LOCUS       NM_031574               2518 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus RAS p21 protein activator 3 (Rasa3), mRNA.
ACCESSION   NM_031574 XM_001075225 XM_225020
VERSION     NM_031574.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2518)
  AUTHORS   Nafisi,H., Banihashemi,B., Daigle,M. and Albert,P.R.
  TITLE     GAP1(IP4BP)/RASA3 mediates Galphai-induced inhibition of
            mitogen-activated protein kinase
  JOURNAL   J Biol Chem 283 (51), 35908-35917 (2008)
   PUBMED   18952607
  REMARK    GeneRIF: novel mechanism for dopamine D2S-induced inhibition of
            ERK1/2 and indicate that RASA3 links Galphai proteins to inhibit
            Gq-induced Ras/ERK1/2 activation.
REFERENCE   2  (bases 1 to 2518)
  AUTHORS   El-Daher,S.S., Patel,Y., Siddiqua,A., Hassock,S., Edmunds,S.,
            Maddison,B., Patel,G., Goulding,D., Lupu,F., Wojcikiewicz,R.J. and
            Authi,K.S.
  TITLE     Distinct localization and function of (1,4,5)IP(3) receptor
            subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly
            purified human platelet membranes
  JOURNAL   Blood 95 (11), 3412-3422 (2000)
   PUBMED   10828023
  REMARK    Erratum:[Blood 2000 Sep 1;96(5):1684]
REFERENCE   3  (bases 1 to 2518)
  AUTHORS   Baba,H., Fuss,B., Urano,J., Poullet,P., Watson,J.B., Tamanoi,F. and
            Macklin,W.B.
  TITLE     GapIII, a new brain-enriched member of the GTPase-activating
            protein family
  JOURNAL   J Neurosci Res 41 (6), 846-858 (1995)
   PUBMED   7500386
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D86045.1.
            
            On or before Oct 2, 2006 this sequence version replaced
            XM_225020.4, XM_001075225.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D86045.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132292
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2518
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..2518
                     /gene="Rasa3"
                     /gene_synonym="R-ras gap"
                     /note="RAS p21 protein activator 3"
                     /db_xref="GeneID:29372"
                     /db_xref="RGD:69365"
     exon            1..68
                     /gene="Rasa3"
                     /gene_synonym="R-ras gap"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..2518
                     /gene="Rasa3"
                     /gene_synonym="R-ras gap"
                     /note="R-Ras GTP activating protein; Ins P4-binding
                     protein; R-ras GTPase activating protein; GAP1(IP4BP)"
                     /codon_start=1
                     /product="ras GTPase-activating protein 3"
                     /protein_id="NP_113762.1"
                     /db_xref="GeneID:29372"
                     /db_xref="RGD:69365"
                     /translation="MAVEEEGLRVFQSVRIKIGEAKNLPSYPGPNKMRDCYCTVNLDQ
                     EEVFRTKIVEKSLCPFYGEDFYCEIPRSFRHLSFYIFDRDVFRRDSIIGKVAIQKEDL
                     QRYHNRDTWFQLQHVDADSEVQGKVHLELRLSEVITDTGVVCHKLAARIFECQGLPIV
                     NGQCDPYATVTLAGPFRSEAKKTKVKKKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEE
                     EDVDKLEIRVDLWNASNLKFGDEFLGELRIPLHVLRYASSYEAWYFLQPRDNGSKSVK
                     PDDLGSLRLNVVYTEDHVFSSEYYSPLRDLLLKSADVEPVSASAAHILGEVCRDKQEA
                     AIPLVRLLLHYGRVVPFISAIASAEVKRTQDPNTIFRGNSLTSKCIDETMKLAGMHYL
                     HVTLKPTIEEICQSHKSCEIDPVKLKDGENLENNMESLRQYVDRIFSVITKSGVSCPT
                     VMCDIFFSLREAAAKRFQDDLDVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQT
