LOCUS       NM_133568               3470 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus RASD family, member 2 (Rasd2), mRNA.
ACCESSION   NM_133568
VERSION     NM_133568.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3470)
  AUTHORS   Mealer,R.G., Murray,A.J., Shahani,N., Subramaniam,S. and
            Snyder,S.H.
  TITLE     Rhes, a striatal-selective protein implicated in Huntington
            disease, binds beclin-1 and activates autophagy
  JOURNAL   J Biol Chem 289 (6), 3547-3554 (2014)
   PUBMED   24324270
  REMARK    GeneRIF: Rhes robustly binds the autophagy regulator Beclin-1,
            decreasing its inhibitory interaction with Bcl-2 independent of
            JNK-1 signaling.
REFERENCE   2  (bases 1 to 3470)
  AUTHORS   Bang,S., Steenstra,C. and Kim,S.F.
  TITLE     Striatum specific protein, Rhes regulates AKT pathway
  JOURNAL   Neurosci Lett 521 (2), 142-147 (2012)
   PUBMED   22683505
  REMARK    GeneRIF: Rhes is a novel striatal regulator of the AKT-mediated
            pathway in the striatum.
REFERENCE   3  (bases 1 to 3470)
  AUTHORS   Subramaniam,S., Sixt,K.M., Barrow,R. and Snyder,S.H.
  TITLE     Rhes, a striatal specific protein, mediates mutant-huntingtin
            cytotoxicity
  JOURNAL   Science 324 (5932), 1327-1330 (2009)
   PUBMED   19498170
  REMARK    GeneRIF: study reports Rhes, which is localized selectively to the
            striatum, binds to mutant huntingtin (mHtt); Rhes induces
            sumoylation of mHtt leading to cytotoxicity; Rhes-mHtt interactions
            can account for the localized neuropathology of Huntington disease
REFERENCE   4  (bases 1 to 3470)
  AUTHORS   Hill,C., Goddard,A., Ladds,G. and Davey,J.
  TITLE     The cationic region of Rhes mediates its interactions with specific
            Gbeta subunits
  JOURNAL   Cell Physiol Biochem 23 (1-3), 1-8 (2009)
   PUBMED   19255495
REFERENCE   5  (bases 1 to 3470)
  AUTHORS   Harrison,L.M., Lahoste,G.J. and Ruskin,D.N.
  TITLE     Ontogeny and dopaminergic regulation in brain of Ras homolog
            enriched in striatum (Rhes)
  JOURNAL   Brain Res 1245, 16-25 (2008)
   PUBMED   18929545
  REMARK    GeneRIF: Data show that Rhes mRNA is expressed at high levels in
            hippocampus and cerebellum during the postnatal period.
REFERENCE   6  (bases 1 to 3470)
  AUTHORS   Spano,D., Branchi,I., Rosica,A., Pirro,M.T., Riccio,A.,
            Mithbaokar,P., Affuso,A., Arra,C., Campolongo,P., Terracciano,D.,
            Macchia,V., Bernal,J., Alleva,E. and Di Lauro,R.
  TITLE     Rhes is involved in striatal function
  JOURNAL   Mol Cell Biol 24 (13), 5788-5796 (2004)
   PUBMED   15199135
REFERENCE   7  (bases 1 to 3470)
  AUTHORS   Vargiu,P., De Abajo,R., Garcia-Ranea,J.A., Valencia,A.,
            Santisteban,P., Crespo,P. and Bernal,J.
  TITLE     The small GTP-binding protein, Rhes, regulates signal transduction
            from G protein-coupled receptors
  JOURNAL   Oncogene 23 (2), 559-568 (2004)
   PUBMED   14724584
  REMARK    GeneRIF: role in signal transduction of this novel Ras family
            member
REFERENCE   8  (bases 1 to 3470)
  AUTHORS   Chan,S.L., Monks,L.K., Gao,H., Deaville,P. and Morgan,N.G.
  TITLE     Identification of the monomeric G-protein, Rhes, as an
            efaroxan-regulated protein in the pancreatic beta-cell
  JOURNAL   Br J Pharmacol 136 (1), 31-36 (2002)
   PUBMED   11976265
REFERENCE   9  (bases 1 to 3470)
  AUTHORS   Vargiu,P., Morte,B., Manzano,J., Perez,J., de Abajo,R., Gregor
            Sutcliffe,J. and Bernal,J.
