LOCUS       NM_001108335            3238 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus RAS protein activator like 1 (Rasal1), mRNA.
ACCESSION   NM_001108335 XM_001076575 XM_341088
VERSION     NM_001108335.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3238)
  AUTHORS   Hong,Y., Han,Y.Q., Wang,Y.Z., Gao,J.R., Li,Y.X., Liu,Q. and
            Xia,L.Z.
  TITLE     Paridis Rhizoma Sapoinins attenuates liver fibrosis in rats by
            regulating the expression of RASAL1/ERK1/2 signal pathway
  JOURNAL   J Ethnopharmacol 192, 114-122 (2016)
   PUBMED   27396351
  REMARK    GeneRIF: Paridis rhizoma sapoinins attenuate CCl4-induced liver
            fibrosis through the regulation of RASAL1/ERK1/2 signal pathway.
REFERENCE   2  (bases 1 to 3238)
  AUTHORS   Yoo,J.C., Lim,Ty., Park,J.S., Hah,Y.S., Park,N., Hong,S.G.,
            Park,J.Y. and Yoon,T.J.
  TITLE     SYT14L, especially its C2 domain, is involved in regulating
            melanocyte differentiation
  JOURNAL   J Dermatol Sci 72 (3), 246-251 (2013)
   PUBMED   23999003
REFERENCE   3  (bases 1 to 3238)
  AUTHORS   Tao,H., Huang,C., Yang,J.J., Ma,T.T., Bian,E.B., Zhang,L., Lv,X.W.,
            Jin,Y. and Li,J.
  TITLE     MeCP2 controls the expression of RASAL1 in the hepatic fibrosis in
            rats
  JOURNAL   Toxicology 290 (2-3), 327-333 (2011)
   PUBMED   22056649
  REMARK    GeneRIF: hypermethylation of RASAL1 is associated with the
            perpetuation of fibroblast activation and fibrogenesis in the liver
REFERENCE   4  (bases 1 to 3238)
  AUTHORS   Liu,Q., Walker,S.A., Gao,D., Taylor,J.A., Dai,Y.F., Arkell,R.S.,
            Bootman,M.D., Roderick,H.L., Cullen,P.J. and Lockyer,P.J.
  TITLE     CAPRI and RASAL impose different modes of information processing on
            Ras due to contrasting temporal filtering of Ca2+
  JOURNAL   J Cell Biol 170 (2), 183-190 (2005)
   PUBMED   16009725
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473973.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001076575.1, XM_341088.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132272, SAMD00132280
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3238
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..3238
                     /gene="Rasal1"
                     /note="RAS protein activator like 1"
                     /db_xref="GeneID:360814"
                     /db_xref="RGD:1311820"
     exon            1..89
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            90..308
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..2649
                     /gene="Rasal1"
                     /note="RAS protein activator like 1 (GAP1 like)"
                     /codon_start=1
                     /product="rasGAP-activating-like protein 1"
                     /protein_id="NP_001101805.1"
                     /db_xref="GeneID:360814"
                     /db_xref="RGD:1311820"
                     /translation="MAKSGSLSIRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTAT
                     IWRSLSPFWGEEYTVHLPLDFHHLAFYVLDEDTVGHDDIIGKISLSKEAITADPRGID
                     SWINLSRVDPDEEVQGEVCLAVKLLEDARGRCLRCHVRQARDLAPRDISGTSDPFARV
                     FWGSRSLETSTIKKTRFPHWDEVLELREAPGTTSPLRVELWDWDMVGKNDFLGMVEFT
                     PQTLQQKPPNGWFRLLPFPRAEDSGGSLGALRLKVRLTEDRVLPSQYYQPLMELLLES
                     VQGPAEEDTTSPLALLEELASGDCRQDLATKLVKLFLGRGLAGPFLDYLTRREVARTN
                     DPNTLFRSNSLASKSMEQFMKLVGMRYLHEVLRPVISRVFEEKKYMELDPSKMDLNRS
                     RRISFKGTPTEEQVRETSLGLLTGYLGSVVDAIVSSAGRCPLALRLAFKQLQQCVEKR
                     FPGMEHQDVKYLATSGFLFLRFFAPAILTPKLFDLRDHHADPQTSRSLLLLAKAVQSI
                     GNLGQQLGQGKEQWLAPLHPFLLQSISRVRDFLDQLVDVDGDEEAGGSTCALVQPSTI
                     VREGFLLKRKEEPASLATRFAFKKRYFRLSGRDLSYSKTPEWQVHSSIPLSCIRAVER
                     VDEGAFQLPHVMQVVTQDGTGASHTTYLQCKNVNDLNQWLSALRKASAPNPGKLAACH
                     PGAFRSGRWTCCLQAERSAVGCSRTHSAVTLGDWSDPLDPDAEAQMVYRQLLLGRDQL
                     RLKLLEDSSLDTAPDVDPGKDSSAVDGPCAEVLAQQREATTRLLQVLEDLEQAHEEFQ
                     KRG"
     exon            309..365
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            366..479
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            480..541
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            542..671
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            672..753
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            754..885
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            886..971
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1089
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1243
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1308
