488             JAXUCZ010000005.1  92645417-92645563   c
            489-579             JAXUCZ010000005.1  92643916-92644006   c
            580-675             JAXUCZ010000005.1  92627809-92627904   c
            676-753             JAXUCZ010000005.1  92625314-92625391   c
            754-869             JAXUCZ010000005.1  92621348-92621463   c
            870-938             JAXUCZ010000005.1  92619991-92620059   c
            939-1023            JAXUCZ010000005.1  92618288-92618372   c
            1024-1112           JAXUCZ010000005.1  92617333-92617421   c
            1113-1347           JAXUCZ010000005.1  92614332-92614566   c
            1348-1485           JAXUCZ010000005.1  92613897-92614034   c
            1486-1630           JAXUCZ010000005.1  92613662-92613806   c
            1631-1712           JAXUCZ010000005.1  92609903-92609984   c
            1713-1827           JAXUCZ010000005.1  92608613-92608727   c
            1828-1947           JAXUCZ010000005.1  92605544-92605663   c
            1948-2024           JAXUCZ010000005.1  92602153-92602229   c
            2025-2405           JAXUCZ010000005.1  92595148-92595528   c
FEATURES             Location/Qualifiers
     source          1..2405
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q31"
     gene            1..2405
                     /gene="Rasef"
                     /note="RAS and EF hand domain containing"
                     /db_xref="GeneID:298138"
                     /db_xref="RGD:1306418"
     CDS             1..2130
                     /gene="Rasef"
                     /codon_start=1
                     /product="ras and EF-hand domain-containing protein"
                     /protein_id="NP_001264263.1"
                     /db_xref="GeneID:298138"
                     /db_xref="RGD:1306418"
                     /translation="MEADADPEELARLRSVFTTYDTNCSGRLERAEFRTLCAELHVAE
                     AEAEAVFLGLDTDRDGAITFPEFARGFRGALGQDSGEAQGLWDAVEPESPGPAWRDFH
                     TRLGEEAQLIPRKEQVSTLYQNINLVEPRLIQPYEHVIRNFLREIRLQSTEMENLAIA
                     VKRAQDKAAIQLSELEEEMDQRIQAVENETRKDEKRKAEEALTDLRRQYETEVGDLQV
                     TIKRLKKLEEQSRKISQKQDVTSLKKQIYDLTTENQKLKKDLLETQTNLAFLQSELDA
                     LKSDYADQTMNSERDLELIREFNEDRSNLERQIEVLQTANRKLHDSNDGLRSALENTY
                     SKLTKSLRMNNISPGNTISSSSPKFNHHSSQPLGYDRSSHSSYADEDCDCLALCDPLQ
                     KMNYEVDSLPESCFDSGLSTLRDSNECDSEVDYKPQEGFQSLHRTEESLEGDTSDTDV
                     PDMRDEETFDCESVASVLHGHPQGSAGEGSTVSSSRKTISALSPETDMVNNTLKSTSQ
                     KAYKIVLAGDAAVGKSSFLMRLCKNEFQGNTSATLGVDFQMKTLMVDGEPTVLQLWDT
                     AGQERFRSIAKSYFRKADGVLLLYDVTCEKSFLNVREWVAMVEDGTHRSVPIMLVGNK
                     ADLRDAATAENQKCISSHLGEKLAMTYGALFCETSAKDGSNVVEAVLHLAREVKKRAE
                     NDDSKSITSLATSTSRKSLQMKNCCNG"
     exon            1..341
                     /gene="Rasef"
                     /inference="alignment:Splign:2.1.0"
     exon            342..488
                     /gene="Rasef"
                     /inference="alignment:Splign:2.1.0"
     exon            489..579
                     /gene="Rasef"
                     /inference="alignment:Splign:2.1.0"
     exon            580..675
                     /gene="Rasef"
                     /inference="alignment:Splign:2.1.0"
     exon            676..753
                     /gene="Rasef"
                     /inference="alignment:Splign:2.1.0"
     exon            754..869
                     /gene="Rasef"
                     /inference="alignment:Splign:2.1.0"
     exon            870..938
                     /gene="Rasef"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1023
                     /gene="Rasef"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1112
                     /gene="Rasef"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1347