                     SRTLTLISKTIQTLGSLSKSKSASFKESYMATFYEFFNEQKYADAVKNFLDLISSSGR
                     RDPKSIEQPILLKEGFMIKRAQGRKRFGMKNFKKRWFRLTNHEFTYQKSKGDQPLCNI
                     PIENILAVERLEEESFRMKNMFQVIQPERALYIQANNCVEAKDWIDILTKVSQCNQKR
                     LTVFHPSAYLNGHWLCCRASSDTAIGCTPCTGGLPANIQLDIDGDRETERIYSLFNLY
                     MGKLEKMQEACGSKSVYDGPEQEEYSTFIIDDPQETYRTLKQVIAGVGTLEQEHAQYR
                     RNKFKKTRYGSQEHPIGDKSFQNYIRQQSEISTHSI"
     exon            69..186
                     /gene="Rasa3"
                     /gene_synonym="R-ras gap"
                     /inference="alignment:Splign:2.1.0"
     exon            187..290
                     /gene="Rasa3"
                     /gene_synonym="R-ras gap"
                     /inference="alignment:Splign:2.1.0"
     exon            291..385
                     /gene="Rasa3"
                     /gene_synonym="R-ras gap"
                     /inference="alignment:Splign:2.1.0"
     exon            386..462
                     /gene="Rasa3"
                     /gene_synonym="R-ras gap"
                     /inference="alignment:Splign:2.1.0"
     exon            463..543
                     /gene="Rasa3"
                     /gene_synonym="R-ras gap"
                     /inference="alignment:Splign:2.1.0"
     exon            544..616
                     /gene="Rasa3"
                     /gene_synonym="R-ras gap"
                     /inference="alignment:Splign:2.1.0"
     exon            617..693
                     /gene="Rasa3"
                     /gene_synonym="R-ras gap"
                     /inference="alignment:Splign:2.1.0"
     exon            694..798
                     /gene="Rasa3"
                     /gene_synonym="R-ras gap"
                     /inference="alignment:Splign:2.1.0"
     exon            799..955
                     /gene="Rasa3"
                     /gene_synonym="R-ras gap"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1104
                     /gene="Rasa3"
                     /gene_synonym="R-ras gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1219
                     /gene="Rasa3"
                     /gene_synonym="R-ras gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1294
                     /gene="Rasa3"
                     /gene_synonym="R-ras gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1418
                     /gene="Rasa3"
                     /gene_synonym="R-ras gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1525
                     /gene="Rasa3"
                     /gene_synonym="R-ras gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1603
                     /gene="Rasa3"
                     /gene_synonym="R-ras gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1681
                     /gene="Rasa3"
                     /gene_synonym="R-ras gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1755
                     /gene="Rasa3"
                     /gene_synonym="R-ras gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1862
                     /gene="Rasa3"
                     /gene_synonym="R-ras gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1945
                     /gene="Rasa3"
                     /gene_synonym="R-ras gap"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2154
                     /gene="Rasa3"
                     /gene_synonym="R-ras gap"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2258
                     /gene="Rasa3"