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1421
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1614
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1752
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1897
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2070
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2208
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2344
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2465
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2542
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..3238
                     /gene="Rasal1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagagacga tgcaagggga tgttcgagct ccctccctcc actcgcatca gacccccagg
       61 gagcgtgcgc cgcctgccgc ccagcgagac cctgcatcca gcccactcgc accccagacc
      121 cgtacctgtg ggaacccgtg gactgcgtgc ttggcccgcc gctgatgaca tgtagggtca
      181 cctcctggtc cagcctcgga acctcggcag actccttgcc tggaaagttt gggactgtgc
      241 gccatggcca agagcggctc tctgagtatc cgcgtggtgg agggacgggc gctgcccgcc
      301 aaggacgtgt ctgggagcag tgacccctac tgtcttgtga aagtggatga tgaggtggtg
      361 gccaggacag caaccatctg gaggagcctg agcccctttt ggggggagga gtacactgtt
      421 caccttccac tggacttcca ccacctggcc ttctacgtgc tggatgagga tactgttgga
      481 cacgacgaca tcattgggaa gatctccttg agcaaagagg cgatcacagc ggaccctcga
      541 gggattgaca gctggatcaa cctgagccga gtggatccag atgaggaagt gcagggtgag
      601 gtctgcctgg ctgtgaagct gctggaggat gctcggggga gatgcctccg ctgccacgtg
      661 agacaggcca gggacctggc ccctcgggac atctctggca catcggaccc atttgcccgt
      721 gtgttctggg gcagccgtag tttggaaact tcgaccatca agaagacccg attcccacat
      781 tgggatgagg tgctggaact acgagaggct ccgggaacca catccccgct gcgagtggaa
      841 ctctgggatt gggacatggt gggcaaaaat gacttcctgg gcatggtgga attcacccca
      901 cagaccctcc agcagaagcc acccaatggc tggttccgtc tcctgccttt tcctagagct
      961 gaggattctg gggggagcct gggtgccctg cggctgaagg tgcgcctcac tgaggaccgg
     1021 gtcctgcctt cccagtacta ccagcctctc atggaactgc ttctggagtc cgtgcaaggg
     1081 ccagccgagg aggacaccac cagccccctg gcattgctag aggagttggc ctctggggac
     1141 tgtcgtcagg accttgccac caaactggtg aagcttttcc tgggccgggg cctggctggg
     1201 ccctttctag attacctcac aaggcgtgag gtggcacgaa ccaatgaccc caacaccctc
     1261 ttccgttcta actccttggc atccaagtcg atggaacagt tcatgaaact cgtgggcatg
     1321 cgctacctgc atgaggtcct gaggccggtg atcagccgcg tcttcgagga gaagaaatat
     1381 atggagctgg acccttccaa gatggacctg aaccgctccc ggagaatctc cttcaagggc
     1441 acacccacgg aggagcaggt gcgggagacc agcctggggc tgctgaccgg atacctgggg
     1501 tccgttgtgg acgccatcgt gagctctgcc gggcgctgcc cacttgccct gcgcttagcc
     1561 tttaagcaac tccagcagtg tgtggagaag cgcttccctg ggatggagca tcaggacgtg
     1621 aagtacttgg ccactagcgg cttcctcttt ctgcggttct ttgcgcccgc catcctcaca
     1681 ccgaagctgt ttgacctcag agaccaccac gcagaccccc agaccagccg ctccctgctg
     1741 ctgcttgcca aggctgtgca gagcattgga aacctgggcc agcagctggg ccagggcaaa
     1801 gagcagtggc tagcccccct ccatcccttc ctgctgcaga gcatctcacg tgtgagggac
     1861 ttcctggacc agctggtgga tgtggatggg gatgaggagg ctgggggatc aacctgcgcc
     1921 ctggtccaac cctcaacaat tgttcgagaa ggctttctgc tgaagcgcaa ggaggagcct
     1981 gcaagcctgg ccacccgctt tgccttcaag aagcgctact tccgactgag tgggcgggac
     2041 ctctcctact ctaagactcc tgagtggcag gttcactcat ccatcccgtt gtcctgcatc
     2101 cgggctgtgg agcgtgtgga tgagggtgcc ttccaactgc cacatgtcat gcaggtggtg
     2161 acacaggatg gcaccggggc atcacacacc acctacctcc agtgcaagaa cgtgaatgac
     2221 ctcaatcaat ggctgtcagc cctgcgcaaa gccagcgccc ccaacccggg caagctggct
     2281 gcttgtcacc ctggtgcctt ccgcagcggg cgctggacct gctgcctcca ggccgagcgc
     2341 tcagctgttg gctgtagccg cacacactca gctgtcacgc tgggagactg gagtgaccca
     2401 ctggatcctg acgccgaagc ccagatggtg tatcgccagc tgctcctggg ccgagaccag
     2461 ctcaggctga aactgctgga ggactccagc ctggacacag ctccagatgt ggaccctggg
     2521 aaggactcca gtgctgtaga tgggccctgt gctgaggttc tagcccagca gagggaggcc
     2581 accacccgtc tgctgcaggt acttgaagac ttggagcaag cccatgagga attccagaaa
     2641 cggggctagg ggaaagtggc cctctaggac actggatgct gagaaggtgc cagagccagt
     2701 tggggacaga gccacggggc ttccctgagc ttactttggc ctaggcatct tcattgtcgt
     2761 ggcttggagc ctcccaaagt gtggtcctgt gtgccctgta gccagccagg gcataggaac
     2821 ctttaagagg gcccagcctt gtaccgactg accaaacctc acttccttct ctgagcctgg
     2881 agcctcagct tcactggata cagctcctcc agtaccggtg gaacccatac cggtggcacc
     2941 catctcaccc caagctgctg ggtgcagctg tacctgaact ccaatcctgg ctgatgcaga
     3001 aaaacactca atatgcttga ccaggaactt cccgtgttat cacttccgtg ggccccggtg
     3061 acctcacaga tccttctgta ccccactttc atctggcagt cccggcctca agcttctggg
     3121 acccggtgtt ctcggaagaa cggactggga gcccagcatg ccaatttgga gcctcgaagc
     3181 tggacacggg ctcttcctcc ctcctatacc ctgtataaag tgacgtgtga gcatgctt
//
