LOCUS       NP_001101805             801 aa            linear   ROD 24-JUN-2024
DEFINITION  rasGAP-activating-like protein 1 [Rattus norvegicus].
ACCESSION   NP_001101805 XP_001076575 XP_341089
VERSION     NP_001101805.1
DBSOURCE    REFSEQ: accession NM_001108335.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 801)
  AUTHORS   Hong,Y., Han,Y.Q., Wang,Y.Z., Gao,J.R., Li,Y.X., Liu,Q. and
            Xia,L.Z.
  TITLE     Paridis Rhizoma Sapoinins attenuates liver fibrosis in rats by
            regulating the expression of RASAL1/ERK1/2 signal pathway
  JOURNAL   J Ethnopharmacol 192, 114-122 (2016)
   PUBMED   27396351
  REMARK    GeneRIF: Paridis rhizoma sapoinins attenuate CCl4-induced liver
            fibrosis through the regulation of RASAL1/ERK1/2 signal pathway.
REFERENCE   2  (residues 1 to 801)
  AUTHORS   Yoo,J.C., Lim,Ty., Park,J.S., Hah,Y.S., Park,N., Hong,S.G.,
            Park,J.Y. and Yoon,T.J.
  TITLE     SYT14L, especially its C2 domain, is involved in regulating
            melanocyte differentiation
  JOURNAL   J Dermatol Sci 72 (3), 246-251 (2013)
   PUBMED   23999003
REFERENCE   3  (residues 1 to 801)
  AUTHORS   Tao,H., Huang,C., Yang,J.J., Ma,T.T., Bian,E.B., Zhang,L., Lv,X.W.,
            Jin,Y. and Li,J.
  TITLE     MeCP2 controls the expression of RASAL1 in the hepatic fibrosis in
            rats
  JOURNAL   Toxicology 290 (2-3), 327-333 (2011)
   PUBMED   22056649
  REMARK    GeneRIF: hypermethylation of RASAL1 is associated with the
            perpetuation of fibroblast activation and fibrogenesis in the liver
REFERENCE   4  (residues 1 to 801)
  AUTHORS   Liu,Q., Walker,S.A., Gao,D., Taylor,J.A., Dai,Y.F., Arkell,R.S.,
            Bootman,M.D., Roderick,H.L., Cullen,P.J. and Lockyer,P.J.
  TITLE     CAPRI and RASAL impose different modes of information processing on
            Ras due to contrasting temporal filtering of Ca2+
  JOURNAL   J Cell Biol 170 (2), 183-190 (2005)
   PUBMED   16009725
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473973.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_001076575.1, XP_341089.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132272, SAMD00132280
                              [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..801
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     Protein         1..801
                     /product="rasGAP-activating-like protein 1"
                     /note="RAS protein activator like 1 (GAP1 like)"
                     /calculated_mol_wt=89466
     Region          6..126
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          134..254
                     /region_name="C2"
                     /note="C2 domain; cl14603"
                     /db_xref="CDD:472691"
     Region          262..548
                     /region_name="RasGAP_RASAL"
                     /note="Ras-GTPase Activating Domain of RASAL1 and similar
                     proteins; cd05135"
                     /db_xref="CDD:213337"
     Site            order(301,337,339,341..342,344,347,351,462,470..471,
                     474..475,478,499,502..503,506,510,512,519..520)
                     /site_type="other"
                     /note="putative RAS interface [polypeptide binding]"
                     /db_xref="CDD:213337"
     Region          552..689
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          681..709
                     /region_name="BTK"
                     /note="BTK motif; pfam00779"
                     /db_xref="CDD:459937"
     CDS             1..801
                     /gene="Rasal1"
                     /coded_by="NM_001108335.1:244..2649"
                     /db_xref="GeneID:360814"
                     /db_xref="RGD:1311820"
ORIGIN      
        1 maksgslsir vvegralpak dvsgssdpyc lvkvddevva rtatiwrsls pfwgeeytvh
       61 lpldfhhlaf yvldedtvgh ddiigkisls keaitadprg idswinlsrv dpdeevqgev
      121 clavklleda rgrclrchvr qardlaprdi sgtsdpfarv fwgsrslets tikktrfphw
      181 devlelreap gttsplrvel wdwdmvgknd flgmveftpq tlqqkppngw frllpfprae
      241 dsggslgalr lkvrltedrv lpsqyyqplm elllesvqgp aeedttspla lleelasgdc
      301 rqdlatklvk lflgrglagp fldyltrrev artndpntlf rsnslasksm eqfmklvgmr
      361 ylhevlrpvi srvfeekkym eldpskmdln rsrrisfkgt pteeqvrets lglltgylgs
      421 vvdaivssag rcplalrlaf kqlqqcvekr fpgmehqdvk ylatsgflfl rffapailtp
      481 klfdlrdhha dpqtsrslll lakavqsign lgqqlgqgke qwlaplhpfl lqsisrvrdf
      541 ldqlvdvdgd eeaggstcal vqpstivreg fllkrkeepa slatrfafkk ryfrlsgrdl
      601 sysktpewqv hssiplscir avervdegaf qlphvmqvvt qdgtgashtt ylqcknvndl
      661 nqwlsalrka sapnpgklaa chpgafrsgr wtcclqaers avgcsrthsa vtlgdwsdpl
      721 dpdaeaqmvy rqlllgrdql rlklledssl dtapdvdpgk dssavdgpca evlaqqreat
      781 trllqvledl eqaheefqkr g
//
