LOCUS       NM_001270954            1592 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus ras related dexamethasone induced 1 (Rasd1),
            mRNA.
ACCESSION   NM_001270954 XM_001077321 XM_340809
VERSION     NM_001270954.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1592)
  AUTHORS   Xin,Y., Chen,J., Zhang,H., Ostrowski,R.P., Liang,Y., Zhao,J.,
            Xiang,X., Liang,F., Fu,W., Huang,H., Wu,X., Su,J., Deng,J. and
            He,Z.
  TITLE     Dexras1 Induces Dysdifferentiation of Oligodendrocytes and Myelin
            Injury by Inhibiting the cAMP-CREB Pathway after Subarachnoid
            Hemorrhage
  JOURNAL   Cells 11 (19), 2976 (2022)
   PUBMED   36230939
  REMARK    GeneRIF: Dexras1 Induces Dysdifferentiation of Oligodendrocytes and
            Myelin Injury by Inhibiting the cAMP-CREB Pathway after
            Subarachnoid Hemorrhage.
            Erratum:[Cells. 2024 Nov 29;13(23):1975. doi:
            10.3390/cells13231975.. PMID: 39682783]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1592)
  AUTHORS   Wang,L., Mitsui,T., Ishida,M., Izawa,M. and Arita,J.
  TITLE     Rasd1 is an estrogen-responsive immediate early gene and modulates
            expression of late genes in rat anterior pituitary cells
  JOURNAL   Endocr J 64 (11), 1063-1071 (2017)
   PUBMED   28835591
  REMARK    GeneRIF: Rasd1 is an estrogen-responsive immediate early gene and
            modulates E2 induction of at least several late genes in anterior
            pituitary cells.
REFERENCE   3  (bases 1 to 1592)
  AUTHORS   Greenwood,M.P., Greenwood,M., Mecawi,A.S., Antunes-Rodrigues,J.,
            Paton,J.F. and Murphy,D.
  TITLE     Rasd1, a small G protein with a big role in the hypothalamic
            response to neuronal activation
  JOURNAL   Mol Brain 9, 1 (2016)
   PUBMED   26739966
  REMARK    GeneRIF: two mechanisms of Rasd1 induction in the hypothalamus,
            were identified.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1592)
  AUTHORS   Hahnova,K., Pacesova,D., Volfova,B., Cervena,K., Kasparova,D.,
            Zurmanova,J. and Bendova,Z.
  TITLE     Circadian Dexras1 in rats: Development, location and responsiveness
            to light
  JOURNAL   Chronobiol Int 33 (2), 141-150 (2016)
   PUBMED   26785766
  REMARK    GeneRIF: The Dexras1 protein is expressed predominantly in the
            dorsomedial part of thesuprachiasmatic nucleus and the light pulse
            has only a limited effect on its expression
REFERENCE   5  (bases 1 to 1592)
  AUTHORS   Wang,Y., Dong,X., Li,Z., Wang,W., Tian,J. and Chen,J.
  TITLE     Downregulated RASD1 and upregulated miR-375 are involved in
            protective effects of calycosin on cerebral ischemia/reperfusion
            rats
  JOURNAL   J Neurol Sci 339 (1-2), 144-148 (2014)
   PUBMED   24548484
  REMARK    GeneRIF: RASD1 is downregulated by calycosin in cerebral
            ischemia/reperfusion injury and provides a protective effect.
REFERENCE   6  (bases 1 to 1592)
  AUTHORS   Beigi,F., Oskouei,B.N., Zheng,M., Cooke,C.A., Lamirault,G. and
            Hare,J.M.
  TITLE     Cardiac nitric oxide synthase-1 localization within the
            cardiomyocyte is accompanied by the adaptor protein, CAPON
  JOURNAL   Nitric Oxide 21 (3-4), 226-233 (2009)
   PUBMED   19800018
REFERENCE   7  (bases 1 to 1592)
  AUTHORS   Lau,K.F., Chan,W.M., Perkinton,M.S., Tudor,E.L., Chang,R.C.,
            Chan,H.Y., McLoughlin,D.M. and Miller,C.C.
  TITLE     Dexras1 interacts with FE65 to regulate FE65-amyloid precursor
            protein-dependent transcription
  JOURNAL   J Biol Chem 283 (50), 34728-34737 (2008)
   PUBMED   18922798
  REMARK    GeneRIF: Dexras1 functions as a suppressor of FE65-APP-mediated
            transcription, and FE65 tyrosine 547 phosphorylation enhances
            FE65-APP-mediated transcription, at least in part, by modulating
            the interaction between FE65 and Dexras1
REFERENCE   8  (bases 1 to 1592)
  AUTHORS   Li,X., Cheng,C., Fei,M., Gao,S., Niu,S., Chen,M., Liu,Y., Guo,Z.,
            Wang,H., Zhao,J., Yu,X. and Shen,A.
  TITLE     Spatiotemporal expression of Dexras1 after spinal cord transection
            in rats
  JOURNAL   Cell Mol Neurobiol 28 (3), 371-388 (2008)
   PUBMED   18219571
  REMARK    GeneRIF: Transient high expression of Dexras1 which localized in
            apoptotic neurons and pathological oligodendrocytes after spinal
            cord transection.
REFERENCE   9  (bases 1 to 1592)
  AUTHORS   Shen,A., Chen,M., Niu,S., Sun,L., Gao,S., Shi,S., Li,X., Lv,Q.,
            Guo,Z. and Cheng,C.