                     /gene="Rasef"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1485
                     /gene="Rasef"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1630
                     /gene="Rasef"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1712
                     /gene="Rasef"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1827
                     /gene="Rasef"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1947
                     /gene="Rasef"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2024
                     /gene="Rasef"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2405
                     /gene="Rasef"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggaggcgg acgcggaccc cgaggaactt gcgcggctgc gctccgtctt cacaacctat
       61 gacacgaact gctccgggcg cctagaacgt gcggagttcc gcacgctgtg cgcggagctg
      121 cacgtggccg aagccgaagc agaggcagtg ttcctggggc tcgacacgga ccgcgatggc
      181 gcaatcacct tcccggagtt cgcgcgtggc ttccgcggag cgctcggcca ggacagcgga
      241 gaggcccaag gcctctggga cgcggtagag cctgagagcc ccggccccgc ctggcgggac
      301 ttccacacgc gcctcggaga ggaggcccag ctcattccca gaaaagaaca agttagtacc
      361 ctgtatcaga acattaacct tgtggaacca agactaatcc agccatatga acatgtgata
      421 aggaactttc tccgtgagat cagactccag agcacagaaa tggaaaactt ggccattgca
      481 gtgaaaagag cccaggacaa ggcggccatt cagctaagtg agctggaaga ggaaatggat
      541 cagaggattc aagctgtgga aaatgagacc cgaaaagatg aaaaacgcaa agctgaggaa
      601 gctctcactg acctcagacg tcagtatgaa acagaagtag gagatttaca agtgaccatt
      661 aaaaggttaa aaaagcttga agagcagtca agaaaaataa gtcaaaagca agatgtgact
      721 tcattaaaga aacaaattta tgatttaaca acggaaaatc aaaaactcaa aaaagatctt
      781 ttggagacac agacaaattt agcctttctt cagagtgaac tagatgcttt gaaaagtgat
      841 tatgctgacc agactatgaa ttctgaacgg gatctggaac taatccgaga gttcaatgaa
      901 gatcgaagta atcttgagag gcaaattgaa gtcctccaaa cagctaaccg gaagcttcat
      961 gatagtaatg acggccttag aagtgccctt gaaaacactt acagcaagct caccaaatcc
     1021 ttgcgtatga ataacatatc accagggaat acaatttcta gcagcagtcc caagtttaat
     1081 catcattctt ctcaaccact gggctacgat aggtcatccc attcttcata tgcagatgag
     1141 gattgtgact gtttggctct ctgtgaccct ctgcagaaga tgaattatga agttgacagc
     1201 ctccccgaaa gctgttttga cagtggcctg tctactctga gagattctaa tgagtgtgat
     1261 tctgaggtgg actacaagcc ccaggaagga tttcagagtt tgcacagaac agaggagagc
     1321 cttgagggag atacgtcaga cacagatgtt cctgatatga gggatgaaga aacattcgat
     1381 tgtgaaagcg tggcctctgt cttacacggg catccccagg ggtctgctgg tgagggcagc
     1441 actgttagtt cctccagaaa gaccatctca gctctttcac ctgaaacaga catggtgaat
     1501 aacaccttga agtccacatc tcagaaggct tacaagattg tgctggccgg tgatgctgca
     1561 gtgggaaagt ccagcttcct catgcgactc tgcaagaatg agtttcaggg aaacacaagt
     1621 gcaaccctag gagttgattt ccaaatgaaa actctgatgg tagatggtga accaacagtc
     1681 cttcagctct gggatacagc tggacaagaa agatttagaa gtatcgccaa gtcttacttc
     1741 cgaaaagcag atggtgtctt actgctgtac gatgttactt gtgagaaaag ctttcttaat
     1801 gtacgagaat gggtagctat ggttgaggat ggaacccaca gatccgttcc tatcatgtta
     1861 gtaggaaaca aggctgatct tcgtgatgct gctactgcag agaatcaaaa gtgtatctca
     1921 tcacatcttg gagaaaaact ggccatgacc tatggggcat tattctgtga aacaagcgcg
     1981 aaagatggct ccaatgtggt ggaagctgtt ctccatcttg ctcgggaagt aaagaaaagg
     2041 gcagagaatg atgacagcaa atccatcacc agtctggcca cttctacttc cagaaagtca
     2101 ctgcagatga agaactgttg caatggctaa agcccagctg tccattgttc gtaaactctt
     2161 tgcttccagg ttactgattg tgggacactg actctcaaag aaacagtgca tcataatgac
     2221 attggcctct gaagaatcat agcctggcaa aatgtactgc tcttccctct tcacagcaac
     2281 cgcaggcttg ctttgttcta tctcagtgag ctatttggga cgtctggcct tacagttcac
     2341 tgagagaaaa tgtgttaatg tttttaatgt gatatagtaa aataaaataa cattctcaga
     2401 tcaaa
//