  TITLE     Thyroid hormone regulation of rhes, a novel Ras homolog gene
            expressed in the striatum
  JOURNAL   Brain Res Mol Brain Res 94 (1-2), 1-8 (2001)
   PUBMED   11597759
REFERENCE   10 (bases 1 to 3470)
  AUTHORS   Falk,J.D., Vargiu,P., Foye,P.E., Usui,H., Perez,J., Danielson,P.E.,
            Lerner,D.L., Bernal,J. and Sutcliffe,J.G.
  TITLE     Rhes: A striatal-specific Ras homolog related to Dexras1
  JOURNAL   J Neurosci Res 57 (6), 782-788 (1999)
   PUBMED   10467249
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Nov 27, 2020 this sequence version replaced NM_133568.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF134409.1, SRR26643295.57274.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-842               JAXUCZ010000019.1  13600028-13600869
            843-1122            JAXUCZ010000019.1  13605404-13605683
            1123-3470           JAXUCZ010000019.1  13608406-13610753
FEATURES             Location/Qualifiers
     source          1..3470
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..3470
                     /gene="Rasd2"
                     /gene_synonym="Rhes"
                     /note="RASD family, member 2"
                     /db_xref="GeneID:171099"
                     /db_xref="RGD:628594"
     exon            1..842
                     /gene="Rasd2"
                     /gene_synonym="Rhes"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1122
                     /gene="Rasd2"
                     /gene_synonym="Rhes"
                     /inference="alignment:Splign:2.1.0"
     CDS             852..1652
                     /gene="Rasd2"
                     /gene_synonym="Rhes"
                     /EC_number="3.6.5.2"
                     /note="SE6C; ras homolog enriched in striatum"
                     /codon_start=1
                     /product="GTP-binding protein Rhes"
                     /protein_id="NP_598252.1"
                     /db_xref="GeneID:171099"
                     /db_xref="RGD:628594"
                     /translation="MMKTLSSGNCTLNVPAKNSYRMVVLGASRVGKSSIVSRFLNGRF
                     EDQYTPTIEDFHRKVYNIHGDMYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDS
                     RESFDEVKRLQKQILEVKSCLKNKTKEAAELPMVICGNKNDHSELCRQVPAMEAELLV
                     SGDENCAYFEVSAKKNTNVNEMFYVLFSMAKLPHEMSPALHHKISVQYGDAFHPRPFC
                     MRRTKVAGAYGMVSPFARRPSVNSDLKYIKAKVLREGQARERDKCSIQ"
     exon            1123..3470
                     /gene="Rasd2"
                     /gene_synonym="Rhes"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtgcagca tccggagctc gagcttgggc catcccgggt ggactccacg ttcgctggcg
       61 ggagaggacg agggaggagc ccaccctaag aaacttctcc cccctttggg gagaggaggc
      121 acagtgctga gcgacggcgg cttcggacga agttggagct gctgagcctc ggggcggcgt
      181 tcaaggctcc ttcccacacg cgcgctgagc gcagctagcg gcgtcgggcg aggagcaagc
      241 ggtggtcctt tccgcgaggg tcagcagccc gacttcgggc agccaggaag gccgcggccc
      301 ggcgcgcaag tccctctacc ctgcacgcgg ccacggcggg agaaggaggt aacgtaagcg
      361 gccaggcggg ttcgtaggct ggagacacac accgatcgtc acccccaaag gtccccctga
      421 gtctccaggg ttcgcttcta catccccgga gtcgtgcccc ctcccccctc agcgcggagc
      481 cccaggcggg gacaccccga attgaacgtt cccaaacctc cgtgcacctg gctcaaccgg
      541 agtcccccgt gtcagggcag ggcaaggccg ccggcggtga gccggagcca gcccagcgcc
      601 ccggctctgc cgagccctcg gagcccaccc atgggtcatc ccctgctctg cgggcctctt
      661 cgccctgtcg cgctcagccc agctccgggc gccgcgcgca ggaggatctg tacgcagtga