                     /gene_synonym="R-ras gap"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2442
                     /gene="Rasa3"
                     /gene_synonym="R-ras gap"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2518
                     /gene="Rasa3"
                     /gene_synonym="R-ras gap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgacgagc agcatggcgg tggaggaaga gggactgcgg gtcttccaga gcgtgaggat
       61 caagattggt gaagccaaga atctcccttc ctacccgggg ccaaacaaga tgagggactg
      121 ctactgcact gtgaacctgg accaggagga ggttttccgg accaaaatcg tagagaagtc
      181 actctgcccc ttttacggag aggactttta ctgtgaaatt cctcggagtt tccgccacct
      241 gtccttttac atttttgata gagacgtttt ccgaagggat tccatcatag gcaaggtggc
      301 catccagaag gaagacttgc aaaggtacca caacagggac acatggttcc agctccagca
      361 tgtggatgct gactcagagg tgcagggcaa ggtccacctg gagctgagac tgagtgaggt
      421 cattacagac actggtgttg tctgtcacaa actcgctgca cgcatcttcg agtgccaggg
      481 actccccatt gtgaacgggc agtgcgaccc ttacgccacc gtgacattgg ccggaccctt
      541 caggtctgaa gcgaagaaaa ccaaggtgaa gaagaaaacc aacaaccccc agttcgatga
      601 ggtgttttat tttgaggtga ccagaccctg cagctacagc aaaaagtccc acttcgactt
      661 cgaggaggag gacgttgaca aacttgaaat ccgagttgac ctctggaacg ccagcaacct
      721 gaagtttggg gatgagtttc tcggggagtt gaggatccct ctccatgtgc tgcgatacgc
      781 cagttcttac gaagcctggt acttcctcca gccccgagac aatggcagta agagcgtgaa
      841 gccagatgac ttagggtcgc tgaggttaaa tgtagtttac acagaagacc acgtcttctc
      901 ctctgagtac tacagcccac tacgtgacct gttactgaag tctgcggatg tggagcctgt
      961 ctcagcttca gcagcgcaca tcctcgggga ggtgtgcaga gataagcaag aggcagccat
     1021 cccgctggta cggctcctgc tgcactatgg cagggtagtg cccttcatca gtgccatcgc
     1081 tagcgcagag gtgaagagga cccaggaccc caataccatc ttccgaggaa actcactgac
     1141 ctctaagtgc atagatgaga caatgaagct ggcgggcatg cactatctcc acgtgaccct
     1201 gaagcccacc attgaggaga tctgccagag ccataagtcc tgtgagatcg accctgtgaa
     1261 actgaaagat ggcgaaaacc ttgagaacaa catggagagc ctgaggcagt atgtggatcg
     1321 aatattcagt gtcatcacta agtcaggggt gagctgcccc accgtcatgt gtgacatctt
     1381 cttctccctg cgggaggcag ctgccaagcg cttccaagat gacttggatg tgaggtatac
     1441 cgccgtgagc agcttcatct tcctgaggtt cttcgctccc gctatcctgt ccccgaacct
     1501 tttccagctg acgccccacc atacggatcc acagacttct agaaccctga cgcttatctc
     1561 aaagaccatc cagacccttg gcagcttgtc caagtccaag tctgccagtt ttaaggagtc
     1621 atacatggcg acgttctatg aattcttcaa tgagcagaag tatgcagatg ccgtaaagaa
     1681 tttcctggat ttgatctcat cctccgggag aagggacccc aagagcatag agcagcccat
     1741 cctgcttaaa gaaggcttca tgatcaagcg ggcccaagga aggaaacgct ttggaatgaa
     1801 gaatttcaag aagaggtggt ttcgcctcac gaaccacgag ttcacctacc agaaaagcaa
     1861 aggtgatcag ccgctctgca acatccccat cgagaacatc ttggccgtgg agaggttaga
     1921 ggaggagtcc ttccgaatga aaaatatgtt ccaggtcatc cagccagagc gtgcactgta
     1981 catccaggcc aacaactgtg tggaggccaa ggactggatt gacatcctca caaaagtgag
     2041 tcagtgcaac cagaagcggc tcacagtctt ccacccatcg gcctacctga acggccactg
     2101 gctttgctgc agggcctctt cagacaccgc tattggctgc actccctgca ctggtgggct
     2161 cccagcaaac atccagctgg acattgatgg ggaccgtgaa acagagcgca tctactctct
     2221 ctttaacctg tacatgggca agttggaaaa gatgcaggag gcctgcggca gcaagtccgt
     2281 atacgatggc cctgagcagg aggaatactc aacattcatc atcgatgacc cccaggagac
     2341 gtacaggacg ctgaagcagg tcatcgctgg ggtggggacc cttgagcagg agcacgcgca
     2401 gtacaggagg aacaagttca agaagacgag atacgggagc caggagcacc ctattggaga
     2461 caagagcttc cagaactaca tcaggcagca gtctgagatc tcaacccatt ccatttaa
//
