LOCUS       NM_001105724            2556 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus RAS p21 protein activator 2 (Rasa2), mRNA.
ACCESSION   NM_001105724 XM_001065409 XM_343450
VERSION     NM_001105724.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2556)
  AUTHORS   Chen,P.C., Yin,J., Yu,H.W., Yuan,T., Fernandez,M., Yung,C.K.,
            Trinh,Q.M., Peltekova,V.D., Reid,J.G., Tworog-Dube,E., Morgan,M.B.,
            Muzny,D.M., Stein,L., McPherson,J.D., Roberts,A.E., Gibbs,R.A.,
            Neel,B.G. and Kucherlapati,R.
  TITLE     Next-generation sequencing identifies rare variants associated with
            Noonan syndrome
  JOURNAL   Proc Natl Acad Sci U S A 111 (31), 11473-11478 (2014)
   PUBMED   25049390
REFERENCE   2  (bases 1 to 2556)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   3  (bases 1 to 2556)
  AUTHORS   Maekawa,M., Li,S., Iwamatsu,A., Morishita,T., Yokota,K., Imai,Y.,
            Kohsaka,S., Nakamura,S. and Hattori,S.
  TITLE     A novel mammalian Ras GTPase-activating protein which has
            phospholipid-binding and Btk homology regions
  JOURNAL   Mol Cell Biol 14 (10), 6879-6885 (1994)
   PUBMED   7935405
REFERENCE   4  (bases 1 to 2556)
  AUTHORS   Maekawa,M., Nakamura,S. and Hattori,S.
  TITLE     Purification of a novel ras GTPase-activating protein from rat
            brain
  JOURNAL   J Biol Chem 268 (30), 22948-22952 (1993)
   PUBMED   8226805
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473954.2.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_343450.3, XM_001065409.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2556
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..2556
                     /gene="Rasa2"
                     /gene_synonym="GAP1M"
                     /note="RAS p21 protein activator 2"
                     /db_xref="GeneID:25597"
                     /db_xref="RGD:3538"
     exon            1..140
                     /gene="Rasa2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..2554
                     /gene="Rasa2"
                     /gene_synonym="GAP1M"
                     /codon_start=1
                     /product="ras GTPase-activating protein 2"
                     /protein_id="NP_001099194.1"
                     /db_xref="GeneID:25597"
                     /db_xref="RGD:3538"
                     /translation="MAAAAPAAAALTEAPAVPGTAEPETGDEDSREVRVLQSLRGRIY
                     EAKNLLPYLGPNKMRDCFCTINLDQEEVYRTQVVEKSLSPYFSEEFYFEIPRTFQYLS
                     FYVYDKNVLQRDLRIGKVAIKKEDLCSHSGKETWFSLQPIDSNSEVQGKVHLELKLNE
                     LITENGTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSNP
                     QFNEVFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNNENLVQDVFLGEIKVPVN
                     VLRNDSSHQAWYLLQPRDNGNKSSKPDDLGSLLLTLCYTEDYVLPSEYYGPLKALLLK
                     SPDVQPVSASAAYILGEICRDQKDAVLPLVRLLLHHNKLVPFITAVADLDLKDTQDAN
                     AIFRGNSLATQCLTEMMKIVGGHYLKVTLKPVLDEICESSKSCEIDPVKLKEGDNVES
                     NKENLYYYVDKVFSAIVGSSVSCPTVMCDIFYSLRQMAAKRFPNNPHVQYSAVSSFVF
                     LRFFAVAILSPHAFHLRPHYPDTQTVRTLTLISKTIQIIGNWGCQSRRKSRFKKSVMC
                     EFLKMFQEERYFTDVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRAQGRTRIGKKN
                     FKKRWFCLTSKELTYHKQQGKDAIYTIPVKNILAVEKLEESSFNKKNMFQVIHTEKTL
                     YIQANNCVEANEWIDMLCRVSRCNHNRLSSFHPSAYLNGNWLCCQETSEGTPGCKPCT
                     AGIPADIQIDIDEDRETERIYSVFTLSLLKLQKMEEACGSIAVYQGPQKEPGYSKFTI
                     EDSVATFKTIQQIKSTIEKLDEPHEKYRKKRSSSAKYGSKENPIVGKIS"
     exon            141..258
                     /gene="Rasa2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            259..362
                     /gene="Rasa2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            363..457
                     /gene="Rasa2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            458..534
                     /gene="Rasa2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            535..618
                     /gene="Rasa2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            619..691
                     /gene="Rasa2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            692..768
                     /gene="Rasa2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            769..870
                     /gene="Rasa2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1027
                     /gene="Rasa2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1176