      721 ccctggagcc cccgcagacg ccgggagact cggcggcggg agccgcaggc ggttccccac
      781 acctccagga gcttccaggg agccctccaa gccgtgctcg gggtccgtcc cgctgttccc
      841 agcccagagc catgatgaag accttgtcca gcgggaactg cacactcaac gtgcccgcta
      901 agaactccta ccgcatggtg gtgctgggtg cctcccgggt gggcaagagc tccattgtct
      961 cccgtttcct taatggccgc tttgaggatc agtacacacc caccatcgag gactttcatc
     1021 gcaaggtgta caacatccat ggggacatgt accagctgga catcctggac acctctggta
     1081 accatccgtt ccctgccatg cgccggctgt ctatcctcac aggagacgtc ttcatcctgg
     1141 tgtttagcct ggatagccgg gagtccttcg acgaggtcaa gcgcctccag aaacagatcc
     1201 tggaggtcaa gtcctgcctg aagaataaga ccaaggaggc cgcagagctg cctatggtga
     1261 tctgtgggaa caagaatgac cacagtgagc tgtgccgcca ggtccctgcc atggaggcgg
     1321 aactgttggt gtccggggat gaaaactgcg cctacttcga ggtgtcagcc aagaagaaca
     1381 cgaacgtaaa cgagatgttc tacgtgctgt tcagcatggc caagctgccc cacgagatga
     1441 gccctgcact gcaccacaag atctccgtgc agtacggtga cgccttccac ccccggccct
     1501 tctgcatgcg tcgcaccaag gtcgcaggtg cctatggcat ggtctcgccc ttcgcccgcc
     1561 gccccagtgt caacagtgac ctcaagtata tcaaggccaa ggtcctacgg gagggccagg
     1621 cccgagagag ggacaagtgc agcatccagt gagaggcagg gacttcgggg agggggcttg
     1681 ggcagtgcct taagggaggt ggctgaggat tcccactgcc cacatcccac agagggccct
     1741 aggtgtgtac actgtgccca ttctcttgat tcctggccac cacctgtgag ctatgattgc
     1801 ggttcctttg tgggaggaca gagatgtgtc tgggggtatg tcagcactca cgccaagaca
     1861 atctcccagt gaccttagag cgggagggat gggggaaagg ccaggaatcc tgcgtcagaa
     1921 gcaagatgct cagtacaagt cacaggatga gaacatctta gccagatgtc ccagccagat
     1981 tccctggtgg cctctgctcc ctctgtgcag acaggcttgg tctctatgcc tctggagaaa
     2041 ccaccctcct gggtcttcag ctcctgccct ctggcccagc tgtgtacccc ctcgcctcca
     2101 acttagcccc tggccactct gacgttgagc caacagagaa acagagacag acagagatgg
     2161 agagacacgt gcctgtgtcc ctcagaccac tgcctcttgg ctacattccc aggcctgtcc
     2221 atataacatt tctcgttgtt ttgaagtgtg tttcctgttc tgtttgcagt agacatgaag
     2281 tccttgtact gtaagagccc aatgccttgt ctttgacagg gtttccctac tcaaatccat
     2341 tgctttagct ggggtctccc ttcctgctcc caggcaggct gtgcagctgg gtcctaccca
     2401 gtgttcatca gcttacaaag agcccacagt gccacagcca ccgcaggacc ctcctgccct
     2461 caggagagga tgatggggct ttgagaatgt gactccaaac ccttccggta actagttcag
     2521 gacagagctc tgactggatg cagctttctt ccgctgtagt cccttaaaca tctgctgagt
     2581 acctactgga tactcggtca cttgtgtgct aggcaacagt aggcgagggg cctcatgtgt
     2641 cccccagctc cagcctctgc ccgtccatgg tgccccttct gcacacacag ctgttagagg
     2701 atgtggaaca gctgagagcc agagccgagt ccaggacagg ttggaaggaa gacttatggt
     2761 gggacttctc ctagcgttca ggctatgcta ggtacacggg agtggggttg agggacgact
     2821 atgaccctga aaaccaaagg tcccgttcac caactcttaa tacatttgtg ctttcgtctc
     2881 catagtactg cagctggccc actgagatgg ctccgtgggc caagacacgt gctgccaagc
     2941 tttcagcctg agttcggttc cagggtccca tgaagtaagg agaggagtaa cttgctagcc
     3001 atcctttgac ctctgcacat gcacacagag tggtgaggct ggcggttatc agaaaccata
     3061 ggaatctacc agtgcattct ctcaaggccc aagtcactca ccgcaggcga ggccagccat
     3121 gggccttcca cacacaccag gtcacaccct gcgctggagc tccctgcgac gacagggatt
     3181 tggatcatgt tacacacccc tcccccagag caatcactga ggtaatctgt ggatgctgtg
     3241 caatgctctt cttaacgcac accaggccca gccctgactc cacacctcaa acagctgccg
     3301 cccagcacaa ctgcttcagc gcttgcttct gtcctgcagt gaccccagcc tcaaccccga
     3361 gagtatacca ggtacttgtc caggcaggtg tttggcctgg ccccatccag tcaggctcca
     3421 ttgcgtggac ctctgtgtac actatcaatt aaagttggtt tgttagcagc
//