  TITLE     Changes in mRNA for CAPON and Dexras1 in adult rat following
            sciatic nerve transection
  JOURNAL   J Chem Neuroanat 35 (1), 85-93 (2008)
   PUBMED   17768032
  REMARK    GeneRIF: Dexras1 is involved in various pathological conditions
            including nerve regeneration, neuron loss or survival and even pain
            processes via regulating nNOS activity or through the downstream
            targets of Dexras1.
REFERENCE   10 (bases 1 to 1592)
  AUTHORS   Fang,M., Jaffrey,S.R., Sawa,A., Ye,K., Luo,X. and Snyder,S.H.
  TITLE     Dexras1: a G protein specifically coupled to neuronal nitric oxide
            synthase via CAPON
  JOURNAL   Neuron 28 (1), 183-193 (2000)
   PUBMED   11086993
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099136.1.
            
            On or before Aug 17, 2012 this sequence version replaced
            XM_340809.5, XM_001077321.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099136.1, CV110404.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1592
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..1592
                     /gene="Rasd1"
                     /note="ras related dexamethasone induced 1"
                     /db_xref="GeneID:64455"
                     /db_xref="RGD:619727"
     exon            1..375
                     /gene="Rasd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..932
                     /gene="Rasd1"
                     /EC_number="3.6.5.2"
                     /note="DEXRAS1 (Dexras1); RAS, dexamethasone-induced 1"
                     /codon_start=1
                     /product="dexamethasone-induced Ras-related protein 1"
                     /protein_id="NP_001257883.1"
                     /db_xref="GeneID:64455"
                     /db_xref="RGD:619727"
                     /translation="MKLAAMIKKMCPSDSELSIPAKNCYRMVILGSSKVGKTAIVSRF
                     LTGRFEDAYTPTIEDFHRKFYSIRGEVYQLDILDTSGNHPFPAMRRLSILTGDVFILV
                     FSLDNRDSFEEVQRLKQQILDTKSCLKNKTKENVDVPLVICGNKGDRDFYREVEQREI
                     EQLVGDDPQRCAYFEISAKKNSSLDQMFRALFAMAKLPSEMSPDLHRKVSVQYCDVLH
                     KKALRNKKLLRAGSGGGGDHGDAFGILAPFARRPSVHSDLMYIREKTSVSSQAKDKER
                     CVIS"
     exon            376..1571
                     /gene="Rasd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgaagccaa actcttccac cactccggcg ccctctgcag ccctctacct tctctcagcc
       61 acgcatctgc cctggggccc ctctgcccaa tgaaactggc cgcgatgatc aagaagatgt
      121 gcccaagcga ctctgaactg agtatcccgg ccaagaactg ctacaggatg gtcatcctcg
      181 gctcatccaa agtgggcaag acggccatcg tgtcgcgctt cctcacgggc cgcttcgagg
      241 acgcttacac ccctaccatt gaagacttcc accgaaagtt ttactcgatc cgcggcgaag
      301 tctaccagtt ggacatactg gacacatctg gcaatcatcc gtttcccgcc atgcggcgcc
      361 tctctatcct cacaggagac gttttcattc tggtgttcag cttagacaac cgcgactcct
      421 tcgaggaggt gcaaaggctc aaacagcaga tcctagacac caagtcctgt ctcaagaaca
      481 aaaccaaaga gaatgtggac gtgccgctgg tcatttgcgg taacaaaggg gaccgggact
      541 tctaccgcga agtggagcag cgggagattg agcagctggt gggcgatgac cctcagcgtt
      601 gtgcctactt cgagatctcg gccaagaaga atagcagcct ggaccagatg ttccgtgcgc
      661 tctttgccat ggccaagctg cctagcgaga tgagccctga cttgcaccgc aaggtgtctg
      721 tgcagtactg tgacgtgctg cacaaaaagg ctctgaggaa caagaagctt ctgcgtgcgg
      781 gcagcggagg tgggggcgac cacggagatg cctttggcat cttggcgccc tttgctcgca
      841 gacctagcgt gcatagcgac ctcatgtaca ttcgtgagaa aaccagtgtc agcagccagg
      901 ctaaggacaa ggagcgctgt gtcatcagtt aggagccccc agggtcagtc agccacacaa
      961 cctgaggacc ttttttgttc aaaagtcaaa tcggtttccc aggctaacct gtgcactccg
     1021 tgccccaaga gcgccagctg gcctcctccc tccctccctg agacccagcc ctgtgcacca
     1081 gggagatgct gccaagacag taagggacag tcatctgctg tgagaggaaa gaactagcta
     1141 agactgggac tttcgcctcc gattctggga tgccaggacc cagcagaggg ttagttggcg
     1201 tttttctcag agactttgag agtgtgtgaa gggcttcggc ctctgagact tcaagtaact
     1261 gtgcggcttg ctgtggggcc aggactaaca gggcattatc tcgtctgtga ttggtgttgc
     1321 catgactgct gtcagccacc tctgtcctca gcaaactgga aactttggct cgaggtgggg
     1381 gttcaatcat agccagacaa cttgtttaca tgtgtgtgtg tgtgtaatta cccaaaagga
     1441 aaacaaaaca caaaacttgc actttaatag ttccagtgtc aacgtgacat gaacaaaatc
     1501 tctacatttc tattgtgtga ggtctttatt atttttttta atttaaaata aaataatttt
     1561 aaaatggaaa aaaaaaaaaa aaaaaaaaaa aa
//