                     /gene="Rasa2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1291
                     /gene="Rasa2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1366
                     /gene="Rasa2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1490
                     /gene="Rasa2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1597
                     /gene="Rasa2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1681
                     /gene="Rasa2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1759
                     /gene="Rasa2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1833
                     /gene="Rasa2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1940
                     /gene="Rasa2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2023
                     /gene="Rasa2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2232
                     /gene="Rasa2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2336
                     /gene="Rasa2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2523
                     /gene="Rasa2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
     exon            2524..2556
                     /gene="Rasa2"
                     /gene_synonym="GAP1M"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcggcacc atggcggcgg cagcgcctgc tgcggcggct ttaaccgagg cgccggccgt
       61 cccgggcacc gcagaacccg agacgggaga cgaggacagt cgtgaggtcc gagtgctgca
      121 gagcctgcgc ggcaggatct atgaagcaaa aaatttattg ccatatcttg gacccaacaa
      181 aatgcgggat tgtttctgca ctataaattt ggaccaggaa gaagtttatc gcacccaggt
      241 tgttgaaaag tctttaagtc catatttcag tgaagaattt tattttgaga ttccaagaac
      301 tttccagtat ttgtcatttt atgtttatga taaaaatgtt ttacaaagag atcttcgtat
      361 aggaaaagta gccatcaaaa aagaagactt gtgcagtcat agtggtaaag aaacttggtt
      421 ttcattgcag cctattgact caaattcaga agttcaggga aaagttcacc ttgaattaaa
      481 actgaatgaa ttgataacag aaaatggaac tgtgtgccag cagcttgttg tacacatcaa
      541 ggcatgccac gggttgcctc ttatcaatgg acaaagctgt gatccttacg caacagtttc
      601 cctcgtgggc ccttccagga atgaccaaaa gaagacaaaa gtaaagaaga aaacaagcaa
      661 tccacagttc aatgaagtct tctactttga ggtaaccaga tccagcagtt acaccaggaa
      721 gtcccagttc caggtggagg aggaagacat tgagaagctg gaaatcagga ttgacttgtg
      781 gaataatgaa aacctagttc aagatgtttt cctgggggag attaaggttc ctgtcaatgt
      841 gttaagaaat gattcctctc atcaagcctg gtacttgcta caaccaagag acaatggaaa
      901 caagtcgtct aaacctgatg acctgggatc cctcctgtta actctgtgtt acacagaaga
      961 ctacgtgctc ccatcagagt actatggacc cttgaaagct ttgctgctaa aatcaccaga
     1021 tgttcagcca gtatccgcct cagctgctta tattttgggt gaaatatgtc gagaccagaa
     1081 ggatgccgtt ttgcccctcg tacgactgtt gctgcatcac aataagcttg ttccctttat
     1141 cactgcggtg gctgacctgg acttgaagga tactcaagat gccaacgcaa tatttagagg
     1201 aaactccctg gctacccagt gtctgactga gatgatgaag atagtgggag ggcactacct
     1261 gaaagtcaca ttgaagcctg ttctggatga gatatgtgag tcctcgaaat cctgtgaaat
     1321 agatcctgtt aagttgaaag agggagataa tgtggagagt aataaggaga atctgtacta
     1381 ctatgtggac aaagtattca gtgcgatcgt aggatcaagt gtgagctgtc ccactgtgat
     1441 gtgtgatatt ttttattctc tgagacagat ggctgctaag agatttccta ataaccctca
     1501 tgttcagtac tctgccgtga gcagctttgt gtttcttcgt ttctttgctg tagcgattct
     1561 gtcacctcat gcttttcatt tgcgacctca ttatccagat acacagacag ttaggacttt
     1621 aactctcatc tcaaaaacca ttcagattat tggaaactgg ggatgtcaat ccagaagaaa
     1681 gtcacggttc aaaaagtcag tcatgtgtga atttctcaaa atgtttcaag aagaaaggta
     1741 ttttacagac gtgaaaaagt tcttggatga aatttcgtct acggaaacta aggagtccag
     1801 tggtacgagt gagcctgtgc acctgaaaga aggtgagatg tataaaagag ctcaaggaag
     1861 aacccgtatt ggaaaaaaga acttcaagaa acgatggttc tgcttgacaa gcaaagagct
     1921 cacctaccac aaacagcaag gcaaagatgc aatttacact attccagtaa agaacattct
     1981 tgctgtggaa aaactggaag aaagctcttt caacaagaaa aatatgttcc aagtgatcca
     2041 tacggagaaa acgctgtaca tccaagcgaa taactgtgtg gaagctaatg agtggatcga
     2101 catgctgtgc agggtgagca ggtgcaacca caacaggctc agctccttcc acccgtcagc
     2161 atatctcaac ggaaactggc tctgctgcca ggagaccagt gaaggcacac caggctgcaa
     2221 gccatgcact gcaggcatcc ctgcagacat ccagatagat attgatgaag acagagaaac
     2281 agaaagaatt tactccgttt ttaccctcag tttacttaaa ctgcagaaga tggaagaggc
     2341 ttgtgggtct atagctgtat atcaggggcc acagaaagaa cctggttatt ctaagttcac
     2401 catcgaggat tctgtcgcaa cctttaagac aattcagcaa ataaaaagca ccatagagaa
     2461 actagatgaa cctcatgaga aatacaggaa gaaaagatcg agtagtgcaa aatacggaag
     2521 caaggaaaat ccaattgtgg gaaaaatatc atagtg
//
